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المؤلفون: Rabia Johnson, Ebrahim Samodien, Lawrence Mabasa, Johan Louw, Nireshni Chellan, Carmen Pheiffer, Melisse Erasmus
المصدر: Molecular Metabolism
Molecular Metabolism, Vol 27, Iss, Pp 1-10 (2019)مصطلحات موضوعية: 0301 basic medicine, HFD, high-fat diet, Antioxidant, SOCS-3, suppressor of cytokine signaling-3, medicine.medical_treatment, Metabolic disease, Review, Pharmacology, medicine.disease_cause, 0302 clinical medicine, IR, insulin resistance, 2. Zero hunger, chemistry.chemical_classification, Neurodegeneration, food and beverages, IKκB, inhibitor of nuclear factor kappa-B kinase subunit beta, Neural mitochondrial dysfunction, 3. Good health, TLR4, Toll Like Receptor 4, medicine.symptom, lcsh:Internal medicine, Longevity, Hypothalamus, 030209 endocrinology & metabolism, Inflammation, POMC, pro-opiomelanocortin, NRF2, nuclear factor (erythroid-derived 2)-like 2 factor, STAT-3, signal transducer and activator of transcription 3, ARC, arcuate nucleus, 03 medical and health sciences, ROS, reactive oxygen species, Nutraceutical, Metabolic Diseases, medicine, Animals, Humans, Obesity, lcsh:RC31-1245, BBB, blood-brain-barrier, Molecular Biology, Nutrition, Reactive oxygen species, business.industry, Polyphenols, Cell Biology, PPs, polyphenols, medicine.disease, Diet, Hypothalamic inflammation, 030104 developmental biology, GTE, green tea extract, Mitochondrial biogenesis, chemistry, Dietary Supplements, NFκB, nuclear factor kappa B, SFAs, saturated fatty acids, business, Oxidative stress
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المؤلفون: Michael M. Swarbrick, Sylvia J. Gasparini, Mark S. Cooper, Holger Henneicke, Jingbao Li, Lauryn L. Cavanagh, Hong Zhou, Colette Fong-Yee, Markus J. Seibel, Elisabeth Karsten, Sarah Kim, Daphne Foong, Ruby C.Y. Lin, Joanne Thai
المصدر: Molecular Metabolism, Vol 42, Iss, Pp 101098-(2020)
Molecular Metabolismمصطلحات موضوعية: 0301 basic medicine, Leptin, Aging, STAT3, signal transducer and activator of transcription 3, Glucose uptake, Mice, Obese, Appetite, Adipose tissue, Mice, 0302 clinical medicine, Glucocorticoid, Insulin, OCR, oxygen consumption rate, media_common, Osteoblast, Age Factors, Brain, Osteocyte, Thermogenesis, medicine.anatomical_structure, Adipose Tissue, Hypothalamus, Body Composition, GTT, glucose tolerance test, Female, Original Article, Signal Transduction, medicine.drug, medicine.medical_specialty, lcsh:Internal medicine, TH, tyrosine hydroxylase, media_common.quotation_subject, Mice, Transgenic, 030209 endocrinology & metabolism, Bone and Bones, ARC, arcuate nucleus, 03 medical and health sciences, Insulin resistance, 11β-HSD, 11β-hydroxy-steroid dehydrogenase, Internal medicine, medicine, Animals, Obesity, IGF-1, insulin-like growth factor 1, lcsh:RC31-1245, Glucocorticoids, Molecular Biology, ITT, insulin tolerance test, business.industry, Body Weight, Arcuate Nucleus of Hypothalamus, UCP1, uncoupling protein-1, Cell Biology, medicine.disease, Mice, Inbred C57BL, BAT, brown adipose tissue, Glucose, 030104 developmental biology, Endocrinology, Insulin Resistance, business, PVN, paraventricular nucleus
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المؤلفون: Estefanía P. Bello, Ramiro Alsina, Viviana Florencia Bumaschny, María B. Tavella, Milagros Trotta, José Luis Ferran, Marcelo Rubinstein
المصدر: Molecular Metabolism, Vol 37, Iss, Pp 100985-(2020)
Molecular Metabolism
