المؤلفون: Vladimir O. Sigin, Alexey I. Kalinkin, Alexandra F. Nikolaeva, Ekaterina O. Ignatova, Ekaterina B. Kuznetsova, Galina G. Chesnokova, Nikolai V. Litviakov, Matvey M. Tsyganov, Marina K. Ibragimova, Ilya I. Vinogradov, Maxim I. Vinogradov, Igor Y. Vinogradov, Dmitry V. Zaletaev, Marina V. Nemtsova, Sergey I. Kutsev, Alexander S. Tanas, Vladimir V. Strelnikov

المصدر: Cancers; Volume 15; Issue 5; Pages: 1630

مصطلحات موضوعية: breast cancer, DNA methylation, RRBS, MSRE-qPCR, predictive markers, neoadjuvant chemotherapy

وصف الملف: application/pdf

Relation: Cancer Biomarkers; https://dx.doi.org/10.3390/cancers15051630

الاتاحة: https://doi.org/10.3390/cancers15051630

المؤلفون: Alexey I. Kalinkin, Vladimir O. Sigin, Ekaterina B. Kuznetsova, Ekaterina O. Ignatova, Ilya I. Vinogradov, Maxim I. Vinogradov, Igor Y. Vinogradov, Dmitry V. Zaletaev, Marina V. Nemtsova, Sergey I. Kutsev, Alexander S. Tanas, Vladimir V. Strelnikov

المصدر: International Journal of Molecular Sciences, Vol 24, Iss 24, p 17343 (2023)

مصطلحات موضوعية: breast cancer, leukotriene receptors, DNA methylation, XmaI-RRBS, Biology (General), QH301-705.5, Chemistry, QD1-999

Relation: https://www.mdpi.com/1422-0067/24/24/17343; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/e17a39ef166046e4a8d47b650602e284

الاتاحة: https://doi.org/10.3390/ijms242417343
https://doaj.org/article/e17a39ef166046e4a8d47b650602e284

المؤلفون: Valentina D. Yakushina, Vladimir V. Strelnikov, Alexander S. Tanas, Alexander V. Lavrov

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/72b9d3fe521f46efad58e14192f452eb

المؤلفون: Dmitry S. Mikhaylenko, Vsevolod B. Matveev, Margarita G. Filippova, Kirill I. Anoshkin, Nikolay A. Kozlov, Alexander V. Khachaturyan, Alexandra V. Semyanikhina, Sergey D. Nifatov, Alexander S. Tanas, Marina V. Nemtsova, Dmitry V. Zaletayev

المصدر: Case Reports in Oncology, Vol 14, Iss 2, Pp 963-971 (2021)

مصطلحات موضوعية: birt-hogg-dube syndrome, case report, dna sequencing, renal cancer, lung cyst, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.karger.com/Article/FullText/516763; https://doaj.org/toc/1662-6575

URL الوصول: https://doaj.org/article/0dd3042c5aff494eb7ffd0085285b07e

المؤلفون: Vladimir V. Strelnikov, Ekaterina B. Kuznetsova, Alexander S. Tanas, Viktoria V. Rudenko, Alexey I. Kalinkin, Elena V. Poddubskaya, Tatiana V. Kekeeva, Galina G. Chesnokova, Ivan D. Trotsenko, Sergey S. Larin, Sergey I. Kutsev, Dmitry V. Zaletaev, Marina V. Nemtsova, Olga A. Simonova

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/9674b2bcc0154773b10c7499d5ce84fc

المؤلفون: A. F. Nikolaeva, V. O. Sigin, A. I. Kalinkin, A. S. Tanas, V. V. Strelnikov, А. Ф. Николаева, В. О. Сигин, А. И. Калинкин, А. С. Танас, В. В. Стрельников

المصدر: Medical Genetics; Том 21, № 1 (2022); 34-43 ; Медицинская генетика; Том 21, № 1 (2022); 34-43 ; 2073-7998

مصطلحات موضوعية: метилчувствительные эндонуклеазы рестрикции, DNA methylation, multiplex PCR, methylation sensitive restriction enzymes, метилирование ДНК, мультиплексная ПЦР

