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1Academic Journal
المؤلفون: Thanh Tuyen Nguyen, Duc Tuan Cao, Hong Ngoc Tran, Thi Hanh Nguyen, Gia Dien Pham, Van Hieu Tran, Quang Duong Pham, Thi Thu Thuy Tran, Minh Tin Vu, Dinh Hoang Vu
مصطلحات موضوعية: Biochemistry, Genetics, Pharmacology, Cancer, Science Policy, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, 3-O-cis-p-coumaroyl trichadenic acid B, 11α,12-[1-(methyl)-2-(4-hydroxy-3-methoxyphenyl)ethane-1,2-dioxy]-urs-12-ene-3β-ol, 11α,12-[2-(methyl)-1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-dioxy]-urs-12-ene-3β-ol, ursane-type triterpenes, Camellia hakodae Ninh, cytotoxic activity
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2Academic Journal
المؤلفون: Makhaeva, G. F., Kovaleva, N. V., Rudakova, E. V., Boltneva, N. P., Grishchenko, M. V., Lushchekina, S. V., Astakhova, T. Y., Serebryakova, O. G., Timokhina, E. N., Zhilina, E. F., Shchegolkov, E. V., Ulitko, M. V., Radchenko, E. V., Palyulin, V. A., Burgart, Y. V., Saloutin, V. I., Bachurin, S. O., Richardson, R. J.
المصدر: International Journal of Molecular Sciences
مصطلحات موضوعية: ACETYLCHOLINESTERASE, ADMET PREDICTION, ALZHEIMER’S DISEASE, ANTIOXIDANT ACTIVITY, AΒ42 SELF-AGGREGATION, BUTYRYLCHOLINESTERASE, METAL CHELATION, PROPIDIUM DISPLACEMENT, SALICYLIC ACID DERIVATIVES, TACRINE CONJUGATES, 2 METHYL N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYL]BENZAMIDE, 2 METHYL N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYL]BENZAMIDE, 2 METHYL N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTYL]BENZAMIDE, 2 [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYLIMINOMETHYL]PHENOL, 2 [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYLIMINOMETHYL]PHENOL, 2 [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTYLIMINOMETHYL]PHENOL, 4,5 DIFLUORO 2 HYDROXY N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYL]BENZAMIDE, 4,5 DIFLUORO 2 HYDROXY N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYL]BENZAMIDE, 4,5 DIFLUORO 2 HYDROXY N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTYL]BENZAMIDE, 4,5 DIFLUORO 2 METHOXY N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYL]BENZAMIDE, 4,5 DIFLUORO 2 METHOXY N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYL]BENZAMIDE, 4,5 DIFLUORO 2 METHOXY N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTYL]BENZAMIDE, AMYLOID BETA PROTEIN[1-42], ANTIOXIDANT, ASCORBIC ACID, CHELATING AGENT, CHOLINESTERASE, CHOLINESTERASE INHIBITOR, COPPER, DONEPEZIL
وصف الملف: application/pdf
Relation: Makhaeva, GF, Kovaleva, NV, Rudakova, EV, Boltneva, NP, Grishchenko, MV, Lushchekina, SV, Astakhova, TY, Serebryakova, OG, Timokhina, EN, Zhilina, EF, Shchegolkov, EV, Ulitko, MV, Radchenko, EV, Palyulin, VA, Burgart, YV, Saloutin, VI, Bachurin, SO & Richardson, RJ 2023, 'Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer’s Disease', International Journal of Molecular Sciences, Том. 24, № 3, 2285. https://doi.org/10.3390/ijms24032285; Makhaeva, G. F., Kovaleva, N. V., Rudakova, E. V., Boltneva, N. P., Grishchenko, M. V., Lushchekina, S. V., Astakhova, T. Y., Serebryakova, O. G., Timokhina, E. N., Zhilina, E. F., Shchegolkov, E. V., Ulitko, M. V., Radchenko, E. V., Palyulin, V. A., Burgart, Y. V., Saloutin, V. I., Bachurin, S. O., & Richardson, R. J. (2023). Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer’s Disease. International Journal of Molecular Sciences, 24(3), [2285]. https://doi.org/10.3390/ijms24032285; Final; All Open Access, Gold, Green; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85148003235&doi=10.3390%2fijms24032285&partnerID=40&md5=fe6438dda642e3160d82a1abfe2c8c8b; https://www.mdpi.com/1422-0067/24/3/2285/pdf?version=1675907905; http://elar.urfu.ru/handle/10995/130201; 85148003235; 000935706300001
الاتاحة: http://elar.urfu.ru/handle/10995/130201
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85148003235&doi=10.3390%2fijms24032285&partnerID=40&md5=fe6438dda642e3160d82a1abfe2c8c8b
https://www.mdpi.com/1422-0067/24/3/2285/pdf?version=1675907905
https://doi.org/10.3390/ijms24032285 -
3Academic Journal
المؤلفون: Pokharkar, O., Zyryanov, G. V., Tsurkan, M. V.
