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المؤلفون: Mo Wang, C. Chris Yun, Yiran Han, Lei Dong, Peijian He
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1073-1092 (2021)مصطلحات موضوعية: 0301 basic medicine, Male, Lipopolysaccharide, RC799-869, RT-PCR, reverse transcriptase polymerase chain reaction, IEC, intestinal epithelial cell, Cell membrane, chemistry.chemical_compound, Transactivation, Mice, 0302 clinical medicine, LPA5, FD-4, fluorescein isothiocyanate-labeled 4 kDa dextran, Lysophosphatidic acid, Intestinal Mucosa, Receptors, Lysophosphatidic Acid, Receptor, Original Research, ATX, autotaxin, IBD, inflammatory bowel disease, Dextran Sulfate, Gastroenterology, Diseases of the digestive system. Gastroenterology, GI, gastrointestinal, Colitis, Cell biology, LPA, medicine.anatomical_structure, TJ, tight junction, shRNA, short hairpin RNA, LPS, lipopolysaccharide, 030211 gastroenterology & hepatology, Signal transduction, JAMs, junctional adhesion molecules, Rac1, LPA, lysophosphatidic acid, LPA5, LPA receptor 5, Barrier, PBS, phosphate-buffered saline, RAC1, ROCK, RhoA-associated kinase, Permeability, TER, transepithelial electrical resistance, Cell Line, GEF, guanine nucleotide exchange factor, 03 medical and health sciences, Stat, signal transducers and activators of transcription, DSS, dextran sulfate sodium, medicine, Animals, Humans, IF, immunofluorescence, GPCR, G protein-coupled receptor, Intestinal permeability, Hepatology, Stat3, NHE3, Na+/H+ exchanger 3, medicine.disease, AJ, adherens junction, EGFR, epidermal growth factor receptor, Disease Models, Animal, 030104 developmental biology, chemistry, Caco-2 Cells, Lysophospholipids, SD, standard deviation
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المؤلفون: Sun Kyung Kim, Sabine Pokutta, Jonathon A. Heier, William I. Weis, Ian W. Dale, Andrew P. Hinck, Adam V. Kwiatkowski
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, ABD, F-actin binding domain, ICD, intercalated disc, cardiomyocyte, macromolecular substances, Biochemistry, Adherens junction, 03 medical and health sciences, Ncadcyto, N-cadherin tail, BS3, bis(sulfosuccinimidyl)suberate, M, middle, α-catenin, Binding site, Molecular Biology, Vinculin binding, Binding Sites, 030102 biochemistry & molecular biology, biology, Chemistry, vinculin, ITC, isothermal titration calorimetry, αE, epithelial, Myocardium, Isothermal titration calorimetry, Cell Biology, Vinculin, β-catenin, tension, Actin cytoskeleton, EGFP, enhanced green fluorescent protein, AJ, adherens junction, isothermal titration calorimetry, Actin Cytoskeleton, 030104 developmental biology, αN, neuronal, Catenin, Proteolysis, Biophysics, biology.protein, TBST, Tris-buffered saline, 0.1% TWEEN 20, affinity, BSA, bovine serum albumin, αT, testes, alpha Catenin, Research Article, Protein Binding
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المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1463-1482 (2021)مصطلحات موضوعية: 0301 basic medicine, Cell Membrane Permeability, GF, germ free, RC799-869, Review, Gut flora, Microbial Metabolites, FICZ, 6-formylindolo(3,2-b) carbazole, EA, ellagic acid, IEC, intestinal epithelial cell, 0302 clinical medicine, ZO, zonula occludens, TNF-α, tumor necrosis factor alpha, Intestinal Mucosa, LCA, lithocholic acid, Barrier function, TNBS, 2,4,6-trinitrobenzene sulfonic acid, NOD, nucleotide-binding and oligomerization domain, biology, Gut barrier, IBD, inflammatory bowel disease, FMT, fecal microbiota transplantation, Microbiota, Human gastrointestinal tract, Gastroenterology, Diseases of the digestive system. Gastroenterology, CLDN, claudin, OCLN, occludin, Cell biology, Gut Epithelium, medicine.anatomical_structure, TJ, tight junction, AhR, aryl hydrocarbon receptor, SCFA, short-chain fatty acid, Metabolome, GP-BAR, G protein–coupled bile acid receptor, LPS, lipopolysaccharide, 030211 gastroenterology & hepatology, ALD, alcoholic liver disease, IBS, irritable bowel syndrome, TPE-CA, total phenolic extracts of Citrus