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICETمصطلحات موضوعية: Leptin, Male, 0301 basic medicine, Pro-Opiomelanocortin, Gene Expression, Mice, Obese, Arc, Arcuate nucleus, Eating, Mice, chemistry.chemical_compound, GABA, 0302 clinical medicine, Dorsomedial hypothalamic nucleus, Glucose homeostasis, Neuropeptide Y, GABAergic Neurons, Neurotransmitter, Arcuate hypothalamic nucleus, GABA, Gamma-aminobutyric acid, GLU, Glutamate, POMC, Proopiomelanocortin, digestive, oral, and skin physiology, purl.org/becyt/ford/3.1 [https], NPY, Neuropeptide Y, Neuropeptide Y receptor, DORSOMEDIAL HYPOTHALAMIC NUCLEUS, OBESITY, GABAergic, purl.org/becyt/ford/3 [https], Female, Original Article, hormones, hormone substitutes, and hormone antagonists, medicine.drug, medicine.medical_specialty, endocrine system, lcsh:Internal medicine, Hypothalamus, TAM, Tamoxifen, 030209 endocrinology & metabolism, In situ hybridization, Energy balance, Biology, ARCUATE HYPOTHALAMIC NUCLEUS, PROOPIOMELANOCORTIN, 03 medical and health sciences, Proopiomelanocortin, Orexigenic, Internal medicine, medicine, Animals, Obesity, lcsh:RC31-1245, Molecular Biology, Body Weight, ENERGY BALANCE, Arcuate Nucleus of Hypothalamus, Cell Biology, DMH, Dorsomedial hypothalamic nucleus, 030104 developmental biology, Endocrinology, Gene Expression Regulation, chemistry, nervous system, PVH, Paraventricular hypothalamic nucleus, biology.protein, Energy Metabolism, LH, Lateral hypothalamic nucleus
وصف الملف: application/pdf
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المؤلفون: Chakera, Ali J., Hurst, Paul S., Spyer, Gill, Ogunnowo-Bada, Emmanuel O., Marsh, William J., Riches, Christine H., Yueh, Chen-Yu, Markkula, S. Pauliina, Dalley, Jeffrey W., Cox, Roger D., Macdonald, Ian A., Amiel, Stephanie A., MacLeod, Kenneth M., Heisler, Lora K., Hattersley, Andrew T., Evans, Mark L.
المساهمون: Dalley, Jeffrey [0000-0002-2282-3660], Evans, Mark [0000-0001-8122-8987], Apollo - University of Cambridge Repository
المصدر: Molecular Metabolism, Vol 17, Iss, Pp 17-27 (2018)
Chakera, A J, Hurst, P S, Spyer, G, Ogunnowo-Bada, E O, Marsh, W J, Riches, C H, Yueh, C Y, Markkula, S P, Dalley, J W, Cox, R D, Macdonald, I A, Amiel, S A, MacLeod, K M, Heisler, L K, Hattersley, A T & Evans, M L 2018, ' Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes ', Molecular Metabolism . https://doi.org/10.1016/j.molmet.2018.08.001
Molecular Metabolismمصطلحات موضوعية: Adult, Blood Glucose, Male, lcsh:Internal medicine, ARC, Arcuate nucleus, Epinephrine, β-cells, HET, Heterozygous, HOM, Homozygous, Mice, Hyperinsulinism, Insulin-Secreting Cells, Glucokinase, Diabetes Mellitus, Animals, Humans, Hypoglycemic Agents, Insulin, Insulin clamp, lcsh:RC31-1245, VMN, Ventromedial hypothalamus, GE, Glucose excited, Mice, Inbred BALB C, SF1, steroidogenic factor 1, Counter-regulation, GI, Glucose inhibited, STZ, Streptozotocin, Middle Aged, Glucagon, Hypoglycemia, GCK, Glucokinase, Disease Models, Animal, Glucose, Glucose Clamp Technique, Original Article, Female, Maturity onset diabetes of young (MODY), WT, Wild type
وصف الملف: application/pdf
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المؤلفون: Henrik Oster, Mareike Bernau, Steffen E. Storck, Claus U. Pietrzik, Riccardo Dore, Alessandro Di Spiezio, Elvira Sonia Sandin, Hendrik Lehnert, Olaf Jöhren, Helge Müller-Fielitz, Walter Mier, Markus Schwaninger
المصدر: Molecular Metabolism, Vol 8, Iss, Pp 13-22 (2018)
