المؤلفون: V. E. Korelina, I. N. Semizorova, I. R. Gazizova, Z. M. Nagornova, В. Е. Корелина, И. Н. Семизорова, И. Р. Газизова, З. М. Нагорнова

المصدر: National Journal glaucoma; Том 23, № 2 (2024); 70-78 ; Национальный журнал Глаукома; Том 23, № 2 (2024); 70-78 ; 2311-6862 ; 2078-4104

مصطلحات موضوعية: психотерапия, retinal ganglion cells, cognitive impairment, psychotherapy, ганглиозные клетки сетчатки, когнитивные нарушения

وصف الملف: application/pdf

Relation: https://www.glaucomajournal.ru/jour/article/view/526/469; Лосев А.Ф., Тахо-Годи А.А. Платон. Диалоги. Пер. с древнегреч. М: Мысль 1986; 607.; Зураева А.М., Джелиева З. Т. Психотерапевтическая работа с больными, имеющими хронические заболевания. Азимут научных исследований: педагогика и психология 2018; 2(23):367-369.; Evans-Lacko S., Aguilar-Gaxiola S., Al-Hamzawi A. et al. Socio-economic variations in the mental health treatment gap for people with anxiety, mood, and substance use disorders: results from the WHO World Mental Health (WMH) surveys. Psychol Med 2018; 48(9):1560- 1571. https://doi.org/10.1017/S0033291717003336.; Rockwood K., Macknight C., Wentzel C. et al. The diagnosis of «mixed» dementia in the Consortium for the Investigation of Vascular Impairment of Cognition (CIVIC). Ann. N.Y. Acad. Sci. 2000; 903:522-528. https://doi.org/10.1111/j.1749-6632.2000.tb06408.x.; Акимова Е.В., Гафаров В.В., Гакова Е.И., Акимов А.М., Каюмова М.М. Изучение связи депрессии и ишемической болезни сердца у мужчин и женщин открытой популяции среднеурбанизированного города Западной Сибири. Кардиоваскулярная терапия и профилактика 2021; 20(2):2557. https://doi.org/10.15829/1728-8800-2021-2557.; Vaccarino V., Badimon L., Bremner J.D. et al. Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation. Eur Heart J 2020; 41(17):1687-1696. https://doi.org/10.1093/eurheartj/ehy913.; Tang B., Yuan S., Xiong Y. et al. Major depressive disorder and cardiometabolic diseases: a bidirectional Mendelian randomisation study. Diabetologia 2020; 63(7):1305-1311.; Менделевич Е.Г. Хроническая мозговая сосудистая недостаточность: клинико-нейровизуализационные параметры, факторы риска и нейро-протективная терапия. РМЖ. 2016; 7:424-428.; Михайлов В.А. Терапия непсихотических психических расстройств в практике невролога. Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева 2014; 4:100-105.; Tariot P.N., Farlow M.R., Grossberg G.T. et al. Memantine treatment in patients with moderate-to-severe Alzheimer disease already receiving donepizil: a randomized controlled trial. JAMA 2004; 291(3):317-324. https://doi.org/10.1001/jama.291.3.317.; Lippi G., Sanchis-Gomar F., Mattiuzzi C., Lavie C.J. Estimating Worldwide Impact of Low Physical Activity on Risk of Developing Ischemic Heart Disease-Related Disability: An Updated Search in the 2019 Global Health Data Exchange (GHDx). Medicines (Basel) 2022; 9(11):55. https://doi.org/10.3390/medicines9110055.; Lee J.Y., Kim J.M., Kim S.H. et al. Epidemiologic Survey Committee of the Korean Ophthalmological Society. Associations Among Pregnancy, Parturition, and Open-angle Glaucoma: Korea National Health and Nutrition Examination Survey 2010 to 2011. J Glaucoma 2019; 28(1):14-19. https://doi.org/10.1097/IJG.0000000000001101.; Корелина В.Е., Газизова И.Р. Возрастные аспекты приверженности терапии глаукомы. Эффективная фармакотерапия 2021; 17(37):34-39. https://doi.org/10.33978/2307-3586-2021-17-37-34-39.; Jean-Louis G., Zizi F., Lazzaro D.R., Wolintz A.H. Circadian rhythm dysfunction in glaucoma: A hypothesis. Journal of Circadian Rhythms 2008; 6:1. https://doi.org/10.1186/1740-3391-6-1.; Panda S., Nayak S.K., Campo B. et al. Illumination of the melanopsin signaling pathway. Science 2005; 28; 307(5709):600-604. https://doi.org/10.1126/science.1105121.; Drouyer E., Dkhissi-Benyahya O., Chiquet C. et al. Glaucoma alters the circadian timing system. PLoS One 2008; 3(12):e3931. https://doi.org/10.1371/journal.pone.0003931.; Губин Д.Г., Малишевская Т.В., Вайнерт Д. и др. Особенности циркадианного ритма внутриглазного давления при стабильной и прогрессирующей первичной открытоугольной глаукоме. Тюменский медицинский журнал 2018; 20(3):3-9.; Козина Е.В. Влияние биологической обратной связи на интраокулярную гемодинамику больных первичной открытоугольной начальной глаукомой. Сибирское медицинское обозрение 2006; 42(5):20-22.; Otori Y., Takahashi G., Urashima M., Kuwayama Y. Evaluating the quality of life of glaucoma patients using the state-trait anxiety inventory. J Glaucoma 2017; 26(11):1025-1029. https://doi.org/10.1097/IJG.0000000000000761.; Takahashi G ., Otori Y., Urashima M. et al. Evaluation of quality of life in Japanese glaucoma patients and its relationship with visual function. J Glaucoma 2016; 25(3):150-56. https://doi.org/10.1097/IJG.0000000000000221.; Габдрахманов Л.М., Газизова И.Р., Селезнев А.В. и др. Психология глаукомного больного. Российский офтальмологический журнал 2020; 13(3):92-96. https://doi.org/10.21516/2072-0076-2020-13-3-92-96; Doustar J., Torbati T., Black K.L., Koronyo Y., Koronyo-Hamaoui M. Optical Coherence Tomography in Alzheimer's Disease and Other Neurodegenerative Diseases. Front Neurol 2017; 19(8):701. https://doi.org/10.3389/fneur.2017.00701.; Grimaldi A., Brighi C., Peruzzi G. et al. Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer’s disease in the 3xTg-AD mouse model. Cell Death Dis 2018; 9(6):685. https://doi.org/10.1038/s41419-018-0740-5.; Лобзин В.Ю., Мальцев Д.С., Струментова Е.С., Бурнашева М.А., Черемисин С.С. Офтальмологические маркеры болезни Альцгеймера. Медицинский алфавит 2022; 1:47-53. https://doi.org/10.33667/2078-5631-2022-1-47-53.; Martucci A., Picchi E., Di Giuliano F. et al. Imaging biomarkers for Alzheimer's disease and glaucoma: Current and future practices. Curr Opin Pharmacol 2022; 62:137-144. https://doi.org/10.1016/j.coph.2021.12.003.; De Lau L.M., Breteler M.M. Epidemiology of Parkinson’s disease. Lancet Neurol 2006; 5(6):525-535. https://doi.org/10.1016/S1474-4422(06)70471-9.; Guzman-Martinez L., Maccioni R.B., Farías G.A., Fuentes P., Navarrete L.P. Biomarkers for Alzheimer's Disease. Curr Alzheimer Res 2019; 16(6):518-528. https://doi.org/10.2174/1567205016666190517121140.; Wostyn P., Audenaert K., De Deyn P.P. Alzheimer's disease and glaucoma: is there a causal relationship? Br J Ophthalmol 2009; 93(12): 1557-1559. https://doi.org/10.1136/bjo.2008.148064.; Bayer A.U., Ferrari F., Erb C. High occurrence rate of glaucoma among patients with Alzheimer's disease. Eur Neurol 2002; 47(3):165-168. https://doi.org/10.1159/000047976.; Tamura H., Kawakami H., Kanamoto T. et al. High frequency of openangle glaucoma in Japanese patients with Alzheimer's disease. J Neurol Sci 2006; 246(1-2):79-83. https://doi.org/10.1016/j.jns.2006.02.009.; Yoneda S., Hara H., Hirata A. et al. Vitreous fluid levels of beta-amyloid(1-42) and tau in patients with retinal diseases. Jpn J Ophthalmol 2005; 49(2):106-108. https://doi.org/10.1007/s10384-004-0156-x.; Nucci C., Martucci A., Martorana A., Sancesario G.M., Cerulli L. Glaucoma progression associated with altered cerebral spinal fluid levels of amyloid beta and tau proteins. Clin Exp Ophthalmol 2011; 39(3):279-281. https://doi.org/10.1111/j.1442-9071.2010.02452.x.; Bayer A.U., Ferrari F., Erb C. High occurrence rate of glaucoma among patients with Alzheimer’s disease. Eur Neurol 2002; 47:165-168. https://doi.org/10.1159/000047976.; Trick G.L., Trick L.R., Morris P., Wolf M. Visual field loss in senile dementia of the Alzheimer’s disease type. Neurology 1995; 45:68-74. https://doi.org/10.1212/wnl.45.1.68.; Den Haan J., Verbraak F.D., Visser P.J., Bouwman F.H. Retinal thickness in Alzheimer’s disease: A systematic review and meta-analysis. Alzheimers Dement (Amst) 2017; 6:162-170. https://doi.org/10.1016/j.dadm.2016.12.014.; Cerquera-Jaramillo M.A., Nava-Mesa M.O., González-Reyes R.E. et al. Visual Features in Alzheimer’s Disease: From Basic Mechanisms to Clinical Overview. Neural Plast 2018; 14:2941783. https://doi.org/10.1155/2018/2941783.; Jones-Odeh E., Hammond C.J. How strong is the relationship between glaucoma, the retinal nerve fibre layer, and neurodegenerative diseases such as Alzheimer’s disease and multiple sclerosis? Eye (Lond) 2015; 29(10):1270-1284. https://doi.org/10.1038/eye.2015.158.; Егоров Е.А., Корелина В.Е., Чередниченко Д.В., Газизова И.Р. Роль нейровоспаления в патогенезе глаукомной оптической нейропатии. Клиническая офтальмология 2022; 22(2):116-121. https://doi.org/10.32364/2311-7729-2022-22-2-116-121.; Mullany S., Xiao L., Qassim A. et al. Normal-tension glaucoma is associated with cognitive impairment. Br J Ophthalmol 2022; 106(7):952-956. https://doi.org/10.1136/bjophthalmol-2020-317461.; Chen Y.Y., Lai Y.J., Yen Y.F. et al. Association between normal tension glaucoma and the risk of Alzheimer's disease: a nationwide population-based cohort study in Taiwan. BMJ Open 2018; 8(11):e022987. https://doi.org/10.1136/bmjopen-2018-022987.; Lai S.W., Lin C.L., Liao K.F. Glaucoma may be a non-memory manifestation of Alzheimer's disease in older people. Int Psychogeriatr 2017; 29:1-7. https://doi.org/10.1017/S1041610217000801.; Kessing L.V., Lopez A.G., Andersen P.K., Kessing S.V. No increased risk of developing Alzheimer disease in patients with glaucoma. J Glaucoma 2007; 16(1):47-51. https://doi.org/10.1097/IJG.0b013e31802b3527.; Lee C.S., Larson E.B., Gibbons L.E. et al. Associations between recent and established ophthalmic conditions and risk of Alzheimer's disease. Alzheimers Dement 2019; 15(1):34-41. https://doi.org/10.1016/j.jalz.2018.06.2856; Nasreddine Z.S., Phillips N.A., Bédirian V. et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 2005; 53(4):695-9. https://doi.org/10.1111/j.1532-5415.2005.53221.x.; Davis D.H., Creavin S.T., Yip J.L. et al. Montreal Cognitive Assessment for the diagnosis of Alzheimer's disease and other dementias. Cochrane Database Syst Rev 2015; 10:CD010775. https://doi.org/10.1002/14651858.CD010775.pub2.; Iseri P.K., Altinaş O., Tokay T., Yüksel N. Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease. J Neuroophthalmol 2006; 26(1):18-24. https://doi.org/10.1097/01.wno.0000204645.56873.26.; Ferrari L., Huang S.C., Magnani G. et al. Optical Coherence Tomography Reveals Retinal Neuroaxonal Thinning in Frontotemporal Dementia as in Alzheimer's Disease. J Alzheimers Dis 2017; 56(3):1101-1107. https://doi.org/10.3233/JAD-160886.; Almeida A.L.M., Pires L.A., Figueiredo E.A. Correlation between cognitive impairment and retinal neural loss assessed by swept-source optical coherence tomography in patients with mild cognitive impairment. Alzheimers Dement (Amst) 2019; 11:659-669. https://doi.org/10.1016/j.dadm.2019.08.006.; Ito Y., Sasaki M., Takahashi H. et al. Quantitative Assessment of the Retina Using OCT and Associations with Cognitive Function. Ophthalmology 2020; 127(1):107-118. https://doi.org/10.1016/j.ophtha.2019.05.021.; Ward D.D., Mauschitz M.M., Bönniger M.M. et al. Association of retinal layer measurements and adult cognitive function: A populationbased study. Neurology 2020; 95(9):e1144-e1152. https://doi.org/10.1212/WNL.0000000000010146.; Rezapour J., Nickels S., Schuster A.K. et al. Prevalence of depression and anxiety among participants with glaucoma in a population-based cohort study: The Gutenberg Health Study. BMC Ophthalmol 2018; 18(1):157. https://doi.org/10.1186/s12886-018-0831-1.; Richards S.H., Anderson L., Jenkinson C.E. et al. Psychological interventions for coronary heart disease: Cochrane systematic review and meta-analysis. Eur J Prev Cardiol 2018; 25(3):247-259. https://doi.org/10.1177/2047487317739978.; Conversano C., Orrù G., Pozza A. et al. Is Mindfulness-Based Stress Reduction Effective for People with Hypertension? A Systematic Review and Meta-Analysis of 30 Years of Evidence. Int J Environ Res Public Health 2021; 18(6):2882. https://doi.org/10.3390/ijerph18062882.; Larionov P. Psychological methods in treatment of essential hypertension. Arterial Hypertension 2021; 25(2):53-62. https://doi.org/10.5603/AH.a2021.0002; Sabel B.A., Wang J., Cárdenas-Morales L., Faiq M., Heim C. Mental stress as consequence and cause of vision loss: the dawn of psychosomatic ophthalmology for preventive and personalized medicine. EPMA J 2018; 9(2):133-160. https://doi.org/10.1007/s13167-018-0136-8.; Bertelmann T., Strempel I. Psychotherapeutic treatment options in glaucoma patients. Klin Monbl Augenheilkd 2021; 238(2):153-160. https://doi.org/10.1055/a-1244-6242.; Dada T., Mondal S., Midha N. et al. Effect of Mindfulness-Based Stress Reduction on Intraocular Pressure in Patients With Ocular Hypertension: A Randomized Control Trial. Am J Ophthalmol 2022; 239:66-73. https://doi.org/10.1016/j.ajo.2022.01.017.; Dada T., Bhai N., Midha N. et al. Effect of Mindfulness Meditation on Intraocular Pressure and Trabecular Meshwork Gene Expression: A Randomized Controlled Trial. Am J Ophthalmol 2021; 223:308-321. https://doi.org/10.1016/j.ajo.2020.10.012.; Корелина В.Е. Изучение коррекции перекисного окисления липидов антиоксидантами при экспериментальной глаукоме (экспериментальное исследование). Автореф. дисс. канд. мед. наук. 1999: 19.; Алексеев В.Н., Корелина В.Е., Шаша Ч. Нейропротекция новым антиоксидантом Рексод при экспериментальной глаукоме. Клиническая офтальмология 2008; 3:82-83.; Bredesen D.E., Sharlin K., Jenkins D. et al. Reversal of Cognitive Decline: 100 Patients. J Alzheimers Dis Parkinsonism 2018; 8:450. https://doi.org/10.4172/2161-0460.1000450.; Konkolÿ Thege B., Petroll C., Rivas C., Scholtens S. The Effectiveness of Family Constellation Therapy in Improving Mental Health: A Systematic Review. Fam Process 2021; 60(2):409-423. https://doi.org/10.1111/famp.12636.; Leaviss J., Davis S., Ren S. et al. Behavioural modification interventions for medically unexplained symptoms in primary care: systematic reviews and economic evaluation. Health Technol Assess. 2020; 24(46):1-490. https://doi.org/10.3310/hta24460; https://www.glaucomajournal.ru/jour/article/view/526