وصف الملف: application/pdf

Relation: https://www.medgen-journal.ru/jour/article/view/2021/1544; Beikircher G., Pulverer W., Hofner M., et al. Multiplexed and sensitive DNA methylation testing using methylation-sensitive restriction enzymes “MSRE-qPCR”. Methods Mol Biol. 2018; 1708: 407-424. doi:10.1007/978-1-4939-7481-8_21.; Radhakrishnan R., Kabekkodu S., Satyamoorthy K. DNA hypermethylation as an epigenetic mark for oral cancer diagnosis. Journal of Oral Pathology and Medicine 2011; 40(9): 665-676.; Kulis M., Esteller M. DNA Methylation and Cancer. Advances in Genetics 2010; 70: 27-56. doi:10.1016/B978-0-12-380866-0.60002-2.; Yoo C.B., Jones P.A. Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov. 2006; 5(1): 37-50.; Esteller M. Epigenetics in Cancer. NEJM 2008; 358(11): 1148-1159.; Tanaka K., Okamoto A. Degradation of DNA by bisulfite treatment. Bioorg Med Chem Lett. 2007 Apr 1; 17(7): 1912-5. doi:10.1016/j.bmcl.2007.01.040.; Raizis A.M., Schmitt F., Jost J.P. A Bisulfite Method of 5-Methylcytosine Mapping That Minimizes Template Degradation. Anal Biochem. 1995; 226(1): 161-166.; Grunau C., Clark S.J., Rosenthal A. Bisulfite genomic sequencing: systematic investigation of critical experimental parameters. Nucleic Acids Res. 2001; 29(13): E65-5. doi:10.1093/nar/29.13.e65.; Amenya H.Z., Tohyama C., Ohsako S. Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver. Sci Rep. 2016; 6: 34989. doi:10.1038/srep34989.; Krygier M., Podolak-Popinigis, Limon J., et al. A simple modification to improve the accuracy of methylation-sensitive restriction enzyme quantitative polymerase chain reaction. Anal Biochem. 2016; 500: 88-90. doi:10.1016/j.ab.2016.01.020.; Umer M., Herceg Z. Deciphering the epigenetic code: An overview of DNA methylation analysis methods. Antioxid Redox Signal. 2013; 18(15): 1972-86. doi:10.1089/ars.2012.4923.; Pajares M.J., Palanca-Ballester C., Urtasun R., et al. Methods for analysis of specific DNA methylation status. Methods 2021; 187: 3-12. doi:10.1016/j.ymeth.2020.06.021.; Dahl C., Guldberg P. DNA methylation analysis techniques. Biogerontology 2003; 4(4): 233-50. doi:10.1023/a:1025103319328.; Lekanne Deprez R.H., Fijnvandraat A.C., Ruijter J.M., et al. Sensitivity and accuracy of quantitative real-time polymerase chain reaction using SYBR green I depends on cDNA synthesis conditions. Anal Biochem. 2002; 307(1): 63-69.; Huggett J.F., Cowen S., Foy C.A. Considerations for digital PCR as an accurate molecular diagnostic tool. Clin Chem. 2015; 61(1): 79-88.; Thomassin H., Kress C., Grange T. MethylQuant: a sensitive method for quantifying methylation of specific cytosines within the genome. Nucleic Acids Res. 2004; 32(21): e168. doi:10.1093/nar/gnh166.; Köchl S., Niederstätter H., Parson W. DNA extraction and quantitation of forensic samples using the phenol-chloroform method and real-time PCR. Methods Mol Biol. 2005; 297: 13-30.; Tolstrup N., Nielsen P.S., Kolberg J.G., et al. OligoDesign: optimal design of LNA (locked nucleic acid) oligonucleotide capture probes for gene expression profiling. Nucleic Acids Res. 2003; 31(13): 3758-62. doi:10.1093/nar/gkg580.; Mouritzen P., Nielsen A.T., Pfundheller H.M., et al. Single nucleotide polymorphism genotyping using locked nucleic acid (LNATM). Expert Rev Mol Diagn. 2003; 3(1): 27-38.; Guescini M., Sisti D., Rocchi M.B.L., et al. Accurate and Precise DNA Quantification in the Presence of Different Amplification Efficiencies Using an Improved Cy0 Method. PLoS One 2013; 8(7): e68481. doi:10.1371/journal.pone.0068481.; Armbruster D.A., Pry T. Limit of blank, limit of detection and limit of quantitation. Clin Biochem Rev. 2008; 29 Suppl 1(Suppl 1): S49-52.; Ucar I., Pebesma E., Azcorra A. Measurement Errors in R. The R Journal. 2019; 10(2): 549-557.; Lebrón R., Gómez-Martín С., Carpena P., et al. NGSmethDB 2017: enhanced methylomes and differential methylation. Nucleic Acids Res. 2017; 45(D1): D97-D103.; Lewin J., Schmitt A.O., Adorján P., et al. Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates. Bioinformatics 2004; 20(17): 3005-12. doi:10.1093/bioinformatics/bth346.; Kurdyukov S, Bullock M. DNA methylation analysis: Choosing the right method. Biology (Basel) 2016; 5(1): 3. doi:10.3390/biology5010003.; https://www.medgen-journal.ru/jour/article/view/2021

