المؤلفون: Peng Chang, Yingying Guo, Dan Chen, Ke Li, Wei Wang, Zhihua Yang, Jingwen Ma, Yun Zeng, Wenhua Zhan, Yonghua Zhan

المصدر: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-21 (2024)

مصطلحات موضوعية: AQ4N, Hypoxia, High-temperature photothermal therapy, Real-time monitoring, Drug resistance, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1477-3155

URL الوصول: https://doaj.org/article/9e306146af1c4c8487aea20ac3f08632

المؤلفون: Zhao XZ, Zhang W, Cao Y, Huang SS, Li YZ, Guo D, Wang XY, Ran HT

المصدر: International Journal of Nanomedicine, Vol Volume 15, Pp 3953-3964 (2020)

مصطلحات موضوعية: lifu, sdt, hmme, aq4n, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: https://www.dovepress.com/a-cleverly-designed-novel-lipid-nanosystem-targeted-retention-controll-peer-reviewed-article-IJN; https://doaj.org/toc/1178-2013

URL الوصول: https://doaj.org/article/a2c58a926dd846398ac96a3603d3717c

المؤلفون: Yue Li, Long Zhao, Xiao-Feng Li

المصدر: Frontiers in Oncology, Vol 11 (2021)

مصطلحات موضوعية: hypoxia, hypoxia-activated prodrugs, tirapazamine, AQ4N, PR-104, EO9, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.700407/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/1b7853fad6d64ad484fc31a37d9046ed

المصدر: A Phase 1/2, Open Label, Dose Escalation Study of AQ4N for Safety, Tolerability, Pharmacokinetics and Activity in Patients With Lymphoid Neoplasms

المصدر: A Phase 1, Open-Label, Dose-Escalation Study of AQ4N Administered Intravenously in Patients With Advanced Malignancies

المؤلفون: Zhonggui He, Yixin Sun, Gang Wang, Linlin Cao, Yang Wang, Qikun Jiang, Jin Sun, Dongyang Zhao

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1382-1396 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: HIF-1α, hypoxia-inducible factor-1α, H2O, water, 3O2, molecular oxygen, medicine.medical_treatment, Photodynamic therapy, Review, MDR1, multidrug resistance 1, 0302 clinical medicine, DC, dendritic cells, polycyclic compounds, General Pharmacology, Toxicology and Pharmaceutics, Hypoxia, Cancer, 0303 health sciences, Oxygen supply, Ce6, chlorin e6, DDS, drug delivery system, CeO2, cerium oxide, HIF, hypoxia-inducible factor, PDT, photodynamic therapy, H2O2, hydrogen peroxide, 030220 oncology & carcinogenesis, APCs, antigen-presenting cells, medicine.symptom, therapeutics, PFC, perfluorocarbon, PS, photosensitizers, PFH, perfluoroethane, Tumor cells, NMR - Nuclear magnetic resonance, TAM, tumor-associated macrophages, 03 medical and health sciences, ROS, reactive oxygen species, AQ4N, banoxantrone, O2.−, superoxide anion, medicine, NMR, nuclear magnetic resonance, EPR, enhanced permeability and retention, MB, methylene blue, CaO2, calcium dioxide, 030304 developmental biology, Tumor hypoxia, OH., hydroxyl radical, business.industry, lcsh:RM1-950, Mn-CDs, magnetofluorescent manganese-carbon dots, Nanomedicine delivery systems, Hypoxia (medical), Hb - Hemoglobin, DOX, doxorubicin, eye diseases, Oxygen, FDA, U.S. Food and Drug Administration, MDSC, myeloid derived suppressive cells, lcsh:Therapeutics. Pharmacology, TPZ, tirapazamine, RBCs, red blood cells, Cancer research, MnO2, manganese dioxide, business, H2O2 - Hydrogen peroxide, HSA, human serum albumin, Hb, hemoglobin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55dbc5e9669afc312da6e54f6cee2e96
https://doi.org/10.1016/j.apsb.2020.01.004

المؤلفون: Wei Zhang, Xingyue Wang, Dan Guo, Yi-Zhen Li, Yang Cao, Shuai-Shuai Huang, Haitao Ran, Xiang-Zhi Zhao

