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1
المؤلفون: Kimberly A. Solomon, Joseph B. Santella, George L. Trainor, Robert C. Newton, Zhang Wang, Dean A. Wacker, George V. De Lucca, Anuk M. Das, Paul Davies, Ui Tae Kim, Maryanne B. Covington, Danielle M. Graden, Gardner Daniel S, Nicole Stowell, Changsheng Zheng, John V. Duncia, Brian J. Vargo, George C. Emmett, Eric A. Wadman, Carl P. Decicco, Patricia K. Welch, Swamy Yeleswaram, Ann Y. Liauw, Soo S. Ko
المصدر: Journal of Medicinal Chemistry. 48:2194-2211
مصطلحات موضوعية: Male, Stereochemistry, Receptors, CCR3, CCR3, Biological Availability, CHO Cells, In Vitro Techniques, Chemical synthesis, Permeability, Mice, Structure-Activity Relationship, Piperidines, Cyclohexanes, In vivo, Cricetinae, Drug Discovery, Hypersensitivity, Animals, Humans, Urea, Potency, Inflammation, Mice, Inbred BALB C, Chemistry, Phenylurea Compounds, Antagonist, Stereoisomerism, In vitro, Eosinophils, Mice, Inbred C57BL, Chemotaxis, Leukocyte, Molecular Medicine, Calcium, Female, Receptors, Chemokine, Caco-2 Cells, CC chemokine receptors, Linker
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2
المؤلفون: Ming Y. He, Robert M. Knabb, Patrick Y.S. Lam, Matthew R. Wright, Joseph M. Luettgen, Christopher D. Ellis, Mimi L. Quan, Richard S. Alexander, Pancras C. Wong, Ann Y. Liauw, Ruth R. Wexler, Francis J. Woerner
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:369-373
مصطلحات موضوعية: Models, Molecular, Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Protein Conformation, Stereochemistry, Clinical Biochemistry, Factor Xa Inhibitor, Biological Availability, Tetrazoles, Pharmaceutical Science, In Vitro Techniques, Biochemistry, Benzamidine, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Thrombin, Drug Discovery, medicine, Animals, Humans, Tetrazole, Molecular Biology, chemistry.chemical_classification, Serine protease, biology, Molecular Mimicry, Organic Chemistry, Trypsin, Kinetics, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Rabbits, Trypsin Inhibitors, Factor Xa Inhibitors, medicine.drug
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3
المؤلفون: Patricia C. Weber, Richard S. Alexander, Charles A. Kettner, Mimi L. Quan, Duncia John, Robert M. Knabb, Mary K. VanAtten, C. Anne Higley, Ruth R. Wexler, Santella Joseph B, Anne Y. Liauw, James Russell Pruitt
المصدر: Bioorganic & Medicinal Chemistry Letters. 8:775-780
مصطلحات موضوعية: Models, Molecular, inorganic chemicals, Steric effects, Molecular model, Clinical Biochemistry, Tetrazoles, Pharmaceutical Science, Peptide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Thrombin, Drug Discovery, medicine, Organic chemistry, Molecular Biology, chemistry.chemical_classification, Binding Sites, Dipeptide, Molecular Structure, biology, Organic Chemistry, Stereoisomerism, Triazoles, Amides, Boronic Acids, Combinatorial chemistry, chemistry, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine, Indicators and Reagents, Discovery and development of direct thrombin inhibitors, medicine.drug
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4
المؤلفون: John Wityak, A. Y. Liauw, J. V. Duncia, Patricia C. Weber, M. J. Thoolen, Santella Joseph B, Charles A. Kettner, Mimi Lifen Quan, Christopher D. Ellis, Celia Dominguez, Ruth R. Wexler, Robert M. Knabb, Jeongsook M. Park
المصدر: Bioorganic & Medicinal Chemistry Letters. 7:1595-1600
مصطلحات موضوعية: chemistry.chemical_classification, Serine protease, congenital, hereditary, and neonatal diseases and abnormalities, biology, Stereochemistry, medicine.drug_class, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, In vitro, Enzyme, Thrombin, chemistry, Enzyme inhibitor, Drug Discovery, biology.protein, medicine, Molecular Medicine, Molecular Biology, circulatory and respiratory physiology, Discovery and development of direct thrombin inhibitors, medicine.drug
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5
المؤلفون: Jeongsook M. Park, M. J. Thoolen, J. V. Duncia, Patricia C. Weber, Charles A. Kettner, Robert M. Knabb, Christopher D. Ellis, Celia Dominguez, Ruth R. Wexler, Santella Joseph B, Mimi Lifen Quan, John Wityak, A. Y. Liauw
المصدر: ChemInform. 28