المصدر: Microbiology Research
مصطلحات موضوعية: 3CLPRO, ANTIVIRAL, MPRO, MARINE DRUGS, NATURAL PRODUCTS, PLPRO, REPURPOSING, S. ARENICOLA, S. PACIFICA, S. TROPICA, SALINISPORA, SARS-COV-2, 27 O DEMETHYL 25 O DESACETYLRIFAMYCIN, 3 AMINO 2 METHYL N (1R)-1 (NAPHTHALEN 1 YL) ETHYL BENZAMIDE, 7 TRIHYDROXY 2 PHENYL 4H CHROMEN 4 ONE, ANTIPROTEALIDE, ARENAMIDE A, ARENAMIDE B, ARENAMIDE C, CORONAVIRUS 3C PROTEASE, CYCLOMARAZINE A, CYCLOMARIN A, CYCLOMARIN D, DEFEROXAMINE, EMERICELLAMIDE, IKARUGAMYCIN, LOMAIVITICIN, LOMAIVITICIN A, LOMAIVITICIN D, LOMAIVITICIN E
وصف الملف: application/pdf
Relation: Pokharkar, O, Zyryanov, G & Tsurkan, M 2023, 'Natural Products from Marine Actinomycete Genus Salinispora Might Inhibit 3CLpro and PLpro Proteins of SARS-CoV-2: An In Silico Evidence', Microbiology Research, Том. 14, № 4, стр. 1907-1941. https://doi.org/10.3390/microbiolres14040130; Pokharkar, O., Zyryanov, G., & Tsurkan, M. (2023). Natural Products from Marine Actinomycete Genus Salinispora Might Inhibit 3CLpro and PLpro Proteins of SARS-CoV-2: An In Silico Evidence. Microbiology Research, 14(4), 1907-1941. https://doi.org/10.3390/microbiolres14040130; Final; All Open Access, Gold; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85180651227&doi=10.3390%2fmicrobiolres14040130&partnerID=40&md5=de82556cb5df0f0ea91eff8ff9536e0d; https://www.mdpi.com/2036-7481/14/4/130/pdf?version=1700042435; http://elar.urfu.ru/handle/10995/131079; 85180651227; 001132291400001
الاتاحة: http://elar.urfu.ru/handle/10995/131079
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85180651227&doi=10.3390%2fmicrobiolres14040130&partnerID=40&md5=de82556cb5df0f0ea91eff8ff9536e0d
https://www.mdpi.com/2036-7481/14/4/130/pdf?version=1700042435
https://doi.org/10.3390/microbiolres14040130 -
4Academic Journal
المؤلفون: MARGIANI, Giulia, CASTELLI, Maria Paola, PINTORI, Nicholas, FRAU, Roberto, ENNAS, Maria Grazia, ORRU, Roberto, SERRA, Valentina, FIORILLO, Edoardo, FADDA, Paola, MARSICANO, Giovanni, DE LUCA, Maria Antonietta
