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المؤلفون: Ki-Suk Kim, Diana M. Farris, Daniel E. Michele, Alfor G. Lewis, Youngsoo Kim, Matthew J. Sorensen, Robert T. Kennedy, Randy J. Seeley, Nadejda Bozadjieva, Steven E. Whitesall, Darleen A. Sandoval, Simon S. Evers
المصدر: Molecular Metabolism
Molecular Metabolism, Vol 32, Iss, Pp 148-159 (2020)مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, endocrine system diseases, OGTT, oral glucose tolerance test, medicine.medical_treatment, Exendin 9-39, Ex9, exendin 9-39, DPP-4, dipeptidyl peptidase-4, Gastroenterology, 0302 clinical medicine, Medicine, Glycemic variability, Continuous glucose monitoring, GIP, gastric inhibitory polypeptide, MAG, mean absolute glucose, PBH, post–bariatric surgery hypoglycemia, 3. Good health, Current medication, Original Article, Epi, epinephrine, Postprandial Hypoglycemia, lcsh:Internal medicine, medicine.medical_specialty, Sleeve gastrectomy, Rat model, 030209 endocrinology & metabolism, Hypoglycemia, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, VSG, vertical sleeve gastrectomy, Gastrectomy, Internal medicine, PYY, peptide YY, 2DG, 2-deoxyglucose, Animals, CGM, continuous glucose monitoring, lcsh:RC31-1245, Molecular Biology, Glycemic, business.industry, RYGB, Roux-en-Y gastric bypass, nutritional and metabolic diseases, Cell Biology, Glucose Tolerance Test, medicine.disease, Post–bariatric surgery hypoglycemia, Rats, Blockade, Disease Models, Animal, 030104 developmental biology, Vertical sleeve gastrectomy, business, NE, norepinephrine, GLP-1R, glucagon-like peptide-1 receptor
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المؤلفون: Emily K. Calton, Mario J. Soares, Kevin N. Keane, Raquel Raizel, Jordan Rowlands, Philip Newsholme
المصدر: Redox Biology
Redox Biology, Vol 12, Iss, Pp 814-820 (2017)مصطلحات موضوعية: 0301 basic medicine, Male, Bioenergetics, Clinical Biochemistry, IPAQ, international physical activity questionnaire, Systemic inflammation, Biochemistry, 0302 clinical medicine, BHI, bioenergetic health index, OCR, oxygen consumption rate, 030212 general & internal medicine, Vitamin D, lcsh:QH301-705.5, lcsh:R5-920, FM, fat mass, Middle Aged, McA, McAuleys index of insulin sensitivity, Insulin sensitivity, Mitochondria, Cytokines, Female, Seasons, medicine.symptom, lcsh:Medicine (General), Whole body, Research Paper, Adult, medicine.medical_specialty, FBG, fasting blood glucose, Energy metabolism, Inflammation, Biology, Peripheral blood mononuclear cell, 03 medical and health sciences, Young Adult, Internal medicine, medicine, Vitamin D and neurology, 2DG, 2-deoxyglucose, Humans, RQ, respiratory quotient, Aged, PBMCs, peripheral blood mononuclear cells, PPR, proton production rate, Organic Chemistry, Calorimetry, Indirect, RMR, resting metabolic rate, FFM, fat free mass, Peripheral blood, 030104 developmental biology, Endocrinology, lcsh:Biology (General), Peripheral blood mononuclear cells, Leukocytes, Mononuclear, Season, Energy Metabolism
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المؤلفون: Ken Nakamura, Kevin Nguyen, Dominik Haddad, Hwajin Kim, Keith A. Vossel, Meredith E. K. Calvert, Lauren Y. Shields, Zak Doric, T. Michael Gill, Joseph H. Garcia, Huihui Li
