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المؤلفون: Takuya Yamamoto, Richard A. Koup, Michael R. Betts, Ole Lund, Marcus Buggert, Johanna Tauriainen, Juliet Wairimu Frederiksen, Marianne Jansson, Martin A. Ivarsson, Jakob Michaëlsson, Anders Sönnerborg, Bo Hejdeman, Annika C. Karlsson
المصدر: PLoS Pathogens, Vol 10, Iss 7, p e1004251 (2014)
PLoS Pathogens; 10(7), no e1004251 (2014)
PLoS Pathogens
Buggert, M, Tauriainen, J, Yamamoto, T, Frederiksen, J W, Ivarsson, M A, Michaelsson, J, Lund, O, Hejdeman, B, Jansson, M, Sonnerborg, A, Koup, R A, Betts, M R & Karlsson, A C 2014, ' T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+T Cells in HIV Infection ', P L o S Pathogens, vol. 10, no. 7, e1004251 . https://doi.org/10.1371/journal.ppat.1004251مصطلحات موضوعية: Male, HIV infection human immunodeficiency virus infection viral disease, immune system disease drug therapy, Cellular differentiation, 10060, Biochemistry studies - General, HIV Infections, CD8-Positive T-Lymphocytes, 34502, Immunology - General and methods, Interleukin 21, Mice, Immunodeficiency Viruses, Animal Cells, Cytotoxic T cell, Eomes expression, IL-2 receptor, 02506, Cytology - Animal, antiretroviral therapy ART therapeutic and prophylactic techniques, clinical techniques, Immune Response, lcsh:QH301-705.5, HIGHLY PATHOGENIC SIV, 22002, Pharmacology - General, PARASITOLOGY, 12512, Pathology - Therapy, Medical Microbiology, Viral Pathogens, Cellular Types, Infection, MICROBIOLOGY, T cell, Immune Cells, IMMUNE, Immunology, T-bet expression, EFFECTOR FUNCTION, 22005, Pharmacology - Clinical pharmacology, Microbiology, Microbiology in the medical area, SDG 3 - Good Health and Well-being, transcription factors, Genetics, Humans, Molecular Biology, Microbial Pathogens, 2B4, Pharmacology, Biochemistry and Molecular Biophysics, CUTTING EDGE, Blood Cells, DISEASE PROGRESSION, MEMORY, Immunity, Biology and Life Sciences, inhibitory receptors, T cell differentiation, HIV-1, 02508, Cytology - Human, Parasitology, lcsh:RC581-607, Viral Diseases, genetic structures, Virus Replication, White Blood Cells, CHRONIC VIRAL-INFECTION, CD8 positive T cell immune system, Antiretroviral Therapy, Highly Active, PD-1, Medicine and Health Sciences, DNA and RNA Reverse Transcribing Viruses Viruses Microorganisms (DNA and RNA Reverse Transcribing Viruses, Microorganisms, Viruses) - Retroviridae [03305] HIV common Human immunodeficiency virus species pathogen, 33502, Virology - General and methods, T Cells, Middle Aged, medicine.anatomical_structure, Infectious Diseases, Female, TRANSCRIPTION FACTOR EOMESODERMIN, Research Article, Adult, lcsh:Immunologic diseases. Allergy, Eomesodermin, Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] human common adult, middle age host female, male, VIROLOGY, Human Medicine, Medical Sciences, Biology, 34508, Immunology - Immunopathology, tissue immunology, Virology, medicine, PD-1 EXPRESSION, Animals, HIV, Cell Biology, Gene Expression Regulation, lcsh:Biology (General), 36006, Medical and clinical microbiology - Virology, Chronic Disease, viral replication, Clinical Immunology, sense organs, CD160, T-Box Domain Proteins, C VIRUS-INFECTION, CD8
وصف الملف: application/pdf
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المؤلفون: Sarah M. Tindall, Karen Swift, Simon V. Avery, Kevin C. F. Fone, Farida Hanim Islahudin, Kang Nee Ting, Richard J. Pleass, Ian R. Mellor, Hans Erik Mølager Christensen
المصدر: Islahudin, F, Tindall, S M, Mellor, I R, Swift, K, Christensen, H E M, Fone, K C F, Pleass, R J, Ting, K-N & Avery, S V 2014, ' The antimalarial drug quinine interferes with serotonin biosynthesis and action ', Scientific Reports, vol. 4, 3618 . https://doi.org/10.1038/srep03618