الاتاحة: https://www.glaucomajournal.ru/jour/article/view/526
https://doi.org/10.53432/2078-4104-2024-23-2-70-78

المؤلفون: T. A. Zhigalskaya, O. I. Krivosheina, V. P. Khazhieva, Т. А. Жигальская, О. И. Кривошеина, В. П. Хажиева

المصدر: Ophthalmology in Russia; Том 20, № 4 (2023); 708-713 ; Офтальмология; Том 20, № 4 (2023); 708-713 ; 2500-0845 ; 1816-5095 ; 10.18008/1816-5095-2023-4

مصطلحات موضوعية: апоптоз, optical neuroretinopathy, retina, retinal ganglion cells, degeneration, apoptosis, оптическая нейроретинопатия, сетчатка, ганглиозные клетки сетчатки, дегенерация

وصف الملف: application/pdf

Relation: https://www.ophthalmojournal.com/opht/article/view/2241/1167; Егоров, Е. А., Еричева В. П. Национальное руководство по глаукоме. М.: ГЭОТАР-Медиа, 2019. С. 3–8.; Tham YC, Li X, Wong TY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;(121):2081–2090. doi:10.1016/j.ophtha.2014.05.013.; Косакян С.М., Робустова О.В., Бессмертный А.М., Калинина О.М., Василенкова Л.В. Эффективность и безопасность комбинированной терапии первичной открытоугольной глаукомы. Вестник офтальмологии. 2020;136(5):96–102. doi:10.17116/oftalma202013605196.; Курышева Н.И., Арджевнишвили Т.Д., Трубилина А.В. Сравнительное исследование ретробульбарного и ретинального кровотока при первичной глаукоме и ее сочетании с ВМД. Новости глаукомы. 2017;1:69–72.; Страхов В.В., Ярцев А.В., Алексеев В.В., Климова О.Н., Казанова С.Ю., Воронин Н.А. Структурно-функциональные изменения слоев сетчатки при первичной глаукоме и возможные пути ретинопротекции. Вестник офтальмологии. 2019;135(2):70–82. doi:10.17116/oftalma201913502170.; Ying H, Yue BY. Optineurin: The autophagy connection. Exp Eye Res. 2016;(144):73–80. doi:10.1016/j.exer.2015.06.029.; Маркелова Е.В., Хохлова А.С., Кириенко А.В., Филина Н.В. Противовоспалительные цитокины и их роль в патогенезе первичной открытоугольной глаукомы. Медицинская иммунология. 2015;17(5):323.; Иванова Н.В., Кондратюк Г.И., Ляшенко Н.И. Структурно-функциональные изменения сетчатки при первичной открытоугольной глаукоме. Российский медицинский журнал. Клиническая офтальмология. 2015;2(15):61–64.; Матвеева Н.Ю., Калиниченко С.Г., Едранов С.С. Морфофункциональная характеристика ганглиозных клеток сетчатки и их состояние при открытоугольной форме глаукомы. Тихоокеанский медицинский журнал. 2015;3:6–10.; Зуева М.В. Динамика гибели ганглиозных клеток сетчатки при глаукоме и ее функциональные маркеры. Национальный журнал глаукома. 2016;1(15):70–85.; VanderWall KB, Lu B, Alfaro JS, Allsop AR, Carr AS, Wang S, Meyer JS. Differential susceptibility of retinal ganglion cell subtypes in acute and chronic models of injury and disease. Sci. Rep. 2020;10:17359. doi:10.1038/s41598-020-71460-6; Perge JA, Nivan JE, Mugnaini E, Balasubramanian V, Sterling P. Why do axons differ in caliber? J Neurosci 2012;32:626–638. doi:10.1523/jneurosci.4254-11.2012.; Morgan JE. Retina ganglion cell degeneration in glaucoma: an opportunity missed? A review. Clin Exp Ophthalmol 2012;40:364–368. doi:10.1111/j.14429071.2012.02789.x.; Della Santina L, Ou Y. Who’s lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma. Exp. Eye Res. 2017;158:43–50. doi:10.1016/j.exer.2016.06.006.; Еричев В.П., Хачатрян Г.К., Хомчик О.В. Современные направления в изучении патогенеза первичной глаукомы. Вестник офтальмологии. 2021;137(5):268–274.; He J, Lu S, Chen L, Tam P, Zhang B, Leung C, Pang C, Tham C, Chu W. Coding Region Mutation Screening in Optineurin in Chinese Normal-Tension Glaucoma Patients. Dis Markers. 2019;5820537. doi:10.1155/2019/5820537.; Chen M, Yu X, Xu J, Ma J, Chen X, Chen B, Gu Y, Wang K. Association of gene polymorphisms with primary open-angle glaucoma: a systematic rewiew and metaanalysis. Investig Ophthalmol Vis Sci. 2019;60(4):1105–1121. doi:10.1167/iovs.1825922.; Романенко И.А. Генетика глаукомы. Военно-медицинский журнал. 2009;6:46–50.; Calkins DJ. Critical pathogenic events underlying progression of neurodegeneration in glaucoma. Prog Retin Eye Res. 2012;31:702–719. doi:10.1016/j.preteyeress.2012.07.001.; Jung H, Kim SY, Canbakis Cecen FS, Cho Y, Kwon SK. Dysfunction of Mitochondrial Ca(2+) Regulatory Machineries in Brain Aging and Neurodegenerative Diseases. Front. Cell Dev. Biol. 2020;8:599792. doi:10.3389/fcell.2020.599792.; Ito YA, Di Polo A. Mitochondrial dynamics, transport, and quality control: A bottleneck for retinal ganglion cell viability in optic neuropathies. Mitochondrion. 2017;36:186–192. doi:10.1016/j.mito.2017.08.014.; Reeves TM, Smith TL, Williamson JC, Phillips LL. Unmyelinated axons show selective rostrocaudal pathology in the corpus callosum after traumatic brain injury. J Neuropathol Exp Neurol 2012;71:198–210. doi:10.1097/nen.0b013e3182482590.; Varnazza S, Tirendi S, Bassi AM, Traverso CE, Sacca SC. Neuroinflammation in primary Open-Angle Glaucoma. Journal of Clinical Medicine. 2020;9(10):3172. doi:10.3390/jcm9103172.; Tsai T, Grotegut P, Reinehr S, Joachim SC. Role of Heart Shock Proteins in Glaucoma. International Journal of Molecular Sciences. 2019;20(20):5160. doi:10.3390/ijms20205160.; Егоров Е.А., Корелина В.Е., Чередниченко Д.В., Газизова И.Р. Роль нейровоспаления в патогенезе глаукомной оптической нейропатии. Клиническая офтальмология. 2022;22(2):116–121.; Fernandez-Albarral JA, Salobrar-Garcia E, Martinez-Paramo R. Retinal glial changes in Alzheimer’s disease — A rewiew. J Ophtalm. 2019;12(3):198–207. doi:10.1016/j.optom.2018.07.001.; Должиков А.А., Победа А.С., Шевченко О.А. Морфофункциональные изменения сетчатки при моделировании глаукомного процесса у крыс. Научные результаты биомедицинских исследований. 2020;6(4):503–514. doi:10.18413/2658-6533-2020-6-4-0-6.; Van Hook MJ, Monaco C, Bierlein ER, Smith JC. Neuronal and Synaptic Plasticity in the Visual Thalamus in Mouse Models of Glaucoma. Front. Cell. Neurosci. 2021;14:626056. doi:10.3389/fncel.2020.626056.; El-Danaf R, Huberman AD. Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types. J Neurosci 2015;35(6):2329–2343. doi:10.1523/jneurosci.1419-14.2015.; Berry RH, Qu J, John SW, Howell GR, Jakobs TC. Synapse loss and dendrite remodeling in a mouse model of glaucoma. PLoS One 2015;10(12):e0144341. doi:10.1371/journal.pone.0144341. eCollection 2015.; Chen Q, Huang S, Ma Q, Lin H, Pan M, Liu X, Lu F, Shen M. Ultra-high resolution profiles of macular intra-retinal layer thicknesses and associations with visual field defects in primary open angle glaucoma. Sci Rep. 2017;7:41100. doi:10.1038/srep41100.; Курышева Н.И., Киселева Т.Н., Арджевнишвили Т.Д. и др. Хориоидея при глаукоме: результаты исследования методом оптической когерентной томографии. Глаукома. 2013;10(3-2):73–82. doi:10.18008/18165095-2013-4-26-31.; Zhang X, Dastiridou A, Francis BA. Baseline Fourier-Domain OCT Structural Risk Factors for Visual Field Progression in the Advanced Imaging for Glaucoma Study. Am J Ophthalmol. 2016;172:94–103. doi:10.1016/j.ajo.2016.09.015.; Weinreb NR, Bowd C, Moghimi S, Tafreshi A, Rausch S, Zangwill LM. Ophthalmic Diagnostic Imaging: Glaucoma. High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics [Internet]. 2019. doi:10.1007/9783-030-16638-0_5.; Курышева Н.И. Роль нарушений ретинальной микроиркуляции в прогрессировании глаукомной оптиконейропатии. Вестник офтальмологии. 2020;136(4):57–65.; Kurysheva N.I., Maslova E.V., Zolnikova I.V., Fomin A.V., Lagutin M.B. A comparative study of structural, functional and circulatory parameters in glaucoma diagnostics. PLoS ONE;2018:13(8).; Kurysheva N.I. Does OCT Angiography of Macula Play a Role in Glaucoma Diagnostics? Ophthalmol Open J. 2016;2(1):1–11. doi:10.17140/OOJ-2-107.; Kurysheva NI, Shatalova EO. Parafoveal vessel Density Dropout May Predict Glaucoma Progression in The Long-Term Follow Up. Journal of Ophthalmology and Research. 2022:5:150–166.; Kurysheva NI, Ryabova TY, Shlapak VN. Heart rate variability: the comparison between high tension and normal tension glaucoma. EPMA Journal. 2018;9:35–45. doi:10.1007/s13167-017-0124-4.; Глазко Н.Г., Егоров А.Е. Анализ состояния микроциркуляторного русла центральной зоны сетчатки у больных глаукомой при проведении нейроретинопротекторной терапии. Клиническая офтальмология. 2021;1(21):3–8. doi:10.32364/2311-7729-2021-21-1-3-8.; Aghaei Fard M, Ritch R. Optical coherence tomography angiography in glaucoma. Ann Transl Med. 2020;8(18):1204. doi:10.21037/atm-20-2828.; Kim JS, Kim YK, Baek SU. Topographic correlation between macular superficial microvessel density and ganglion cell-inner plexiform layer thickness in glaucomasuspect and early normal-tension glaucoma. Br J Ophthalmol. 2020;104(1):104–109. doi:10.1136/bjophthalmol-2018-313732.; Hou H, Moghimi S, Zangwill LL. Macula Vessel Density and Thikness in Early Primary Open-Angle Glaucoma. Am J Ophthalmol. 2019;199:120–132. doi:10.1016/j.ajo.2018.11.012.; Курышева Н.И., Маслова Е.В., Трубилина А.В. Снижение перипапиллярного кровотока как фактор развития и прогрессирования первичной открытоугольной глаукомы. Российский офтальмологический журнал. 2016;3:34–41.; Жукова С.И., Юрьева Т.И., Помкина И.В., Грищук А.С. Особенности хориоретинального кровотока у больных с открытоугольной глаукомой. Сибирский научный медицинский журнал. 2018;38(5):38–44.; Жукова С.И., Юрьева Т.Н., Микова О.И., Самсонов Д.Ю., Григорьева А.В., Пятова Ю.С. ОКТ-ангиография в оценке хориоретинального кровотока при колебании внутриглазного давления у больных первичной открытоугольной глаукомой. Клиническая офтальмология. 2016;16(3):98–103.; Pelligrini M, Vagge A, Ferro Desideri LF, et al. Optical Coherence Tomography Angiography in Neurodegenerative disorders. J Clin Med. 2020;9(6):1706. doi:10.3390/jcm9061706.; Бгатова Н.П., Обанина Н.А., Еремина А.В., Трунов А.Н., Черных В.В. Структура сосудистого русла и интерстиция сетчатки глаза человека при терминальной стадии первичной открытоугольной глаукомы. Российский офтальмологический журнал. 2022;15(2):121–128. doi:10.21516/2072-0076-2022-15-2-supplement-121-128.; Shiihara H, Terasaki H, Sonoda S. Objective evaluation of size and shape of superficial foveal avascular zone in normal subjects by optical coherence tomography angiography. Sci rep. 2018;8(1):10143. doi:10.1038/s41598-018-28530-7.; Kwon G, Сhoi G, Shin GW. Alterations of the Foveal Avascular Zone Measured by Optical Coherence Tomography Angiography in Glaucoma Patients with Central Visual Field Defects. Invest Ophthalmol with Sci. 2017;58(3):1637–1645. doi:10.1167/iovs.16-21079.; https://www.ophthalmojournal.com/opht/article/view/2241

الاتاحة: https://www.ophthalmojournal.com/opht/article/view/2241
https://doi.org/10.18008/1816-5095-2023-4-708-713

المؤلفون: M. V. Zueva, A. N. Zhuravleva, A. N. Bogolepova, М. В. Зуева, А. Н. Журавлева, А. Н. Боголепова

المصدر: Ophthalmology in Russia; Том 19, № 3 (2022); 532-540 ; Офтальмология; Том 19, № 3 (2022); 532-540 ; 2500-0845 ; 1816-5095 ; 10.18008/1816-5095-2022-3

مصطلحات موضوعية: нейропротекция, Alzheimer’s disease, retina, dendrites, retinal ganglion cells, neuroprotection, болезнь Альцгеймера, сетчатка, дендриты, ганглиозные клетки сетчатки