aurantium L, NLR, nucleotide-binding and oligomerization domain-like receptor, digestive system, Permeability, UDCA, ursodeoxycholic acid, CDCA, chenodeoxycholic acid, TEER, transepithelial electrical resistance, 03 medical and health sciences, Immune system, FXR, farnesoid X receptor, DSS, dextran sulfate sodium, UroA, urolithin A, PKC, protein kinase C, medicine, Animals, Humans, ET, ellagitannin, MLCK, myosin light-chain kinase, EGF, epidermal growth factor, TLR, Toll like receptor, Tight Junction Proteins, Hepatology, GLP, glucagon-like peptide, CLA, conjugated linoleic acid, GJ, gap junction, biology.organism_classification, sEH, soluble epoxide hydrolase, AJ, adherens junction, Gastrointestinal Microbiome, IL, interleukin, MUC2, mucin 2, 030104 developmental biology, DCA, deoxycholic acid, Metagenomics, Gut Barrier Function, GPCR, G protein–coupled receptor, Function (biology)
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المؤلفون: Michael S. Donnenberg, Karen M. Scanlon, John J. Garber, Scott B. Snapper, Jerrold R. Turner, Emily M. Mallick, John M. Leong
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 273-288 (2018)مصطلحات موضوعية: 0301 basic medicine, EPEC, enteropathogenic Escherichia coli, Apical junction complex, Occludin, ADF, actin depolymerization factor, ZO-1, zonula occludens-1, PCR, polymerase chain reaction, Arp, actin-related protein, Cytoskeleton, EspF, Original Research, N-WASP, Neural Wiskott-Aldrich Syndrome protein, EHEC, enterohemorrhagic Escherichia coli, Tight junction, Effector, Chemistry, Gastroenterology, AE, attaching-and-effacing, Intestinal epithelium, Cell biology, TJ, tight junction, shRNA, short hairpin RNA, EcoRI, E. coli RY13 I, FITC, fluorescein isothiocyanate, PBS, phosphate-buffered saline, iNWKO, intestine Neural Wiskott-Aldrich Syndrome protein knockout, macromolecular substances, Junction Regulation, TER, transepithelial electrical resistance, SNX9KD, sorting nexin 9 knockdown, Adherens junction, 03 medical and health sciences, SNX9, sorting nexin 9, DBS100, David B. Schauer 100, lcsh:RC799-869, N-WASP, EM, electron microscopy, KO, knockout, NWKD, Neural Wiskott-Aldrich Syndrome protein knockdown, Hepatology, Tir, translocated intimin receptor, EspF, early secreted antigenic target-6 (ESX)-1 secretion-associated protein F, Actin cytoskeleton, AJ, adherens junction, AJC, apical junction complex, Sorting nexin, 030104 developmental biology, Crb, Crumbs, lcsh:Diseases of the digestive system. Gastroenterology, CR, Citrobacter rodentium
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المؤلفون: Tingxi Yu, Myriam Gorospe, Suraj K. Jaladanki, Shaoyang Lan, Jian-Ying Wang, Hee K. Chung, Douglas J. Turner, Jun-Jie Piao, Jean-Pierre Raufman, Lan Xiao
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 4, Pp 611-625 (2020)مصطلحات موضوعية: 0301 basic medicine, Male, Lipopolysaccharide, Mucin 2, IEC, intestinal epithelial cell, chemistry.chemical_compound, Mice, Long Noncoding RNAs, 0302 clinical medicine, Intestine, Small, miRNA, microRNA, Original Research, Goblet cells, Mice, Knockout, Gastroenterology, Cell biology, Organoids, medicine.anatomical_structure, TJ, tight junction, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, embryonic structures, CLP, cecal ligation and puncture, LPS, lipopolysaccharide, 030211 gastroenterology & hepatology, Female, RNA, Long Noncoding, FITC, fluorescein isothiocyanate, Paneth Cells, digestive system, Permeability, TEER, transepithelial electrical resistance, 03 medical and health sciences, Sepsis, Organoid, medicine, Autophagy, Animals, Humans, lcsh:RC799-869, Gut permeability, Mucosal Defense, Goblet cell, miR, microRNA (miR)-675, Hepatology, Mucin, Mucus, AJ, adherens junction, ZO-1, zonula occludens 1, Disease Models, Animal, 030104 developmental biology, chemistry, lcsh:Diseases of the digestive system. Gastroenterology, lncRNA, long noncoding RNA, Caco-2 Cells, Immunostaining
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المؤلفون: Loxham, Matthew, Davies, Donna E.