Molecular Metabolismمصطلحات موضوعية: Male, 0301 basic medicine, Leptin, HFD, high-fat diet, Endothelial cells, White adipose tissue, CSF, cerebrospinal fluid, Mice, 0302 clinical medicine, CPP, conditioned place preference, BBB, blood–brain barrier, Cells, Cultured, media_common, digestive, oral, and skin physiology, i.p., intraperitoneal, medicine.anatomical_structure, LepR, Blood-Brain Barrier, Blood–brain barrier, Obesity, Reward, Median eminence, qPCR, quantitative polymerase chain reaction, Receptors, Leptin, Original Article, Choroid plexus, medicine.medical_specialty, lcsh:Internal medicine, media_common.quotation_subject, Hyperphagia, Biology, VTA, ventral tegmental area, BC, bottle choice test, Capillary Permeability, ARC, arcuate nucleus, 03 medical and health sciences, PBS, phosphate buffered saline, Internal medicine, medicine, Animals, lcsh:RC31-1245, Molecular Biology, Circumventricular organs, Blood-Nerve Barrier, Leptin receptor, NCD, normal chow diet, Appetite, Cell Biology, 030104 developmental biology, Endocrinology, LepR, leptin receptor, Choroid Plexus, BSA, bovine serum albumin, PFA, paraformaldehyde, 030217 neurology & neurosurgery, DAPI, 4′,6-diamidino-2-phenylindole
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المؤلفون: Dadak, Selma, Beall, Craig, Vlachaki Walker, Julia M., Soutar, Marc P.M., McCrimmon, Rory J., Ashford, Michael L.J.
المصدر: Neuroscience
مصطلحات موضوعية: endocrine system, Neuroscience(all), CPT1, carnitine palmitolytransferase-1, Hypothalamus, ACC, acetyl-CoA carboxylase, GE, glucose-excited, AMP-Activated Protein Kinases, AMP-PNP, 5′-adenylylimidodiphosphate, CSF, cerebrospinal fluid, Article, VMN, ventromedial nucleus, Cell Line, Membrane Potentials, ARC, arcuate nucleus, oleate, Mice, POMC, proopiomelanocortin, Adenosine Triphosphate, KATP Channels, Animals, fatty acid oxidation, Membrane Potential, Mitochondrial, Neurons, AMPK, adenosine 5′-monophophate-activated protein kinase, GI, glucose-inhibited, glucose sensing, Arcuate Nucleus of Hypothalamus, KATP, mitochondria, KATP, ATP-sensitive potassium channel, oleate, Glucose, UCP, uncoupling protein, hormones, hormone substitutes, and hormone antagonists, Oleic Acid
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المصدر: Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 4, Pp 366-373 (2017)مصطلحات موضوعية: 0301 basic medicine, Male, HFD, high-fat diet, MBH, mediobasal hypothalamus, Energy homeostasis, Pomc, proopiomelanocortin, VMN, ventromedial nucleus, Mice, Gliosis, NF-κB, nuclear factor kappa B, RER, respiratory exchange ratio, Cells, Cultured, 2. Zero hunger, Bdnf, brain-derived neurotrophic factor, Cart, cocaine- and amphetamine-regulated transcript, TMX, tamoxifen, digestive, oral, and skin physiology, NF-kappa B, food and beverages, 3. Good health, I-kappa B Kinase, medicine.anatomical_structure, GTT, glucose tolerance test, LPS, lipopolysaccharide, Tumor necrosis factor alpha, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, IHC, immunohistochemistry, Astrocyte, Signal Transduction, Ccl2, C–C motif chemokine ligand 2, lcsh:Internal medicine, medicine.medical_specialty, Hypothalamus, Inflammation, Il, interleukin, CCL2, Biology, Brief Communication, Diet, High-Fat, Cocaine and amphetamine regulated transcript, ir, immunoreactivity, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, ARC, arcuate nucleus, Internal medicine, medicine, Animals, Obesity, lcsh:RC31-1245, Molecular Biology, Agrp, Agouti-related peptide, ITT, insulin tolerance test, Npy, neuropeptide Y, Brain-derived neurotrophic factor, Iba1, ionized calcium binding adaptor molecule 1, Tnfa, tumor necrosis factor α, DMH, dorsomedial hypothalamus, GFAP, glial fibrillary acidic protein, nutritional and metabolic diseases, Cell Biology, DIO, diet-induced obesity, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Metabolism, Astrocytes, Agouti-related peptide, IKKβ, inhibitor of kappa B kinase beta
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المؤلفون: Deborah J. Clegg, Ammy M. Santiago, Vanessa H. Routh