مصطلحات موضوعية: 3 (1 Naphthoyl) 1 Pentylindole, 6 Iodo 3 (4 Methoxybenzoyl) 2 Methyl 1 (2 Morpholinoethyl)Indole, Adaptor Protein, Cannabinoid 1 Receptor, Cyclooxygenase 2, Excitatory Amino Acid Transporter 2, Glial Fibrillary Acidic Protein, Interleukin 2, Interleukin 3, Ionized Calcium Binding Adaptor Molecule 1, Monocyte Chemotactic Protein 1, Rantes, Unclassified Drug, 1-Pentyl-3-(1-Naphthoyl)Indole, Calcium, Calcium Carbonate, Cannabinoid Receptor Agonist, Indole Derivative, Interleukin 13, Naphthalene Derivative, Adolescence, Adolescent, Adult, Adulthood, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Article, Behavior Assessment
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5Academic Journal
مصطلحات موضوعية: Biophysics, Biochemistry, Biotechnology, Ecology, Inorganic Chemistry, Hematology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, 323.15 K, 2- methyl -4-methylamino, RAD, mole fraction, solubility, 323.15 K 2- Methyl -4-methylamino, DMF, EG, solute, water content, 5 K intervals, HPLC, Saturated Solubility Determination, RMSD, Several Aqueous Cosolvent Systems, model
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6Academic Journal
المؤلفون: Konstantin F. Suzdalev (11217603), Julia V. Vyalyh (7474085), Valery V. Tkachev (1916929), Ekaterina A. Lysenko (11217606), Oleg N. Burov (2053717), Anton V. Lisovin (7474091), Mikhail E. Kletskii (2496400), Sergey V. Kurbatov (7474094)
مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Genetics, Pharmacology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, 2- methyl -3-acylindoles, Carbon Disulfide, PCM, Li atom, PBE, 1PBE, indole core, lithium diisopropyl amide, MP, One-Pot Route, thiopyrane ring, aim calculations, thione, 2- methyl group, ion-pair formation, CS 2, Lithium-Promoted Cycloaddition
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7Academic Journal
المؤلفون: Koval'chukova O.V., Mordovina N.I., Kuz'mina N.E., Nikitin S.V., Zaǐtsev B.E., Strashnova S.B., Palkina K.K.
المصدر: Crystallography Reports
مصطلحات موضوعية: 2 methyl 3 chloro 9 hydroxypyrido[1,2 a]pyrimidin 4 one, ampholyte, bis(2 methyl 3 chloro 9 hydroxypyrido[1,2 a]pyrimidin 4 onium)perchlorate, cation, dimer, perchlorate, solvent, unclassified drug, article, crystal structure, hydrogen bond, infrared radiation, molecule, pH, proton transport, spectroscopy, structure activity relation, synthesis, X ray diffraction
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8Academic Journal
المؤلفون: Kovalchukova O.V., Kuz'mina N.E., Zaitsev B.E., Strashnova S.B., Palkina K.K.
