المؤلفون: Ulviye Acar Çevik, Betül Kaya, Ismail Celik, Mithun Rudrapal, Gourav Rakshit, Arzu Karayel, Serkan Levent, Derya Osmaniye, Begüm Nurpelin Sağlık Özkan, Merve Baysal, Özlem Atlı Ekliog̈lu, Yusuf Özkay, Zafer Asım Kaplancıklı

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Sociology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, silico adme profiles, nih3t3 cell lines, 56 ± 0, 422 ± 0, 420 ± 0, 34 ± 0, molecular modeling studies, 4h , 4b , 02 μm ), 13 , promising binding affinity, target enzyme topoisomerase, significant inhibitory activity, a549 cell line, h , 50 , potential binding interactions, evaluated using swissadme

Relation: https://figshare.com/articles/journal_contribution/New_Benzimidazole-Triazole_Derivatives_as_Topoisomerase_I_Inhibitors_Design_Synthesis_Anticancer_Screening_and_Molecular_Modeling_Studies/25357237

الاتاحة: https://doi.org/10.1021/acsomega.3c10345.s001
https://figshare.com/articles/journal_contribution/New_Benzimidazole-Triazole_Derivatives_as_Topoisomerase_I_Inhibitors_Design_Synthesis_Anticancer_Screening_and_Molecular_Modeling_Studies/25357237

المؤلفون: Wei Ge, Weikang Ming, Zhenkun Li, Yunyan Tang, Ya-Nan Li, Jue Yang, Xiaojiang Hao, Chunmao Yuan

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Neuroscience, Pharmacology, Cancer, Hematology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, soluble derivative might, potential antileukemia agent, >] benzofuran scaffold, 88 ± 0, 19 ± 0, 11 ± 0, thus inducing apoptosis, 01 μm ), substituted rocaglaol derivatives, soluble rocaglaol derivatives, 50 , 02 μm, b <, aglaia <, positive control, physicochemical properties, mtt assay, marker proteins, like properties, isolated mainly

Relation: https://figshare.com/articles/journal_contribution/Design_and_Synthesis_of_Cytotoxic_Water-Soluble_Rocaglaol_Derivatives_against_HEL_Cells_by_Inhibiting_Fli_1/25044033

الاتاحة: https://doi.org/10.1021/acs.jnatprod.3c00948.s001
https://figshare.com/articles/journal_contribution/Design_and_Synthesis_of_Cytotoxic_Water-Soluble_Rocaglaol_Derivatives_against_HEL_Cells_by_Inhibiting_Fli_1/25044033

المؤلفون: Ulviye Acar Çevik, Betül Kaya, Ismail Celik, Mithun Rudrapal, Gourav Rakshit, Arzu Karayel, Serkan Levent, Derya Osmaniye, Begüm Nurpelin Sağlık Özkan, Merve Baysal, Özlem Atlı Ekliog̈lu, Yusuf Özkay, Zafer Asım Kaplancıklı

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Sociology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, silico adme profiles, nih3t3 cell lines, 56 ± 0, 422 ± 0, 420 ± 0, 34 ± 0, molecular modeling studies, 4h , 4b , 02 μm ), 13 , promising binding affinity, target enzyme topoisomerase, significant inhibitory activity, a549 cell line, h , 50 , potential binding interactions, evaluated using swissadme

Relation: https://figshare.com/articles/journal_contribution/New_Benzimidazole-Triazole_Derivatives_as_Topoisomerase_I_Inhibitors_Design_Synthesis_Anticancer_Screening_and_Molecular_Modeling_Studies/25357237

الاتاحة: https://doi.org/10.1021/acsomega.3c10345.s001

المؤلفون: Zihui Yang (5491397), Yue Sun (197395), Qingsong Liu (381059), Aliang Li (11649426), Wenyan Wang (171659), Wen Gu (129075)