المصدر: Molecular Metabolism, Vol 5, Iss 10, Pp 823-833 (2016)
Molecular Metabolismمصطلحات موضوعية: 0301 basic medicine, ER, estrogen receptor, AMP-activated kinase, Estrogen receptor, Energy homeostasis, AICAR, aminoimidazole-4-carboxamide-1-β-d-ribofuranoside, PVDF, polyvinylidene difluoride, 0302 clinical medicine, AMP-activated protein kinase, Glucose homeostasis, HRP, horse radish peroxidase, Arc (protein), GI, glucose-inhibited, IR, input resistance, VMN, ventromedial hypothalamic nucleus, NGS, non-glucose sensing, CC, compound C, Glucose excited neurons, 17βE, 17β-estradiol, Original Article, VL-VMN, ventrolateral VMN, medicine.medical_specialty, lcsh:Internal medicine, Vm, membrane potential, Glucose inhibited neurons, GE, glucose-excited, POMC, pro-opiomelanocortin, Biology, PHTPP, phenyltrifluoromethylpyrazolophenol, 03 medical and health sciences, Sexual dimorphism, ARC, arcuate nucleus, Arcuate nucleus, Internal medicine, medicine, TTX, tetrodotoxin, lcsh:RC31-1245, Molecular Biology, VMH, ventromedial hypothalamus, 17β-estradiol, Cell Biology, SF-1, steroidogenic factor, Electrophysiology, AMPK, AMP-activated protein kinase, 030104 developmental biology, Endocrinology, Ventromedial hypothalamic nucleus, biology.protein, MPP, methylphenolpyrazole, GABA, γ-aminobutyric acid, 030217 neurology & neurosurgery, BSA-17βE, bovine serum albumin-conjugated 17βE, Hormone
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المؤلفون: Miguel López
المصدر: Molecular Metabolism
Molecular Metabolism, Vol 8, Iss C, Pp 211-213 (2018)مصطلحات موضوعية: Leptin, endocrine system, lcsh:Internal medicine, Pro-Opiomelanocortin, PSNA, parasympathetic nerve activity, STAT3, signal transducer and activator of transcription 3, SNA, parasympathetic nerve activity, Autonomic regulation, POMC, proopiomelanocortin, HFD, high fat diet, Autonomic nervous system, Medicine, Autonomic Pathways, lcsh:RC31-1245, MC3/4R, melanocortin 3 or 4 receptor, Molecular Biology, GFP, green fluorescent protein, Melanocortins, Neurons, ICV, intracerebroventricular, PI3K, phosphatidylinositol-3 kinase, AgRP, agouti-related peptide, business.industry, digestive, oral, and skin physiology, Cardiovascular regulation, WAT, white adipose tissue, Cell Biology, ARC, arcuate nucleus of the hypothalamus, BAT, brown adipose tissue, nervous system, LepR, leptin receptor, Commentary, α–MSH, α–melanocyte-stimulating hormone, Original Article, Energy homeostasis, Melanocortin, business, GABA, γ-aminobutyric acid, PRV, pseudorabies virus, Neuroscience, hormones, hormone substitutes, and hormone antagonists
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المؤلفون: Paul T. Pfluger, Sonja C. Schriever, Katrin Pfuhlmann, Luke Harrison
المصدر: Mol. Metab. 24, 149-155 (2019)
Molecular Metabolismمصطلحات موضوعية: 0301 basic medicine, Male, Weight loss, HFD, high-fat diet, ARC, Arcuate nucleus, RG, reactive gliosis, Mice, 0302 clinical medicine, EX4, exendin-4, Gliosis, Glial fibrillary acidic protein, biology, Chemistry, NEFA, non-esterified fatty acid, Microfilament Proteins, Astrogliosis, medicine.anatomical_structure, Hypothalamus, Reactive Gliosis, Obesity, Astrocyte, Weight Loss, Inflammation, medicine.symptom, Iba1, ionized calcium-binding adapter molecule 1, Agonist, medicine.medical_specialty, medicine.drug_class, HC, diet switch, Calorie restriction, AgRP, agouti related neuropeptide, 030209 endocrinology & metabolism, Brief Communication, CNS, central nervous system, 03 medical and health sciences, POMC, proopiomelanocortin, Internal medicine, Glial Fibrillary Acidic Protein, medicine, CR, calorie restriction, Animals, Molecular Biology, Caloric Restriction, FA, fatty acid, Calcium-Binding Proteins, GFAP, glial fibrillary acidic protein, Arcuate Nucleus of Hypothalamus, Cell Biology, DIO, diet-induced obesity, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Astrocytes, biology.protein, Exenatide, Anti-Obesity Agents, Reactive gliosis