مصطلحات موضوعية: chemistry.chemical_classification, Serine protease, congenital, hereditary, and neonatal diseases and abnormalities, biology, Chemistry, Stereochemistry, General Medicine, Thrombin, Enzyme, Coagulation cascade, medicine, biology.protein, circulatory and respiratory physiology, medicine.drug, Discovery and development of direct thrombin inhibitors
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6
المؤلفون: Mercy Ramanjulu, Ann Y. Liauw, Thomas P. Maduskuie, Jere E. Meredith, Jeffrey N. Higaki, Robert Zaczek, Barbara Cordell, Arthur H. Roach, Dietmar A. Seiffert, David Robertson, Padmaja Kasireddy-Polam, Lorin A. Thompson, Marcie A. Glicksman, Stephen E. Mercer, Andrew P. Combs, Richard E. Olson, Rui-Qin Liu
المصدر: Bioorganicmedicinal chemistry letters. 16(9)
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Cell Line, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, In vivo, Alzheimer Disease, Drug Discovery, Endopeptidases, medicine, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Caprolactam, Humans, Enzyme Inhibitors, Molecular Biology, biology, Organic Chemistry, Stereoisomerism, Succinates, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Lactam, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase
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7
المؤلفون: Jennifer J Y, Liauw, Wei-Keat, Cheah
المصدر: Asian journal of surgery. 28(3)
مصطلحات موضوعية: Abdomen, Acute, Adult, Aged, 80 and over, Male, Laparotomy, Singapore, Length of Stay, Middle Aged, Risk Assessment, Cohort Studies, Radiography, Survival Rate, Treatment Outcome, Intestine, Small, Humans, Minimally Invasive Surgical Procedures, Female, Laparoscopy, Intestinal Obstruction, Aged, Follow-Up Studies, Retrospective Studies
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8
المؤلفون: P C Y Liauw, A S H Ng, L. H. Lee
المصدر: Thrombosis and Haemostasis. 76:628-630
مصطلحات موضوعية: medicine.medical_specialty, Pregnancy, Mechanical Mitral Valve, medicine.drug_class, business.industry, Internal medicine, medicine, Cardiology, Low molecular weight heparin, Hematology, medicine.disease, business
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9
المؤلفون: Joseph M. Luettgen, Robert M. Knabb, Ming Y. He, Mimi L. Quan, Matthew R. Wright, Pancras C. Wong, Patrick Y.S. Lam, Ruth R. Wexler, Ann Y. Liauw, Christopher D. Ellis, Karen A. Rossi
المصدر: Bioorganicmedicinal chemistry letters. 13(6)
مصطلحات موضوعية: Models, Molecular, medicine.drug_mechanism_of_action, medicine.drug_class, Clinical Biochemistry, Factor Xa Inhibitor, Pharmaceutical Science, Biological Availability, Carboxamide, In Vitro Techniques, Biochemistry, Amidine, chemistry.chemical_compound, Thrombin, Dogs, Fibrinolytic Agents, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Serine protease, biology, Organic Chemistry, Isoxazoles, Kinetics, Enzyme, chemistry, Coagulation, Enzyme inhibitor, biology.protein, Molecular Medicine, Indicators and Reagents, Rabbits, medicine.drug, Factor Xa Inhibitors, Half-Life
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10
المؤلفون: Mimi L. Quan, Ann Y. Liauw, Christopher D. Ellis, James R. Pruitt, David J. Carini, Lori L. Bostrom, Peggy P. Huang, Kimberly Harrison, Robert M. Knabb, Martin J. Thoolen, Pancras C. Wong, Ruth R. Wexler
المصدر: Journal of medicinal chemistry. 42(15)
مصطلحات موضوعية: Models, Molecular, medicine.drug_mechanism_of_action, Stereochemistry, Factor Xa Inhibitor, Pharmacology, Acetates, Chemical synthesis, Structure-Activity Relationship, Thrombin, Arteriovenous Shunt, Surgical, Fibrinolytic Agents, Drug Discovery, Antithrombotic, medicine, Structure–activity relationship, Animals, Humans, Binding Sites, biology, Chemistry, Biphenyl Compounds, Thrombosis, Isoxazoles, Trypsin, Coagulation, Enzyme inhibitor, biology.protein, Molecular Medicine, Rabbits, medicine.drug, Factor Xa Inhibitors
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11
المؤلفون: Mimi L. Quan, Christopher D. Ellis, Ann Y. Liauw, Richard S. Alexander, Robert M. Knabb, Gilbert Lam, Matthew R. Wright, Pancras C. Wong, Ruth R. Wexler
المصدر: Journal of medicinal chemistry. 42(15)
مصطلحات موضوعية: Models, Molecular, Binding Sites, Thrombin, Tetrazoles, Thrombosis, Isoxazoles, Crystallography, X-Ray, Structure-Activity Relationship, Arteriovenous Shunt, Surgical, Dogs, Fibrinolytic Agents, Drug Discovery, Molecular Medicine, Animals, Humans, Trypsin, Rabbits, Trypsin Inhibitors, Factor Xa Inhibitors