المؤلفون: McFaline-Figueroa, J, Sun, Lu, Youssef, Gilbert, Huang, Raymond, Li, Gang, Kim, Jiyoon, Lee, Eudocia, Nayak, Lakshmi, Chukwueke, Ugonma, Beroukhim, Rameen, Batchelor, Tracy, Chiocca, E, Everson, Richard, Doherty, Lisa, Stefanik, Jennifer, Partridge, Kathryn, Spearman, Amanda, Myers, Alexa, Westergaard, Catharina, Russ, Alyssa, Lavallee, Maria, Smokovich, Anna, LaForest-Roys, Corey, Garcia Fox, Rachel, McCluskey, Christine, Bi, Wenya, Arnaout, Omar, Peruzzi, PierPaolo, Cosgrove, G, Ligon, Keith, Arrillaga-Romany, Isabel, Clarke, Jennifer, Reardon, David, Cloughesy, Timothy, Prins, Robert, Wen, Patrick

المصدر: Nature Communications. 15(1)

مصطلحات موضوعية: Humans, Glioblastoma, Antibodies, Monoclonal, Humanized, Neoadjuvant Therapy, Male, Female, Neoplasm Recurrence, Local, Middle Aged, Programmed Cell Death 1 Receptor, Brain Neoplasms, Immune Checkpoint Inhibitors, Aged, Immunotherapy, Adult, Cohort Studies, Gene Expression Regulation, Neoplastic, Treatment Outcome

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0g72g9bm
https://escholarship.org/content/qt0g72g9bm/qt0g72g9bm.pdf

المؤلفون: Paczkowska, Julia, Tang, Ming, Wright, Kyle, Song, Li, Luu, Kelsey, Shanmugam, Vignesh, Welsh, Emma, Weirather, Jason, Besson, Naomi, Olszewski, Harrison, Porter, Billie, Pfaff, Kathleen, Redd, Robert, Cader, Fathima, Mandato, Elisa, Ouyang, Jing, Calabretta, Eleonora, Bai, Gali, Lawton, Lee, Armand, Philippe, Rodig, Scott, Liu, Xiaole, Shipp, Margaret

المصدر: Nature Communications. 15(1)

مصطلحات موضوعية: Humans, Hodgkin Disease, Programmed Cell Death 1 Receptor, Immunity, Innate, Immune Checkpoint Inhibitors, Drug Resistance, Neoplasm, Interleukin-1beta, Tumor Microenvironment, Adaptive Immunity, CD4-Positive T-Lymphocytes, Monocytes, B-Lymphocytes, Reed-Sternberg Cells, Macrophages, Male, Female

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3gb893gs
https://escholarship.org/content/qt3gb893gs/qt3gb893gs.pdf

المؤلفون: López Estévez, Sergio

Thesis Advisors: Martínez Perea, Vicente

المصدر: TDX (Tesis Doctorals en Xarxa)

مصطلحات موضوعية: Dolor visceral, Visceral pain, Inflamació intestinal, Inflamación intestinal, Intestinal inflammation, Receptor sigma tipus 1, Receptor sigma tipo 1, Sigma 1 receptor, Ciències de la Salut

وصف الملف: application/pdf

URL الوصول: http://hdl.handle.net/10803/674510

المصدر: Hyperinsulinemia in Prediabetes Mediated by Interleukin-1β- The Hyper-PreDIL-Study

المصدر: IL-1-receptor Antagonist During Cephalic Phase of Insulin Secretion in Health and Type 2 Diabetes

المصدر: Personalized Immunotherapy in Sepsis: a Multicentre and Multinational, Double-blind, Double-dummy Randomized Clinical Trial

المؤلفون: National Institute on Aging (NIA), University of Virginia

المصدر: Interleukin-1 Blockade in Acute Myocardial Infarction to Prevent Heart Failure: The Virginia - Anakinra Remodeling Trial 4

المؤلفون: Swedish Orphan Biovitrum

المصدر: Phase 2 Pilot Study to Evaluate Efficacy and Safety of Anakinra to Prevent CD19-Targeted CAR-T Cell-Related Cytokine Release Syndrome (CRS) and Neurotoxicity in Patients With B Cell Lymphoma

المؤلفون: National Cancer Institute (NCI)

المصدر: Pilot Study of Anakinra to Mitigate CAR-T Toxicity in Subjects With Relapsed or Refractory Large B-Cell Lymphoma