وصف الملف: application/pdf

Relation: https://www.ophthalmojournal.com/opht/article/view/1917/1010; Quigley H.A., Broman A.T. The number of people with glaucoma worldwide in 2010 and 2020. Br. J. Ophthalmol. 2006;90:262–267. DOI:10.1136/bjo.2005.081224; Pascolini D., Mariotti S.P. Global estimates of visual impairment: 2010. Br J Ophthalmol. 2012;96:614–618. DOI:10.1136/bjophthalmol-2011-300539; Tham Y.-Ch., Li X., Wong T.Y., Quigley H.A., Aung T., Cheng Ch-Y. Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040. A Systematic Review and Meta-Analysis. Ophthalmology. 2014;121(11):2081–2090. DOI:10.1016/j.ophtha.2014.05.013; Quigley H.A. Neuronal death in glaucoma. Prog Retin Eye Res 1999;18:39–57. DOI:10.1016/s1350-9462(98)00014-7; Yucel Y., Gupta N. Glaucoma of the brain: a disease model for the study of transsynaptic neural degeneration. Prog Brain Res. 2008;173:465–478. DOI:10.1016/S0079-6123(08)01132-1; Sommer A. Intraocular pressure and glaucoma. Am. J. Ophthalmol. 1989;107:186– 188. DOI:10.1016/0002-9394(89)90221-3; Peters D., Bengtsson B., Heijl A. Factors associated with lifetime risk of open-angle glaucoma blindness. Acta Ophthalmol. 2014;92:421–425. DOI:10.1111/aos.12203; Сollaborative normal-tension glaucoma study group. The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Am. J. Ophthalmol. 1998;126:498–505. DOI:10.1016/s0002-9394(98)00272-4; Williams P.A., Thirgood R.A., Oliphant H., Frizzati A., Littlewood E., Votruba M., Good M.A., Williams J., Morgan J.E. Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer’s disease. Neurobiol. Aging. 2013;34(7):1799–1806. DOI:10.1016/j.neurobiolaging.2013.01.006; Blanks J.C., Schmidt S.Y., Torigoe Y., Porrello K.V., Hinton D.R., Blanks R.H. Retinal pathology in Alzheimer’s disease. II. Regional neuron loss and glial changes in GCL. Neurobiol. Aging. 1996;17:385–395. DOI:10.1016/0197-4580(96)00009-7; Johnson L.V., Leitner W.P., Rivest A.J., Staples M.K., Radeke M.J., Anderson D.H. The Alzheimer’s A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci USA. 2002;99:11830–11835. DOI:10.1073/pnas.192203399; Wostyn P., Audenaert K., De Deyn P.P. Alzheimer’s disease: cerebral glaucoma? Medical Hypotheses. 2010;74(6):973–977. DOI:10.1016/j.mehy.2009.12.019; Koronyo-Hamaoui M., Koronyo Y., Ljubimov A.V., Miller C.A., Ko M.K., Black K.L., Schwartz M., Farkas D.L. Identification of amyloid plaques in retinas from Alzheimer’s patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. Neuroimage. 2011;54,204–217. DOI:10.1016/j.neuroimage.2010.06.020; Curcio C.A., Drucker D.N. Retinal ganglion cells in Alzheimer’s disease and aging. Ann. Neurol. 1993;33:248–257. DOI:10.1002/ana.410330305; Paquet C., Boissonnot M., Roger F., Dighiero P., Gil R., Hugon J. Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer’s disease. Neurosci. Lett. 2007;420:97–99. DOI:10.1016/j.neulet.2007.02.090; Боголепова А.Н., Махнович Е.В., Журавлева А.Н. Коморбидность болезни Альцгеймера и геронтоофтальмологических заболеваний. Журнал неврологии и психиатрии имени С.С. Корсакова. 2019;119(9):17–22. DOI:10.17116/jnevro201911909117; Guo L., Salt T.E., Luong V., Wood N., Cheung W., Maass A., Ferrari G., Russo-Marie F., Sillito A.M., Cheetham M.E., Moss S.E., Fitzke F.W., Cordeiro M.F. Targeting amyloid-beta in glaucoma treatment. Proc. Natl. Acad. Sci. U.S.A. 2007;104:13444– 13449. DOI:10.1073/pnas.0703707104; No authors listed. The advanced glaucoma intervention study (AGIS): 7. the relationship between control of intraocular pressure and visual field deterioration. Am. J. Ophthalmol. 2000;130:429–440. DOI:10.1016/s0002-9394(00)00538-9; Della Santina L., Inman D.M., Lupien C.B., Horner P.J., Wong R.O. Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma. J. Neurosci. 2013;33:17444–17457. DOI:10.1523/JNEUROSCI.5461-12.2013; El-Danaf R.N., Huberman A.D. Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types. J Neurosci. 2015;35(6):2329–2343. DOI:10.1523/JNEUROSCI.1419-14.2015; Sabharwal J., Seilheimer R.L., Tao X., Cowan C.S., Frankfort B.J., Wu S.M. Elevated IOP alters the space–time profiles in the center and surround of both ON and OFF RGCs in mouse. Proc Natl Acad Sci U.S.A. 2017;114:8859–8864. DOI:10.1073/pnas.1706994114; Della Santina L., Ou Y. Who’s lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma. Exp. Eye Res. 2017;158:43–50. DOI:10.1016/j.exer.2016.06.006; Tao X., Sabharwal J., Seilheimer R.L., Wu S.M., Frankfort B.J. Mild Intraocular Pressure Elevation in Mice Reveals Distinct Retinal Ganglion Cell Functional Thresholds and Pressure-Dependent Properties. J. Neurosci. 2019;39(10):1881–1891. DOI:10.1523/JNEUROSCI.2085-18.2019; Son J.L., Soto I., Oglesby E., Lopez-Roca T., Pease M. E., Quigley H.A., MarchArmstrong N. Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss. Glia. 2010;58(7):780–789. DOI:10.1002/glia.20962; Guo L., Salt T.E., Maass A., Luong V., Moss S.E., Fitzke F.W., Cordeiro M.F. Assessment of neuroprotective effects of glutamate modulation on glaucomarelated retinal ganglion cell apoptosis in vivo. Invest. Ophthalmol. Vis. Sci. 2006;47:626–633. DOI:10.1167/iovs.05-0754; Sladek A.L., Nawy S. Ocular Hypertension Drives Remodeling of AMPA Receptors in Select Populations of Retinal Ganglion Cells. Front. Synaptic Neurosci. 2020;12:30. Published 2020 Jul 24. DOI:10.3389/fnsyn.2020.00030; Farlow M.R. NMDA receptor antagonists: a new therapeutic approach for Alzheimer’s disease. Geriatrics. 2004;59:22–27.; Prati F., Cavalli A., Bolognesi M.L. Navigating the chemical space of multitargetdirected ligands: from hybrids tofragments in Alzheimer’s disease. Molecules. 2016;21(4): Article 466. 12 p. DOI:10.3390/molecules21040466; Loffler K.U., Edward D.P., Tso M.O. Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina. Invest. Ophthalmol. Visual. Sci. 1995;36:24–31.; Salt T.E., Nizari S., Cordeiro M.F., Russ H., Danysz W. Effect of the Ab Aggregation Modulator MRZ-99030 on Retinal Damage in an Animal Model of Glaucoma. Neurotox Res. 2014;26:440–446. DOI:10.1007/s12640-014-9488-6; Morquette J.B., Di Polo A. Dendritic and synaptic protection: is it enough to save the retinal ganglion cell body and axon? J. Neuroophthalmol. 2008;28:144–154. DOI:10.1097/wno.0b013e318177edf0; Klunk W.E., Engler H., Nordberg A., Wang Y., Blomqvist G., Holt D.P., Bergstrom M., Savitcheva I., Huang G.F., Estrada S., Ausen B., Debnath M.L., Barletta J., Price J.C., Sandell J., Lopresti B.J., Wall A., Koivisto P., Antoni G., Mathis C.A., Langstrom B. Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann. Neurol. 2004;55:306–319. DOI:10.1002/ana.20009; McEvoy L.K., Brewer J.B. Quantitative structural MRI for early detection of Alzheimer’s disease. Expert Rev. Neurother. 2010;10:1675–1688. DOI:10.1586/ern.10.162; Selkoe D.J. Alzheimer’s disease is a synaptic failure. Science. 2002;298:789–791. DOI:10.1126/science.1074069; Cordeiro M.F., Guo L., Coxon K.M., Duggan J., Nizari S., Normando E.M., Sensi S.L., Sillito A.M., Fitzke F.W., Salt T.E., Moss S.E. Imaging multiple phases of neurodegeneration: a novel approach to assessing cell. Cell Death Dis. 2010;1:3. DOI:10.1038/cddis.2009.3; Koronyo Y., Salumbides B.C., Black K.L., Koronyo-Hamaoui M. Alzheimer’s disease in the retina: imaging retinal aß plaques for early diagnosis and therapy assessment. Neurodegener. Dis. 2012;10:285–293. DOI:10.1159/000335154. Epub 2012 Feb 10.; Morgan J.E., Datta A.V., Erichsen J.T., Albon J., Boulton M.E. Retinal ganglion cell remodelling in experimental glaucoma. Adv Exp Med Biol. 2006;572:397–402. DOI:10.1007/0-387-32442-9_56; Weber A.J., Kaufman P.L., Hubbard W.C. Morphology of single ganglion cells in the glaucomatous primate retina. Invest. Ophthalmol. Vis. Sci. 1998;39:2304–2320.; Williams P.A., Piechota M., von Ruhland C., Taylor E., Morgan J.E., Votruba M. Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity. Brain. 2012;135:493–505. DOI:10.1093/brain/awr330; Scheff S.W., Price D.A., Schmitt F.A., Mufson E.J. Hippocampal synaptic loss in early Alzheimer’s disease and mild cognitive impairment. Neurobiol. Aging. 2006;27:1372–1384. DOI:10.1016/j.neurobiolaging.2005.09.012. Epub 2005 Nov 9.; Beckers A., Moons L. Dendritic shrinkage after injury: a cellular killer or a necessity for axonal regeneration? Neural Regen Res. 2019;14(8):1313–1316. DOI:10.4103/1673-5374.253505; O’Brien J., Bloomfield S.A. Plasticity of Retinal Gap Junctions: Roles in Synaptic Physiology and Disease. Ann. Rev. Vis. Sci. 2018;4:79–100. DOI:10.1146/annurevvision-091517-034133; Dutescu R.M., Li Q.X., Crowston J., Masters C.L., Baird P.N., Culvenor J.G. Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer’s disease. Graefes. Arch. Clin. Exp. Ophthalmol. 2009;247:1213–1221. DOI:10.1007/s00417-009-1060-3; Lee V., Rekhi E., Hoh Kam J., Jeffery G. Vitamin D rejuvenates aging eyes by reducing inflammation, clearing amyloid beta. Neurobiol. Aging. 2012;33:2382–2389. DOI:10.1016/j.neurobiolaging.2011.12.002; Ohno-Matsui K. Parallel findings in age-related macular degeneration and Alzheimer’s disease. Prog. Retin. Eye Res. 2011;30:217–238. DOI:10.1016/j.preteyeres.2011.02.004; Osborne N.N. Pathogenesis of ganglion “cell death” in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria. Prog. Brain Res. 2008;173:339– 352. DOI:10.1016/S0079-6123(08)01124-2; Wang L., Dong J., Cull G., Fortune B., Cioffi G.A. Varicosities of intraretinal ganglion cell axons in human and nonhuman primates. Invest. Ophthalmol. Vis. Sci. 2003;44:2–9. DOI:10.1167/iovs.02-0333; Calkins M.J., Manczak M., Mao P., Shirendeb U., Reddy P.H. Impaired mitochondrial biogenesis, defective axonal transport of mitochondria. Hum. Mol. Genet. 2011;20:4515–4529. DOI:10.1093/hmg/ddr381. Epub 2011 Aug 25.; McAllister A.K. Neurotrophins and neuronal differentiation in the central nervous system. Cellular and Molecular Life Sciences (CMLS). 2001;58(8):1054–1060. DOI:10.1007/PL00000920; Зуева М.В. Созревание и пластичность зрительной системы: нейрогенез, синаптогенез и миелиногенез. I. Сетчатка и ретино-геникулятные проекции. Вестник офтальмологии. 2012;128(3):37–41.; McAllister A.K. Cellular and Molecular Mechanisms of Dendrite Growth. Cerebral Cortex. 2020; Nov. 10(10):963–973. DOI:10.1093/cercor/10.10.963; Francardo V., Schmitz Y., Sulzer D., Cenci M.A. Neuroprotection and neurorestoration as experimental therapeutics for Parkinson’s disease. Exp. Neurol. 2017;298:137–147. DOI:10.1016/j.expneurol.2017.10.001; Gidday J.M. Adaptive Plasticity in the Retina: Protection against acute injury and neurodegenerative disease by conditioning stimuli. Conditioning Medicine. 2018;1(2):85–97.; Franceschi C., Garagnani P., Morsiani C., Conte M., Santoro A., Grignolio A., Monti D., Capri M., Salvioli S. The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates. Front. Med., 12 March 2018, DOI:10.3389/fmed.2018.00061; Morgan J.E. Retina ganglion cell degeneration in glaucoma: an opportunity missed? A review. Clin. Exp. Ophthalmol. 2012;40:364–368. DOI:10.1111/j.14429071.2012.02789.x; Ly T., Gupta N., Weinreb R.N., Kaufman P.L., Yucel Y.H. Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma. Vis. Res. 2011;51(2):243–250. DOI:10.1016/j.visres.2010.08.003; Kalesnykas G., Oglesby E.N., Zack D.J., Cone F.E., Steinhart M.R., Tian J., Pease M.E., Quigley H.A. Retinal ganglion cell morphology after optic nerve crush and experimental glaucoma. Invest Ophthalmol Vis Sci. 2012;53(7):3847–3857. Published 2012 Jun 22. DOI:10.1167/iovs.12-9712; Agostinone J., Alarcon-Martinez L., Gamlin C., Yu W.Q., Wong R.O.L., Di Polo A. Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury. Brain. 2018;141:1963–1980. DOI:10.1093/brain/awy142; Beckers A., Van Dyck A., Bollaerts I., Van Houcke J., Lefevere E., Andries L., Agostinone J., Van Hove I., Di Polo A., Lemmens K., Moons L. An antagonistic axon-dendrite interplay enables efficient neuronal repair in the adult Zebrafish central nervous system. Mol Neurobiol. 2018 56(5):3175–3192. DOI:10.1007/s12035-018-1292-5; Chung S.H., Awal M.R., Shay J., McLoed M.M., Mazur E., Gabel C.V. Novel DLKindependent neuronal regeneration in Caenorhabditis elegans shares links with activity-dependent ectopic outgrowth. Proc Natl Acad Sci U.S.A. 2016;113:E2852– 2860. DOI:10.1093/brain/awy142; Han S.M., Baig H.S., Hammarlund M. Mitochondria localize to injured axons to support regeneration. Neuron. 2016;92:1308–1323. DOI:10.1016/j.neuron.2016.11.025; Mar F.M., Simoes A.R., Leite S., Morgado M.M., Santos T.E., Rodrigo I.S., Teixeira C.A., Misgeld T., Sousa M.M. CNS axons globally increase axonal transport after peripheral conditioning. J Neurosci. 2014;34:5965–5970. DOI:10.1523/JNEUROSCI.4680-13.2014; Cai Q., Sheng Z.H. Mitochondrial transport and docking in axons. Exp Neurol. 2009;218:257–267. DOI:10.1016/j.expneurol.2009.03.024; Drummond E.S., Rodger J., Penrose M., Robertson D., Hu Y., Harvey A.R. Effects of intravitreal injection of a Rho-GTPase inhibitor (BA-210), or CNTF combined with an analogue of cAMP, on the dendritic morphology of regenerating retinal ganglion cells. Restor Neurol Neurosci. 2014;32:391–402. DOI:10.3233/RNN-130360; McAllister A.K., Katz L.C., Lo D.C. Neurotrophin regulation of cortical dendritic growth requires activity. Neuron. 1996;17:1057–1064. DOI:10.1016/s08966273(00)80239-1; Lom B., Cohen-Cory S. Brain-derived neurotrophic factor differentially regulates retinal ganglion cell dendritic and axonal arborization in vivo. J. Neurosci. 1999;19:9928–9938. DOI:10.1523/JNEUROSCI.19-22-09928; Rauskolb S., Zagrebelsky M., Dreznjak A., Deogracias R., Matsumoto T., Wiese S., Erne B., Sendtner M., Schaeren-Wiemers N., Korte M., Barde Y-A. Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth. J. Neurosci. 2010;30:1739–1749. DOI:10.1523/JNEUROSCI.5100-09.2010; Di Polo A., Aigner L.J., Dunn R.J., Bray G.M., Aguayo A.J. Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells. Proc. Natl. Acad. Sci. USA. 1998;95:3978– 3983. DOI:10.1073/pnas.95.7.3978; Weber A.J., Harman C.D. BDNF preserves the dendritic morphology of alpha and beta ganglion cells in the cat retina after optic nerve injury. Invest. Ophth. Vis. Sci. 2008;49:2456–2463. DOI:10.1167/iovs.07-1325; Rodger J., Drummond E.S., Hellstrom M., Robertson D., Harvey A.R. Long-term gene therapy causes transgene-specific changes in the morphology of regenenerating retinal ganglion cells. PLoS One. 2012;7:e31061. DOI:10.1371/journal.pone.0031061; Binley K.E., Ng W.S., Barde Y.-A., Song B., Morgan J.E. Brain-derived neurotrophic factor prevents dendritic retraction of adult mouse retinal ganglion cells. Eur. J. Neurosci. 2016;44:2028–2039. DOI:10.1111/ejn.13295; https://www.ophthalmojournal.com/opht/article/view/1917