الاتاحة: https://www.medgen-journal.ru/jour/article/view/2021
https://doi.org/10.25557/2073-7998.2022.01.34-43

المؤلفون: A. S. Tanas, A. I. Kalinkin, M. V. Nemtsova, E. B. Kuznetsova, T. V. Kekeeva, I. Y. Vinogradov, M. I. Vinogradov, I. I. Vinogradov, D. V. Zaletaev, V. V. Strelnikov, А. С. Танас, А. И. Калинкин, М. В. Немцова, Е. Б. Кузнецова, Т. В. Кекеева, И. Ю. Виноградов, М. И. Виноградов, И. И. Виноградов, Д. В. Залетаев, В. В. Стрельников

المصدر: Medical Genetics; Том 20, № 11 (2021); 12-17 ; Медицинская генетика; Том 20, № 11 (2021); 12-17 ; 2073-7998

مصطلحات موضوعية: моноаллельное метилирование ДНК, genome wide analysis of DNA methylation, monoallelic DNA methylation, широкогеномный анализ метилирования ДНК

وصف الملف: application/pdf

Relation: https://www.medgen-journal.ru/jour/article/view/1994/1529; Gimelbrant A., Hutchinson J.N., Thompson B.R., Chess A. Widespread monoallelic expression on human autosomes. Science. 2007;318(5853):1136-1140.; Fedoriw A., Mugford J., Magnuson T. Genomic imprinting and epigenetic control of development. Cold Spring Harbor perspectives in biology. 2012;4(7):a008136.; Steyaert S., Van Criekinge W., De Paepe et al. SNP-guided identification of monoallelic DNA-methylation events from enrichment-based sequencing data. Nucleic acids research. 2014;42(20):e157.; da Rocha S.T., Gendrel A.V. The influence of DNA methylation on monoallelic expression. Essays in biochemistry. 2019;63(6):663-676.; Milani L., Lundmark A., Nordlund J. et al. Allele-specific gene expression patterns in primary leukemic cells reveal regulation of gene expression by CpG site methylation Genome research. 2009;19(1):1-11.; Fraenkel S., Mostoslavsky R., Novobrantseva et al. Allelic choice governs somatic hypermutation in vivo at the immunoglobulin κ-chain locus. Nature immunology. 2007;8(7):715-722.; Lomvardas S., Barnea G., Pisapia D.J. et al. Interchromosomal interactions and olfactory receptor choice. Cell. 2006;126(2):403-413.; Serre D., Lee B.H., Ting A.H. MBD-isolated Genome Sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome. Nucleic acids research. 2010;38(2):391-399.; Harris R.A., Wang T., Coarfa С. et al. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nature biotechnology. 2010;28(10):1097-1105.; Mayo O. A century of Hardy-Weinberg equilibrium. Twin Research and Human Genetics. 2008;11(3):249-256.; Tanas A.S., Sigin V.O., Kalinkin A.I. et al. Genome-wide methylotyping resolves breast cancer epigenetic heterogeneity and suggests novel therapeutic perspectives. Epigenomics. 2019;11(6):605-617.; McCabe M.T., Brandes J.C., Vertino P.M. Cancer DNA methylation: molecular mechanisms and clinical implications. Clinical Cancer Research. 2009;15(12):3927-3937.; Scala G., Federico A., Palumbo D., Cocozza S., Greco D. DNA sequence context as a marker of CpG methylation instability in normal and cancer tissues. Scientific reports. 2020;10(1): 1-11.; Martin-Trujillo A., Vidal E., Monteagudo-Sánchez A. et al. Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors. Nature communications. 2017;8(1):1-12.; https://www.medgen-journal.ru/jour/article/view/1994