المصدر: Doklady Physical Chemistry
مصطلحات موضوعية: 2 methyl 1,3 diazole, 2 methyl 1,3 diazolium hydrobis(oxamate), alcohol, ammonium 2,3,5,6 tetraoxo 4 nitropyridinate, anion, carbon, carbonyl derivative, hydrogen, ion, maleic anhydride, oxamic acid, pyridine, pyridine derivative, pyrrole derivative, reagent, unclassified drug, aqueous solution, article, atom, chemical bond, crystal structure, decomposition, dissolution, heating, hydrogen bond, methodology, precipitation, room temperature, solvation, ultraviolet spectroscopy
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9Academic Journal
المؤلفون: Dinesh J. Paymode (1478746), N. Vasudevan (1710154), Saeed Ahmad (704441), Appasaheb L. Kadam (5931209), Flavio S.P. Cardoso (11198965), Justina M. Burns (2204383), Daniel W. Cook (2796130), Rodger W. Stringham (2265970), David R. Snead (2147977)
مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Ecology, Plant Biology, Virology, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, 2- methyl tetrahydrofuran, crystallization procedures, API, molnupiravir isobutyryl oxime ester, cytosine ring, Cytidine Followed, 7 volumes, purification conditions, Selective Esterification, ester cleavage, Direct Hydroxamination, PMI, Two-Step Process, manufacturing route, sustainability
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10Academic Journal
المؤلفون: Lenka Loukotová (5047283), Pavel Švec (9728612), Ondřej Groborz (9728627), Tomáš Heizer (11200059), Hynek Beneš (3993560), Helena Raabová (11200062), Tereza Bělinová (11200065), Vít Herynek (2180164), Martin Hrubý (2264950)
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Mental Health, Space Science, Chemical Sciences not elsewhere classified, PhOx, grad, PMeOx 70, gradient, drug loading capacity, glass transition intervals, monomer, Analogous Amphiphilic Gradient, 2- methyl -2-oxazoline, 2- phenyl -2-oxazoline, block analogs, BuPhOx, drug delivery systems, block copolymers
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11Academic Journal
المؤلفون: Nazia R. Zaman (8306625), Umar F. Chowdhury (11506788), Rifath N. Reza (11506791), Farhana T. Chowdhury (11506794), Mrinmoy Sarker (11506797), Muhammad M. Hossain (11506800), Md. Ahedul Akbor (11506803), Al Amin (9286650), Mohammad Riazul Islam (4164457), Haseena Khan (4164442)
مصطلحات موضوعية: Biochemistry, Microbiology, Pharmacology, Biotechnology, Ecology, Science Policy, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, suppressing phytopathogenic fungi, safe biocontrol agent, potential biochemical pathways, iaa ), siderophore, hplc purified fraction, div >< p, dioxooctadecyl )- pyrrolidine, bacteria fixes nitrogen, 12 ’- hydroxy, nz antagonizes phytopathogen, 1 -( 1, macrophomina phaseolina <, burkholderia contaminans <, inhibit melanin synthesis, nz using napdos, 2 ’- methyl, melanin synthesis, phaseolina <
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12Academic Journal
المؤلفون: Nazia R. Zaman (8306625), Umar F. Chowdhury (11506788), Rifath N. Reza (11506791), Farhana T. Chowdhury (11506794), Mrinmoy Sarker (11506797), Muhammad M. Hossain (11506800), Md. Ahedul Akbor (11506803), Al Amin (9286650), Mohammad Riazul Islam (4164457), Haseena Khan (4164442)
مصطلحات موضوعية: Biochemistry, Microbiology, Pharmacology, Biotechnology, Ecology, Science Policy, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, suppressing phytopathogenic fungi, safe biocontrol agent, potential biochemical pathways, iaa ), siderophore, hplc purified fraction, div >< p, dioxooctadecyl )- pyrrolidine, bacteria fixes nitrogen, 12 ’- hydroxy, nz antagonizes phytopathogen, 1 -( 1, macrophomina phaseolina <, burkholderia contaminans <, inhibit melanin synthesis, nz using napdos, 2 ’- methyl, melanin synthesis, phaseolina <
