نتائج البحث - "A(2A)R"

المساهمون: Department of Medical Pharmacology, College of Medicine, University of Arizona, Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine, Neuroscience Graduate Interdisciplinary Program, University of Arizona, Comprehensive Pain and Addiction-Center (CPA-C), University of Arizona Health Sciences, Center of Excellence in Addiction Studies (CEAS), University of Arizona, Department of Neuroscience, College of Science, University of Arizona, James C. Wyant College of Optical Sciences, University of Arizona

المصدر: Neuroscience letters ; 789 ; 136864 ; Ireland

مصطلحات موضوعية: 5-HT(2A)R, Kv7 ion channels, Pain, Prelimbic cortex, Retigabine, Spared nerve injury (SNI)

Relation: Vizcarra, V. S., Barber, K. R., Franca-Solomon, G., Majuta, L., Smith, A., Langlais, P. R., Largent-Milnes, T. M., Vanderah, T. W., & Riegel, A. C. (2022). Targeting 5-HT2A receptors and Kv7 channels in PFC to attenuate chronic neuropathic pain in rats using a spared nerve injury model. Neuroscience Letters, 789.; http://hdl.handle.net/10150/666404; Neuroscience Letters

الاتاحة: http://hdl.handle.net/10150/666404
https://doi.org/10.1016/j.neulet.2022.136864

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8

Academic Journal

Myelin Defects in Niemann–Pick Type C Disease: Mechanisms and Possible Therapeutic Perspectives

المؤلفون: Antonietta Bernardo, Chiara De Nuccio, Sergio Visentin, Alberto Martire, Luisa Minghetti, Patrizia Popoli, Antonella Ferrante

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 16; Pages: 8858

مصطلحات موضوعية: Niemann–Pick type C disease, myelination, oligodendrocytes, cholesterol, mitochondrial impairment, A 2A R, adenosine

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Neurobiology; https://dx.doi.org/10.3390/ijms22168858

الاتاحة: https://doi.org/10.3390/ijms22168858

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9

Academic Journal

Downregulation of CD73/A2AR-Mediated Adenosine Signaling as a Potential Mechanism of Neuroprotective Effects of Theta-Burst Transcranial Magnetic Stimulation in Acute Experimental Autoimmune Encephalomyelitis

المؤلفون: Milorad Dragić, Milica Zeljković, Ivana Stevanović, Marija Adžić, Andjela Stekić, Katarina Mihajlović, Ivana Grković, Nela Ilić, Tihomir V. Ilić, Nadežda Nedeljković, Milica Ninković

المصدر: Brain Sciences; Volume 11; Issue 6; Pages: 736

مصطلحات موضوعية: CD73, adenosine, A 2A R, A 1 R, neuroinflammation, theta-burst stimulation, rTMS, purinergic signaling

وصف الملف: application/pdf

Relation: Sensory and Motor Neuroscience; https://dx.doi.org/10.3390/brainsci11060736

الاتاحة: https://doi.org/10.3390/brainsci11060736

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10

Academic Journal

Ligand-Dependent Conformational Transitions in Molecular Dynamics Trajectories of GPCRs Revealed by a New Machine Learning Rare Event Detection Protocol

المؤلفون: Ambrose Plante, Harel Weinstein

المصدر: Molecules; Volume 26; Issue 10; Pages: 3059

مصطلحات موضوعية: ligand-induced GPCR structure and dynamics, function-related conformational transitions, pharmacological efficacy, serotonin 5-HT 2A R receptor, inverse agonist, functional selectivity, molecular dynamics simulations, non-negative factorization, drug discovery

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules26103059

الاتاحة: https://doi.org/10.3390/molecules26103059

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11

Academic Journal

Structure-based identification of dual ligands at the A(2A)R and PDE10A with anti-proliferative effects in lung cancer cell-lines

المؤلفون: Kalash, L, Winfield, I, Safitri, D, Bermudez, M, Carvalho, S, Glen, R, Ladds, G, Bender, A

Relation: Journal of Cheminformatics; http://hdl.handle.net/10044/1/93855

الاتاحة: http://hdl.handle.net/10044/1/93855
https://doi.org/10.1186/s13321-021-00492-5

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12

Academic Journal

Guanosine-Mediated Anxiolytic-Like Effect: Interplay with Adenosine A1 and A2A Receptors