الاتاحة: https://www.medgen-journal.ru/jour/article/view/1994
https://doi.org/10.25557/2073-7998.2021.11.12-17

المؤلفون: О. Е. Andreeva, V. О. Sigin, V. V. Strelnikov, A. S. Tanas, A. M. Scherbakov, M. A. Krasilnikov

المصدر: Сибирский онкологический журнал, Vol 18, Iss 5, Pp 45-53 (2019)

مصطلحات موضوعية: breast cancer, tamoxifen, exosomes, hormonal resistance, methylation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.siboncoj.ru/jour/article/view/1187; https://doaj.org/toc/1814-4861; https://doaj.org/toc/2312-3168

URL الوصول: https://doaj.org/article/9729f0103a7845e3b9701d8f57c8986b

المؤلفون: Ekaterina A. Alekseeva, Olga V. Babenko, Valentina M. Kozlova, Tatiana L. Ushakova, Tatiana P. Kazubskaya, Marina V. Nemtsova, Galina G. Chesnokova, Dmitry S. Mikhaylenko, Irina V. Bure, Alexey I. Kalinkin, Ekaterina B. Kuznetsova, Alexander S. Tanas, Sergey I. Kutsev, Dmitry V. Zaletaev, Vladimir V. Strelnikov

المصدر: Cancers; Volume 13; Issue 20; Pages: 5068

مصطلحات موضوعية: hereditary retinoblastoma, RB1, penetrance, expressivity, parental origin, low penetrance mutation, NGS

وصف الملف: application/pdf

Relation: Cancer Pathophysiology; https://dx.doi.org/10.3390/cancers13205068

الاتاحة: https://doi.org/10.3390/cancers13205068

المؤلفون: Marina V. Nemtsova, Alexey I. Kalinkin, Ekaterina B. Kuznetsova, Irina V. Bure, Ekaterina A. Alekseeva, Igor I. Bykov, Tatiana V. Khorobrykh, Dmitry S. Mikhaylenko, Alexander S. Tanas, Vladimir V. Strelnikov

المصدر: Cancers; Volume 13; Issue 18; Pages: 4586

مصطلحات موضوعية: gastric cancer, epigenetic regulation genes, somatic mutations, molecular genetic markers

وصف الملف: application/pdf

Relation: Cancer Biomarkers; https://dx.doi.org/10.3390/cancers13184586

الاتاحة: https://doi.org/10.3390/cancers13184586

المؤلفون: Olga A. Simonova, Ekaterina B. Kuznetsova, Alexander S. Tanas, Viktoria V. Rudenko, Elena V. Poddubskaya, Tatiana V. Kekeeva, Ivan D. Trotsenko, Sergey S. Larin, Sergei I. Kutsev, Dmitry V. Zaletaev, Marina V. Nemtsova, Vladimir V. Strelnikov

المصدر: Biomedicines; Volume 8; Issue 5; Pages: 116

مصطلحات موضوعية: matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases, DNA methylation, breast cancer, methylation-sensitive restriction enzyme digestion PCR (MSRE-PCR), genome-wide DNA methylation analysis

وصف الملف: application/pdf

Relation: Cell Biology and Pathology; https://dx.doi.org/10.3390/biomedicines8050116

الاتاحة: https://doi.org/10.3390/biomedicines8050116

المؤلفون: N. L. Sheremet, I. G. Grushke, N. V. Zhorzholadze, I. A. Ronzina, V. V. Kadyshev, E. A. Alekseeva, A. S. Tanas, V. V. Strelnikov, Н. Л. Шеремет, И. Г. Грушкэ, Н. В. Жоржоладзе, И. А. Ронзина, В. В. Кадышев, Е. А. Алексеева, А. С. Танас, В. В. Стрельников