وصف الملف: application/pdf
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المؤلفون: John Y.L. Chiang, Jessica M. Ferrell
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 2, Pp 113-122 (2015)مصطلحات موضوعية: CRY, cryptochrome, FEO, food entrainable oscillator, TGR5, G protein-coupled bile acid receptor, Disease, Type 2 diabetes, Review, Shift work, SHP, small heterodimer partner, NAD+, nicotinamide adenine dinucleotide, LDL, low-density lipoprotein, CYPs, cytochrome P450 enzymes, HLF, hepatic leukemia factor, BMAL1, brain and muscle ARNT-like 1, HIP, hypoxia inducing protein, General Pharmacology, Toxicology and Pharmaceutics, RORα, retinoid-related orphan receptor α, FOXO3, forkhead box O3, RHT, retinohypothalamic tract, Circadian rhythm, CLOCK, circadian locomotor output cycles kaput, GLUT2, glucose transporter 2, Sleep in non-human animals, Metabolic syndrome, RORE, ROR-response element, Liver, CAR, constitutive androstane receptor, E-box, enhance box, medicine.medical_specialty, SIRT1, sirtuin 1, DBP, D-site binding protein, PER, period, TEF, thyrotroph embryonic factor, ARC, arcuate nucleus, Internal medicine, LRH1, liver receptor homolog 1, medicine, FXR, farnesoid-X receptor, SCN, suprachiasmatic nucleus, business.industry, lcsh:RM1-950, HDAC3, histone deacetylase 3, EMT, emergency medical technician, FASPS, familial advanced sleep-phase syndrome, medicine.disease, CYP7A1, cholesterol 7α-hydroxylase, Obesity, lcsh:Therapeutics. Pharmacology, Endocrinology, TTFL, transcriptional translational feedback loop, FAA, food anticipatory activity, business, Dyslipidemia
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المؤلفون: Diana L, Williams, Nicole A, Lilly, Ian J, Edwards, Pallas, Yao, James E, Richards, Stefan, Trapp
المصدر: Neuropharmacology
مصطلحات موضوعية: Male, Patch-Clamp Techniques, NTS, nucleus of the solitary tract, BNST, CeA, central amygdaloid nucleus, PB, phosphate buffer, SHi, septohippocampal nucleus, Preproglucagon, Proglucagon, LS, lateral septum, MPA, medial preoptic area, Membrane Potentials, MS, medial septum, Eating, Mice, AAV, adeno-associated virus, HFD, high fat diet, Glucagon-Like Peptide 1, Food intake, NAc, nucleus accumbens, Ex9, exendin (9-39), digestive, oral, and skin physiology, MeA, medial amygdaloid nucleus, GLP-1, glucagon-like peptide-1, 3V, third ventricle, Electrophysiology, GLP-1R, GLP-1 receptor, opt, optic tract, Pir, piriform cortex, VMN, ventromedial nucleus of the hypothalamus, MnPO, median preoptic nucleus, Channelrhodopsin, PPG, Glucagon-like peptide-1 receptor, MM, medial mammillary nucleus, hormones, hormone substitutes, and hormone antagonists, endocrine system, VP, ventral pallidum, Mice, Transgenic, Stress, PPG, preproglucagon, VTA, ventral tegmental area, Article, Quinoxalines, Animals, Arc, arcuate nucleus, ME, median eminence, TTX, tetrodotoxin, BNST, bed nucleus of the stria terminalis, Analysis of Variance, Dose-Response Relationship, Drug, DMH, dorsomedial hypothalamus, Peptide Fragments, Mice, Inbred C57BL, Luminescent Proteins, ACSF, artificial cerebrospinal fluid, LV, lateral ventricle, Septal Nuclei, PFA, paraformaldehyde, Excitatory Amino Acid Antagonists, Stress, Psychological, PVN, paraventricular nucleus
