المؤلفون: Silm, Kätlin, Yang, Jing, Marcott, Pamela F, Asensio, Cedric S, Eriksen, Jacob, Guthrie, Daryl A, Newman, Amy H, Ford, Christopher P, Edwards, Robert H

المصدر: Neuron. 102(4)

مصطلحات موضوعية: Biological Psychology, Biomedical and Clinical Sciences, Neurosciences, Psychology, Mental Health, Underpinning research, 1.1 Normal biological development and functioning, Neurological, Adaptor Protein Complex 3, Animals, Calcium Channels, Dopamine, Dopaminergic Neurons, Exocytosis, Glutamic Acid, Mesencephalon, Mice, Neurons, Neurotransmitter Agents, Synaptic Vesicles, AP-3, Ca++ channel coupling, VGLUT, VMAT, adaptor protein 3, dopamine, frequency dependence, glutamate, neurotransmitter corelease, release probability, synaptic vesicle, vesicular glutamate transporter, vesicular monoamoine transporter, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/882831g7

المؤلفون: Siyu Guo, Xueyuan Sun, Ruihua Li, Tianyao Zhang, Fengxian Hu, Feng Liu, Qiang Hua

المصدر: Bioresources and Bioprocessing, Vol 9, Iss 1, Pp 1-16 (2022)

مصطلحات موضوعية: Actinosynnema pretiosum, CRISPR–Cas9, Bidirectional promoters, Ansamitocin P-3 (AP-3), Extender unit, Technology, Chemical technology, TP1-1185, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2197-4365

URL الوصول: https://doaj.org/article/11f1a44889394f8bb94ecc4d89dde297

المؤلفون: Chen, Shih-Yu, Ho, Chun-Ta, Liu, Wei-Wen, Lucanic, Mark, Shih, Hsiu-Ming, Huang, Pei-Hsin, Cheng, Hwai-Jong

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 115(35)

مصطلحات موضوعية: Neurosciences, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Neurological, Animals, Axons, Caenorhabditis elegans, Caenorhabditis elegans Proteins, DNA-Binding Proteins, Nerve Tissue Proteins, Protein Transport, Sumoylation, Transcription Factors, axon guidance, MAX-1 SUMOylation, AP-3 complex, UNC-5 receptor, C. elegans

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9tz5f0pc

المؤلفون: Shamsul Morshed, Most Naoshia Tasnin, Takashi Ushimaru

المصدر: BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-10 (2020)

مصطلحات موضوعية: AP-3 pathway, ESCRT, Microautophagy, Pho8, Vph1, VPS pathway, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12860-020-00314-w; https://doaj.org/toc/2661-8850

URL الوصول: https://doaj.org/article/8ec4e64dc78a4bf4acb7aeb7edb86c8a

المؤلفون: Stolp, Zachary D., Kulkarni, Madhura, Liu, Yining, Zhu, Chengzhang, Jalisi, Alizay, Lin, Si, Casadevall, Arturo, Cunningham, Kyle W., Pineda, Fernando J., Teng, Xinchen, Hardwick, J. Marie

المصدر: Stolp, Z. D., Kulkarni, M., Liu, Y., Zhu, C., Jalisi, A., Lin, S., Casadevall, A., Cunningham, K. W., Pineda, F. J., Teng, X., & Hardwick, J. M. (2022). Yeast cell death pathway requiring AP-3 vesicle trafficking leads to vacuole/lysosome membrane permeabilization. Cell Reports, 39(2), 110647. ; doi:10.1016/j.celrep.2022.110647

مصطلحات موضوعية: Yeast, Programmed cell death, Vesicle trafficking, AP-3, Vacuole, Cryptococcus, Yck3, Regulated cell death, Lysosome, Vacuolar membrane permeabilization