المصدر: The Journal of Allergy and Clinical Immunology
مصطلحات موضوعية: AhR, Aryl hydrocarbon receptor, tight junction, eQTL, Expression quantitative trait locus, AJ, Adherens junction, Respiratory Mucosa, SC, Subject cluster, BHR, Bronchial hyperresponsiveness, GC, Gene cluster, CDHR3, Cadherin-related family member 3, PCDH1, Protocadherin 1, NK, Natural killer, homeostasis, ILC, Innate lymphoid cell, cytokine, EGFR, Epidermal growth factor receptor, ORMDL3, Orosomucoid-like 3, Animals, Humans, Genetic Predisposition to Disease, innate immunity, TSLP, Thymic stromal lymphopoietin, SNP, Single nucleotide polymorphism, DUOX1, Dual oxidase 1, Reviews and Feature Article, TJ, Tight junction, DC, Dendritic cell, Asthma, Phenotype, GST, Glutathione-S-transferase, ILC2, Type 2 innate lymphoid cell, GWAS, Genome-wide association study, TLR, Toll-like receptor
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المؤلفون: Michaela Lang, Šárka Pospíšilová, Christoph Gasche, Melanie Borgmann, Boris Tichy, Maren Pflueger, Vineeta Khare, Harald Hundsberger, Alex Lyakhovich, Rayko Evstatiev, Gloria Luciani, Christoph Campregher, Kyle Dammann
المصدر: Biochemical Pharmacology
مصطلحات موضوعية: Male, MAPK/ERK pathway, Biochemistry, Mice, 0302 clinical medicine, Mesalamine, Wnt Signaling Pathway, beta Catenin, 0303 health sciences, Cell adhesion molecule, Anti-Inflammatory Agents, Non-Steroidal, Wnt signaling pathway, Intestinal Polyps, Adhesion, Cadherins, Intercellular adhesion molecule, Neoplasm Proteins, 3. Good health, Cell biology, surgical procedures, operative, 030220 oncology & carcinogenesis, Colonic Neoplasms, CRC, colorectal cancer, Female, RNA Interference, MAP Kinase Signaling System, education, Down-Regulation, Biology, Article, 03 medical and health sciences, Cell Line, Tumor, Animals, Anticarcinogenic Agents, Humans, IBD, inflammatory bowel diseases, Cell adhesion, 030304 developmental biology, Pharmacology, Cadherin, Gene Expression Profiling, Soluble cell adhesion molecules, E-cadherin, AJ, adherens junction, digestive system diseases, UC, ulcerative colitis, p21-Activated Kinases, Beta-catenin, Cancer research, PAK1, PAK1, p21 activated kinase 1
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المؤلفون: Ali, Shawki, Declan F, McCole
المصدر: Cellular and Molecular Gastroenterology and Hepatology
مصطلحات موضوعية: MLCK, myosin light chain kinase, TNF, tumor necrosis factor, PDZ, PSD95-DlgA-zonula occludens-1 homology domain, AIEC, adherent-invasive Escherichia coli, IBD, inflammatory bowel disease, NOD2, nucleotide-binding oligomerization domain 2, Inflammatory Bowel Disease, NF-κB, nuclear factor-κB, Review, JAM-A, junctional adhesion molecule-A, AJ, adherens junction, LPF, long polar fimbriae, Tight Junctions, IEC, intestinal epithelial cell, IL, interleukin, UC, ulcerative colitis, TJ, tight junction, MLC, myosin light chain, ZO, zonula occludens, CEACAM6, carcinoembryonic antigen–related cell-adhesion molecule, CD, Crohn’s disease, IFN, interferon, AJC, apical junctional complex, BP, bacterial peptidoglycans, Intestinal Permeability
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المؤلفون: Terry Lechler
المصدر: Tissue Barriers