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المؤلفون: Joel K. Elmquist, Christina A. Mosher, Jeffrey M. Zigman, Tiemin Liu, Sherri Osborne-Lawrence, Eric D. Berglund, Qian Wang, Brittany L. Mason, Aki Uchida, Angela K. Walker, Chen Liu, Jen Chieh Chuang
المصدر: Molecular Metabolism
مصطلحات موضوعية: Phox2b, paired-like homeobox 2b, AgRP, Agouti-related peptide, Pepck, phosphoenolpyruvate carboxykinase, 0302 clinical medicine, Food intake, GHRH, Growth-hormone-releasing hormone, NAc, nucleus accumbens, GHSR, growth hormone secretagogue receptor, ghrelin receptor, 0303 health sciences, Ghrelin receptor, digestive, oral, and skin physiology, DG, dentate gyrus, Growth hormone–releasing hormone, Neuropeptide Y receptor, Ghrelin O-acyltransferase, Ghrelin, VGAT, vesicular GABA transporter, hormones, hormone substitutes, and hormone antagonists, Hnf4α, hepatocyte nuclear factor 4α, medicine.drug, medicine.medical_specialty, NPY, neuropeptide Y, POMC, pro-opiomelanocortin, Biology, Brief Communication, CNS, central nervous system, Glucagon, VTA, ventral tegmental area, Blood glucose homeostasis, 03 medical and health sciences, ARC, arcuate nucleus, Arcuate nucleus, Internal medicine, Orexigenic, medicine, Molecular Biology, 030304 developmental biology, Pcx, pyruvate carboxylase, Cell Biology, Foxo1, Forkhead box protein O1, Endocrinology, nervous system, GABA, gamma-aminobutyric acid, BAC, bacterial artificial chromosome, GOAT, ghrelin O-acyltransferase, AgRP, Agouti-related peptide, DVC, dorsal vagal complex, 030217 neurology & neurosurgery, G6p, glucose-6 phosphatase
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المؤلفون: Jean-Marie Launay, Yves Rouillé, Patty Chen, Marc Foretz, Christophe Magnan, Ralf Jockers, Koichiro Ozawa, Stéphanie Migrenne, Jacques Mallet, Toru Hosoi, Clara Roujeau, Virginie Vauthier, Chamsy Sarkis, Julie Dam
المساهمون: Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Génétique moléculaire de la neurotransmission et des processus neurodégénératifs (LGMNPN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hiroshima University, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université Paris Descartes - Paris 5 (UPD5), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Génétique moléculaire de la neurotransmission et des processus neurodégénératifs ( LGMNPN ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Biologie Fonctionnelle et Adaptative ( BFA ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre d’Infection et d’Immunité de Lille (CIIL) - U1019 - UMR 8204 ( CIIL ), Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR142-Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Université Paris Descartes - Paris 5 ( UPD5 ), HAL UPMC, Gestionnaire
المصدر: Molecular metabolism
Molecular metabolism, Elsevier, 2017, 6 (1), pp.159-172. ⟨10.1016/j.molmet.2016.10.009⟩
Molecular metabolism, 2017, 6 (1), pp.159-172. ⟨10.1016/j.molmet.2016.10.009⟩
Molecular metabolism, Elsevier, 2017, 6 (1), pp.159-172. 〈10.1016/j.molmet.2016.10.009〉
Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 1, Pp 159-172 (2017)مصطلحات موضوعية: Leptin, Male, 0301 basic medicine, OB-RGRP/Endospanin1, ip, intraperitoneal, medicine.medical_treatment, Mice, Obese, Mice, 0302 clinical medicine, HFD, high fat diet, Homeostasis, Glucose homeostasis, Insulin, Receptor, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Glucose tolerance test, Arc (protein), medicine.diagnostic_test, BW, body weight, LIF, leukemia inhibitory factor, Diabetes, Intracellular Signaling Peptides and Proteins, [ SDV.MHEP.EM ] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Leptin receptor, Receptors, Leptin, GTT, glucose tolerance test, Original Article, Signal