Relation: https://doi.org/10.1016/j.celrep.2022.110647; Stolp, Z. D., Kulkarni, M., Liu, Y., Zhu, C., Jalisi, A., Lin, S., Casadevall, A., Cunningham, K. W., Pineda, F. J., Teng, X., & Hardwick, J. M. (2022). Yeast cell death pathway requiring AP-3 vesicle trafficking leads to vacuole/lysosome membrane permeabilization. Cell Reports, 39(2), 110647.; https://hdl.handle.net/1912/29159

الاتاحة: https://hdl.handle.net/1912/29159

المؤلفون: Begley, Matthew, Aragon, Mahira, Baker, Richard W

المصدر: Proc Natl Acad Sci U S A ; ISSN:1091-6490 ; Volume:121 ; Issue:52

مصطلحات موضوعية: AP-3, cargo sorting, endosome, vesicle coat

Relation: https://doi.org/10.1073/pnas.2411974121; https://pubmed.ncbi.nlm.nih.gov/39705307; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670113/

الاتاحة: https://doi.org/10.1073/pnas.2411974121
https://pubmed.ncbi.nlm.nih.gov/39705307
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670113/

المؤلفون: Tongngok, Pajaree

المساهمون: Baron, Martin

مصطلحات موضوعية: 570, Notch, Deltex, HOPS, AP-3, endocytosis, neurogenesis

URL الوصول: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.764206

المؤلفون: Arora, Deepanksha, Van Damme, Daniël

المصدر: PLANT PHYSIOLOGY ; ISSN: 0032-0889 ; ISSN: 1532-2548

مصطلحات موضوعية: Biology and Life Sciences, Plant Science, Genetics, Physiology, CLATHRIN-MEDIATED ENDOCYTOSIS, AP-3 ADAPTER COMPLEX, TRANS-GOLGI NETWORK, DOMAIN-CONTAINING PROTEINS, LIGAND-INDUCED ENDOCYTOSIS, RECOGNITION RECEPTOR FLS2, BORATE TRANSPORTER BOR1, COATED VESICLES, DEPENDENT ENDOCYTOSIS, MEMBRANE TRAFFICKING

وصف الملف: application/pdf

Relation: https://biblio.ugent.be/publication/8694765; http://hdl.handle.net/1854/LU-8694765; http://dx.doi.org/10.1093/plphys/kiab077; https://biblio.ugent.be/publication/8694765/file/8694767

الاتاحة: https://biblio.ugent.be/publication/8694765
http://hdl.handle.net/1854/LU-8694765
https://doi.org/10.1093/plphys/kiab077
https://biblio.ugent.be/publication/8694765/file/8694767

المؤلفون: Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Kim Ghilarducci, Saïd Kourrich, Laurent Cappadocia, Marc P. Lussier

المصدر: Cells; Volume 10; Issue 11; Pages: 3063

مصطلحات موضوعية: RNF13, AP-3 complex, endosomes, lysosomes, intracellular trafficking, genetic mutations, developmental and epileptic encephalopathy-73

وصف الملف: application/pdf

Relation: Autophagy; https://dx.doi.org/10.3390/cells10113063

الاتاحة: https://doi.org/10.3390/cells10113063

المؤلفون: Peden, Andrew A., Oorschot, Viola, Hesser, Boris A., Austin, Cary D., Scheller, Richard H., Klumperman, Judith

المصدر: The Journal of Cell Biology, 2004 Mar . 164(7), 1065-1076.

URL الوصول: https://www.jstor.org/stable/1622120

المؤلفون: Peden, Andrew Alexander

المساهمون: Robinson, Margaret

مصطلحات موضوعية: 572, AP-3, Clathrin, Membrane transport, Trafficking, Adaptor complex, delta subunit, beta3A subunit

URL الوصول: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553191

المؤلفون: Darsow, Tamara, Burd, Christopher G., Emr, Scott D.

المصدر: The Journal of Cell Biology, 1998 Aug . 142(4), 913-922.