المؤلفون: Monica Frinchi, Vincenzo Verdi, Fulvio Plescia, Francisco Ciruela, Maria Grillo, Roberta Garozzo, Daniele F. Condorelli, Patrizia Di Iorio, Francesco Caciagli, Renata Ciccarelli, Natale Belluardo, Valentina Di Liberto, Giuseppa Mudò

المصدر: International Journal of Molecular Sciences; Volume 21; Issue 23; Pages: 9281

مصطلحات موضوعية: guanosine, adenosine, behavior, A 1 R, A 2A R, caffeine

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Role of Xenobiotics; https://dx.doi.org/10.3390/ijms21239281

الاتاحة: https://doi.org/10.3390/ijms21239281

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13

Academic Journal

Adenosine A1-A2A Receptor-Receptor Interaction: Contribution to Guanosine-Mediated Effects

المؤلفون: Débora Lanznaster, Caio M. Massari, Vendula Marková, Tereza Šimková, Romain Duroux, Kenneth A. Jacobson, Víctor Fernández-Dueñas, Carla I. Tasca, Francisco Ciruela

المصدر: Cells; Volume 8; Issue 12; Pages: 1630

مصطلحات موضوعية: guanosine, neuroprotection, oxygen/glucose deprivation, NanoBRET, A 1 R/A 2A R heteromer

وصف الملف: application/pdf

Relation: Cell Signaling; https://dx.doi.org/10.3390/cells8121630

الاتاحة: https://doi.org/10.3390/cells8121630

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14

Structure‐based identification of dual ligands at the A 2A R and PDE10A with anti‐proliferative effects in lung cancer cell‐lines

المؤلفون: Leen Kalash, Marcel Bermudez, Graham Ladds, Ian Winfield, Dewi Safitri, Sabrina Carvalho, Robert C. Glen, Andreas Bender

المساهمون: Kalash, Leen [0000-0002-1751-6658], Safitri, Dewi [0000-0003-2260-3892], Bermudez, Marcel [0000-0002-7421-3282], Glen, Robert [0000-0003-1759-2914], Ladds, Graham [0000-0001-7320-9612], Apollo - University of Cambridge Repository

المصدر: Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-17 (2021)
Journal of Cheminformatics

مصطلحات موضوعية: 0301 basic medicine, Technology, Chemistry, Multidisciplinary, NSCLC, law.invention, Docking, lcsh:Chemistry, 0302 clinical medicine, law, Receptor, MD simulations, Computer Science, Information Systems, lcsh:T58.5-58.64, In Silico Structure Generation: Recent Developments, Applications, and Challenges, Anti-proliferative, Chemistry, lcsh:Information technology, A(2A)R, Phosphodiesterase, 0303 Macromolecular and Materials Chemistry, Computer Graphics and Computer-Aided Design, Computer Science Applications, 030220 oncology & carcinogenesis, Physical Sciences, Computer Science, Interdisciplinary Applications, Lung cancer, 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften, Research Article, Virtual screening, Anti‐proliferative, Structure-based design, Library and Information Sciences, 03 medical and health sciences, Dual target, medicine, Physical and Theoretical Chemistry, Science & Technology, PDE10A, Cancer, medicine.disease, Structure‐based design, 030104 developmental biology, lcsh:QD1-999, Docking (molecular), Computer Science, Cancer research, Triazoloquinazolines, Suppressor, A2AR

وصف الملف: text/xml; application/zip; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a6d65238905c66462260ad45998e0f

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15

Academic Journal

Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT 2A or 5-HT 2C receptors

المؤلفون: Seitz Patricia K, Bremer Nicole M, McGinnis Andrew G, Cunningham Kathryn A, Watson Cheryl S

المصدر: BMC Neuroscience, Vol 13, Iss 1, p 25 (2012)

مصطلحات موضوعية: Serotonin, 5-HT 2A R, 5-HT 2C R, Intracellular calcium, pERK, Cell signaling, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurophysiology and neuropsychology, QP351-495

Relation: http://www.biomedcentral.com/1471-2202/13/25; https://doaj.org/toc/1471-2202; https://doaj.org/article/7a7eef5d5b7c42cc8b952c13e8788623

الاتاحة: https://doi.org/10.1186/1471-2202-13-25
https://doaj.org/article/7a7eef5d5b7c42cc8b952c13e8788623

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