المصدر: Medical Genetics; Том 19, № 8 (2020); 40-41 ; Медицинская генетика; Том 19, № 8 (2020); 40-41 ; 2073-7998

مصطلحات موضوعية: клинико-генетические корреляции, Stargardt disease, ABCA4 gene, phenotype-genotype correlations, болезнь Штаргардта, ABCA4

وصف الملف: application/pdf

Relation: https://www.medgen-journal.ru/jour/article/view/1673/1309; https://www.medgen-journal.ru/jour/article/view/1673

الاتاحة: https://www.medgen-journal.ru/jour/article/view/1673

المؤلفون: K. O. Karandasheva, M. S. Pashchenko, K. I. Anoshkin, E. B. Kuznetsova, A. S. Tanas, V. V. Strelnikov, К. О. Карандашева, М. С. Пащенко, К. И. Аношкин, Е. Б. Кузнецова, А. С. Танас, В. В. Стрельников

المصدر: Medical Genetics; Том 19, № 6 (2020); 10-11 ; Медицинская генетика; Том 19, № 6 (2020); 10-11 ; 2073-7998

مصطلحات موضوعية: NF2, neurofibromatosis type 2, NF1, нейрофиброматоз 2 типа

وصف الملف: application/pdf

Relation: https://www.medgen-journal.ru/jour/article/view/1381/1023; https://www.medgen-journal.ru/jour/article/view/1381

الاتاحة: https://www.medgen-journal.ru/jour/article/view/1381

المؤلفون: A. I. Kalinkin, V. O. Sigin, V. V. Strelnikov, A. S. Tanas, А. И. Калинкин, В. О. Сигин, В. В. Стрельников, А. С. Танас

المصدر: Medical Genetics; Том 19, № 6 (2020); 18-19 ; Медицинская генетика; Том 19, № 6 (2020); 18-19 ; 2073-7998

مصطلحات موضوعية: циклофосфамид, leukotriene receptors, DNA methylation, chemotherapy drugs, лейкотриеновые рецепторы, метилирование ДНК

وصف الملف: application/pdf

Relation: https://www.medgen-journal.ru/jour/article/view/1385/1027; https://www.medgen-journal.ru/jour/article/view/1385

الاتاحة: https://www.medgen-journal.ru/jour/article/view/1385

المؤلفون: M. V. Nemtsova, A. I. Kalinkin, E. B. Kuznetsova, E. A. Alekseeva, I. V. Bure, D. S. Mikhaylenko, A. S. Tanas, V. V. Strelnikov, М. В. Немцова, А. И. Калинкин, Е. Б. Кузнецова, Е. А. Алексеева, И. В. Буре, Д. С. Михайленко, А. С. Танас, В. В. Стрельников

المصدر: Medical Genetics; Том 19, № 6 (2020); 75-76 ; Медицинская генетика; Том 19, № 6 (2020); 75-76 ; 2073-7998

مصطلحات موضوعية: соматические мутации, genes, epigenetic regulators, NGS, somatic mutations, гены эпигенетические регуляторы, высокопроизводительное секвенирование (NGS)

وصف الملف: application/pdf

Relation: https://www.medgen-journal.ru/jour/article/view/1410/1052; https://www.medgen-journal.ru/jour/article/view/1410

الاتاحة: https://www.medgen-journal.ru/jour/article/view/1410

المؤلفون: Dmitry S. Mikhaylenko, Alexander S. Tanas, Dmitry V. Zaletaev, Marina V. Nemtsova

المصدر: Journal of Oncology, Vol 2020 (2020)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Relation: http://dx.doi.org/10.1155/2020/7363102; https://doaj.org/toc/1687-8450; https://doaj.org/toc/1687-8469; https://doaj.org/article/daebe059674d4191a3cd2f9ebde0c3da

الاتاحة: https://doi.org/10.1155/2020/7363102
https://doaj.org/article/daebe059674d4191a3cd2f9ebde0c3da