الاتاحة: https://www.ophthalmojournal.com/opht/article/view/1917
https://doi.org/10.18008/1816-5095-2022-3-532-540

المؤلفون: M. V. Zueva, A. N. Zhuravleva, A. N. Bogolepova, М. В. Зуева, А. Н. Журавлева, А. Н. Боголепова

المصدر: Ophthalmology in Russia; Том 18, № 2 (2021); 198-207 ; Офтальмология; Том 18, № 2 (2021); 198-207 ; 2500-0845 ; 1816-5095 ; 10.18008/1816-5095-2021-2

مصطلحات موضوعية: нейропротекция, Alzheimer’s disease, retina, dendrites, retinal ganglion cells, neuroprotection, болезнь Альцгеймера, сетчатка, дендриты, ганглиозные клетки сетчатки

وصف الملف: application/pdf

Relation: https://www.ophthalmojournal.com/opht/article/view/1533/818; Quigley H.A., Broman A.T. The number of people with glaucoma worldwide in 2010 and 2020. Br. J. Ophthalmol. 2006;90:262–267. DOI:10.1136/bjo.2005.081224; Pascolini D., Mariotti S.P. Global estimates of visual impairment: 2010. Br J Ophthalmol. 2012;96:614–618. DOI:10.1136/bjophthalmol-2011-300539; Tham Y.-Ch., Li X., Wong T.Y., Quigley H.A., Aung T., Cheng Ch-Y. Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040. A Systematic Review and Meta-Analysis. Ophthalmology. 2014;121(11):2081–2090. DOI:10.1016/j.ophtha.2014.05.013; Quigley H.A. Neuronal death in glaucoma. Prog Retin Eye Res. 1999;18:39–57. DOI:10.1016/s1350-9462(98)00014-7; Yucel Y., Gupta N. Glaucoma of the brain: a disease model for the study of transsynaptic neural degeneration. Prog Brain Res. 2008;173:465–478. DOI:10.1016/S00796123(08)01132-1; Sommer A. Intraocular pressure and glaucoma. Am. J. Ophthalmol. 1989;107:186– 188. DOI:10.1016/0002-9394(89)90221-3; Peters D., Bengtsson B., Heijl A. Factors associated with lifetime risk of open-angle glaucoma blindness. Acta Ophthalmol. 2014;92:421–425. DOI:10.1111/aos.12203; No authors listed The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma: collaborative normal-tension glaucoma study group. Am. J. Ophthalmol. 1998;126:498–505. DOI:10.1016/s0002-9394(98)00272-4; Williams P.A., Thirgood R.A., Oliphant H., Frizzati A., Littlewood E., Votruba M., Good M.A., Williams J., Morgan J.E. Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer’s disease. Neurobiol. Aging. 2013;34(7):1799–1806. DOI:10.1016/j.neurobiolaging.2013.01.006; Blanks J.C., Schmidt S.Y., Torigoe Y., Porrello K.V., Hinton D.R., Blanks R.H. Retinal pathology in Alzheimer’s disease. II. Regional neuron loss and glial changes in GCL. Neurobiol. Aging. 1996;17:385–395. DOI:10.1016/0197-4580(96)00009-7; Johnson L.V., Leitner W.P., Rivest A.J., Staples M.K., Radeke M.J., Anderson D.H. The Alzheimer’s A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci USA. 2002;99:11830–11835. DOI:10.1073/pnas.192203399; Wostyn P., Audenaert K., De Deyn P.P. Alzheimer’s disease: cerebral glaucoma? Medical Hypotheses. 2010;74(6):973–977. DOI:10.1016/j.mehy.2009.12.019; Koronyo-Hamaoui M., Koronyo Y., Ljubimov A.V., Miller C.A., Ko M.K., Black K.L., Schwartz M., Farkas D.L. Identification of amyloid plaques in retinas from Alzheimer’s patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. Neuroimage. 2011;54,204–217. DOI:10.1016/j.neuroimage.2010.06.020; Curcio C.A., Drucker D.N. Retinal ganglion cells in Alzheimer’s disease and aging. Ann. Neurol. 1993;33:248–257. DOI:10.1002/ana.410330305; Paquet C., Boissonnot M., Roger F., Dighiero P., Gil R., Hugon J. Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer’s disease. Neurosci. Lett. 2007;420:97–99. DOI:10.1016/j.neulet.2007.02.090; Боголепова А.Н., Махнович Е.В., Журавлева А.Н. Коморбидность болезни Альцгеймера и геронтоофтальмологических заболеваний. Журнал неврологии и психиатрии имени С.С. Корсакова. 2019;119(9):17–22. DOI:10.17116/jnevro201911909117; Guo L., Salt T.E., Luong V., Wood N., Cheung W., Maass A., Ferrari G., Russo-Marie F., Sillito A.M., Cheetham M.E., Moss S.E., Fitzke F.W., Cordeiro M.F. Targeting amyloid-beta in glaucoma treatment. Proc. Natl. Acad. Sci. U.S.A. 2007;104:13444– 13449. DOI:10.1073/pnas.0703707104; The AGIS Investigator. The advanced glaucoma intervention study (AGIS): 7. the relationship between control of intraocular pressure and visual field deterioration. Am. J. Ophthalmol. 2000;130:429–440. DOI:10.1016/s0002-9394(00)00538-9; Della Santina L., Inman D.M., Lupien C.B., Horner P.J., Wong R.O. Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma. J. Neurosci. 2013;33:17444–17457. DOI:10.1523/JNEUROSCI.5461-12.2013; El-Danaf R.N., Huberman A.D. Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types. J Neurosci. 2015;35(6):2329–2343. DOI:10.1523/JNEUROSCI.1419-14.2015; Sabharwal J., Seilheimer R.L., Tao X., Cowan C.S., Frankfort B.J., Wu S.M. Elevated IOP alters the space–time profiles in the center and surround of both ON and OFF RGCs in mouse. Proc Natl Acad Sci U.S.A. 2017;114:8859–8864. DOI:10.1073/pnas.1706994114; Della Santina L., Ou Y. Who’s lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma. Exp. Eye Res. 2017;158:43–50. DOI:10.1016/j.exer.2016.06.006; Tao X., Sabharwal J., Seilheimer R.L., Wu S.M., Frankfort B.J. Mild Intraocular Pressure Elevation in Mice Reveals Distinct Retinal Ganglion Cell Functional Thresholds and Pressure-Dependent Properties. J. Neurosci. 2019;39(10):1881–1891. DOI:10.1523/JNEUROSCI.2085-18.2019; Son J.L., Soto I., Oglesby E., Lopez-Roca T., Pease M. E., Quigley H.A., MarchArmstrong N. Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss. Glia. 2010;58(7):780–789. DOI:10.1002/glia.20962; Guo L., Salt T.E., Maass A., Luong V., Moss S.E., Fitzke F.W., Cordeiro M.F. Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo. Invest. Ophthalmol. Vis. Sci. 2006;47:626–633. DOI:10.1167/iovs.05-0754; Sladek A.L., Nawy S. Ocular Hypertension Drives Remodeling of AMPA Receptors in Select Populations of Retinal Ganglion Cells. Front. Synaptic Neurosci. 2020;12:30. Published 2020 Jul 24. DOI:10.3389/fnsyn.2020.00030; Farlow M.R. NMDA receptor antagonists: a new therapeutic approach for Alzheimer’s disease. Geriatrics. 2004;59:22–27.; Prati F., Cavalli A., Bolognesi M.L. Navigating the chemical space of multitargetdirected ligands: from hybrids tofragments in Alzheimer’s disease. Molecules. 2016;21(4):Article 466, 12 p. DOI:10.3390/molecules21040466; Loffler K.U., Edward D.P., Tso M.O. Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina. Invest. Ophthalmol. Visual. Sci. 1995;36:24–31.; Salt T.E., Nizari S., Cordeiro M.F., Russ H., Danysz W. Effect of the Ab Aggregation Modulator MRZ-99030 on Retinal Damage in an Animal Model of Glaucoma. Neurotox Res. 2014;26:440–446. DOI:10.1007/s12640-014-9488-6; Астахов Ю.С., Бутин Е.В., Морозова Н.В., Соколов В.О., Флоренцева С.С. Опыт применения «Ретиналамина» в лечении глаукомной нейрооптикопатии и возрастной макулярной дегенерации. Офтальмологические ведомости. 2013;6(2):45–49.; Morquette J.B., Di Polo A. Dendritic and synaptic protection: is it enough to save the retinal ganglion cell body and axon? J. Neuroophthalmol. 2008;28:144–154. DOI:10.1097/wno.0b013e318177edf0; Klunk W.E., Engler H., Nordberg A., Wang Y., Blomqvist G., Holt D.P., Bergstrom M., Savitcheva I., Huang G.F., Estrada S., Ausen B., Debnath M.L., Barletta J., Price J.C., Sandell J., Lopresti B.J., Wall A., Koivisto P., Antoni G., Mathis C.A., Langstrom B. Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann. Neurol. 2004;55:306–319. DOI:10.1002/ana.20009; McEvoy L.K., Brewer J.B. Quantitative structural MRI for early detection of Alzheimer’s disease. Expert Rev. Neurother. 2010;10:1675–1688. DOI:10.1586/ern.10.162 35. Selkoe D.J. Alzheimer’s disease is a synaptic failure. Science. 2002;298:789–791. DOI:10.1126/science.1074069; Cordeiro M.F., Guo L., Coxon K.M., Duggan J., Nizari S., Normando E.M., Sensi S.L., Sillito A.M., Fitzke F.W., Salt T.E., Moss S.E. Imaging multiple phases of neurodegeneration: a novel approach to assessing cell. Cell Death Dis. 2010;1:3. DOI:10.1038/cddis.2009.3; Koronyo Y., Salumbides B.C., Black K.L., Koronyo-Hamaoui M. Alzheimer’s disease in the retina: imaging retinal aß plaques for early diagnosis and therapy assessment. Neurodegener. Dis. 2012;10:285–293. DOI:10.1159/000335154; Morgan J.E., Datta A.V., Erichsen J.T., Albon J., Boulton M.E. Retinal ganglion cell remodelling in experimental glaucoma. Adv Exp Med Biol. 2006;572:397–402. DOI:10.1007/0-387-32442-9_56; Weber A.J., Kaufman P.L., Hubbard W.C. Morphology of single ganglion cells in the glaucomatous primate retina. Invest. Ophthalmol. Vis. Sci. 1998;39:2304–2320.; Williams P.A., Piechota M., von Ruhland C., Taylor E., Morgan J.E., Votruba M. Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity. Brain. 2012;135:493–505. DOI:10.1093/brain/awr330; Scheff S.W., Price D.A., Schmitt F.A., Mufson E.J. Hippocampal synaptic loss in early Alzheimer’s disease and mild cognitive impairment. Neurobiol. Aging. 2006;27:1372–1384. DOI:10.1016/j.neurobiolaging.2005.09.012. Epub 2005 Nov 9.; Beckers A., Moons L. Dendritic shrinkage after injury: a cellular killer or a necessity for axonal regeneration? Neural Regen Res. 2019;14(8):1313–1316. DOI:10.4103/1673-5374.253505; O’Brien J., Bloomfield S.A. Plasticity of Retinal Gap Junctions: Roles in Synaptic Physiology and Disease. Ann. Rev. Vis. Sci. 2018;4:79–100. DOI:10.1146/annurevvision-091517-034133; Dutescu R.M., Li Q.X., Crowston J., Masters C.L., Baird P.N., Culvenor J.G. Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer’s disease. Graefes. Arch. Clin. Exp. Ophthalmol. 2009;247:1213–1221. DOI:10.1007/s00417-009-1060-3; Lee V., Rekhi E., Hoh Kam J., Jeffery G. Vitamin D rejuvenates aging eyes by reducing inflammation, clearing amyloid beta. Neurobiol. Aging. 2012;33:2382–2389. DOI:10.1016/j.neurobiolaging.2011.12.002; Ohno-Matsui K. Parallel findings in age-related macular degeneration and Alzheimer’s disease. Prog. Retin. Eye Res. 2011;30:217–238. DOI:10.1016/j.preteyeres.2011.02.004; Osborne N.N. Pathogenesis of ganglion “cell death” in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria. Prog. Brain Res. 2008;173:339– 352. DOI:10.1016/S0079-6123(08)01124-2; Wang L., Dong J., Cull G., Fortune B., Cioffi G.A. Varicosities of intraretinal ganglion cell axons in human and nonhuman primates. Invest. Ophthalmol. Vis. Sci. 2003;44:2–9. DOI:10.1167/iovs.02-0333; Calkins M.J., Manczak M., Mao P., Shirendeb U., Reddy P.H. Impaired mitochondrial biogenesis, defective axonal transport of mitochondria. Hum. Mol. Genet. 2011;20:4515–4529. DOI:10.1093/hmg/ddr381; McAllister A.K. Neurotrophins and neuronal differentiation in the central nervous system. Cellular and Molecular Life Sciences (CMLS). 2001;58(8):1054–1060. DOI:10.1007/PL00000920; Зуева М.В. Созревание и пластичность зрительной системы: нейрогенез, синаптогенез и миелиногенез. I. Сетчатка и ретино-геникулятные проекции. Вестник офтальмологии. 2012;128(3):37–41.; McAllister A.K. Cellular and Molecular Mechanisms of Dendrite Growth. Cerebral Cortex. 2020;10(10):963–973. DOI:10.1093/cercor/10.10.963; Francardo V., Schmitz Y., Sulzer D., Cenci M.A. Neuroprotection and neurorestoration as experimental therapeutics for Parkinson’s disease. Exp. Neurol. 2017;298:137–147. DOI:10.1016/j.expneurol.2017.10.001; Gidday J.M. Adaptive Plasticity in the Retina: Protection against acute injury and neurodegenerative disease by conditioning stimuli. Conditioning Medicine. 2018;1(2):85–97.; Franceschi C., Garagnani P., Morsiani C., Conte M., Santoro A., Grignolio A., Monti D., Capri M., Salvioli S. The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates. Front. Med., 12 March 2018, DOI:10.3389/fmed.2018.00061; Jakobs T.C., Libby R.T., Ben Y., John S.W., Masland R.H. Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J. Cell Biol. 2005;171:313–325. DOI:10.1083/jcb.200506099; Morgan J.E. Retina ganglion cell degeneration in glaucoma: an opportunity missed? A review. Clin. Exp. Ophthalmol. 2012;40:364–368. DOI:10.1111/j.14429071.2012.02789.x; Ly T., Gupta N., Weinreb R.N., Kaufman P.L., Yucel Y.H. Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma. Vis. Res. 2011;51(2):243–250. DOI:10.1016/j.visres.2010.08.003; Kalesnykas G., Oglesby E.N., Zack D.J., Cone F.E., Steinhart M.R., Tian J., Pease M.E., Quigley H.A. Retinal ganglion cell morphology after optic nerve crush and experimental glaucoma. Invest Ophthalmol Vis Sci. 2012;53(7):3847–3857. DOI:10.1167/iovs.12-9712; Agostinone J., Alarcon-Martinez L., Gamlin C., Yu W.Q., Wong R.O.L., Di Polo A. Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury. Brain. 2018;141:1963–1980. DOI:10.1093/brain/awy142; Beckers A., Van Dyck A., Bollaerts I., Van Houcke J., Lefevere E., Andries L., Agostinone J., Van Hove I., Di Polo A., Lemmens K., Moons L. An antagonistic axondendrite interplay enables efficient neuronal repair in the adult Zebrafish central nervous system. Mol Neurobiol. 2018 56(5):3175–3192. DOI:10.1007/s12035-0181292-5; Chung S.H., Awal M.R., Shay J., McLoed M.M., Mazur E., Gabel C.V. Novel DLKindependent neuronal regeneration in Caenorhabditis elegans shares links with activity-dependent ectopic outgrowth. Proc Natl Acad Sci 2016;113:E2852–2860. DOI:10.1093/brain/awy142; Han S.M., Baig H.S., Hammarlund M. Mitochondria localize to injured axons to support regeneration. Neuron. 2016;92:1308–1323. DOI:10.1016/j.neuron.2016.11.025; Mar F.M., Simoes A.R., Leite S., Morgado M.M., Santos T.E., Rodrigo I.S., Teixeira C.A., Misgeld T., Sousa M.M. CNS axons globally increase axonal transport after peripheral conditioning. J Neurosci. 2014;34:5965–5970. DOI:10.1523/JNEU ROSCI.4680-13.2014; Cai Q., Sheng Z.H. Mitochondrial transport and docking in axons. Exp Neurol. 2009;218:257–267. DOI:10.1016/j.expneurol.2009.03.024; Drummond E.S., Rodger J., Penrose M., Robertson D., Hu Y., Harvey A.R. Effects of intravitreal injection of a Rho-GTPase inhibitor (BA-210), or CNTF combined with an analogue of cAMP, on the dendritic morphology of regenerating retinal ganglion cells. Restor Neurol Neurosci. 2014;32:391–402. DOI:10.3233/RNN-130360; McAllister A.K., Katz L.C., Lo D.C. Neurotrophin regulation of cortical dendritic growth requires activity. Neuron. 1996;17:1057–1064. DOI:10.1016/s08966273(00)80239-1; Lom B., Cohen-Cory S. Brain-derived neurotrophic factor differentially regulates retinal ganglion cell dendritic and axonal arborization in vivo. J. Neurosci. 1999;19:9928–9938. DOI:10.1523/JNEUROSCI.19-22-09928; Rauskolb S., Zagrebelsky M., Dreznjak A., Deogracias R., Matsumoto T., Wiese S., Erne B., Sendtner M., Schaeren-Wiemers N., Korte M., Barde Y-A. Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth. J. Neurosci. 2010;30:1739–1749. DOI:10.1523/JNEUROSCI.5100-09.2010; Di Polo A., Aigner L.J., Dunn R.J., Bray G.M., Aguayo A.J. Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells. Proc. Natl. Acad. Sci. 1998;95:3978–3983. DOI:10.1073/pnas.95.7.3978; Weber A.J., Harman C.D. BDNF preserves the dendritic morphology of alpha and beta ganglion cells in the cat retina after optic nerve injury. Invest. Ophth. Vis. Sci. 2008;49:2456–2463. DOI:10.1167/iovs.07-1325; Rodger J., Drummond E.S., Hellstrom M., Robertson D., Harvey A.R. Long-term gene therapy causes transgene-specific changes in the morphology of regenenerating retinal ganglion cells. PLoS One. 2012;7:e31061. DOI:10.1371/journal.pone.0031061; Binley K.E., Ng W.S., Barde Y.-A., Song B., Morgan J.E. Brain-derived neurotrophic factor prevents dendritic retraction of adult mouse retinal ganglion cells. Eur. J. Neurosci. 2016;44:2028–2039. DOI:10.1111/ejn.13295; https://www.ophthalmojournal.com/opht/article/view/1533