مصطلحات موضوعية: Biochemistry, Microbiology, Pharmacology, Biotechnology, Ecology, Plant Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, scanning electron microscopy, damaged cell structures, 51 ± 2, vivo antifungal assay, vitro antifungal assay, 645 ± 0, 53 ± 0, 140 ± 0, 01 ± 0, molecular dynamics simulation, 5j , 4i , 4g , morphological investigation revealed, sdh inhibition assay, 30 novel thiophene, oxadiazole carboxamide derivatives, 50 , 02 μm ), novel sdh inhibitors, potent antifungal activity, 1 ∼ 1

Relation: https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Antifungal_Activity_of_Novel_Thiophene_Furan-1_3_4-Oxadiazole_Carboxamides_as_Potent_Succinate_Dehydrogenase_Inhibitors/16934226

الاتاحة: https://doi.org/10.1021/acs.jafc.1c03857.s001

المؤلفون: Qian Li (114642), Shuxian Li (176926), Jingquan Sha (2383369), Xiao Li (107004), Yunheng Cai (11690990), Jinghua Yang (31382), Junran Wang (11690993)

مصطلحات موضوعية: Biochemistry, Cell Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, obtain highly sensitive, human serum samples, graphitic carbon nitride, colorimetric test paper, also successfully designed, 6 , 4 , 3 , lower detection limit, enabling rapid detection, 2 , successfully fabricated, colorimetric sensing, n <, type polyoxometalate, synergistic effect, selective nanozymes, model reaction, like activities, hydrogen peroxide, customized cavities, ascorbic acid, >) nanocomposites, 02 μm

Relation: https://figshare.com/articles/journal_contribution/NiMo_sub_6_sub_ZIF-67_Nanostructures_on_Graphitic_Carbon_Nitride_for_Colorimetric_Sensing_of_Hydrogen_Peroxide_and_Ascorbic_Acid/17003627

الاتاحة: https://doi.org/10.1021/acsanm.1c02693.s001

المؤلفون: Zihui Yang (5491397), Yue Sun (197395), Qingsong Liu (381059), Aliang Li (11649426), Wenyan Wang (171659), Wen Gu (129075)

مصطلحات موضوعية: Biochemistry, Microbiology, Pharmacology, Biotechnology, Ecology, Plant Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, scanning electron microscopy, damaged cell structures, 51 ± 2, vivo antifungal assay, vitro antifungal assay, 645 ± 0, 53 ± 0, 140 ± 0, 01 ± 0, molecular dynamics simulation, 5j , 4i , 4g , morphological investigation revealed, sdh inhibition assay, 30 novel thiophene, oxadiazole carboxamide derivatives, 50 , 02 μm ), novel sdh inhibitors, potent antifungal activity, 1 ∼ 1

Relation: https://figshare.com/articles/dataset/Design_Synthesis_and_Antifungal_Activity_of_Novel_Thiophene_Furan-1_3_4-Oxadiazole_Carboxamides_as_Potent_Succinate_Dehydrogenase_Inhibitors/16934229

الاتاحة: https://doi.org/10.1021/acs.jafc.1c03857.s002

المؤلفون: Ana Flávia Borsoi, Alessandro Silva Ramos, Nathalia Sperotto, Bruno Lopes Abbadi, Fernanda Souza Macchi Hopf, Adilio da Silva Dadda, Raoní Scheibler Rambo, Mauro Neves Muniz, Josiane Delgado Paz, Estevão Silveira Grams, Fernanda Fries da Silva, Kenia Pissinate, Luiza Galina, Laura Calle González, Lovaine Silva Duarte, Marcia Alberton Perelló, Alexia de Matos Czeczot, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Evolutionary Biology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, mic ≤ 0, maintaining low rates, colony forming units, 2 -( quinolin, 02 μm ), 10 , mycobacterium tuberculosis <, exploring scaffold hopping, yloxy )­ acetamides, drug candidate telacebec, 1 , qcrb <, bc <, hopping strategy, >< sub, t313a ), selectivity index, resistant strains, resistant strain, proposed design, novel series, macrophage model

Relation: https://figshare.com/articles/journal_contribution/Exploring_Scaffold_Hopping_for_Novel_2_Quinolin-4-yloxy_acetamides_with_Enhanced_Antimycobacterial_Activity/25382507

الاتاحة: https://doi.org/10.1021/acsmedchemlett.3c00570.s002