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13Academic Journal
المؤلفون: Nazia R. Zaman (8306625), Umar F. Chowdhury (11506788), Rifath N. Reza (11506791), Farhana T. Chowdhury (11506794), Mrinmoy Sarker (11506797), Muhammad M. Hossain (11506800), Md. Ahedul Akbor (11506803), Al Amin (9286650), Mohammad Riazul Islam (4164457), Haseena Khan (4164442)
مصطلحات موضوعية: Biochemistry, Microbiology, Pharmacology, Biotechnology, Ecology, Science Policy, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, suppressing phytopathogenic fungi, safe biocontrol agent, potential biochemical pathways, iaa ), siderophore, hplc purified fraction, div >< p, dioxooctadecyl )- pyrrolidine, bacteria fixes nitrogen, 12 ’- hydroxy, nz antagonizes phytopathogen, 1 -( 1, macrophomina phaseolina <, burkholderia contaminans <, inhibit melanin synthesis, nz using napdos, 2 ’- methyl, melanin synthesis, phaseolina <
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14Academic Journal
المؤلفون: Nazia R. Zaman (8306625), Umar F. Chowdhury (11506788), Rifath N. Reza (11506791), Farhana T. Chowdhury (11506794), Mrinmoy Sarker (11506797), Muhammad M. Hossain (11506800), Md. Ahedul Akbor (11506803), Al Amin (9286650), Mohammad Riazul Islam (4164457), Haseena Khan (4164442)
مصطلحات موضوعية: Biochemistry, Microbiology, Pharmacology, Biotechnology, Ecology, Science Policy, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, suppressing phytopathogenic fungi, safe biocontrol agent, potential biochemical pathways, iaa ), siderophore, hplc purified fraction, div >< p, dioxooctadecyl )- pyrrolidine, bacteria fixes nitrogen, 12 ’- hydroxy, nz antagonizes phytopathogen, 1 -( 1, macrophomina phaseolina <, burkholderia contaminans <, inhibit melanin synthesis, nz using napdos, 2 ’- methyl, melanin synthesis, phaseolina <
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15Academic Journal
المؤلفون: Nazia R. Zaman (8306625), Umar F. Chowdhury (11506788), Rifath N. Reza (11506791), Farhana T. Chowdhury (11506794), Mrinmoy Sarker (11506797), Muhammad M. Hossain (11506800), Md. Ahedul Akbor (11506803), Al Amin (9286650), Mohammad Riazul Islam (4164457), Haseena Khan (4164442)
مصطلحات موضوعية: Biochemistry, Microbiology, Pharmacology, Biotechnology, Ecology, Science Policy, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, suppressing phytopathogenic fungi, safe biocontrol agent, potential biochemical pathways, iaa ), siderophore, hplc purified fraction, div >< p, dioxooctadecyl )- pyrrolidine, bacteria fixes nitrogen, 12 ’- hydroxy, nz antagonizes phytopathogen, 1 -( 1, macrophomina phaseolina <, burkholderia contaminans <, inhibit melanin synthesis, nz using napdos, 2 ’- methyl, melanin synthesis, phaseolina <
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16Academic Journal
المؤلفون: David Babuka (5566658), Kristyna Kolouchova (5566655), Lenka Loukotova (11784627), Ondrej Sedlacek (1811383), Ondrej Groborz (10681075), Aneta Skarkova (10681078), Alexander Zhigunov (1719478), Ewa Pavlova (1782535), Richard Hoogenboom (1372614), Martin Hruby (1744801), Petr Stepanek (1744798)
مصطلحات موضوعية: Biophysics, Medicine, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, various biomedical applications, transmission electron microscopy, saxs ), one, provide important insight, nuclear magnetic resonance, indicates great potential, dls ), small, hydrophobic monomers 2, antituberculosis drug rifampicin, gradient monomer distributions, hydrophilic monomer 2, show advantageous properties, assembled amphiphilic polymers, 2 ‑ methyl, monomer ratio, polymers using, gradient copolymers, 2 ‑<, drug encapsulation
Relation: https://figshare.com/articles/journal_contribution/Self-Assembly_Drug_Encapsulation_and_Cellular_Uptake_of_Block_and_Gradient_Copolymers_of_2_Methyl-2-oxazine_and_2_i_n_i_Propyl_butyl-2-oxazoline/17113989