الاتاحة: https://www.ophthalmojournal.com/opht/article/view/1533
https://doi.org/10.18008/1816-5095-2021-2-198-207

المؤلفون: V. V. Neroev, T. N. Kiseleva, Ì. S. Zaitsev

المصدر: Российский офтальмологический журнал, Vol 11, Iss 3, Pp 101-106 (2018)

مصطلحات موضوعية: стресс эндоплазматического ретикулума, окислительный стресс, молекулярные шапероны, ганглиозные клетки сетчатки, зрительный нерв, антоцианозиды, endoplasmic reticulum stress, oxidative stress, molecular chaperones, retinal ganglion cells, optic nerve, anthocyanoisides, Ophthalmology, RE1-994

وصف الملف: electronic resource

Relation: https://roj.igb.ru/jour/article/view/177; https://doaj.org/toc/2072-0076; https://doaj.org/toc/2587-5760

URL الوصول: https://doaj.org/article/65a3b64731364c86918c8a123b84de5b

المؤلفون: V. V. Neroev, M. V. Zueva, A. N. Zhuravleva, I. V. Tsapenko, В. В. Нероев, М. В. Зуева, А. Н. Журавлева, И. В. Цапенко

المصدر: Ophthalmology in Russia; Том 17, № 3s (2020); 533-541 ; Офтальмология; Том 17, № 3s (2020); 533-541 ; 2500-0845 ; 1816-5095 ; 10.18008/1816-5095-2020-3s

مصطلحات موضوعية: ганглиозные клетки сетчатки, retinal plasticity, preclinical diagnostics, electrophysiological studies, retinal ganglion cells, ретинальная пластичность, доклиническая диагностика, электрофизиологические исследования