المؤلفون: A. I. Kalinkin, V. O. Sigin, E. O. Ignatova, M. A. Frolova, E. B. Kuznetsova, I. Y. Vinogradov, M. I. Vinogradov, I. I. Vinogradov, M. V. Nemtsova, D. V. Zaletaev, A. S. Tanas, V. V. Strelnikov

المصدر: Russian Journal of Genetics. 58:835-843

مصطلحات موضوعية: Genetics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::95a207d0b897c4a3fb320ece83de6bc3
https://doi.org/10.1134/s1022795422070080

المؤلفون: K. O. Karandasheva, M. S. Pashchenko, N. A. Demina, I. A. Akimova, O. N. Makienko, M. S. Petuhova, L. A. Bessonova, I. V. Anisimova, A. S. Tanas, D. V. Zaletaev, V. V. Strelnikov, E. B. Kuznetsova, К. О. Карандашева, М. С. Пащенко, Н. А. Дёмина, И. А. Акимова, О. Н. Макиенко, М. С. Петухова, Л. А. Бессонова, И. В. Анисимова, А. С. Танас, Д. В. Залетаев, В. В. Стрельников, Е. Б. Кузнецова

المصدر: Medical Genetics; Том 18, № 5 (2019); 28-36 ; Медицинская генетика; Том 18, № 5 (2019); 28-36 ; 2073-7998

مصطلحات موضوعية: NGS, NF1, соматический мозаицизм, высокопроизводительное параллельное секвенирование, neurofibromatosis, genetic mosaicism

وصف الملف: application/pdf

Relation: https://www.medgen-journal.ru/jour/article/view/684/419; https://www.medgen-journal.ru/jour/article/view/684

الاتاحة: https://www.medgen-journal.ru/jour/article/view/684
https://doi.org/10.25557/2073-7998.2019.05.28-36

المؤلفون: T. V. Kekeeva, T. A. Zhinzhilo, Y. N. Nenakhova, V. K. Lyadov, S. Yu. Bogomazova, V. V. Rudenko, E. B. Kuznetsova, A. S. Tanas, D. V. Zaletaev, V. V. Strelnikov, Т. В. Кекеева, Т. А. Жинжило, Ю. Н. Ненахова, В. К. Лядов, С. Ю. Богомазова, В. В. Руденко, Е. Б. Кузнецова, А. С. Танас, Д. В. Залетаев, В. В. Стрельников

المصدر: Medical Genetics; Том 17, № 10 (2018); 38-41 ; Медицинская генетика; Том 17, № 10 (2018); 38-41 ; 2073-7998

مصطلحات موضوعية: blood plasma, неоадъювантная химиотерапия, маркеры метилирования, плазма крови, Breast cancer, neoadjuvant chemotherapy, methylation markers