URL الوصول: https://www.jstor.org/stable/1618888

المؤلفون: Schoppe, Jannis, Mari, Muriel, Yavavli, Erdal, Auffarth, Kathrin, Cabrera, Margarita, Walter, Stefan, Froehlich, Florian, Ungermann, Christian

المصدر: Schoppe , J , Mari , M , Yavavli , E , Auffarth , K , Cabrera , M , Walter , S , Froehlich , F & Ungermann , C 2020 , ' AP-3 vesicle uncoating occurs after HOPS-dependent vacuole tethering ' , EMBO Journal , vol. 39 , no. 20 , e105117 . https://doi.org/10.15252/embj.2020105117

مصطلحات موضوعية: AP-3, Arf1 GAP, HOPS, vacuole, Vps41, ADAPTER PROTEIN COMPLEX, YEAST R-SNARE, RAB INTERACTIONS, ALKALINE-PHOSPHATASE, SELECTIVE TRANSPORT, MEMBRANE-TRANSPORT, ARF FAMILY, GOLGI, RECRUITMENT, FUSION

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/3b7ab1b4-74b8-4e28-9f06-d7ffef71224e
https://research.rug.nl/en/publications/3b7ab1b4-74b8-4e28-9f06-d7ffef71224e
https://doi.org/10.15252/embj.2020105117
https://pure.rug.nl/ws/files/154942134/AP_3_vesicle_uncoating_occurs_after_HOPS_dependent_vacuole_tethering.pdf

المؤلفون: Yanjuan Chen, Yiping Chen, Hua Jiang, Deren Lu, Tingting Hu, Gang Bi, Yuping Ran, Baofeng Yu, Hui Dong, Dan Su

المصدر: Frontiers in Microbiology, Vol 10 (2019)

مصطلحات موضوعية: homo-hexamer, 2-aminomuconate deaminase, YjgF/YER057c/UK114 family, RidA subfamily, Pseudomonas species AP–3, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmicb.2019.02079/full; https://doaj.org/toc/1664-302X

URL الوصول: https://doaj.org/article/ac03c952d03d406a9c1cc282a53368d0

المؤلفون: Andrea L. Ambrosio, Santiago M. Di Pietro

المصدر: Platelets, Vol 28, Iss 2, Pp 138-146 (2017)

مصطلحات موضوعية: ap-3 complex, bloc, hermansky–pudlak syndrome, hops, protein traffic, rab38, Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/0953-7104; https://doaj.org/toc/1369-1635

URL الوصول: https://doaj.org/article/281b15913724464ab70e0a34bc3e79d0

المؤلفون: John J. Shin, Qurratulain Aftab, Pamela Austin, Jennifer A. McQueen, Tak Poon, Shu Chen Li, Barry P. Young, Calvin D. Roskelley, Christopher J. R. Loewen

المصدر: Disease Models & Mechanisms, Vol 9, Iss 9, Pp 1039-1049 (2016)

مصطلحات موضوعية: AP-3 complex, Hap1 cells, Mitochondria, PAN complex, Intracellular acid stress, Metabolism, Medicine, Pathology, RB1-214

وصف الملف: electronic resource

Relation: http://dmm.biologists.org/content/9/9/1039; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

URL الوصول: https://doaj.org/article/e4ad6a9d9de942b1a8efd2584d4da9bd

المؤلفون: Jing Zhi Anson Tan, Paul Anthony Gleeson

المصدر: Cells; Volume 8; Issue 6; Pages: 531

مصطلحات موضوعية: trans -Golgi network, adaptor proteins, AP-1, AP-3, AP-4, GGAs, protein sorting, post-Golgi transport