المصدر: International Journal of Nanomedicine

مصطلحات موضوعية: Cell, Biophysics, Contrast Media, Mice, Nude, Pharmaceutical Science, Breast Neoplasms, Bioengineering, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Theranostic Nanomedicine, Biomaterials, Mammary carcinoma, Drug Delivery Systems, International Journal of Nanomedicine, Cell Line, Tumor, HMME, Drug Discovery, medicine, Animals, Humans, Lipid bilayer, Cytotoxicity, Ultrasonography, Interventional, SDT, Original Research, LIFU, Liposome, AQ4N, Chemistry, Organic Chemistry, Sonodynamic therapy, General Medicine, 021001 nanoscience & nanotechnology, Lipids, In vitro, 0104 chemical sciences, Drug Liberation, Hematoporphyrins, medicine.anatomical_structure, Liposomes, Drug delivery, Nanoparticles, Female, Rabbits, Corrigendum, 0210 nano-technology, Oligopeptides, Biomedical engineering

وصف الملف: text/html

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e027053c9d938a3f368fccdeba88a44
http://europepmc.org/articles/PMC7280061

المؤلفون: Williams, K.J., Albertella, M.R., Fitzpatrick, B., Loadman, Paul, Shnyder, Steven, Chinje, E.C., Telfer, B.A., Dunk, C.R., Harris, P.A., Stratford, I.J.

مصطلحات موضوعية: REF 2014, Xenograft, Hypoxia, Pro-drug, Pre-clinical, AQ4N radio/chemotherapy, Anti-tumor therapy, Experimental tumors, AQ4N

الاتاحة: http://hdl.handle.net/10454/4561

المؤلفون: Djidja, M-C., Francese, S., Claude, E., Loadman, Paul, Sutton, Chris W., Shnyder, Steven, Cooper, Patricia A., Patterson, Laurence H., Carolan, V.A., Clench, M.R.

مصطلحات موضوعية: Hypoxia, MALDI, Ion mobility, Mass spectrometry imaging, AQ4N

الاتاحة: http://hdl.handle.net/10454/9533

المؤلفون: Sarah Storr, Andrew R. Green, Stewart G. Martin, Smarakan Sneha, Klaus Pors, Radhika Aiyappa, Simon C. Baker

المصدر: Biomedicines
Biomedicines, Vol 9, Iss 290, p 290 (2021)

مصطلحات موضوعية: Cell signaling, CYP1B1, CYP1A1, duocarmycin, Medicine (miscellaneous), Cytochrome P450, Review, Bioinformatics, General Biochemistry, Genetics and Molecular Biology, Breast cancer, Therapeutic index, breast cancer, medicine, lcsh:QH301-705.5, bioprecursor, biology, AQ4N, business.industry, medicine.disease, CYP2W1, phortress, lcsh:Biology (General), biology.protein, prodrug, business, Drug metabolism, Hormone

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document; PDF

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632c9132d62bf55dcb28015d26fbaf58
https://pubmed.ncbi.nlm.nih.gov/33809117

المؤلفون: Steward, W.P., Middleton, M., Benghiat, A., Loadman, Paul, Hayward, C., Walter, S., Ford, S., Halbert, G., Patterson, Laurence H., Talbot, D.

مصطلحات موضوعية: AQ4N, Bioreductive, Pharmacodynamics, Pharmacokinetics, Phase I study

الاتاحة: http://hdl.handle.net/10454/3982

المؤلفون: Albertella, M.R., Loadman, Paul, Jones, P.H., Phillips, Roger M., Rampling, R., Burnet, N., Alcock, C., Anthoney, Alan, Vjaters, E., Dunk, C.R., Harris, P.A., Wong, A., Lalani, A.S., Twelves, Christopher J.

مصطلحات موضوعية: REF 2014, Hypoxia, Bioreductive prodrug, Topoisomerase II inhibitor, Pharmacodynamics, Tumor-targeting, AQ4N

الاتاحة: http://hdl.handle.net/10454/4535

المؤلفون: Roger M. Phillips

المصدر: Cancer Chemotherapy and Pharmacology

مصطلحات موضوعية: 0301 basic medicine, PR-104, TH-4000, Cancer Research, RM, EO9, Bioreductive drugs, medicine.medical_treatment, Antineoplastic Agents, Review Article, Biology, Pharmacology, Toxicology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Delivery Systems, Neoplasms, medicine, Tumor Microenvironment, Cytotoxic T cell, Animals, Humans, Pharmacology (medical), Prodrugs, Hypoxia, TH-302, chemistry.chemical_classification, Chemotherapy, Tumor microenvironment, Hypoxia-activated prodrugs, AQ4N, Prodrug, Hypoxia (medical), Cell Hypoxia, Radiation therapy, Oxygen, 030104 developmental biology, Enzyme, Oncology, chemistry, 030220 oncology & carcinogenesis, Drug Design, medicine.symptom, Tirapazamine, Oxidoreductases

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc65b09df4a911605216c6b945fe936c
https://eprints.hud.ac.uk/id/eprint/26511/12/PhillipsFiguresMaintext.pdf