وصف الملف: application/pdf

Relation: https://www.ophthalmojournal.com/opht/article/view/1314/738; Нероев В.В., Зуева М.В., Журавлева А.Н., Цапенко И.В. Структурно‑функциональные нарушения при глаукоме: перспективы доклинической диагностики. Часть 1. Насколько релевантен поиск того, что первично? Офтальмология. 2020;17(3):336–343.; Crish S.D., Sappington R.M., Inman D.M., Horner P.J., Calkins D.J. Distal axonopathy with structural persistence in glaucomatous neurodegeneration. Proc. Natl. Acad. Sci. USA. 2010; 107:5196–5201. DOI:10.1073/pnas.0913141107; Calkins D.J., Horner P.J. The cell and molecular biology of glaucoma: axonopathy and the brain. Invest. Ophthalmol. Vis. Sci. 2012;53:2482–2484. DOI:10.1167/iovs.12‑9483i; Calkins D.J. Critical pathogenic events underlying progression of neurodegeneration in glaucoma. Prog. Retin. Eye Res. 2012;31:702–719. DOI:10.1016/j.preteyeres.2012.07.001; Porciatti V., Ventura L.M. Retinal ganglion cell functional plasticity and optic neuropathy: a comprehensive model. J Neuroophthalmol. 2012;32(4):354–358. DOI:10.1097/WNO.0b013e3182745600; Crish S.D., Dapper J.D., MacNamee S.E., Balaram P., Sidorova T.N., Lambert W.S., Calkins D.J. Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target. Neuroscience 2013;229:55–70. DOI:10.1016/j.neuroscience.2012.10.069; Зуева М.В. Динамика гибели ганглиозных клеток сетчатки при глаукоме и ее функциональные маркеры. Национальный журнал глаукома. 2016;15(1):70–85.; Howell G.R., Libby R.T., Jakobs T.C., Smith R.S., Phalan F.C., Barter J.W., Barbay J.M., Marchant J.K., Mahesh N., Porciatti V., Whitmore A.V., Masland R.H., John S.W. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J. Cell Biol. 2007;179:1523–1537. DOI:10.1083/jcb.200706181; Soto I., Oglesby E., Buckingham B.P., Son J.L., Roberson E.D., Steele M.R., Inman D.M., Vetter M.L., Horner P.J., Marsh‑Armstrong N. Retinal ganglion cells down‑regulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model. J Neurosci. 2008;28:548 –561. DOI:10.1523/JNEUROSCI.3714‑07.2008; Baltan S., Inman D.M., Danilov C.A., Morrison R.S., Calkins D.J., Horner P.J. Metabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degeneration. J. Neurosci. 2010;30:5644–5652. DOI:10.1523/JNEUROSCI.5956‑09.2010; Cone F.E., Gelman S.E., Son J.L., Pease M.E., Quigley H.A. Differential susceptibility to experimental glaucoma among 3 mouse strains using bead and viscoelastic injection. Exp Eye Res. 2010;91:415–424. DOI:10.1016/j.exer.2010.06.018; Sappington R.M., Carlson B.J., Crish S.D., Calkins D.J. The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice. Invest Ophthalmol Vis Sci. 2010;51:207–216. DOI:10.1167/iovs.09‑3947; Chen H., Wei X., Cho K.S., Chen G., Sappington R., Calkins D.J., Chen D.F. Optic neuropathy due to microbead‑induced elevated intraocular pressure in the mouse. Invest. Ophthalmol. Vis. Sci. 2011;52:36–44. DOI:10.1167/iovs.09‑5115; Lambert W.S., Ruiz L., Crish S.D., Wheeler L.A., Calkins D.J. Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons. Mol. Neurodegener. 2011;6:4. DOI:10.1186/1750‑1326‑6‑4; Harwerth R.S., Crawford M.L., Frishman L.J., Viswanathan S., Smith E.L. 3rd, Carter‑Dawson L. Visual field defects and neural losses from experimental glaucoma. Prog. Retin. Eye Res. 2002;21:91–125.; Gupta N., Yucel Y.H. Brain changes in glaucoma. Eur. J. Ophthalmol.2003;13(3):S32–S35.; Yucel Y.H., Zhang Q., Weinreb R.N., Kaufman P.L., Gupta N. Effects of retinal ganglion cell loss on magno‑, parvo‑, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma. Prog. Retin. Eye Res. 2003;22:465–481.; Gupta N., Ang L.C., Noel de Tilly L., Bidaisee L., Yucel Y.H. Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Br. J. Ophthalmol. 2006;90(6):674–678. DOI:10.1136/bjo.2005.086769; Weber A.J., Chen H., Hubbard W.C., Kaufman P.L. Experimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus. Invest. Ophthalmol. Vis. Sci. 2000;41:1370–1379.; Viswanathan S., Frishman L.J., Robson J.G. The uniform field and pattern ERG in macaques with experimental glaucoma: removal of spiking activity. Invest. Ophthalmol. Vis. Sci. 2000; 41(9):2797–2810.; Saleh M., Nagaraju M., Porciatti V. Longitudinal evaluation of retinal ganglion cell function and IOP in the DBA/2J mouse model of glaucoma. Invest. Ophthalmol. Vis. Sci. 2007;48:4564–4572. DOI:10.1167/iovs.07‑0483; Buckingham B.P., Inman D.M., Lambert W., Oglesby E., Calkins D.J., Steele M.R., Vetter M.L., Marsh‑Armstrong N., Horner P.J. Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. J. Neurosci. 2008; 28:2735–2744. DOI:10.1523/JNEUROSCI.4443‑07.2008; Holcombe D.J., Lengefeld N., Gole G.A., Barnett N.L. Selective inner retinal dysfunction precedes ganglion cell loss in a mouse glaucoma model. Br. J. Ophthalmol. 2008;92:683–688. DOI:10.1136/bjo.2007.133223; Bach M., Hoffmann M.B. Update on the pattern electroretinogram in glaucoma. Optom. Vis. Sci. 2008;85:386–395. DOI:10.1097/opx.0b013e318177ebf3; Nagaraju M., Saleh M., Porciatti V. IOP‑dependent retinal ganglion cell dysfunction in glaucomatous DBA/2J mice. Invest. Ophthalmol. Vis. Sci. 2007;48:4573–4579. DOI:10.1167/iovs.07‑0582; Porciatti V., Nagaraju M. Head‑up tilt lowers IOP and improves RGC dysfunction in glaucomatous DBA/2J mice. Exp. Eye Res. 2010;90:452–460. DOI:10.1016/j.exer.2009.12.005; Fortune B., Burgoyne C.F., Cull G.A., Reynaud J., Wang L. Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 2012;53:3939–3950. DOI:10.1167/iovs.12‑9979; Frankfort B.J., Khan A.K., Tse D.Y., Chung I., Pang J.J., Yang Z., Gross R.L., Wu S.M. Elevated intraocular pressure causes inner retinal dysfunction before cell loss in a mouse model of experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54:762–770. DOI:10.1167/iovs.12‑10581; Yucel Y., Gupta N. Glaucoma of the brain: a disease model for the study of transsynaptic neural degeneration. Prog Brain Res. 2008;173:465–478. DOI:10.1016/S0079‑6123(08)01132‑1; Porciatti V., Ventura L.M. Physiological significance of steady‑state PERG losses in glaucoma: clues from simulation of abnormalities in normal subjects. J. Glaucoma. 2009;18(7):535–542. DOI:10.1097/ijg.0b013e318193c2e1; Ventura L.M., Sorokac N., De Los Santos R., Feuer W.J., Porciatti V. The relationship between retinal ganglion cell function and retinal nerve fiber thickness in early glaucoma. Invest. Ophthalmol. Vis. Sci. 2006;47(9):3904–3911. DOI:10.1167/iovs.06‑0161; Banitt M.R., Ventura L.M., Feuer W.J., Savatovsky E., Luna G., Shif O., Bosse B., Porciatti V. Progressive loss of retinal ganglion cell function precedes structural loss by several years in glaucoma suspects. Invest. Ophthalmol. Vis. Sci. 2013;54:2346–2352. DOI:10.1167/iovs.12‑11026; Morgan J.E., Tribble J.R. Microbead models in glaucoma. Exp. Eye Res. 2015;141:9–14. DOI:10.1016/j.exer.2015.06.020; Santina L.D., Inman D.M., Lupien C.B., Horner F.J., Wong R.O.L. Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma. J Neurosci. 2013;33(44):17444–17457. DOI:10.1523/JNEUROSCI.5461‑12.2013; Lacor P.N., Buniel M.C., Furlow P.W., Clemente A.S., Velasco P.T., Wood M., Viola K.L., Klein W.L. Abeta oligomer‑induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer’s disease. J. Neurosci. 2007;27:796–807. DOI:10.1523/JNEUROSCI.3501‑06.2007; Yoshiyama Y., Higuchi M., Zhang B., Huang S.M., Iwata N., Saido T.C., Maeda J., Suhara T., Trojanowski J.Q., Lee V.M. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 2007;53:337–351. DOI:10.1016/j.neuron.2007.01.010; Liu M., Duggan J., Salt T.E., Cordeiro M.F. Dendritic changes in visual pathways in glaucoma and other neurodegenerative conditions. Exp. Eye Res. 2011;92:244–250. DOI:10.1016/j.exer.2011.01.014; Pavlidis M., Stupp T., Naskar R., Cengiz C., Thanos S. Retinal ganglion cells resistant to advanced glaucoma: a postmortem study of human retinas with the carbocyanine dye DiI. Invest. Ophthalmol. Vis Sci. 2003;44:5196–5205. DOI:10.1167/iovs.03‑0614; Jakobs T.C., Libby R.T., Ben Y., John S.W., Masland R.H. Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J. Cell Biol. 2005;171:313–325. DOI:10.1083/jcb.200506099; Shou T., Liu J., Wang W., Zhou Y., Zhao K. Differential dendritic shrinkage of alpha and beta retinal ganglion cells in cats with chronic glaucoma. Invest. Ophthalmol. Vis. Sci 2003;44:3005–3010. DOI:10.1167/iovs.02‑0620; Weber A.J., Kaufman P.L., Hubbard W.C. Morphology of single ganglion cells in the glaucomatous primate retina. Invest. Ophthalmol. Vis. Sci. 1998;39:2304–2320.; Morquette J.B., Di Polo A. Dendritic and synaptic protection: is it enough to save the retinal ganglion cell body and axon? J. Neuroophthalmol. 2008;28:144–154. DOI:10.1097/wno.0b013e318177edf0; Yucel Y.H., Gupta N., Zhang Q., Mizisin A.P., Kalichman M.W., Weinreb R.N. Memantine protects neurons from shrinkage in the lateral geniculate nucleus in experimental glaucoma. Arch. Ophthalmol. 2006;124:217–225. DOI:10.1001/archopht.124.2.217; Gupta N., Zhang Q., Kaufman P.L., Weinreb R.N., Yucel Y.H. Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain. Exp. Eye Res. 2007;84:176–184. DOI:10.1016/j.exer.2006.09.013; Ly T., Gupta N., Weinreb R.N., Kaufman P.L., Yucel Y.H. Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma. Vis. Res. 2011;51(2):243–250. DOI:10.1016/j.visres.2010.08.003; Morgan J.E. Retina ganglion cell degeneration in glaucoma: an opportunity missed? A review. Clin. Exp. Ophthalmol. 2012;40:364–368. DOI:10.1111/j.1442‑9071.2012.02789.x; Wilsey L.J., Fortune B. Electroretinography in glaucoma diagnosis. Curr. Opin. Ophthalmol. 2016;27(2):118–124. DOI:10.1097/ICU.0000000000000241; North R.V., Jones A.L., Drasdo N., Wild J.M., Morgan J.E. Electrophysiological evidence of early functional damage in glaucoma and ocular hypertension. Invest. Ophthalmol. Vis. Sci. 2010;51:1216–1222. DOI:10.1167/iovs.09‑3409; Bach M., Unsoeld A.S., Philippin H., Staubach F., Maier P., Walter H.S., Bomer T.G., Funk J. Pattern ERG as an early glaucoma indicator in ocular hypertension: a longterm, prospective study. Invest. Ophthalmol. Vis. Sci. 2006;47:4881–4887. DOI; 1167/iovs.05‑0875; Bach M., Ramharter‑Sereinig A. Pattern electroretinogram to detect glaucoma: comparing the PERGLA and the PERG Ratio protocols. Doc. Ophthalmol. 2013;127:227–238. DOI:10.1007/s10633‑013‑9412‑z; Bach M., Poloshek C.M. Electrophysiology and glaucoma: current status and future challenges. Cell Tissue Res. 2013;353(2):287–296. DOI:10.1007/s00441‑013‑1598‑6; Bode S.F., Jehle T., Bach M. Pattern electroretinogram in glaucoma suspects: new findings from a longitudinal study. Invest. Ophthalmol. Vis. Sci. 2011;52:4300–4306. DOI:10.1167/iovs.10‑6381; Luo X. Frishman L.J. Retinal pathway origins of the pattern electroretinogram (PERG). Invest. Ophthalmol. Vis. Sci. 2011;52:8571–8584.; Feng L., Zhao Y., Yoshida M., Chen H., Yang J.F., Kim T.S., Cang J., Troy J.B., Liu X. Sustained ocular hypertension induces dendritic degeneration of mouse retinal ganglion cells that depends on cell type and location. Invest. Ophthalmol. Vis. Sci. 2013;54:1106–1117. DOI:10.1167/ iovs.12‑10791; Mavilio A., Scrimieri F., Errico D. Can variability of pattern ERG signal help to detect retinal ganglion cells dysfunction in glaucomatous eyes? BioMed Research International. 2015;2015:article ID 571314, 11 pages. DOI:10.1155/2015/571314; Slotnick S.D., Klein S.A., Carney T., Sutter E., Dastmalchi S. Using multi‑stimulus VEP source localization to obtain a retinotopic map of human primary visual cortex. Clin. Neurophysiol. 1999;110:1793–1800.; Di Russo F., Martinez A., Sereno M.I., Pitzalis S., Hillyard S.A. Cortical sources of the early components of the visual evoked potential. Hum. Brain Mapp. 2002;15:95–111.; Viswanathan S., Frishman L.J., Robson J.G., Harwerth R.S., Smith E. The photopic negative response of the macaque electroretinogram: reduction by experimental glaucoma. Invest Ophthalmol Vis Sci. 1999;40:1124–1136.; Viswanathan S., Frishman L.J., Robson J.G., Walters J.W. The photopic negative response of the flash electroretinogram in primary open angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2001;42:514–522.; Rangaswamy V.N., Shirato S., Kaneko M., Digby B.I., Robson J.G., Frishman L.J. Effects of spectral characteristics of ganzfeld stimuli on the photopic negative response (PhNR) of the ERG. Invest. Ophthalmol. Vis. Sci. 2007;48(10):4818–4828. DOI:10.1167/iovs.07‑0218; Sustar M., Cvenkel B., Brecelj J. The effect of broadband and monochromatic stimuli on the photopic negative response of the electroretinogram in normal subjects and in open‑angle glaucoma patients. Doc. Ophthalmol. 2009;118:167–177. DOI:10.1007/s10633‑008‑9150‑9; Colotto A., Falsini B., Salgarello T., Iarossi G., Galan M.E., Scullica L. Photopic negative response of the human ERG: losses associated with glaucomatous damage. Invest. Ophthalmol. Vis. Sci. 2000;41:2205–2211.; Rangaswamy N.V., Frishman L.J., Dorotheo E.U., Schiffman J.S., Bahrani H.M., Tang R.A. Photopic ERGs in patients with optic neuropathies: comparison with primate ERGs after pharmacologic blockade of inner retina. Invest. Ophthalmol. Vis. Sci. 2004;45:3827–3837. DOI:10.1167/iovs.04‑0458; Machida S., Raz‑Prag D., Fariss R.N., Sieving P.A., Bush R.A. Photopic ERG negative response from amacrine cell signaling in RCS rat retinal degeneration. Invest. Ophthalmol. Vis. Sci. 2008;49:442–452. DOI:10.1167/iovs.07‑0291; Machida S., Tamada K., Oikawa T., Gotoh Y., Nishimura T., Kaneko M., Kurosaka D. Comparison of photopic negative response of full‑field and focal electroretinograms in detecting glaucomatous eyes. J. Ophthalmology. 2011;2011:article ID 564131, 11 pages. DOI:10.1155/2011/564131; Machida S., Kaneko M., Kurosaka D. Regional variations in correlation between photopic negative response of focal electoretinograms and ganglion cell complex in glaucoma. Curr. Eye Res. 2015 Apr;40(4):439–449. DOI:10.3109/02713683.2014.922196; Kaneko M., Machida S., Hoshi Y., Kurosaka D. Alterations of photopic negative response of multifocal electroretinogram in patients with glaucoma. Curr. Eye Res. 2014;40:77–86. DOI:10.3109/02713683.2014.915575; Preiser D., Lagreze W.A., Bach M., Poloschek C.M. Photopic negative response versus pattern electroretinogram in early glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54:1182–1191. DOI:10.1167/iovs.12‑11201; Cvenkel B., Sustar M., Perovšek D. Ganglion cell loss in early glaucoma, as assessed by photopic negative response, pattern electroretinogram, and spectral‑domain optical coherence tomography. Doc. Ophthalmol. 2017;135(1):17–28. DOI:10.1007/s10633‑017‑9595‑9; Fortune B., Bui B.V., Cull G., Wang L., Cioffi G.A. Inter‑ocular and inter‑session reliability of the electroretinogram photopic negative response (PhNR) in non-human primates. Exp. Eye Res. 2004;78:83–93. DOI:10.1016/j.exer.2003.09.013; Tang J., Edwards T., Crowston J.G., Sarossy M. The test‑retest reliability of the photopic negative response (PhNR). Trans. Vis. Sci. Tech. 2014;3(6):1. eCollection 2014. DOI:10.1167/tvst.3.6.1; Wu Z., Hadoux X., Hui F., Sarossy M.G., Crowston J.G. Photopic Negative Response Obtained Using a Handheld Electroretinogram Device: Determining the Optimal Measure and Repeatability. Trans Vis. Sci. Technol. 2016;5(4):8. eCollection 2016. DOI:10.1167/tvst.5.4.8; Chong R.S., Martin K.R. Glial cell interactions and glaucoma. Curr. Opin. Ophthalmol. 2015;26(2):73–77. DOI:10.1097/ICU.0000000000000125; Kimelberg H.K. Functions of mature mammalian astrocytes: a current view. Neuroscientist. 2010;16:79–106. DOI:10.1177/1073858409342593; Morgan J.E. Optic nerve head structure in glaucoma: astrocytes as mediators of axonal damage. Eye (Lond). 2000;14(Pt 3B):437–444. DOI:10.1038/eye.2000.128; Wang M., Ma W., Zhao L., Fariss R.N., Wong W.T. Adaptive Muller cell responses to microglial activation mediate neuroprotection and coordinate inflammation in the retina. J Neuroinflammation. 2011;8:173. DOI:10.1186/1742‑2094‑8‑173; Lebrun‑Julien F., Duplan L., Pernet V., Osswald I., Sapieha P., Bourgeois P., Dickson K., Bowie D., Barker P.A., Di Polo A. Excitotoxic death of retinal neurons in vivo occurs via a non‑cell‑autonomous mechanism. J. Neurosci. 2009;29:5536–5545. DOI:10.1523/JNEUROSCI.0831‑09.2009; Wang M., Wang X., Zhao L., Ma W., Rodriguez I.R., Fariss R.N., Wong W.T. Macroglia–microglia interactions via TSPO signaling regulates microglial activation in the mouse retina. J. Neurosci. 2014;34:3793–3806. DOI:10.1523/JNEUROSCI.3153‑13.2014; Kugler P., Beyer A. Expression of glutamate transporters in human and rat retina and rat optic nerve. Histochem. Cell Biol. 2003;120:199–212. DOI:10.1007/s00418‑003‑0555‑y; Pease M.E., Zack D.J., Berlinicke C., Bloom K., Cone F., Wang Y., Klein R.L., Hauswirth W.W., Quigley H.A. Effect of CNTF on retinal ganglion cell survival in experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 2009;50:2194–2200. DOI:10.1167/iovs.08‑3013; Bringmann A., Iandiev I., Pannicke T., Wurm A., Hollborn M., Wiedemann P., Osborn N.B., Reichenbach A. Cellular signaling and factors involved in Muller cell gliosis: neuroprotective and developmental effects. Prog. Retin. Eye Res. 2009;28:423–451. DOI:10.1016/j.preteyeres.2009.07.001; Gao F., Ji M., Wu J.H., Wang Z.F. Roles of retinal Müller cells in health and glaucoma [Article in Chinese]. Sheng Li Xue Bao. 2013;65(6):654–663. DOI:10.1007/s00441‑013‑1666‑y; Зуева М.В., Цапенко И.В. Клетки Мюллера: спектр и профиль глио‑нейрональных взаимодействий в сетчатке. Российский физиологический журнал им. Сеченова. 2004;90(8):435–436.; Нероев В.В., Зуева М.В., Цапенко И.В., Рябина М.В., Лю Хун. Функциональная диагностика ретинальной ишемии: 1 — реакция клеток Мюллера на ранних стадиях диабетической ретинопатии. Вестник офтальмологии. 2004;120(5):21–24.; Зуева М.В., Цапенко И.В. Структурно‑функциональная организация клеток Мюллера: роль в развитии и патологии сетчатки. В кн: Клиническая физиология зрения. Очерки. Под ред. Шамшиновой А.М. М.: Научно‑медицинская фирма МБН, 2006:128–191.; Зуева М.В., Нероев В.В., Цапенко И.В., Сарыгина О.И., Гринченко М.И., Зайцева С.И. Топографическая диагностика нарушений ретинальной функции при регматогенной отслойке сетчатки методом ритмической ЭРГ широкого спектра частот. Российский офтальмологический журнал. 2009;1(2):18–23.; Li H., Tran V.V., Hu Y., Saltzman W.M., Barnstable C.J., Tombran‑Tink J. A PEDF N‑terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres. Exp. Eye Res. 2006;83:824–833. DOI:10.1016/j.exer.2006.04.014; Gwon J.S., Kim I.B., Lee M.Y., Oh S.J., Chun M.H. Expression of clusterin in Müller cells of the rat retina after pressureinduced ischemia. Glia. 2004;47:35–45. DOI:10.1002/glia.20021; Pannicke T., Iandiev I., Uckermann O., Biedermann B., Kutzera F., Wiedemann P., Wolburg H., Reichenbach A., Bringmann A. A potassium channel‑linked mechanism of glial cell swelling in the postischemic retina. Mol. Cell. Neurosci. 2004;26:493–502. DOI:10.1016/j.mcn.2004.04.005; Hirrlinger P.G., Ulbricht E., Iandiev I., Reichenbach A., Pannicke T. Alterations in protein expression and membrane properties during Müller cell gliosis in a murine model of transient retinal ischemia. Neurosci. Lett. 2010;472:73–78. DOI:10.1016/j.neulet.2010.01.062; Wurm A., Iandiev I., Uhlmann S., Wiedemann P., Reichenbach A., Bringmann A., Pannicke T. Effects of ischemia‑reperfusion on physiological properties of Müller glial cells in the porcine retina. Invest. Ophthalmol. Vis. Sci. 2011;52:3360–3367.; Da T., Verkman A.S. Aquaporin‑4 gene disruption in mice protects against impaired retinal function and cell death after ischemia. Invest. Ophthalmol. Vis. Sci. 2004;45:4477–4483. DOI:10.1167/iovs.04‑0940; Iandiev I., Pannicke T., Biedermann B., Wiedemann P., Reichenbach A., Bringmann A. Ischemia‑reperfusion alters the immunolocalization of glial aquaporins in rat retina. Neurosci. Lett. 2006;408:108–112. DOI:10.1016/j.neulet.2006.08.084; Нероев В.В., Зуева М.В., Катаргина Л.А. Прорывные технологии в офтальмологии: фундаментальные науки в решении проблем патологии сетчатки и зрительного нерва. Российский офтальмологический журнал. 2013;2(2):4–8; Lee J.H., Shin J.M., Shin Y.J., Chun M.H., Oh S.J. Immunochemical changes of calbindin, calretinin and SMI32 in ischemic retinas induced by increase of intraocular pressure and by middle cerebral artery occlusion. Anat. Cell Biol. 2011;44:25–34. DOI:10.5115/acb.2011.44.1.25; Chan H.H.‑L., Ng Y.‑f., Chu P. H.‑W. Applications of the multifocal electroretinogram in the detection of glaucoma. Clin. Exp. Optom. 2011;94(3):247–258. DOI:10.1111/j.1444‑0938.2010.00571.x; Hood D., Frishman LJ, Saszik S., Viswanathan S. Retinal origins of the primate multifocal ERG: implications for the human response. Invest. Ophthalmol. Vis. Sci. 2002;43:1673–1685.; Hood D.C., Greenstein V.C. Multifocal VEP and ganglion cell damage: Applications and limitations for the study of glaucoma. Prog. Ret. Eye Res. 2003;22:201–251.; Hood D.C., Zhang X., Greenstein V.C., Kangovi S., Odel J.G., Liebmann J.M., Ritch R. An interocular comparison of the multifocal VEP: a possible technique for detecting local damage to the optic nerve. Invest Ophthalmol Vis. Sci. 2000;41:1580–1587.; Harrison W.W., Viswanathan S., Malinovsky V.E. Multifocal pattern electroretinogram: cellular origins and clinical implications. Optom. Vis. Sci. 2006;83:473–485. DOI:10.1097/01.opx.0000218319.61580.a5; Wilsey L., Gowrisankaran S, Cull G., Hardin C., Burgoyne CF, Fortune B. Comparing three different modes of electroretinography in experimental glaucoma: diagnostic performance and correlation to structure. Doc. Ophthalmol. 2017;134(2):111–128. DOI:10.1007/s10633‑017‑9578‑x; https://www.ophthalmojournal.com/opht/article/view/1314