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Male, 0301 basic medicine, Aging, Aβ, amyloid beta, amyloid precursor protein, Neurodegenerative, Mitochondrion, Alzheimer's Disease, Hippocampus, Mitochondrial Dynamics, Medical and Health Sciences, Biochemistry, mitoCa2+, mitochondrial Ca2+, Transgenic, cytCa2+, cytosolic calcium, Mice, Amyloid beta-Protein Precursor, DNM1L, neurodegenerative disease, Amyloid precursor protein, 2.1 Biological and endogenous factors, Hippocampal, Drp1cKO, hAPP mice that lack Drp1 in the CA1 and other forebrain neurons, Aetiology, Phosphorylation, Neurons, EYFP-ER, EYFP targeted to the ER, MAMs, mitochondria-associated ER membranes, biology, Chemistry, Neurodegeneration, neurodegeneration, Brain, CA1 Region, Biological Sciences, Mitochondria, Cell biology, Neurological, Female, Mitochondrial fission, Alzheimer’s disease, Research Article, Dynamins, Biochemistry & Molecular Biology, Amyloid beta, amyloid precursor protein (APP), Mice, Transgenic, Drp1, CCD, charge coupled device, AD, Alzheimer’s disease, MCU, mitochondrial uniporter, MPTP, mitochondrial permeability transition pore, mitochondrial calcium, 03 medical and health sciences, APP, amyloid precursor protein, Alzheimer Disease, Memory, Acquired Cognitive Impairment, medicine, 2DG, 2-deoxyglucose, Animals, Humans, Learning, NCLX, mitochondrial Na+/Ca2+ exchanger, CA1 Region, Hippocampal, Molecular Biology, Drp1, dynamin-related protein 1, 030102 biochemistry & molecular biology, Animal, mitochondrial fission, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Cell Biology, medicine.disease, PFA, 4% paraformaldehyde, Brain Disorders, Disease Models, Animal, Cytosol, MWM, Morris water maze, 030104 developmental biology, Mitochondrial permeability transition pore, Disease Models, Chemical Sciences, biology.protein, Dementia, Calcium, hAPP, human amyloid precursor protein
وصف الملف: application/pdf
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المؤلفون: Yi Ren, Han-Ming Shen
المصدر: Redox Biology
Redox Biology, Vol 25, Iss, Pp-(2019)مصطلحات موضوعية: AMPK, AICAR, 5-aminoimidazole-4-carboxamide ribonucleotide, MAGE A3/6, melanoma-associated antigen 3/6, OXPHOS, oxidative phosphorylation, DHA, dehydroascorbic acid, PPAR, peroxisome proliferator-activated receptor, ACC, acetyl-CoA carboxylase, AMP-Activated Protein Kinases, Biochemistry, G6PD, glucose-6-phosphate dehydrogenase, NADPH, reduced nicotinamide adenine dinucleotide phosphate, 0302 clinical medicine, ARE, antioxidant response, 6PGD, 6-phosphogluconate dehydrogenase, HIF-1α, hypoxia-inducible factor 1-α, GR, glutathione reductase, PPP, the pentose phosphate pathway, Glycolysis, lcsh:QH301-705.5, Cancer, Glucose metabolism, α-KG, α-ketoglutaric acid, Kinase, FAS, fatty acid synthesis, GSSG, oxidized glutathione, SREBP, sterol regulatory element binding protein, ME, malic enzyme, Cell biology, ECM, extracellular matrix, NRF2, nuclear factor (erythroid-derived 2)-like 2, COX-2, cyclooxygenase-2, CRC, colorectal cancer, KEAP1, Kelch-like ECH-associated protein 1, lcsh:Medicine (General), 3PG, 3-phosphoglyceric acid, R-5P, ribose 5-phosphate, KRAS, Kirsten rat sarcoma, IDH, isocitrate dehydrogenase, GLUT1, glucose transporter 1, Pentose phosphate pathway, 6P-2DG, 6-phospho 2-deoxygluconate, mTORC1, mTOR Complex 1, Article, 03 medical and health sciences, LKB1, liver kinase B1, RAPTOR, regulatory-associated protein of mammalian target of rapamycin, ULK1, UNC-51-like kinase 1, Humans, PGC-1α, peroxisome proliferator-activated receptor γ coactivator 1-α, Protein kinase A, Fatty acid metabolism, HK, hexokinase, NQO1, NADPH dehydrogenase (quinone 1), Metabolic pathway, 030104 developmental biology, Glucose, 6P-G, 6-phosphogluconate, NADP+, nicotinamide adenine dinucleotide phosphate, CRM, calorie restriction mimetic, UCP2, mitochondrial uncoupling protein 2, CAT, catalase, 030217 neurology & neurosurgery, FAO, fatty acid oxidation, MAPK, mitogen-activated protein kinase, 0301 basic medicine, ERK2, extracellular signal-regulated kinase 2, GSH, reduced glutathione, PDAC, pancreatic ductal adenocarcinoma, Clinical Biochemistry, FASN, fatty acid synthase, 5TG, 5-thioglucose, HO-1, heme oxygenase 1, medicine.disease_cause, chemistry.chemical_compound, UBE2O, (E3-independent) E2 ubiquitin-conjugating