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المؤلفون: Ling Shao, Zhang-Xu Liu, Janet Kwok, Katherine Donovan, Brian T. Lee, Andrea Iorga, Layla Shojaie, Heather S. Johnson, Lily Dara, Mariam Aghajan, Jo Suda
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Male, MAP Kinase Kinase 4, RHIM, RIP homotypic interaction motif, receptor interacting protein, Apoptosis, Pharmacology, ASK1, apoptosis signal-regulating kinase 1, Biochemistry, Severity of Illness Index, necrosis, Mice, GSH, glutathione, AAC, asparagine, TBP, TATA box binding protein, ASK1, GAC, aspartic acid, drug action, TNFAIP3, RIPK1/3, receptor interacting protein kinase-1/3, TNF, tumor necrosis factor, Chemistry, Kinase, Co-IP, Coimmunoprecipitation, digestive, oral, and skin physiology, A20HepCKO, targeted hepatocyte A20 knockout, PHB1, prohibitin-1, cell death, TNFAIP3, TNF-induced protein 3, also known as A20, Liver, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Receptor-Interacting Protein Serine-Threonine Kinases, JNK, c-Jun N-terminal kinase, LPS, lipopolysaccharide, Chemical and Drug Induced Liver Injury, Protein Binding, Research Article, Programmed cell death, hepatotoxicity, RIPK1, RCD, regulated cell death, MAP Kinase Signaling System, Necroptosis, necroptosis, APAP, acetaminophen, Mice, Transgenic, ASO, antisense oligonucleotide, MKK4, MAP2 kinase mitogen-activated protein kinase 4, MAP Kinase Kinase Kinase 5, RIPK3, drug induced liver injury, 03 medical and health sciences, ROS, reactive oxygen species, Downregulation and upregulation, RIPK1HepCKO, targeted hepatocyte RIPK1 knockout, ALT, alanine aminotransferase, Animals, Molecular Biology, Tumor Necrosis Factor alpha-Induced Protein 3, Acetaminophen, DYKDDDK Tag, Flag Tag, MLKL, mixed lineage kinase domain like pseudokinase, 030102 biochemistry & molecular biology, RIPK1D138N, kinase dead RIPK1 knock-in, Nec-1, necrostatin-1, DMSO, Dimethyl sulfoxide, Cell Biology, 030104 developmental biology, Gene Expression Regulation, MAPK, mitogen-activated protein kinases, siRNA, small interfering RNA, Hepatocytes, NFkB, nuclear factor kB, NAPQI, N-acetyl-p-benzoquinone imine, PMH, primary mouse hepatocyte