Scientific Reportsمصطلحات موضوعية: Kynurenine pathway, 60504, Parasitology - Medical, plasma blood and lymphatics, 10060, Biochemistry studies - General, Tryptophan Hydroxylase, Pharmacology, Fungi Plantae (Fungi, Microorganisms, Nonvascular Plants, Plants) - Ascomycetes [15100] Saccharomyces cerevisiae species, Neuroblastoma, chemistry.chemical_compound, FALCIPARUM-MALARIA, qv_257, qv_256, BRAIN, Neurotransmitter, 15002, Blood - Blood and lymph studies, Quinine, 22002, Pharmacology - General, 36008, Medical and clinical microbiology - Mycology, Multidisciplinary, TRYPTOPHAN-HYDROXYLASE, TPH2, PLASMA, 38510, Chemotherapy - Antiparasitic agents, PROLIFERATION, 38502, Chemotherapy - General, methods and metabolism, Hematology, 12512, Pathology - Therapy, 15006, Blood - Blood, lymphatic and reticuloendothelial pathologies, 60502, Parasitology - General, 15004, Blood - Blood cell studies, RECEPTORS, qv_126, Biochemistry, Serotonin Production, DEPLETION, drug development, enzyme mechanisms, malaria, mechanism of action, BEHAVIOR, medicine.drug, Serotonin, quinine 130-95-0 antiinfective-drug, antiparasitic-drug, Fungi Plantae (Fungi, Microorganisms, Nonvascular Plants, Plants) - Fungi Imperfecti or Deuteromycetes [15500] Candida albicans species, INHIBITION, neurotransmitter serotonin-5 5-HT receptor synthesis, Saccharomyces cerevisiae, Biology, Human Medicine, Medical Sciences, qv_38, 22005, Pharmacology - Clinical pharmacology, Article, Antimalarials, KYNURENINE PATHWAY, SDG 3 - Good Health and Well-being, Cell Line, Tumor, medicine, Humans, tryptophan 73-22-3, Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] SHSY5Y cell line cell_line human neuroblastoma cells, 10064, Biochemistry studies - Proteins, peptides and amino acids, Tryptophan, Tryptophan hydroxylase, wc_750, chemistry, 02508, Cytology - Human, Parasitology, malaria Malaria (MeSH) blood and lymphatic disease, parasitic disease drug therapy, symptom, MULTIDISCIPLINARY, tryptophan hydroxylase TPH2 9037-21-2 EC 1.14.16.4
وصف الملف: application/pdf; PDF
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3Electronic Resource
المؤلفون: Islahudin, Farida, Tindall, Sarah M., Mellor, Ian R., Swift, Karen, Christensen, Hans Erik Mølager, Fone, Kevin C. F., Pleass, Richard J., Ting, Kang-Nee, Avery, Simon V.
المصدر: Islahudin , F , Tindall , S M , Mellor , I R , Swift , K , Christensen , H E M , Fone , K C F , Pleass , R J , Ting , K-N & Avery , S V 2014 , ' The antimalarial drug quinine interferes with serotonin biosynthesis and action ' , Scientific Reports , vol. 4 , 3618 .
مصطلحات الفهرس: MULTIDISCIPLINARY, TRYPTOPHAN-HYDROXYLASE, KYNURENINE PATHWAY, FALCIPARUM-MALARIA, RECEPTORS, BRAIN, DEPLETION, BEHAVIOR, PROLIFERATION, INHIBITION, PLASMA, malaria Malaria (MeSH) blood and lymphatic disease, parasitic disease drug therapy, symptom, Fungi Plantae (Fungi, Microorganisms, Nonvascular Plants, Plants) - Ascomycetes [15100] Saccharomyces cerevisiae species, Fungi Plantae (Fungi, Microorganisms, Nonvascular Plants, Plants) - Fungi Imperfecti or Deuteromycetes [15500] Candida albicans species, Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] SHSY5Y cell line cell_line human neuroblastoma cells, neurotransmitter serotonin-5 5-HT receptor synthesis, quinine 130-95-0 antiinfective-drug, antiparasitic-drug, tryptophan 73-22-3, tryptophan hydroxylase TPH2 9037-21-2 EC 1.14.16.4, 02508, Cytology - Human, 10060, Biochemistry studies - General, 10064, Biochemistry studies - Proteins, peptides and amino acids, 12512, Pathology - Therapy, 15002, Blood - Blood and lymph studies, 15004, Blood - Blood cell studies, 15006, Blood - Blood, lymphatic and reticuloendothelial pathologies, 22002, Pharmacology - General, 22005, Pharmacology - Clinical pharmacology, 36008, Medical and clinical microbiology - Mycology, 38502, Chemotherapy - General, methods and metabolism, 38510, Chemotherapy - Antiparasitic agents, 60502, Parasitology - General, 60504, Parasitology - Medical, Human Medicine, Medical Sciences, plasma blood and lymphatics, Hematology, Parasitology, Pharmacology, dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being, article
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4Electronic ResourceT-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+T Cells in HIV Infection
المؤلفون: Buggert, Marcus, Tauriainen, Johanna, Yamamoto, Takuya, Frederiksen, Juliet Wairimu, Ivarsson, Martin A., Michaelsson, Jakob, Lund, Ole, Hejdeman, Bo, Jansson, Marianne, Sonnerborg, Anders, Koup, Richard A., Betts, Michael R., Karlsson, Annika C.