مصطلحات موضوعية: Histology, tight junction, Cell, Arp2/3 complex, YAP1, macromolecular substances, Review, Biochemistry, ZO, zonula occludens, epidermis, medicine, Arp, Actin-related protein, Cell adhesion, Actin, Epidermis (botany), biology, FRAP, fluorescence recovery after photobleaching, Cell Biology, Phenotype, AJ, adherens junction, Cell biology, EGFR, epidermal growth factor receptor, N-WASP, neural Wiskott-Aldrich synrome protein, medicine.anatomical_structure, FAK, focal adhesion kinase, biology.protein, Function (biology)
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المؤلفون: Christoph Gasche, Kyle Dammann, Alex Lyakhovich, Vineeta Khare, Michaela Lang, Christoph Campregher
المصدر: Biochemical Pharmacology
مصطلحات موضوعية: Male, Glycosylation, Biochemistry, CDH1, Mice, chemistry.chemical_compound, 0302 clinical medicine, N-linked glycosylation, Intestinal mucosa, Intestinal Mucosa, Mesalamine, chemistry.chemical_classification, 5-ASA, 0303 health sciences, medicine.diagnostic_test, Anti-Inflammatory Agents, Non-Steroidal, Cadherins, 3. Good health, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, CRC, colorectal cancer, GnT-III, Female, HT29 Cells, Colon, Gastrointestinal Pharmacology, Mice, Transgenic, Biology, 03 medical and health sciences, Western blot, medicine, Animals, Humans, IBD, inflammatory bowel diseases, 030304 developmental biology, Pharmacology, Cadherin, E-cadherin, HCT116 Cells, Molecular biology, digestive system diseases, AJ, adherens junction, Mice, Inbred C57BL, UC, ulcerative colitis, chemistry, Ulcerative colitis, Tumor progression, GnT-III, N-acetylglucosaminyltransferase-III, biology.protein, PAK1, p21 activated kinase 1, Glycoprotein
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المؤلفون: Saverio Francesco Retta, Angela Glading
المصدر: The International Journal of Biochemistry & Cell Biology
مصطلحات موضوعية: 0301 basic medicine, Hemangioma, Cavernous, Central Nervous System, Redox signaling, Vascular homeostasis, Disease, ICH, intracerebral hemorrhage, Bioinformatics, medicine.disease_cause, Biochemistry, 0302 clinical medicine, KLF, Kruppel-like factor, TGFβ, transforming growth factor beta, Cerebrovascular disease, Blood-brain barrier dysfunction, fCCM, familial form of CCM, Neovascularization, Pathologic, VEGF, vascular endothelial growth factor, Penetrance, sCCM, sporadic form of CCM, 3. Good health, NVU, neurovascular unit, medicine.symptom, Signal transduction, medicine.medical_specialty, Cerebral cavernous malformation (CCM), Inflammation, Biology, Article, 03 medical and health sciences, ROS, reactive oxygen species, Internal medicine, medicine, Genetic predisposition, Autophagy, Humans, EndMT, endothelial-to-mesenchymal transition, CCM1/KRIT1, Vascular permeability, CCM2, CCM3/PDCD10, Cerebral Cavernous Malformation (CCM), angiogenesis, antioxidant response, autophagy, blood-brain barrier dysfunction, inflammation, oxidative stress, redox signaling, vascular homeostasis, vascular permeability, Vascular disease, Antioxidant response, COX-2, cycloxygenase-2, BMP, bone morphogenetic protein, Cell Biology, medicine.disease, AJ, adherens junction, CCM, cerebral cavernous malformation, 030104 developmental biology, Endocrinology, Oxidative stress, Angiogenesis, 030217 neurology & neurosurgery