وصف الملف: application/pdf

Relation: https://www.medgen-journal.ru/jour/article/view/592/373; Лазарева М.А., Павлов М.В., Шумская И.С., Овчинникова Е.Г., Ильинская О.Е., Орлова А.Г., Шахова Н.М., Масленникова А.В. Анализ эффективности неоадъювантной химиотерапии рака молочной железы. Онкогинекология. 2016. 4, 26-33.; Parekh T, Dodwell D, Sharma N, Shaaban A. Radiological and pathological predictors of response to neoadjuvant chemotherapy in breast cancer: a brief literature review. Pathobiology. 2015 82(3-4):124-32.; Fayanju OM, Ren Y, Thomas SM, Greenup RA, Plichta JK, Rosenberger L, Tamirisa N, Force J, Boughey JC, Hyslop T, Hwang ES. The Clinical Significance of Breast-only and Node-only Pathologic Complete Response (pCR) After Neoadjuvant Chemotherapy (NACT): A Review of 20,000 Breast Cancer Patients in the National Cancer Data Base (NCDB). Ann Surg. 2018. doi:10.1097/SLA.0000000000002953.; Watanabe Y, Maeda I, Oikawa R, Wu W, Tsuchiya K, Miyoshi Y, Itoh F, Tsugawa K, Ohta T. Aberrant DNA methylation status of DNA repair genes in breast cancer treated with neoadjuvant chemotherapy. Genes Cells. 2013. 18(12):1120-30.; Tsang JS, Vencken S, Sharaf O, Leen E, Kay EW, McNamara DA, Deasy J, Mulligan ED. Global DNA methylation is altered by neoadjuvant chemoradiotherapy in rectal cancer and may predict response to treatment - A pilot study. Eur J Surg Oncol. 2014. 40(11):1459-66.; Takahashi H, Kagara N, Tanei T, Naoi Y, Shimoda M, Shimomura A, Shimazu K, Kim S, Noguchi S. Correlation of Methylated Circulating Tumor DNA With Response to Neoadjuvant Chemotherapy in Breast Cancer Patients. Clinical Breast Cancer. 2017. 17(1):61-69e3.; Bhangu J, Beer A, Mittlbock M, Tamandl D, Pulverer W, Taghizadeh H, Stremitzer S, Kaczirek K, Gruenberger T, Gnant M, Bergmann M, Mannhalter C, Weinhousel A, Oehler R, Bachleitner-Hofmann T. Circulating Free Methylated Tumor DNA Markers for Sensitive Assessment of Tumor Burden and Early Response Monitoring in Patients Receiving Systemic Chemotherapy for Colorectal Cancer Liver Metastasis. Ann Surg. 2018. doi:10.1097/SLA.0000000000002901.; Гарбуков Е.Ю., Слонимская Е.М., Красулина Н.А., Дорошенко А.В., Кокорина Ю.Л. Неоадъювантная терапия при раке молочной железы. Сибирский онкологический журнал. 2005. 2 (14):63.; Tanas A.S., Poddubskaya E.V., Kekeeva T.V., Trotsenko I.D., Kuznetsova E.B., Zaletayev D.V., Strelnikov V.V. Breast cancer molecular classification based on DNA methylation assessed by reduced representation bisulfite sequencing. Eur J Hum Genet. 2015. 23 (S1):263.; Сигин В.О., Кузнецова Е.Б., Симонова О.А., Жевлова А.И., Литвяков Н.В., Слонимская Е.М., Цыганов М.М., Володин И.В., Шикеева А.А., Стрельников В.В., Залетаев Д.В., Танас А.С. Медицинская ДНК-технология оценки чувствительности опухолей молочной железы люминального В подтипа к неоадъювантной химиотерапии с применением антрациклинов на основе маркеров метилирования ДНК. Медицинская генетика. 2017;16(10):29-35.; Wang X, Xiao F, Li Q, Liu J, He Y,1 K. Qing-Peng. Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway. Oncotarget. 2017. 8(7):11868-11876.; Shen-Gunther J, Wang CM, Poage GM, Lin CL, Perez L, Banks NA, Huang TH. Molecular Pap smear: HPV genotype and DNA methylation of ADCY8, CDH8, and ZNF582 as an integrated biomarker for high-grade cervical cytology. Clin Epigenetics. 2016. 8:96. doi:10.1186/s13148-016-0263-9.; https://www.medgen-journal.ru/jour/article/view/592

الاتاحة: https://www.medgen-journal.ru/jour/article/view/592
https://doi.org/10.25557/2073-7998.2018.10.38-41

المؤلفون: V. O. Sigin, E. B. Kuznetsova, O. A. Simonova, A. I. Zhevlova, N. V. Litviakov, E. M. Slonimskaya, M. M. Tsyganov, I. V. Volodin, A. A. Shikeeva, V. V. Strelnikov, D. V. Zaletaev, A. S. Tanas, В. О. Сигин, Е. Б. Кузнецова, О. А. Симонова, А. И. Жевлова, Н. В. Литвяков, Е. М. Слонимская, М. М. Цыганов, И. В. Володин, А. А. Шикеева, В. В. Стрельников, Д. В. Залетаев, А. С. Танас

المصدر: Medical Genetics; Том 16, № 10 (2017); 29-35 ; Медицинская генетика; Том 16, № 10 (2017); 29-35 ; 2073-7998

مصطلحات موضوعية: multilocus methylation sensitive restriction enzyme PCR, неоадъювантная химиотерапия, широкогеномный анализ метилирования ДНК, многолокусная метилчувствительная ПЦР, Breast cancer, neoadjuvant chemotherapy, genome wide analysis of DNA methylation