المصدر: Buggert , M , Tauriainen , J , Yamamoto , T , Frederiksen , J W , Ivarsson , M A , Michaelsson , J , Lund , O , Hejdeman , B , Jansson , M , Sonnerborg , A , Koup , R A , Betts , M R & Karlsson , A C 2014 , ' T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+T Cells in HIV Infection ' , P L o S Pathogens , vol. 10 , no. 7 , e1004251 .
مصطلحات الفهرس: DNA and RNA Reverse Transcribing Viruses Viruses Microorganisms (DNA and RNA Reverse Transcribing Viruses, Microorganisms, Viruses) - Retroviridae [03305] HIV common Human immunodeficiency virus species pathogen, Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] human common adult, middle age host female, male, 2B4, CD160, Eomes expression, inhibitory receptors, PD-1, T-bet expression, transcription factors, 02506, Cytology - Animal, 02508, Cytology - Human, 10060, Biochemistry studies - General, 12512, Pathology - Therapy, 22002, Pharmacology - General, 22005, Pharmacology - Clinical pharmacology, 33502, Virology - General and methods, 34502, Immunology - General and methods, 34508, Immunology - Immunopathology, tissue immunology, 36006, Medical and clinical microbiology - Virology, Biochemistry and Molecular Biophysics, Clinical Immunology, Infection, Pharmacology, HIV infection human immunodeficiency virus infection viral disease, immune system disease drug therapy, viral replication, Human Medicine, Medical Sciences, CD8 positive T cell immune system, antiretroviral therapy ART therapeutic and prophylactic techniques, clinical techniques, MICROBIOLOGY, PARASITOLOGY, VIROLOGY, CHRONIC VIRAL-INFECTION, TRANSCRIPTION FACTOR EOMESODERMIN, HIGHLY PATHOGENIC SIV, C VIRUS-INFECTION, DISEASE PROGRESSION, PD-1 EXPRESSION, CUTTING EDGE, EFFECTOR FUNCTION, MEMORY, IMMUNE, dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being, article
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5Electronic Resource
المؤلفون: Hansen, Anders N., Bendiksen, Christine D., Sylvest, Lene, Friis, Tina, Staerk, Dan, Jorgensen, Flemming Steen, Olsen, Christian A., Houen, Gunnar
المصدر: Hansen , A N , Bendiksen , C D , Sylvest , L , Friis , T , Staerk , D , Jorgensen , F S , Olsen , C A & Houen , G 2012 , ' Synthesis and Antiangiogenic Activity of N-Alkylated Levamisole Derivatives ' , P L o S One , vol. 7 , no. 9 , pp. Article No.: e45405 .
مصطلحات الفهرس: cell morphology, structure-activity relationship, tumor Neoplasms (MeSH) neoplastic disease drug therapy, Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] HUVEC cell line cell_line human umbilical vein endothelial cells NHDF cell line cell_line normal human dermal fibroblast cells, (S)-levamisole hydrochloride antineoplastic-drug synthesis efficacy, N-methyllevamisole antineoplastic-drug synthesis efficacy, para-bromolevamisole antineoplastic-drug synthesis efficacy, suramin 145-63-1 antineoplastic-drug efficacy, 02508, Cytology - Human, 10060, Biochemistry studies - General, 12512, Pathology - Therapy, 22002, Pharmacology - General, 22005, Pharmacology - Clinical pharmacology, 24004, Neoplasms - Pathology, clinical aspects and systemic effects, 24008, Neoplasms - Therapeutic agents and therapy, 32500, Tissue culture, apparatus, methods and media, cell culture laboratory techniques, culturing techniques, in vitro angiogenesis assay laboratory techniques, Pharmacology, Tumor Biology, dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, SDG 3 - Good Health and Well-being, article