المؤلفون: Stephanie R. McKeown, Margaret Murray, R Gallagher, O P Friery, David G. Hirst, Irene McIntyre, Ciara Hughes, ES Galligan, Laurence H. Patterson

المصدر: British Journal of Cancer

مصطلحات موضوعية: Male, Cancer Research, Cyclophosphamide, medicine.medical_treatment, Anthraquinones, Antineoplastic Agents, Mice, Inbred Strains, Pharmacology, chemistry.chemical_compound, Mice, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Prodrugs, Chemotherapy, Mice, Inbred C3H, tirapazamine, AQ4N, Triazines, Mammary Neoplasms, Experimental, Regular Article, Drug Synergism, Drug interaction, Nitrogen mustard, cyclophosphamide, anti-tumour effect, medicine.anatomical_structure, Cell killing, Oncology, chemistry, Toxicity, Female, Bone marrow, Tirapazamine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6015e8ec5be415ffc5574cf053e9debf
http://europepmc.org/articles/PMC2363362

المؤلفون: Stephanie R. McKeown, Laurence H. Patterson

المصدر: British Journal of Cancer

مصطلحات موضوعية: Cancer Research, topoisomerase II, medicine.medical_treatment, Anthraquinones, Antineoplastic Agents, Radiation-Protective Agents, Pharmacology, Biology, bioreductive, In vivo, Neoplasms, medicine, Bystander effect, Animals, Humans, Prodrugs, Chemotherapy, AQ4N, Neoplasms, Experimental, Cell cycle, Prodrug, Mini-review, Cell Hypoxia, in vivo, Oncology, Mechanism of action, Enzyme inhibitor, biology.protein, medicine.symptom, Topoisomerase-II Inhibitor, prodrug, Tirapazamine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f538a5ca4ec28571e3f0b2a5358d03
http://europepmc.org/articles/PMC2363465

المؤلفون: Denny, William

مصطلحات موضوعية: banoxantrone (AQ4N), bioreduction, cancer therapy, hypoxia-activated prodrug, PR-104, TH-302, tiropazamine, DINITROBENZAMIDE MUSTARD PR-104A, POSITRON-EMISSION-TOMOGRAPHY, DNA CROSS-LINKING, II MARKER LESION, CELL LUNG-CANCER, N-OXIDE PRODRUG, TUMOR-CELLS, EXTRAVASCULAR TRANSPORT, ANTITUMOR AGENTS, SOLID TUMORS

وصف الملف: application/pdf

Relation: Future Oncology; Future Oncology 6(3):419-428 Mar 2010; http://hdl.handle.net/2292/9243

الاتاحة: http://hdl.handle.net/2292/9243
https://doi.org/10.2217/FON.10.1

المؤلفون: Atkinson, S.J., Loadman, Paul, Sutton, Chris W., Patterson, Laurence H., Clench, M.R.

مصطلحات موضوعية: Mass spectrometry, AQ4N, Bioreductive prodrug, Anti-tumor activity, Chemotherapy, MALDI-MSI

الاتاحة: http://hdl.handle.net/10454/4572

المؤلفون: L H, Patterson, S R, McKeown, K, Ruparelia, J A, Double, M C, Bibby, S, Cole, I J, Stratford

المصدر: British Journal of Cancer

مصطلحات موضوعية: Male, AQ4N, thiotepa, cisplatin, Anthraquinones, Antineoplastic Agents, Drug Synergism, Mice, Inbred Strains, Regular Article, Neoplasms, Experimental, Cell Hypoxia, Drug Administration Schedule, Mice, Antineoplastic Combined Chemotherapy Protocols, Animals, Prodrugs, cyclophosphamide, bioreduction, radiotherapy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::fb439b44564f13fbeee3d240154817f5
https://pubmed.ncbi.nlm.nih.gov/10864207

المؤلفون: Lh Patterson, Sr Mckeown

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/62/3e/Br_J_Cancer_2000_Dec_83(12)_1589-1593.tar.gz

مصطلحات موضوعية: bioreductive, prodrug, topoisomerase II, in vivo, AQ4N, Tirapazamine TUMOUR HYPOXIA AND BIOREDUCTIVE DRUGS

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.281.1261

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.281.1261

المؤلفون: R Gallagher, Cm Hughes, Mm Murray, Op Friery, Lh Patterson, Dg Hirst, Sr Mckeown

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/90/39/Br_J_Cancer_2001_Aug_85(4)_625-629.tar.gz

مصطلحات موضوعية: AQ4N + cisplatin

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.8636

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.8636