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/cells8060531

الاتاحة: https://doi.org/10.3390/cells8060531

المؤلفون: Tavares, Lucas Alves

Thesis Advisors: Silva, Luis Lamberti Pinto da

مصطلحات موضوعية: 2 depletion, acts in the CD4 down-regulation induced by Nef. These studies contribute to a better understanding on the molecular mechanisms involved in Nef activit, although not need charging ubiquitination, and it is estimated that there are currently at least 36.9 million people infected with the virus. During the replication cycle, and only the AP-1 variant comprising ?2, another subunit of AP-1, AP-1, AP-1 subunits. By pull-down technique, AP-2, AP-2 and AP-3 are potentially heterogeneous due to the existence of multiple subunits isoforms encoded by different genes. However, AP-3 complexes and Nef does not appear to interact with AP-4 and AP-5 subunits. However, being an important protein in the endo-lysosomal system. Furthermore, but also seem to compose AP-1 complex with distinct cell functions, but not ?1, but not ?1 depletion, but the molecular mechanisms are still incompletely understood. Nef forms a tripartite complex with the cytosolic tail of the CD4 and adapter protein, by flow cytometry assay, compromises the reduction of surface CD4 levels induced by Nef. Immunofluorescence microscopy analysis also revealed that ?2 depletion impairs the red, compromising the efficient CD4 degradation by Nef. Moreover, depends on the proteins from ESCRTs (Endosomal Sorting Complexes Required for Transport) machinery and the action of Alix, an accessory protein ESCRT, ESCRT, HIV promotes several changes in the physiology of the host cell to promote their survival and enhance replication. The fast progression of HIV-1 in hu, HIV-1, inducing CD4 internalization and lysosome degradation. Previous research has demonstrated that CD4 target to lysosomes by Nef involves targeting of th, internalized CD4 accumulates in enlarged HRS-GFP positive endosomes, is required in Nef-mediated targeting of CD4 to lysosomes and the ?2 participation in this process is conserved by Nef from different viral strains. F, MVB, Nef, not ?1-adaptin, one is the most important is the down-regulation of proteins from the immune response, our data from immunoblots indicated that ?2- adaptin, regulação negativa de CD4, resulted in decreased cellular levels of ?1 and ?2 and, resulting in CD4 accumulation in primary endosomes. Knockdown of ?1A, such as the CD4 receptor. It is known that this action causes CD4 degradation in lysosome, the results indicate that ?-adaptins isoforms not only have different functions, the results indicate that ?2-adaptin is a molecule that is essential for CD4 targeting by Nef to ESCRT/MVB pathway, The Human Immunodeficiency Virus (HIV) is the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a disease which has a global distr, the role of Nef interaction with AP-1 or AP-3 in CD4 down-regulation is poorly understood. Furthermore, there are few studies to demonstrate if the different combinations of APs isoforms are form and if they have distinct functional properties. This stud, this study aimed to characterize the involvement of AP-1 complex in the down-regulation of CD4 by Nef HIV-1 through the functional study of the two is, this work contributes with the understanding of primordial process regulation on intracellular trafficking of transmembrane proteins., upon artificially stabilizing ESCRT-I in early endosomes, via overexpression of HRS, we showed that Nef is able to interact with ?2. In addition, where co-localize with ?2. Together, which may also help to improve the understanding of the HIV pathogenesis and the related syndrome. In addition, y1-adaptina, y2-adaptina

وصف الملف: application/pdf

الاتاحة: http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06012017-113215/

المؤلفون: Neuffer, Samantha

مصطلحات موضوعية: AP-3 complex, gene expression analysis, melanoma, Cellular biology, albinism, zebrafish, Genetic Engineering

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3d25a108325c24d894e923a7a7b293f4

المؤلفون: Nag, Sudeshna, Rani, Shikha, Mahanty, Sarmistha, Bissig, Christin, Arora, Pooja, Azevedo, Cristina, Saiardi, Adolfo, van der Sluijs, Peter, Delevoye, Cedric, van Niel, Guillaume, Raposo, Graca, Setty, Subba Rao Gangi

المساهمون: Sub Cellular Protein Chemistry, Cellular Protein Chemistry

مصطلحات موضوعية: Rab4A, AP-3, Rabenosyn-5, Rabaptin-5, Rabip4′, Sorting endosome, Melanosome biogenesis

وصف الملف: image/pdf

Relation: https://dspace.library.uu.nl/handle/1874/376544

الاتاحة: https://dspace.library.uu.nl/handle/1874/376544