Transduction, STAT3 Transcription Factor, lcsh:Internal medicine, medicine.medical_specialty, Hypothalamus, T2D, type 2 diabetes, Biology, Diet, High-Fat, ARC, arcuate nucleus, 03 medical and health sciences, Internal medicine, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, medicine, Animals, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Obesity, lcsh:RC31-1245, Endo1, Endospanin1, Molecular Biology, [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology, PI3K/AKT/mTOR pathway, PLA, proximity ligation assay, Body Weight, Arcuate Nucleus of Hypothalamus, DIO, diet-induced obesity, Cell Biology, OBR, leptin receptor, Mice, Inbred C57BL, Glucose, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, CD, chow diet, Carrier Proteins, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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المؤلفون: Zhiping P. Pang, Weiping Han
المصدر: Bioscience Reports
Bioscience Reports, Vol 32, Iss 5 (2012)مصطلحات موضوعية: cognition, Central Nervous System, Leptin, STAT3, signal transducer and activator of transcription 3, lcsh:Life, lcsh:QR1-502, Review Article, Biochemistry, Synaptic Transmission, lcsh:Microbiology, NMDAR, NMDA receptor, LTP, long-term potentiation, Postsynaptic potential, MSH, melanocyte stimulating hormone, Homeostasis, Insulin, NAc, nucleus accumbens, JAK2, Janus kinase 2, AgRP, agouti-related peptide, Neuronal Plasticity, diabetes, neurodegeneration, DA, dopaminergic, PBN, parabrachial nucleus, Ghrelin, LepRb, leptin receptor long isoform, medicine.anatomical_structure, Hypothalamus, IR, insulin receptor, neural circuitry, GHSR, growth hormone secretagogue receptor, MC3R, melanocortin 3 receptor, NMDA receptor, KA, kainic acid, GABAA, γ-aminobutyric acid A, PI3K, phosphoinositide 3-kinase, medicine.medical_specialty, LTD, long-term depression, energy homoeostasis, TH, tyrosine hydroxylase, Central nervous system, hormone, Biophysics, NPY, neuropeptide Y, Endocrine System, AMPA receptor, POMC, pro-opiomelanocortin, Biology, Neurotransmission, CNS, central nervous system, VTA, ventral tegmental area, Receptors, N-Methyl-D-Aspartate, S4, ARC, arcuate nucleus, Receptors, GABA, Internal medicine, Neuroplasticity, medicine, Animals, Humans, Receptors, AMPA, Molecular Biology, GluR, glutamate receptor, AMPAR, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor, NMDA, N-methyl-D-aspartate, IPSC, inhibitory postsynaptic current, VMH, ventromedial hypothalamus, Cell Biology, LHA, lateral hypothalamic area, Axons, Hormones, EPSC, excitatory postsynaptic current, lcsh:QH501-531, Endocrinology, MC, melanocortin, Synaptic plasticity, Synapses, Energy Metabolism, Neuroscience, GABA, γ-aminobutyric acid, MAPK, mitogen-activated protein kinase
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المؤلفون: Marc Claret, Agharul I. Choudhury, Mark A. Smith, Kazunari Hisadome, Michael L.J. Ashford, Dominic J. Withers
المصدر: Neuroscience
مصطلحات موضوعية: Patch-Clamp Techniques, Potassium Channels, Pro-Opiomelanocortin, Time Factors, K+ channel, 8-OH-DPAT, 8-hydroxy-2-(di-n-propylamino) tetralin, 5-HT, Action Potentials, 5-HT1F receptor, Mice, chemistry.chemical_compound, 0302 clinical medicine, Agouti-Related Protein, Neuropeptide Y, hypothalamus, α-me 5-HT, α-methyl 5-HT, Neurotransmitter, GFP, green fluorescent protein, Neurons, α-MSH, alpha-melanocyte stimulating hormone, 0303 health sciences, education.field_of_study, ΔVm, change in membrane potential, General Neuroscience, POMC, Hyperpolarization (biology), Neuropeptide Y receptor, medicine.anatomical_structure, Serotonin Antagonists, Melanocortin, TEA, tetraethylammonium