المؤلفون: National Center for Advancing Translational Sciences (NCATS)

المصدر: Pilot Study of Pre-emptive Anakinra for the Prevention of Severe Cytokine Release Syndrome in Children and Young Adults With B-Acute Lymphoblastic Leukemia Receiving Chimeric Antigen Receptor (CAR) T Cells
Gazeau N, Liang EC, Wu QV, Voutsinas JM, Barba P, Iacoboni G, Kwon M, Ortega JLR, Lopez-Corral L, Hernani R, Ortiz-Maldonado V, Martinez-Cibrian N, Martinez AP, Maziarz RT, Williamson S, Nemecek ER, Shadman M, Cowan AJ, Green DJ, Kimble E, Hirayama AV, Maloney DG, Turtle CJ, Gauthier J. Anakinra for Refractory Cytokine Release Syndrome or Immune Effector Cell-Associated Neurotoxicity Syndrome after Chimeric Antigen Receptor T Cell Therapy. Transplant Cell Ther. 2023 Jul;29(7):430-437. doi: 10.1016/j.jtct.2023.04.001. Epub 2023 Apr 7.
Hines MR, Knight TE, McNerney KO, Leick MB, Jain T, Ahmed S, Frigault MJ, Hill JA, Jain MD, Johnson WT, Lin Y, Mahadeo KM, Maron GM, Marsh RA, Neelapu SS, Nikiforow S, Ombrello AK, Shah NN, Talleur AC, Turicek D, Vatsayan A, Wong SW, Maus MV, Komanduri KV, Berliner N, Henter JI, Perales MA, Frey NV, Teachey DT, Frank MJ, Shah NN. Immune Effector Cell-Associated Hemophagocytic Lymphohistiocytosis-Like Syndrome. Transplant Cell Ther. 2023 Jul;29(7):438.e1-438.e16. doi: 10.1016/j.jtct.2023.03.006. Epub 2023 Mar 9.
Rejeski K, Subklewe M, Aljurf M, Bachy E, Balduzzi A, Barba P, Bruno B, Benjamin R, Carrabba MG, Chabannon C, Ciceri F, Corradini P, Delgado J, Di Blasi R, Greco R, Houot R, Iacoboni G, Jager U, Kersten MJ, Mielke S, Nagler A, Onida F, Peric Z, Roddie C, Ruggeri A, Sanchez-Guijo F, Sanchez-Ortega I, Schneidawind D, Schubert ML, Snowden JA, Thieblemont C, Topp M, Zinzani PL, Gribben JG, Bonini C, Sureda A, Yakoub-Agha I. Immune effector cell-associated hematotoxicity: EHA/EBMT consensus grading and best practice recommendations. Blood. 2023 Sep 7;142(10):865-877. doi: 10.1182/blood.2023020578.
Kineret. Package Insert. Biovitrum AB. December 18th.
Lee DW, Santomasso BD, Locke FL, Ghobadi A, Turtle CJ, Brudno JN, Maus MV, Park JH, Mead E, Pavletic S, Go WY, Eldjerou L, Gardner RA, Frey N, Curran KJ, Peggs K, Pasquini M, DiPersio JF, van den Brink MRM, Komanduri KV, Grupp SA, Neelapu SS. ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells. Biol Blood Marrow Transplant. 2019 Apr;25(4):625-638. doi: 10.1016/j.bbmt.2018.12.758. Epub 2018 Dec 25.
Strati P, Jallouk A, Deng Q, Li X, Feng L, Sun R, Adkins S, Johncy S, Cain T, Steiner RE, Ahmed S, Chihara D, Fayad LE, Iyer SP, Horowitz S, Nastoupil LJ, Nair R, Hassan A, Daoud TE, Hawkins M, Rodriguez MA, Shpall EJ, Ramdial JL, Kebriaei P, Hong DS, Westin JR, Neelapu SS, Green MR. A phase 1 study of prophylactic anakinra to mitigate ICANS in patients with large B-cell lymphoma. Blood Adv. 2023 Nov 14;7(21):6785-6789. doi: 10.1182/bloodadvances.2023010653. No abstract available.
Liang EC, Albittar A, Portuguese AJ, Huang JJ, Wuliji N, Wu Q, De Los Reyes J, Pin N, Torkelson A, Kirchmeier DR. Planned Interim Analysis of a Phase 2 Investigator-Initiated Trial of Anakinra to Prevent CRS and Neurotoxicity after Treatment with Lisocabtagene Maraleucel. Transplantation and Cellular Therapy. 2024;30(2):S179-S80.
Frigault MJ, Gallagher KM, Wehrli M, Valles B, Casey K, Lindell K, Trailor M, Cho H, Brown JL, Horick NK. A phase II trial of anakinra for the prevention of CAR-T cell mediated neurotoxicity. Blood. 2021;138:2814.
Park JH, Nath K, Devlin SM, Sauter CS, Palomba ML, Shah G, Dahi P, Lin RJ, Scordo M, Perales MA, Shouval R, Tomas AA, Cathcart E, Mead E, Santomasso B, Holodny A, Brentjens RJ, Riviere I, Sadelain M. CD19 CAR T-cell therapy and prophylactic anakinra in relapsed or refractory lymphoma: phase 2 trial interim results. Nat Med. 2023 Jul;29(7):1710-1717. doi: 10.1038/s41591-023-02404-6. Epub 2023 Jul 3.
Hines MR, Keenan C, Maron Alfaro G, Cheng C, Zhou Y, Sharma A, Hurley C, Nichols KE, Gottschalk S, Triplett BM, Talleur AC. Hemophagocytic lymphohistiocytosis-like toxicity (carHLH) after CD19-specific CAR T-cell therapy. Br J Haematol. 2021 Aug;194(4):701-707. doi: 10.1111/bjh.17662. Epub 2021 Jul 15.
Dreyzin A, Jacobsohn D, Angiolillo A, Wistinghausen B, Schore RJ, Perez E, Wells E, Terao J, Bonifant C, Rohatgi R, Dave H, Vatsayan A. Intravenous anakinra for tisagenlecleucel-related toxicities in children and young adults. Pediatr Hematol Oncol. 2022 May;39(4):370-378. doi: 10.1080/08880018.2021.1988012. Epub 2021 Oct 21. No abstract available.
Lichtenstein DA, Schischlik F, Shao L, Steinberg SM, Yates B, Wang HW, Wang Y, Inglefield J, Dulau-Florea A, Ceppi F, Hermida LC, Stringaris K, Dunham K, Homan P, Jailwala P, Mirazee J, Robinson W, Chisholm KM, Yuan C, Stetler-Stevenson M, Ombrello AK, Jin J, Fry TJ, Taylor N, Highfill SL, Jin P, Gardner RA, Shalabi H, Ruppin E, Stroncek DF, Shah NN. Characterization of HLH-like manifestations as a CRS variant in patients receiving CD22 CAR T cells. Blood. 2021 Dec 16;138(24):2469-2484. doi: 10.1182/blood.2021011898.
Diorio C, Vatsayan A, Talleur AC, Annesley C, Jaroscak JJ, Shalabi H, Ombrello AK, Hudspeth M, Maude SL, Gardner RA, Shah NN. Anakinra utilization in refractory pediatric CAR T-cell associated toxicities. Blood Adv. 2022 Jun 14;6(11):3398-3403. doi: 10.1182/bloodadvances.2022006983. No abstract available.
Summerlin J, Wells DA, Anderson MK, Halford Z. A Review of Current and Emerging Therapeutic Options for Hemophagocytic Lymphohistiocytosis. Ann Pharmacother. 2023 Jul;57(7):867-879. doi: 10.1177/10600280221134719. Epub 2022 Nov 9.
Hines MR, von Bahr Greenwood T, Beutel G, Beutel K, Hays JA, Horne A, Janka G, Jordan MB, van Laar JAM, Lachmann G, Lehmberg K, Machowicz R, Miettunen P, La Rosee P, Shakoory B, Zinter MS, Henter JI. Consensus-Based Guidelines for the Recognition, Diagnosis, and Management of Hemophagocytic Lymphohistiocytosis in Critically Ill Children and Adults. Crit Care Med. 2022 May 1;50(5):860-872. doi: 10.1097/CCM.0000000000005361. Epub 2021 Oct 5.
Shakoory B, Carcillo JA, Chatham WW, Amdur RL, Zhao H, Dinarello CA, Cron RQ, Opal SM. Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial. Crit Care Med. 2016 Feb;44(2):275-81. doi: 10.1097/CCM.0000000000001402.
Sonmez HE, Demir S, Bilginer Y, Ozen S. Anakinra treatment in macrophage activation syndrome: a single center experience and systemic review of literature. Clin Rheumatol. 2018 Dec;37(12):3329-3335. doi: 10.1007/s10067-018-4095-1. Epub 2018 Apr 16.
Mehta P, Cron RQ, Hartwell J, Manson JJ, Tattersall RS. Silencing the cytokine storm: the use of intravenous anakinra in haemophagocytic lymphohistiocytosis or macrophage activation syndrome. Lancet Rheumatol. 2020 Jun;2(6):e358-e367. doi: 10.1016/S2665-9913(20)30096-5. Epub 2020 May 4.
Charlesworth JEG, Kavirayani A. Intravenous anakinra for the treatment of haemophagocytic lymphohistiocytosis/macrophage activation syndrome: A systematic review. Eur J Haematol. 2023 Sep;111(3):458-476. doi: 10.1111/ejh.14029. Epub 2023 Jun 21.
Norelli M, Camisa B, Barbiera G, Falcone L, Purevdorj A, Genua M, Sanvito F, Ponzoni M, Doglioni C, Cristofori P, Traversari C, Bordignon C, Ciceri F, Ostuni R, Bonini C, Casucci M, Bondanza A. Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells. Nat Med. 2018 Jun;24(6):739-748. doi: 10.1038/s41591-018-0036-4. Epub 2018 May 28.
Giavridis T, van der Stegen SJC, Eyquem J, Hamieh M, Piersigilli A, Sadelain M. CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade. Nat Med. 2018 Jun;24(6):731-738. doi: 10.1038/s41591-018-0041-7. Epub 2018 May 28.
McNerney KO, Si Lim SJ, Ishikawa K, Dreyzin A, Vatsayan A, Chen JJ, Baggott C, Prabhu S, Pacenta HL, Philips C, Rossoff J, Stefanski HE, Talano JA, Moskop A, Verneris M, Myers D, Karras NA, Brown P, Bonifant CL, Qayed M, Hermiston M, Satwani P, Krupski C, Keating AK, Baumeister SHC, Fabrizio VA, Chinnabhandar V, Egeler E, Mavroukakis S, Curran KJ, Mackall CL, Laetsch TW, Schultz LM. HLH-like toxicities predict poor survival after the use of tisagenlecleucel in children and young adults with B-ALL. Blood Adv. 2023 Jun 27;7(12):2758-2771. doi: 10.1182/bloodadvances.2022008893.
Kadauke S, Myers RM, Li Y, Aplenc R, Baniewicz D, Barrett DM, Barz Leahy A, Callahan C, Dolan JG, Fitzgerald JC, Gladney W, Lacey SF, Liu H, Maude SL, McGuire R, Motley LS, Teachey DT, Wertheim GB, Wray L, DiNofia AM, Grupp SA. Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial. J Clin Oncol. 2021 Mar 10;39(8):920-930. doi: 10.1200/JCO.20.02477. Epub 2021 Jan 8.
Schultz LM, Baggott C, Prabhu S, Pacenta HL, Phillips CL, Rossoff J, Stefanski HE, Talano JA, Moskop A, Margossian SP, Verneris MR, Myers GD, Karras NA, Brown PA, Qayed M, Hermiston M, Satwani P, Krupski C, Keating AK, Wilcox R, Rabik CA, Fabrizio VA, Rouce RH, Chinnabhandar V, Kunicki M, Barsan VV, Goksenin AY, Li Y, Mavroukakis S, Egeler E, Curran KJ, Mackall CL, Laetsch TW. Disease Burden Affects Outcomes in Pediatric and Young Adult B-Cell Lymphoblastic Leukemia After Commercial Tisagenlecleucel: A Pediatric Real-World Chimeric Antigen Receptor Consortium Report. J Clin Oncol. 2022 Mar 20;40(9):945-955. doi: 10.1200/JCO.20.03585. Epub 2021 Dec 9.
Pasquini MC, Hu ZH, Curran K, Laetsch T, Locke F, Rouce R, Pulsipher MA, Phillips CL, Keating A, Frigault MJ, Salzberg D, Jaglowski S, Sasine JP, Rosenthal J, Ghosh M, Landsburg D, Margossian S, Martin PL, Kamdar MK, Hematti P, Nikiforow S, Turtle C, Perales MA, Steinert P, Horowitz MM, Moskop A, Pacaud L, Yi L, Chawla R, Bleickardt E, Grupp S. Real-world evidence of tisagenlecleucel for pediatric acute lymphoblastic leukemia and non-Hodgkin lymphoma. Blood Adv. 2020 Nov 10;4(21):5414-5424. doi: 10.1182/bloodadvances.2020003092. Erratum In: Blood Adv. 2021 Feb 23;5(4):1136. doi: 10.1182/bloodadvances.2021004265. Blood Adv. 2022 Mar 22;6(6):1731. doi: 10.1182/bloodadvances.2021005069.
Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, Bittencourt H, Bader P, Verneris MR, Stefanski HE, Myers GD, Qayed M, De Moerloose B, Hiramatsu H, Schlis K, Davis KL, Martin PL, Nemecek ER, Yanik GA, Peters C, Baruchel A, Boissel N, Mechinaud F, Balduzzi A, Krueger J, June CH, Levine BL, Wood P, Taran T, Leung M, Mueller KT, Zhang Y, Sen K, Lebwohl D, Pulsipher MA, Grupp SA. Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia. N Engl J Med. 2018 Feb 1;378(5):439-448. doi: 10.1056/NEJMoa1709866.

المؤلفون: Kite, A Gilead Company

المساهمون: Marcela V. Maus, M.D.,Ph.D., Sponsor-Investigator

المصدر: A Phase 2 Trial of Anakinra for the Prevention of CAR-T Cell Mediated Neurotoxicity

المؤلفون: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

المساهمون: Mark Hall, Chief, Division of Critical Care Medicine

المصدر: Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS (TRIPS)

المؤلفون: The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

المساهمون: Kanecia Obie Zimmerman, Associate Professor of Pediatrics

المصدر: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
Job KM, Dallmann A, Parry S, Saade G, Haas DM, Hughes B, Berens P, Chen JY, Fu C, Humphrey K, Hornik C, Balevic S, Zimmerman K, Watt K. Development of a Generic Physiologically-Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk. Clin Pharmacol Ther. 2022 May;111(5):1111-1120. doi: 10.1002/cpt.2530. Epub 2022 Mar 5.

المصدر: IL-1 Receptor Antagonist to Prevent Severe Chimeric Antigen Receptor T-Cell Related Encephalopathy Syndrome

المصدر: Anakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple Sclerosis

المؤلفون: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

المصدر: An Observational Study of IL1 Inhibition for Blocking ACVR1-Induced Flare Activity and Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva (FOP)
Haviv R, Zeitlin L, Moshe V, Ziv A, Rabinowicz N, De Benedetti F, Prencipe G, Matteo V, De Cunto CL, Hsiao EC, Uziel Y. Long-term use of interleukin-1 inhibitors reduce flare activity in patients with fibrodysplasia ossificans progressiva. Rheumatology (Oxford). 2024 Sep 1;63(9):2597-2604. doi: 10.1093/rheumatology/keae255.
Haviv R, Moshe V, De Benedetti F, Prencipe G, Rabinowicz N, Uziel Y. Is fibrodysplasia ossificans progressiva an interleukin-1 driven auto-inflammatory syndrome? Pediatr Rheumatol Online J. 2019 Dec 21;17(1):84. doi: 10.1186/s12969-019-0386-6.

المؤلفون: Novoplansky, Ofra, Jagadeeshan, Sankar, Prasad, Manu, Yegodayev, Ksenia, Marripati, Divyasree, Shareb, Raghda, Greenshpan, Yariv, Mathukkada, Sooraj, Ben-Lulu, Talal, Bhattacharya, Baisali, Porgador, Angel, Kong, Dexin, Brägelmann, Johannes, Gutkind, J, Elkabets, Moshe

المصدر: Journal of Experimental and Clinical Cancer Research. 43(1)

مصطلحات موضوعية: Adagrasib, Cell-autonomous, Drug resistance, HER signaling, Head and neck cancer, KRASG12C mutation, PD-L1/PD1, Sotorasib, Tumor microenvironment, Mice, Animals, Head and Neck Neoplasms, Proto-Oncogene Proteins p21(ras), Humans, Drug Resistance, Neoplasm, Mutation, Programmed Cell Death 1 Receptor, Cell Line, Tumor

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0bq0p8k9
https://escholarship.org/content/qt0bq0p8k9/qt0bq0p8k9.pdf

المؤلفون: Campbell, Michael, Wolf, Denise, Yau, Christina, Brown-Swigart, Lamorna, Wulfkuhle, Julie, Gallagher, Isela, Zhu, Zelos, Bolen, Jennifer, Vandenberg, Scott, Hoyt, Clifford, Mori, Hidetoshi, Borowsky, Alexander, Sit, Laura, Perlmutter, Jane, Asare, Smita, Nanda, Rita, Liu, Minetta, Yee, Douglas, DeMichele, Angela, Hylton, Nola, Pusztai, Lajos, Berry, Donald, Hirst, Gillian, Petricoin, Emanuel, Veer, Laura, Esserman, Laura

المصدر: Cell Reports Medicine. 5(11)

مصطلحات موضوعية: breast cancer, immune checkpoint blockade, multiplex immunofluorescence, predictive markers, spatial metrics, Humans, Female, Neoadjuvant Therapy, Breast Neoplasms, Immune Checkpoint Inhibitors, Biomarkers, Tumor, Tumor Microenvironment, B7-H1 Antigen, Neoplasm Staging, Middle Aged, Programmed Cell Death 1 Receptor, Treatment Outcome

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5tj3272c
https://escholarship.org/content/qt5tj3272c/qt5tj3272c.pdf

المؤلفون: Flanagan, Kevin, Earls, Jon, Hiken, Jeffrey, Wellinghoff, Rachel, Ponder, Michelle, McLeod, Howard, Westra, William, Vavinskaya, Vera, Sutton, Leisa, Deichaite, Ida, Macdonald, Orlan, Welaya, Karim, Wade, James, Azzi, Georges, Pippas, Andrew, Slim, Jennifer, Bank, Bruce, Sui, Xingwei, Kossman, Steven, Shenkenberg, Todd, Alexander, Warren, Price, Katharine, Ley, Jessica, Messina, David, Glasscock, Jarret, Colevas, A, Cohen, Ezra, Adkins, Douglas, Duncavage, Eric

المصدر: Journal for ImmunoTherapy of Cancer. 12(11)

مصطلحات موضوعية: biomarker, head and neck cancer, immune checkpoint inhibitor, next generation sequencing (NGS), tumor mutation burden (TMB), Humans, Squamous Cell Carcinoma of Head and Neck, Male, Female, Head and Neck Neoplasms, Middle Aged, Immune Checkpoint Inhibitors, Aged, Programmed Cell Death 1 Receptor, Neoplasm Recurrence, Local, Neoplasm Metastasis, Biomarkers, Tumor, Adult

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3nx7z3ph
https://escholarship.org/content/qt3nx7z3ph/qt3nx7z3ph.pdf

المؤلفون: Henrich, Timothy J, Bosch, Ronald J, Godfrey, Catherine, Mar, Hanna, Nair, Apsara, Keefer, Michael, Fichtenbaum, Carl, Moisi, Daniela, Clagett, Brian, Buck, Amanda M, Deitchman, Amelia N, Aweeka, Francesca, Li, Jonathan Z, Kuritzkes, Daniel R, Lederman, Michael M, Hsue, Priscilla Y, Deeks, Steven G, Team, the ACTG A5337, Campbell, Danielle, Cutler, Corey, Dorosh, Michael, Ha, Belinda, Hawkins, Elizabeth, Hensel, Christopher, Khairalla, Nayri, Knowles, Kevin, Lee, Sulggi A, Pedersen, Susan, Ritz, Justin, Ryder, Dylan, Sekaly, Rafick, Shugarts, David L, Straub, Becky, Zolopa, Andrew

المصدر: Cell Reports Medicine. 5(10)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Infectious Diseases, Sexually Transmitted Infections, HIV/AIDS, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals, Infection, Good Health and Well Being, Humans, HIV Infections, HIV-1, CD8-Positive T-Lymphocytes, CD4-Positive T-Lymphocytes, DNA, Viral, Sirolimus, Male, Female, Adult, Middle Aged, Immune Checkpoint Proteins, Cell Cycle, Programmed Cell Death 1 Receptor, ACTG A5337 Team, HIV curative strategies, HIV immunology, HIV persistence, HIV reservoirs, antiproliferative medications, immunotherapy, intact proviral HIV-1 DNA, mTOR inhibition, sirolimus, Biomedical and clinical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4sx4v665
https://escholarship.org/content/qt4sx4v665/qt4sx4v665.pdf