الاتاحة: https://www.ophthalmojournal.com/opht/article/view/1314
https://doi.org/10.18008/1816-5095-2020-3S-533-541

المؤلفون: S. Avetisov E., V. Erichev P., T. Yaremenko V., С. Аветисов Э., В. Еричев П., Т. Яременко В.

المصدر: National Journal glaucoma; Том 18, № 1 (2019); 85-94 ; Национальный журнал Глаукома; Том 18, № 1 (2019); 85-94 ; 2311-6862 ; 2078-4104

مصطلحات موضوعية: glaucoma, neuroprotection, ganglion cell complex, intraocular treatment, глаукома, нейропротекция, ганглиозные клетки сетчатки, внутриглазное давление

وصف الملف: application/pdf

Relation: https://www.glaucomajournal.ru/jour/article/view/236/244; Quigley H.A., Broman A.T. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006; 90(3): 262-267.; Kingman S. Glaucoma is second leading cause of blindness globally. Bull World Health Organ. 2004; 82(11): 887-888.; Resnikoff S. et al. Global data on visual impairment in the year 2002. Bull World Health Organ. 2004; 82(11): 844-851.; European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition - Part 1Supported by the EGS Foundation. Br J Ophthalmol. 2017; 101(4): 1-72.; Kaushik S., Pandav S.S., Ram J. Neuroprotection in glaucoma. J Postgrad Med. 2003; 49(1): 90-95.; Егоров Е.А., Егорова Т.Е., Шрамко Ю.Г. Эффективность применения Ретиналамина у пациентов с компенсированной первичной открытоугольной глаукомой. РМЖ Клиническая офтальмология. 2014; 15(4): 188-193.; The Glaucoma Book: A Practical, Evidence-Based Approach to Patient Care. Ed. Schacknow P.N., Samples J.R. New York: Springer-Verlag; 2010.; Dielemans I. et al. The prevalence of primary open-angle glaucoma in a population-based study in The Netherlands. The Rotterdam Study. Ophthalmology. 1994; 101(11):1851-1855.; Haefliger I.O., Fleischhauer J.C., Flammer J. In glaucoma, should enthusiasm about neuroprotection be tempered by the experience obtained in other neurodegenerative disorders? Eye Lond Engl. 2000; 14(Pt 3B): 464-472.; Levin L.A. Direct and indirect approaches to neuroprotective therapy of glaucomatous optic neuropathy. Surv Ophthalmol. 1999; 43 (Suppl 1):98-101.; Osborne N.N. et al. Neuroprotection in relation to retinal ischemia and relevance to glaucoma. Surv Ophthalmol. 1999; 43 (Suppl 1): 102-128.; Salt T., Cordeiro M. Glutamate excitotoxicity in glaucoma. Eye Lond Engl. 2006; 20(6):730-732.; Miguel-Hidalgo J.J. et al. Neuroprotection by memantine against neurodegeneration induced by beta-amyloid (1-40). Brain Res. 2002; 958(1): 210-221.; Levy D.I., Lipton S.A. Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor-mediated neuronal death. Neurology. 1990; 40(5): 852-852.; Sisk D.R., Kuwabara T. Histologic changes in the inner retina of albino rats following intravitreal injection of monosodium L-glutamate. Graefes Arch Clin Exp Ophthalmol. 1985; 223(5):250-258.; Osborne N.N. et al. Ganglion cell death in glaucoma: what do we really know? Br J Ophthalmol. 1999; 83(8):980-986.; Garcia-Campos J. et al. Morphological and functional changes in experimental ocular hypertension and role of neuroprotective drugs. Histol Histopathol. 2007; 22(12): 1399-1411.; Naskar R., Dreyer E.B. New horizons in neuroprotection. Surv Ophthalmol. 2001; 45(Suppl 3):250-255; discussion S273-276.; Sucher N.J., Lipton S.A., Dreyer E.B. Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Res. 1997; 37(24):3483-3493.; Fang J.H. et al. Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage. BMC Neurosci. 2010; 11:31.; Kapin M.A. et al. Neuroprotective effects of eliprodil in retinal excitotoxicity and ischemia. Invest Ophthalmol Vis Sci. 1999; 40(6): 1177-1182.; Brooks D.E. et al. Vitreous body glutamate concentration in dogs with glaucoma. Am J Vet Res. 1997; 58(8):864-867.; Dreyer E.B. et al. Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch. Ophthalmol Chic. 1960. 1996; 114(3):299-305.; Carter-Dawson L. et al. Vitreal glutamate concentration in monkeys with experimental glaucoma. Invest Ophthalmol Vis Sci. 2002; 43(8):2633-2637.; Lipton S.A. Possible role for memantine in protecting retinal ganglion cells from glaucomatous damage. Surv Ophthalmol. 2003; 48 (Suppl 1):38-46.; Guo L. et al. Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo. Invest Ophthalmol Vis Sci. 2006; 47(2):626-633.; Lipton S.A. Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide. Trends Neurosci. 1993; 16(12):527-532.; Vorwerk C.K. et al. Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine. Invest Ophthalmol Vis Sci. 1996; 37(8):1618-1624.; Lagreze W.A. et al. Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia. Invest Ophthalmol Vis Sci. 1998; 39(6):1063-1066.; Hare W.A. et al. Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, I: Functional measures. Invest Ophthalmol Vis Sci. 2004; 45(8): 2625-2639.; Stout A.K. et al. Glutamate-induced neuron death requires mitochondrial calcium uptake. Nat Neurosci. 1998; 1(5):366-373.; Crish S.D., Calkins D.J. Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms. Neuroscience. 2011; 176:1-11.; Yamada H. et al. Neuroprotective effect of calcium channel blocker against retinal ganglion cell damage under hypoxia. Brain Res. 2006; 1071(1):75-80.; Koseki N. et al. Effects of oral brovincamine on visual field damage in patients with normal-tension glaucoma with low-normal intraocular pressure. J Glaucoma. 1999; 8(2):117-123.; Koseki N. et al. A placebo-controlled 3-year study of a calcium blocker on visual field and ocular circulation in glaucoma with low-normal pressure. Ophthalmology. 2008; 115(11):2049-2057.; Langham M.E. Ocular blood flow and vision in healthy and glaucomatous eyes. Surv Ophthalmol. 1994; 38:161-S168.; Prunte C., Orgul S., Flammer J. Abnormalities of microcirculation in glaucoma: facts and hints. Curr Opin Ophthalmol. 1998; 9(2):50-55.; Tielsch J.M. et al. Hypertension, perfusion pressure, and primary open-angle glaucoma. A population-based assessment. Arch Ophthalmol. 1995; 113(2):216-221.; Takayama J. et al. Time course of the change in optic nerve head circulation after an acute increase in intraocular pressure. Invest Ophthalmol Vis Sci. 2003; 44(9):3977-3985.; Izzotti A., Bagnis A., Sacca S.C. The role of oxidative stress in glaucoma. MutatRes. 2006; 612(2):105-114.; Ferreira S.M. et al. Oxidative stress markers in aqueous humor of glaucoma patients. Am J Ophthalmol. 2004; 137(1):62-69.; Мищенко Н.П., Федореев С.А., Догадова Л.П. Препарат гистохром для офтальмологии. Вестник Дальневосточного отделения Российской академии наук. 2004; 3.; Azzi A., Stocker A. Vitamin E: non-antioxidant roles. Prog Lipid Res. 2000; 39(3):231-255.; Tran K., Chan A.C. R-alpha-tocopherol potentiates prostacyclin release in human endothelial cells. Evidence for structural specificity of the tocopherol molecule. Biochim Biophys Acta. 1990; 1043(2):189-197.; Chatelain E. et al. Inhibition of smooth muscle cell proliferation and protein kinase C activity by tocopherols and tocotrienols. Biochim Biophys Acta. 1993; 1176(1-2):83-89.; Антоненко Ю.Н. и др. Производное пластохинона, адресованное в митохондрии, как средство, прерывающее программу старения 1. Катионные производные пластохинона: синтез и исследование in vitro. Биохимия. 2008; 73(12):1589-1606.; Birks J., Grimley Evans J. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst. Rev. 2007(2):. CD003120.; Ghiso J.A. et al. Alzheimer’s disease and glaucoma: mechanistic similarities and differences. J Glaucoma. 2013; 22(5):36-38.; Ritch R. Potential role for Ginkgo biloba extract in the treatment of glaucoma. Med Hypotheses. 2000; 54(2):221-235.; Sacca S.C. et al. Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma. Arch Ophthalmol. Chic. Ill 1960. 2005; 123(4):458-463.; Eckert A. et al. Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761. Ann N YAcad. Sci. 2005; 1056:474-485.; Quaranta L. et al. Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma. Ophthalmology. 2003; 110(2):359-362; discussion 362-364.; Guo X. et al. Effect of Ginkgo biloba on visual field and contrast sensitivity in Chinese patients with normal tension glaucoma: a randomized, crossover clinical trial. Invest Ophthalmol Vis Sci. 2014; 55(1):110-116.; Le Bars P.L., Kastelan J. Efficacy and safety of a Ginkgo biloba extract. Public Health Nutr. 2000; 3(4):495-499.; Johnson J.E. et al. Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells. J Neurosci Off J Soc Neurosci. 1986; 6(10):3031-3038.; Sawai H. et al. Brain-derived neurotrophic factor and neurotro-phin-4/5 stimulate growth of axonal branches from regenerating retinal ganglion cells. J Neurosci Off J Soc Neurosci. 1996; 16(12): 3887-3894.; Mey J., Thanos S. Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo. Brain Res. 1993; 602(2):304-317.; Donello J.E. et al. Alpha2-adrenoreceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia. J Pharmacol Exp Ther. 2001; 296(1):216-223.; Kalapesi F.B., Coroneo M.T., Hill M.A. Human ganglion cells express the alpha-2 adrenergic receptor: relevance to neuroprotection. Br J Ophthalmol. 2005; 89(6):758-763.; Yoles E., Wheeler L.A., Schwartz M. Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration. Invest Ophthalmol Vis Sci. 1999; 40(1):65-73.; Lambert W.S. et al. Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons. Mol Neurodegener. 2011; 6(1):4.; Krupin T. et al. A randomized trial of brimonidine versus timolol in preserving visual function: results from the Low-Pressure Glaucoma Treatment Study. Am J Ophthalmol. 2011; 151(4):671-681.; Sena D.F., Lindsley K. Neuroprotection for treatment of glaucoma in adults. Cochrane Database Syst Rev. 2013; 2: CD006539.; Абизгильдина Г.Ш. Опыт комбинированного лечения глаукомной оптической нейропатии. Медицинский Вестник Башкортостана. 2014; 9(2).; Pease M.E. et al. Effect of CNTF on retinal ganglion cell survival in experimental glaucoma. Invest Ophthalmol Vis Sci. 2009; 50(5): 2194-2200.; Liu B., Neufeld A.H. Nitric oxide synthase-2 in human optic nerve head astrocytes induced by elevated pressure in vitro. Arch Ophthalmol. 2001; 119(2):240-245.; Neufeld A.H., Sawada A., Becker B. Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. Proc Natl Acad. Sci. U. S. A. 1999; 96(17):9944-9948.; Geyer O. et al. Nitric oxide synthase inhibitors protect rat retina against ischemic injury. FEBS Lett. 1995; 374(3):399-402.; Егоров Е.А., Брежнев А.Ю., Егоров А.Е. Нейропротекция при глаукоме: современные возможности и перспективы. РМЖ. Клиническая офтальмология. 2014; 2:108-112.; Егоров Е.А. Нейропротекторы в лечении ранних стадий первичной открытоугольной глаукомы. РМЖ. Клиническая офтальмология. 2015; 3:154-159.; Астахов Ю.С., Бутин Е.В., Морозова Н.В., Соколов В.О. Результаты применения ретиналамина у больных с первичной открытоугольной глаукомой. Глаукома. 2006; 2:43-47.; Егоров Е.А., Егорова Т.Е., Шрамко Ю.Г. Эффективность применения Ретиналамина у пациентов с компенсированной первичной открытоугольной глаукомой. РМЖ. Клиническая Офтальмология. 2014; 14(4):188-193.; Ильина С.Н., Ломаник И.Ф., Логош С.М., Шавловская Т.В. Ретина-ламин в нейропротекторной терапии больных первичной открытоугольной глаукомой. Офтальмология Восточная Европа. 2012; 4:96-101.; Мазунин И.Ю. Результаты применения нейроретинапротекто-ра “Ретиналамин” после лазерной трабекулопластики при лечении компенсированной первичной открытоугольной глаукомы. Медицинский Альманах. 2014; 1(31):69-73.; Малишевская Т.Н., Долгова И.Г. Сравнительный анализ эффективности различных методов нейропротекторной терапии больных первичной стабилизированной глаукомой в далекозашедшей стадии. Национальный журнал глаукома. 2016; 15(2):84-92-92.; Рожко Ю.И., Марченко Л.Н., Чилд Н.А. и др. Нейроретинопротекторное действие кортексина и ретиналамина в терапии открытоугольной глаукомы. Проблемы здоровья и экологии. 2010; 3(25).; https://www.glaucomajournal.ru/jour/article/view/236