enzyme, Neoplasms, FADH2, the quinone form flavin adenine dinucleotide, Trx, thioredoxin, BRAF, B-Raf proto-oncogene, 2DG-6P, 2-deoxyglucose 6-phosphate, lcsh:R5-920, GPx, glutathione peroxidase, Chemistry, AMPK, 5′ AMP-activated protein kinase, mTOR, the mechanistic target of rapamycin, Glc, glucose, NOX, NADPH oxidases, NADH, the reduced nicotinamide adenine dinucleotide, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, SGLT2, sodium/glucose cotransporter 2, Oxidation-Reduction, CaMKKβ, calcium/calmodulin-dependent protein kinase kinase β, TCA, tricarboxylic acid cycle, CPT1, carnitine palmitoyltransferase 1, PI3K, phosphoinositide-3-kinase, ETC, electron transport chain, G-6P, glucose 6-phosphate, TSC2, tuberous sclerosis complex 2, ROS, reactive oxygen species, MTP, mitochondrial trifunctional protein, NSCLC, non-small cell lung cancer, SOD, superoxide dismutase, medicine, Animals, 2DG, 2-deoxyglucose, MEF, mouse embryonic fibroblasts, TP, trifunctional protein, KO, knockout, MEK, MAPK Kinase, Organic Chemistry, SCD1, stearoyl-CoA desaturase-1, HNE, 4-hydroxy-2-nonenal, TRIM28, tripartite motif-containing 28, PTEN, phosphatase and tensin homolog, Oxidative Stress, lcsh:Biology (General), NAC, N-acetyl cysteine, Reactive oxygen species, Oxidative stress
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المؤلفون: Charles Affourtit, Raid B. Nisr
المصدر: Biochimica et Biophysica Acta
مصطلحات موضوعية: DMEM, Dulbecco's modified Eagle medium, medicine.medical_treatment, Palmitic Acid, Mitochondrion, Biochemistry, Hepes, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, Oxidative Phosphorylation, 0302 clinical medicine, Uncoupling protein, Insulin, Glycolysis, Anaerobiosis, FCCP, trifluorocarbonylcyanide phenylhydrazone, 0303 health sciences, Insulin sensitivity, 3. Good health, Mitochondria, medicine.anatomical_structure, Glycogenesis, UCP, uncoupling protein, Protons, Mitochondrial proton leak, Cell respiratory control, medicine.medical_specialty, Cell Respiration, Biophysics, Skeletal muscle cells, Oxidative phosphorylation, Biology, Article, Cell Line, 03 medical and health sciences, Oxygen Consumption, Internal medicine, medicine, 2DG, 2-deoxyglucose, Animals, Humans, Muscle, Skeletal, 030304 developmental biology, ECAR, extracellular acidification rate, Mitochondrial coupling efficiency, Skeletal muscle, Cell Biology, Rats, Endocrinology, Glucose, Anaerobic glycolysis, BSA, bovine serum albumin, FCS, fetal calf serum, 030217 neurology & neurosurgery
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المصدر: Redox Biology, Vol 10, Iss C, Pp 243-250 (2016)
Redox Biologyمصطلحات موضوعية: 0301 basic medicine, Male, Bioenergetics, UCP, uncoupling proteins, Clinical Biochemistry, Peripheral Blood Mononuclear Cells, Biochemistry, Calcitriol receptor, 0302 clinical medicine, Absorptiometry, Photon, BHI, bioenergetic health index, Leukocytes, Glycolysis, OCR, oxygen consumption rate, Vitamin D, lcsh:QH301-705.5, Whole blood, lcsh:R5-920, Proton leak, 25(OH)D, FM, fat mass, Middle Aged, Mitochondria, Parathyroid Hormone, Body Composition, VDR, vitamin D receptor, Female, medicine.symptom, lcsh:Medicine (General), Research Paper, Adult, medicine.medical_specialty, Cell Respiration, 030209 endocrinology & metabolism, Inflammation, Biology, Calorimetry, Peripheral blood mononuclear cell, 03 medical and health sciences, Young Adult, Internal medicine, Respiration, medicine, Vitamin D and neurology, Humans, 2DG, 2-deoxyglucose, RQ, respiratory quotient, Aged, PBMCs, peripheral blood mononuclear cells, PPR, proton production rate, Organic Chemistry, RMR, resting metabolic rate, FFM, fat free mass, 030104 developmental biology, Endocrinology, lcsh:Biology (General), Leukocytes, Mononuclear, Energy Metabolism