وصف الملف: application/pdf

Relation: https://www.medgen-journal.ru/jour/article/view/334/250; Kaufmann M., von Minckwitz G., Mamounas E.P., et al. Recommendations from an international consensus conference on the current status and future of neoadjuvant systemic therapy in primary breast cancer. Ann Surg Oncol. 2012; 19(5): 1508-1516.; Litviakov N.V., Cherdyntseva N.V., Tsyganov M.M., Slonimskaya Е.M., Ibragimova M.K., Kazantseva P.V., Kzhyshkowska Julia, Choinzonov E.L. Deletions of multidrug resistance gene loci in breast cancer leads to the down-regulation of its expression and predict tumor response to neoadjuvant chemotherapy. Oncotarget. 2016; 7(7): 7829-7841.; Казанцева П.В., Цыганов М.М., Слонимская Е.М., Литвяков Н.В., Чердынцева Н.В., Ибрагимова М.К., Дорошенко А.В., Тарабановская Н.А., Паталяк С.В. Молекулярно-генетические маркеры эффективности неоадъювантной химиотерапии с применением антрациклинов у больных раком молочной железы. Сибирский онкологический журнал. 2016; 15(2): 29-35.; М.М. Цыганов, А.Г. Щербакова Метилирование промоторов генов множественной лекарственной устойчивости в опухолевой ткани молочной железы и эффект неоадъювантной химиотерапии. Сибирский онкологический журнал. 2012; 172-173; Стрельников В.В. Основные направления молекулярно-генетических исследований в онкологии // Медицинская генетика. - 2012. - №10; Aubele M. et al. The Predictive Value of PITX2 DNA Methylation for High-Risk Breast Cancer Therapy: Current Guidelines, Medical Needs, and Challenges //Disease Markers. - 2017. - Т. 2017.; Akiyama Y. et al. GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer //Molecular and cellular biology. - 2003. - Т. 23. - №. 23. - С. 8429-8439.; Cancer Genome Atlas Network Et al. Comprehensive molecular portraits of human breast tumors. Nature. 2012; 490(7418): 61-70; Tanas A.S., Borisova M.E., Kuznetsova E.B., Rudenko V.V., Karandasheva K.O., Nemtsova M.V., Izhevskaya V.L., Simonova O.A., Larin S.S., Zaletaev D.V., Strelnikov V.V. Rapid and Affordable Genome-Wide Bisulfite DNA Sequencing by XmaI-reduced Representation Bisulfite Sequencing. Epigenomics. 2017; 9(6): 833-847.; Стрельников В.В., Танас А.С., Руденко В.В., Кузнецова Е.Б., Залетаев Д.В. Геномный анализ метилирования ДНК с использованием секвенирования нового поколения. Медицинская генетика. 2014; 13(3): 32-37.; Танас А.С., Кузнецова Е.Б., Борисова М.Э., Руденко В.В., Залетаев Д.В., Стрельников В.В. Дизайн метода бисульфитного секвенирования ограниченных наборов геномных локусов (RRBS) для анализа метилирования CpG-островков человека в больших выборках. Молекулярная биология. 2015; 49(4): 689-699.; Raizis A. M., Schmitt F., Jost J. P. A bisulfite method of 5-methylcytosine mapping that minimizes template degradation. Analytical biochemistry. 1995; 226(1): 161-166.; Olova N., Krueger F., Andrews S., Oxley D.O., Branco M.R., Reik W. Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data. bioRxiv. 2017: 165449.; Melnikov A.A., Gartenhaus R.B., Levenson A.S., Motchoulskaia N.A., Levenson V.V. MSRE-PCR for analysis of gene-specific DNA methylation. Nucleic acids research. 2005; 33(10): e93.; Стрельников В.В., Танас А.С., Кузнецова Е.Б. Методология локус-специфического анализа метилирования ДНК. Издательство: LAP Lambert Academic Publishing. ISBN 9783659670411; 2014; 104 С.; https://www.medgen-journal.ru/jour/article/view/334

الاتاحة: https://www.medgen-journal.ru/jour/article/view/334