chloride, Serotonin, Neuroscience(all), Green Fluorescent Proteins, Population, NPY, neuropeptide Y, RIPCre, Mice, Transgenic, In Vitro Techniques, Biology, Biophysical Phenomena, AgRP, agouti-related protein, ARC, arcuate nucleus, 03 medical and health sciences, POMC, proopiomelanocortin, Central melanocortin system, Proopiomelanocortin, Potassium Channel Blockers, medicine, Animals, RIPCre, rat insulin 2 promoter Cre recombinase transgene, TTX, tetrodotoxin, 5-CT, 5-carboxamidotryptamine, education, 030304 developmental biology, Integrases, Arcuate Nucleus of Hypothalamus, Neural Inhibition, PBG, 1-phenylbiguanide, LHA, lateral hypothalamic area, Electric Stimulation, Rats, nervous system, chemistry, Cellular Neuroscience, Insulin Receptor Substrate Proteins, biology.protein, Neuron, Neuroscience, 030217 neurology & neurosurgery, PVN, paraventricular nucleus
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17
المؤلفون: Sara G. Vienberg, C. Ronald Kahn, André Kleinridders, Ryo Suzuki
المصدر: Molecular Metabolism
مصطلحات موضوعية: medicine.medical_specialty, Very low-density lipoprotein, Angptl4, Low-density lipoprotein receptor-related protein 8, Angptl4, angiopoietin-like 4, media_common.quotation_subject, POMC, pro-opiomelanocortin, Brief Communication, CNS, central nervous system, STZ, streptozotocin, Angiopoietin, AgRP, agouti-related protein, 03 medical and health sciences, chemistry.chemical_compound, ARC, arcuate nucleus, 0302 clinical medicine, ANGPTL4, Internal medicine, FFA, free fatty acid, medicine, Molecular Biology, 030304 developmental biology, media_common, 2. Zero hunger, 0303 health sciences, Lipoprotein lipase, Triglyceride, TG, triglyceride, Chemistry, digestive, oral, and skin physiology, nutritional and metabolic diseases, Appetite, Lipid metabolism, Cell Biology, Endocrinology, LPL, lipoprotein lipase, NPY, neuropeptide-Y, Biochemistry, CART, cocaine-and-amphetamine-regulated transcript, lipids (amino acids, peptides, and proteins), 030217 neurology & neurosurgery
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18
المصدر: ASN NEURO
ASN Neuro, Vol 5 (2013)مصطلحات موضوعية: ROCK, Rho-associated kinase, RHOA, Pro-Opiomelanocortin, Inflammasomes, Adipose tissue, Mice, MYPT1, myosin phosphatase target subunit 1, cardiovascular disease, Neuropeptide Y, pathophysiology, biology, General Neuroscience, HRP, horseradish peroxidase, VAT, visceral adipose tissue, Inflammasome, S11, NLRP3, NOD-like receptor family, pyrin domain containing 3, STAT, signal transducer and activator of transcription, Adipose Tissue, DAMPS, damage–associated molecular pattern molecules, Receptors, Leptin, Female, Signal transduction, medicine.symptom, JAK, Janus kinase, signal transduction, medicine.drug, Research Article, STAT3 Transcription Factor, medicine.medical_specialty, Hypothalamus, NPY, neuropeptide Y, Adipokine, Inflammation, ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD, q.v.), S8, CVD, cardiovascular disease, S3, CNS, central nervous system, IACUC, Institutional Animal Care and Use Committee, lcsh:RC321-571, ARC, arcuate nucleus, SCI, spinal cord injury, POMC, proopiomelanocortin, Internal medicine, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, neuroendocrine, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Pancreas, Spinal Cord Injuries, Leptin receptor, Myocardium, Janus Kinase 2, RBD, Rho-binding domain, spinal cord injury, IL, interleukin, Mice, Inbred C57BL, Endocrinology, biology.protein, Neurology (clinical), PFA, paraformaldehyde, Janus kinase, Carrier Proteins, rhoA GTP-Binding Protein, metabolism, FAO, fatty acid oxidation, PVN, paraventricular nucleus