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17Academic Journal
المؤلفون: Qian Luo (610818), Zhe Wang (41178), Yuzhuo Chen (9410515), Shanjun Mao (1554487), Kejun Wu (4800972), Kaichao Zhang (11081960), Qichuan Li (11081963), Guofeng Lv (11081966), Guodong Huang (1595956), Haoran Li (424403), Yong Wang (12837)
مصطلحات موضوعية: Biochemistry, Cell Biology, Biotechnology, Evolutionary Biology, Sociology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, 2- methyl -3-butyn, Systematic studies, Chain Alkylamines, DETA-modified Pd catalyst, Dynamic Modification, DETA-modified Pd catalyst exhibits, Pd catalyst, adsorbate conditions, Lindlar catalyst, Selective Hydrogenation, alkene selectivity, chemical production, Palladium Catalysts, 20 times, Pd surface, modification strategy, adsorption behaviors, DMSI
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18Academic Journal
المؤلفون: Leonid I. Kaberov (3633982), Zhansaya Kaberova (11036833), Anastasiia Murmiliuk (5778806), Jiří Trousil (6428603), Ondřej Sedláček (2819158), Rafal Konefal (2554375), Alexander Zhigunov (1719478), Ewa Pavlova (1782535), Martin Vít (11036836), Daniel Jirák (1723831), Richard Hoogenboom (1372614), Sergey K. Filippov (1296339)
مصطلحات موضوعية: Biophysics, Medicine, Cell Biology, Pharmacology, Biotechnology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, amphiphilic polymer structure, 19 F MRI contrast agents, CF 3 EtOx, 19 F MRI studies, core, cationic chain end, 19 F Imaging, gradient, contrast agents, copolymers, SAXS, micelle, 19 F MRI, terpolymer, Optimal Self-Assembled Structure, 2- methyl -2-oxazoline, TEM, transmission electron microscopy, less-nucleophilic CF 3 EtOx monomer, analogue block copolymer structures
Relation: https://figshare.com/articles/journal_contribution/Fluorine-Containing_Block_and_Gradient_Copoly_2-oxazoline_s_Based_on_2_3_3_3-Trifluoropropyl_-2-oxazoline_A_Quest_for_the_Optimal_Self-Assembled_Structure_for_sup_19_sup_F_Imaging/14866765
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19Academic Journal
المؤلفون: Douglas S. Williamson (2188903), Garrick P. Smith (3023454), Gitte K. Mikkelsen (2231557), Thomas Jensen (92927), Pamela Acheson-Dossang (4540645), Lassina Badolo (827449), Simon T. Bedford (4540642), Victoria Chell (3749047), I-Jen Chen (2297146), Pawel Dokurno (2188936), Morten Hentzer (2210332), Samantha Newland (4540639), Stuart C. Ray (9620234), Terry Shaw (2188924), Allan E. Surgenor (2188933), Lindsey Terry (2188939), Yikang Wang (2188945), Kenneth V. Christensen (4540633)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Chemical Sciences not elsewhere classified, vivo PK profile, LRRK 2 inhibition, LRRK 2 kinase domain surrogates, 2- methyl substituent, Compounds 44, Ala 2016, pyrimidine-Derived Leucine-Rich Rep., kinase 2, X-ray structures, LRRK 2, structure-guided elaboration, Ala 147, Checkpoint Kinase 1, chemical probes, species disconnects, CHK 1 10- point, PK profile, X-ray structure, LRRK 2 G 2019S c K i 0.7 nM, mouse model, pyrazol -4-yl, Surrogate Inhibitors
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20Academic Journal
المؤلفون: Vladimir B. Orel (4960915), Nadezhda M. Vitkovskaya (4960912), Alexander S. Bobkov (4574476), Nadezhda V. Semenova (2624194), Elena Yu. Schmidt (2007184), Boris A. Trofimov (723086)
مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Sociology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, cascade assemblies, KOH, acetylene, acetone, 2- methyl -3-butyn, ketone molecules, aldol condensation, isophorone skeleton, Experimental Study, cascade reactions, Aldol Condensation Versus Superbase., side reactions, formation, cyclohex -2-enone structure, condensation products, B 2PLYP quantum-chemical approach, interaction