-
1Academic Journal
المؤلفون: E. B. Tatarnikova, O. I. Krivosheina, E. V. Ivanova, Е. Б. Татарникова, О. И. Кривошеина, Е. В. Иванова
المصدر: Medical Immunology (Russia); Том 24, № 1 (2022); 31-40 ; Медицинская иммунология; Том 24, № 1 (2022); 31-40 ; 2313-741X ; 1563-0625
مصطلحات موضوعية: инфекция, pathogenesis, autoimmune inflammation, T cells, cytokines, infection, патогенез, аутоиммунное воспаление, Т-клетки, цитокины
وصف الملف: application/pdf
Relation: https://www.mimmun.ru/mimmun/article/view/2395/1500; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2395/8783; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2395/8784; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2395/8785; https://www.mimmun.ru/mimmun/article/downloadSuppFile/2395/8786; Баулина Н.М., Кулакова О.Г., Фаворова О.О. МикроРНК: роль в развитии аутоиммунного воспаления.// Acta Naturae (русскоязычная версия), 2016. Т. 8, № 1. C. 23-36.; Запускалов И.В., Кривошеина О.И., Хороших Ю.И. Патогенетические закономерности поражения центральных отделов глазного дна на фоне периферического увеита // Практическая медицина, 2012. № 4-2 (59). C. 100-104.; Хороших Ю.И., Иванова Е.В., Дениско М.С. Периферический увеит и миопия. // Современные технологии в офтальмологии, 2017. № 3. С. 156-157.; Agarwal M., Majumder P.D., Babu K., Konana V.K., Goyal M., Touhami S., Stanescu-Segall D., Bodaghi B. Drug-induced uveitis: A review. Indian J. Ophthalmol., 2020, Vol. 68, no. 9, pp. 1799-1807.; Aggarwal R., Ringold S., Khanna D., Neogi T., Johnson S.R., Miller A., Brunner H.I., Ogawa R., Felson D., Ogdie A., Aletaha D., Feldman B.M. Distinctions between diagnostic and classification criteria? Arthritis Care Res. (Hoboken), 2015, Vol. 67, no. 7, pp. 891-897.; Agrawal R., Iyer J., Connolly J., Iwata D., Teoh S. Cytokines and biologics in non-infectious autoimmune uveitis: bench to bedside. Indian J. Ophthalmol., 2014, Vol. 62, no. 1, pp. 74-81.; Berker N., Sen E., Elgin U., Atilgan C.U., Dursun E., Yilmazbas P. Analysis of clinical features and visual outcomes of pars planitis. Int. Ophthalmol., 2018, Vol. 38, no. 2, pp. 727-736.; Blum-Hareuveni T., Seguin-Greenstein S., Kramer M,, Hareuveni G, Sharon Y., Friling R., Sharief L., Lightman S., Tomkins-Netzer O. Risk factors for the development of cataract in children with uveitis. Am. J. Ophthalmol., 2017, Vol. 177, pp. 139-143.; Cimino L., Aldigeri R., Marchi S., Mastrofilippo V., Viscogliosi F., Coassin M., Soldani A., Savoldi L., De Fanti A., Belloni L., Zerbini A., Parmeggiani M., Chersich M., Soriano A., Salvarani C., Fontana L. Changes in patterns of uveitis at a tertiary referral center in Northern Italy: analysis of 990 consecutive cases. Int. Ophthalmol., 2018, Vol. 38, no. 1, pp. 133-142.; Conway M.D., Stern E., Enfield D.B., Peyman G.A. Management of cataract in uveitis patients. Curr. Opin. Ophthalmol., 2018, Vol. 29, no. 1, pp. 69-74.; Cunningham E.T. Jr, Pavesio C.E., Goldstein D.A., Forooghian F., Zierhut M. Multiple Sclerosis-Associated Uveitis. Ocul. Immunol. Inflamm., 2017, