المؤلفون: Kevin B. Teuscher, Jonathan J. Mills, Jianhua Tian, Changho Han, Kenneth M. Meyers, Jiqing Sai, Taylor M. South, Mackenzie M. Crow, Mayme Van Meveren, John L. Sensintaffar, Bin Zhao, Kangsa Amporndanai, William J. Moore, Gordon M. Stott, William P. Tansey, Taekyu Lee, Stephen W. Fesik

مصطلحات موضوعية: Biochemistry, Genetics, Pharmacology, Biotechnology, Evolutionary Biology, Cancer, Hematology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, ray structural analysis, 5 ­( 2, associated protein wdr5, >)- one core, advanced wdr5 win, study opens avenues, orally bioavailable benzoxazepinone, cancer drug discovery, 4 ]­ oxazepin, based wdr5 win, 7 , potent wdr5 inhibitors, wdr5 win, based discovery, site inhibitors, cancer therapeutics, bicyclic core, h <, f <, based counterparts

Relation: https://figshare.com/articles/journal_contribution/Structure-Based_Discovery_of_Potent_Orally_Bioavailable_Benzoxazepinone-Based_WD_Repeat_Domain_5_Inhibitors/24795038

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01529.s001
https://figshare.com/articles/journal_contribution/Structure-Based_Discovery_of_Potent_Orally_Bioavailable_Benzoxazepinone-Based_WD_Repeat_Domain_5_Inhibitors/24795038

المؤلفون: Yueshan Li (2106667), Liting Zhang (2883890), Ruicheng Yang (6188681), Zeen Qiao (6066263), Ming Wu (238132), Chong Huang (799290), Chenyu Tian (7900979), Xinling Luo (11910086), Wei Yang (109917), Yun Zhang (131894), Linli Li (436139), Shengyong Yang (2123410)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, interacting protein kinase, downstream signal protein, 026 ± 0, 008 μm ), >)‑ one derivatives, >)- one derivatives, promising lead compound, colorectal cancer effects, catenin signaling pathway, selective tnik inhibitors, potent tnik inhibitors, 21k , 5 ­( 2, 4 ]­ oxazepin, colorectal cancer, catenin pathway, tnik inhibitors, active one, vitro <, h <

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_3_4-Dihydrobenzo_i_f_i_1_4_oxazepin-5_2_i_H_i_one_Derivatives_as_a_New_Class_of_Selective_TNIK_Inhibitors_and_Evaluation_of_Their_Anti-Colorectal_Cancer_Effects/17909678

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00672.s001

المؤلفون: Kevin B. Teuscher, Jonathan J. Mills, Jianhua Tian, Changho Han, Kenneth M. Meyers, Jiqing Sai, Taylor M. South, Mackenzie M. Crow, Mayme Van Meveren, John L. Sensintaffar, Bin Zhao, Kangsa Amporndanai, William J. Moore, Gordon M. Stott, William P. Tansey, Taekyu Lee, Stephen W. Fesik

مصطلحات موضوعية: Biochemistry, Genetics, Pharmacology, Biotechnology, Evolutionary Biology, Cancer, Hematology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, ray structural analysis, 5 ­( 2, associated protein wdr5, >)- one core, advanced wdr5 win, study opens avenues, orally bioavailable benzoxazepinone, cancer drug discovery, 4 ]­ oxazepin, based wdr5 win, 7 , potent wdr5 inhibitors, wdr5 win, based discovery, site inhibitors, cancer therapeutics, bicyclic core, h <, f <, based counterparts

Relation: https://figshare.com/articles/dataset/Structure-Based_Discovery_of_Potent_Orally_Bioavailable_Benzoxazepinone-Based_WD_Repeat_Domain_5_Inhibitors/24795041

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01529.s002
https://figshare.com/articles/dataset/Structure-Based_Discovery_of_Potent_Orally_Bioavailable_Benzoxazepinone-Based_WD_Repeat_Domain_5_Inhibitors/24795041

المؤلفون: Yueshan Li (2106667), Liting Zhang (2883890), Ruicheng Yang (6188681), Zeen Qiao (6066263), Ming Wu (238132), Chong Huang (799290), Chenyu Tian (7900979), Xinling Luo (11910086), Wei Yang (109917), Yun Zhang (131894), Linli Li (436139), Shengyong Yang (2123410)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, interacting protein kinase, downstream signal protein, 026 ± 0, 008 μm ), >)‑ one derivatives, >)- one derivatives, promising lead compound, colorectal cancer effects, catenin signaling pathway, selective tnik inhibitors, potent tnik inhibitors, 21k , 5 ­( 2, 4 ]­ oxazepin, colorectal cancer, catenin pathway, tnik inhibitors, active one, vitro <, h <

Relation: https://figshare.com/articles/dataset/Discovery_of_3_4-Dihydrobenzo_i_f_i_1_4_oxazepin-5_2_i_H_i_one_Derivatives_as_a_New_Class_of_Selective_TNIK_Inhibitors_and_Evaluation_of_Their_Anti-Colorectal_Cancer_Effects/17909693

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00672.s004

المؤلفون: Yueshan Li (2106667), Liting Zhang (2883890), Ruicheng Yang (6188681), Zeen Qiao (6066263), Ming Wu (238132), Chong Huang (799290), Chenyu Tian (7900979), Xinling Luo (11910086), Wei Yang (109917), Yun Zhang (131894), Linli Li (436139), Shengyong Yang (2123410)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, interacting protein kinase, downstream signal protein, 026 ± 0, 008 μm ), >)‑ one derivatives, >)- one derivatives, promising lead compound, colorectal cancer effects, catenin signaling pathway, selective tnik inhibitors, potent tnik inhibitors, 21k , 5 ­( 2, 4 ]­ oxazepin, colorectal cancer, catenin pathway, tnik inhibitors, active one, vitro <, h <

Relation: https://figshare.com/articles/dataset/Discovery_of_3_4-Dihydrobenzo_i_f_i_1_4_oxazepin-5_2_i_H_i_one_Derivatives_as_a_New_Class_of_Selective_TNIK_Inhibitors_and_Evaluation_of_Their_Anti-Colorectal_Cancer_Effects/17909684

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00672.s002

المؤلفون: Yueshan Li (2106667), Liting Zhang (2883890), Ruicheng Yang (6188681), Zeen Qiao (6066263), Ming Wu (238132), Chong Huang (799290), Chenyu Tian (7900979), Xinling Luo (11910086), Wei Yang (109917), Yun Zhang (131894), Linli Li (436139), Shengyong Yang (2123410)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, interacting protein kinase, downstream signal protein, 026 ± 0, 008 μm ), >)‑ one derivatives, >)- one derivatives, promising lead compound, colorectal cancer effects, catenin signaling pathway, selective tnik inhibitors, potent tnik inhibitors, 21k , 5 ­( 2, 4 ]­ oxazepin, colorectal cancer, catenin pathway, tnik inhibitors, active one, vitro <, h <

Relation: https://figshare.com/articles/dataset/Discovery_of_3_4-Dihydrobenzo_i_f_i_1_4_oxazepin-5_2_i_H_i_one_Derivatives_as_a_New_Class_of_Selective_TNIK_Inhibitors_and_Evaluation_of_Their_Anti-Colorectal_Cancer_Effects/17909687

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00672.s003