الاتاحة: https://www.glaucomajournal.ru/jour/article/view/236
https://doi.org/10.25700/NJG.2019.01.10

المؤلفون: A. A. Antonov, A. S. Makarova, V. S. Reshchikova, А. А. Антонов, А. С. Макарова, В. С. Рещикова

المصدر: National Journal glaucoma; Том 16, № 3 (2017); 98-102 ; Национальный журнал Глаукома; Том 16, № 3 (2017); 98-102 ; 2311-6862 ; 2078-4104

مصطلحات موضوعية: пигментный эпителий, peptide drugs, retinal ganglion cells, optic nerve fibres, pigment epithelium, пептидные препараты, ганглиозные клетки сетчатки, волокна зрительного нерва, глаукома

وصف الملف: application/pdf

Relation: https://www.glaucomajournal.ru/jour/article/view/168/167; Хавинсон В.Х., Кузник Б.И., Рыжак Г.А. Пептидные биорегуляторы — новый класс геропротекторов. Сообщение 1. Результаты экспериментальных исследований. Успехи геронтологии 2012; 25(4):696-708. [Khavinson V.Kh., Kuznik B.I., Ryzhak G.A. Peptide bioregulators: the new class of geroprotectors. Message 1. Experimental studies results. Advances in gerontology 2012; 25(4):696-708. (In Russ.)].; Хавинсон В.Х., Разумовский М.И., Балашов Н.В. и др. Влияние пептидов сетчатки на регенерацию нейрорецепторного аппарата глаза. Реактивность и регенерация тканей 1990:15. [Khavinson V.Kh., Razumovskiy M.I., Balashov N.V. et al. Retinal peptide influence on the neuroreceptive eye mechanism regeneration. Reaktivnost’ I regeneratsiya tkanei 1990:15. (In Russ.)].; Харинцева С.В. Влияние ретилина на фибринолитическую и коагуляционную активность слезной жидкости у больных с тромбозами вен сетчатки. Экологические интоксикации: биохимия, фармакология, клиника: тезисы докладов Всеросс. конф. Чита, 1996; 283-285. [Kharintseva S.V. Retilin influence on the tear coagulative activity in the patients with retinal vein trombosis. Ecological intoxications: biochemistry, pharmacology, clinics: theses of All-Russ. conference. Chita, 1996; 283-285. (In Russ.)].; Анисимов С.В., Бохелер К.Р., Хавинсон В.Х., Анисимов В.Н. Изучение действия пептидов вилона и эпиталона на экспрессию генов в сердце мыши с помощью технологии на основе микрочипов. Бюллетень экспериментальной биологии 2002; 133:340-347. [Anisimov S.V., Bokheler K.R., Khavinson V.N. Study of vilon and epithalon peptides on the gene expression in murine heart with microchip technology. Bulletin of experimental biology 2002; 133:340-347. (In Russ.)].; Анисимов В.Н., Хавинсон В.Х., Алимова И.Н., Провинциали М., Манчини Р., Франчески К. Эпиталон угнетает развитие опухолей и экспрессию онкогена HER-2/NEU в опухолях молочной железы у трансгенных мышей с ускоренным старением. Бюллетень экспериментальной биологии и медицины 2002; 133(2):199-202. [Anisimov V.N., Khavinson V.Kh., Alimova I.N., Provintsiali M., Manchini R., Francheski K. Epithalon inhibits tumor development and HER-2/NEU oncogene expression in the mammae tumors in transgenic mice with accelerated aging. Bulletin of experimental biology and medicine 2002; 133(2): 199-202. (In Russ.)].; Бродский В.Я., Хавинсон В.Х., Золотарев Ю.А., Нечаева Н.В., Малинин В.В., Новикова Т.Е. и др. Ритм синтеза белка в культурах гепатоцитов крыс разного возраста. Норма и действие пептида ливагена. Известия РАН. Серия биологическая 2001; 5:517-521. [Brodskiy V.Ya., Khavinson V.Kh., Zolotarev Yu.A., Nechaeva N.V., Malinin V.V., Novikova T.E. et al. Protein syntesis rhythm in hepatocytic cultures of mice of different age. Biology Bulletin 2001; 5:517-521. (In Russ.)].; Гончарова Н.Д., Хавинсон В.Х., Лапин Б.А. Регулирующее влияние эпиталона на продукцию мелатонина и кортизола у старых обезьян. Бюллетень экспериментальной биологии и медицины 2001; 131(4):466-468. [Goncharova N.D., Khavinson V.Kh., Lapin B.A. Regulatory effect of Epithalon on production of melatonin and cortisol in old monkeys. Bulletin of experimental biology and medicine 2001; 131(4):466-468. (In Russ.)].; Трофимова С.В., Хавинсон В.Х. Сетчатка и старение. Успехи геронтологии 2002; 9:79-82. [Trofinova S.V., Khavinson V.Kh. Retina and aging. Advances in gerontology 2002; 9:79-82. (In Russ.)].; Хавинсон В.Х., Земчихина В.Н., Трофимова С.В., Малинин В.В. Влияние пептидов на пролиферативную активность клеток и пигментного эпителия. Бюллетень экспериментальной биологии и медицины 2003; 135(6):700-702. [Khavinson V.Kh., Zemchikhina V.N., Trofimova S.V., Malinin V.V. Peptide influence on the cell and pigment epithelium proliferative activity. Bulletin of experimental biology and medicine 2003; 135(6):700-702. (In Russ.)].; Алексеев В.Н., Чурилина Н.Ю., Павлова Е.А. Морфометрическое обоснование нейропротекторного действия пептидов при первичной открытоугольной глаукоме. Успехи современного естествознания 2008; 2:49-51. [Alekseev V.N., Churilina N.Yu., Pavlova E.A. Morphometric justification of peptide neuroprotective activity in primary open-angle glaucoma. Advances in current natural sciences 2008; 2:49-51. (In Russ.)].; Бикбов М.М., Файзрахманов Р.Р., Ярмухаметова А.Л., Бикбулатов Р.М. Макулярная дегенерация сетчатки в эксперименте. Медицинский вестник Башкортостана 2012; 7(3):53-56. [Bikbov M.M., Faizrakhmanov R.R., Yarmukhametova A.L., Bikbulatov R.M. Retinal macular degeneration in experimental study. Meditsinskiy vestnik Baskorstana 2012; 7(3):53-56. (In Russ.)].; Исайкина Н.В., Запускалов И.В., Кривошеина О.И. Возможность применения ретиналамина методом эпиретинального введения. Современные проблемы науки и образования 2015; 6:320-326. [Isaykina N.V., Zapuskalov I.V., Krivosheina O.I. Possible application of retinalamin in form of epiretinal therapy. Modern problems of science and education 2015; 6:320-326. (In Russ.)].; https://www.glaucomajournal.ru/jour/article/view/168

الاتاحة: https://www.glaucomajournal.ru/jour/article/view/168

المؤلفون: ПАНОВА ИРИНА ЕВГЕНЬЕВНА, ЕРМАК ЕЛЕНА МИХАЙЛОВНА, ШАИМОВА ТАТЬЯНА АНАТОЛЬЕВНА, ГАЛИН АЛЕКСЕЙ ЮРЬЕВИЧ

مصطلحات موضوعية: ВОЗРАСТНАЯ МАКУЛЯРНАЯ ДЕГЕНЕРАЦИЯ,AGE-RELATED MACULAR DEGENERATION,ГЛАУКОМА,GLAUCOMA,ХОРИОИДАЛЬНЫЙ КРОВОТОК,CHOROIDAL BLOOD FLOW,ГАНГЛИОЗНЫЕ КЛЕТКИ СЕТЧАТКИ,RETINAL GANGLION CELLS

وصف الملف: text/html

الاتاحة: http://cyberleninka.ru/article/n/morfometricheskie-i-gemodinamicheskie-osobennosti-techeniya-vozrastnoy-makulyarnoy-distrofii-pri-sochetannoy-patologii-vozrastnaya
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المؤلفون: Худоногов, Александр

مصطلحات موضوعية: ПЕРВИЧНАЯ ОТКРЫТОУГОЛЬНАЯ ГЛАУКОМА, КОМПЬЮТЕРНАЯ ПЕРИМЕТРИЯ, ГЛАУКОМНАЯ ОПТИЧЕСКАЯ НЕЙРОПАТИЯ, СИНЕКОЛБОЧКОВАЯ ЭЛЕКТРОРЕТИНОГРАММА, ГАНГЛИОЗНЫЕ КЛЕТКИ СЕТЧАТКИ

وصف الملف: text/html

الاتاحة: http://cyberleninka.ru/article/n/funktsionalnye-metody-issledovaniya-v-ranney-diagnostike-pervichnoy-otkrytougolnoy-glaukomy
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المؤلفون: Юрьева, Т., Худоногов, А.

مصطلحات موضوعية: ОСЦИЛЛЯТОРНЫЕ ПОТЕНЦИАЛЫ,ГЛАУКОМНАЯ ОПТИЧЕСКАЯ НЕЙРОПАТИЯ,ПЕРВИЧ НАЯ ОТКРЫТОУГОЛЬНАЯ ГЛАУКОМА,СИНЕКОЛБОЧКОВАЯ ЭЛЕКТРОРЕТИНОГРАММА,ГАНГЛИОЗНЫЕ КЛЕТКИ СЕТЧАТКИ

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الاتاحة: http://cyberleninka.ru/article/n/effektivnost-elektrofiziologicheskih-metodov-diagnostiki-doperimetricheskoy-stadii-glaukomy
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مصطلحات موضوعية: Ophthalmology, ганглиозные клетки сетчатки, внутриглазное давление (ВГД), optical coherence tomography, primary open-angle glaucoma (POAG), retinal ganglion cells, perimetry, периметрия, Кокарнит, Cocarnit, оптическая когерентная томография, первичная открытоугольная глаукома (ПОУГ), intraocular pressure (IOP)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1c53e8b1732af7ee13027c227706b4b5

مصطلحات موضوعية: нейропротекция, ганглиозные клетки сетчатки, glaucoma, внутриглазное давление, ganglion cell complex, neuroprotection, intraocular treatment, глаукома

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::91d802c93b1817157673bc0222289a01

المصدر: Известия Самарского научного центра Российской академии наук.

مصطلحات موضوعية: АПОПТОЗ, ГАНГЛИОЗНЫЕ КЛЕТКИ СЕТЧАТКИ, СФИНГОЛИПИДЫ, ПСИХОСОЦИАЛЬНЫЙ СТРЕСС, СТРЕСС-РЕЗИСТЕНТНОСТЬ

وصف الملف: text/html

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______2806::fff4d36fa766000d85412ea6aca7a5b3
http://cyberleninka.ru/article/n/vliyanie-hronicheskogo-psihosotsialnogo-stressa-na-intensivnost-degenerativnyh-izmeneniy-v-setchatke-u-krys-s-razlichnoy-stress

المصدر: Офтальмологические ведомости.

مصطلحات موضوعية: ВОЗРАСТНАЯ МАКУЛЯРНАЯ ДЕГЕНЕРАЦИЯ,AGE-RELATED MACULAR DEGENERATION,ГЛАУКОМА,GLAUCOMA,ХОРИОИДАЛЬНЫЙ КРОВОТОК,CHOROIDAL BLOOD FLOW,ГАНГЛИОЗНЫЕ КЛЕТКИ СЕТЧАТКИ,RETINAL GANGLION CELLS

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http://cyberleninka.ru/article/n/morfometricheskie-i-gemodinamicheskie-osobennosti-techeniya-vozrastnoy-makulyarnoy-distrofii-pri-sochetannoy-patologii-vozrastnaya

المصدر: Сибирский медицинский журнал (Иркутск).

مصطلحات موضوعية: ПЕРВИЧНАЯ ОТКРЫТОУГОЛЬНАЯ ГЛАУКОМА, КОМПЬЮТЕРНАЯ ПЕРИМЕТРИЯ, ГЛАУКОМНАЯ ОПТИЧЕСКАЯ НЕЙРОПАТИЯ, СИНЕКОЛБОЧКОВАЯ ЭЛЕКТРОРЕТИНОГРАММА, ГАНГЛИОЗНЫЕ КЛЕТКИ СЕТЧАТКИ

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http://cyberleninka.ru/article_covers/14720584.png

المصدر: Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук.

مصطلحات موضوعية: ОСЦИЛЛЯТОРНЫЕ ПОТЕНЦИАЛЫ, ГЛАУКОМНАЯ ОПТИЧЕСКАЯ НЕЙРОПАТИЯ, ПЕРВИЧНАЯ ОТКРЫТОУГОЛЬНАЯ ГЛАУКОМА, СИНЕКОЛБОЧКОВАЯ ЭЛЕКТРОРЕТИНОГРАММА, ГАНГЛИОЗНЫЕ КЛЕТКИ СЕТЧАТКИ

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http://cyberleninka.ru/article_covers/15248259.png

المصدر: Вестник Оренбургского государственного университета.

مصطلحات موضوعية: ОСЦИЛЛЯТОРНЫЕ ПОТЕНЦИАЛЫ,ГЛАУКОМНАЯ ОПТИЧЕСКАЯ НЕЙРОПАТИЯ,ПЕРВИЧ НАЯ ОТКРЫТОУГОЛЬНАЯ ГЛАУКОМА,СИНЕКОЛБОЧКОВАЯ ЭЛЕКТРОРЕТИНОГРАММА,ГАНГЛИОЗНЫЕ КЛЕТКИ СЕТЧАТКИ

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______2806::9e31b64b8ca2eff03d858bcad7f1e0e4
http://cyberleninka.ru/article/n/effektivnost-elektrofiziologicheskih-metodov-diagnostiki-doperimetricheskoy-stadii-glaukomy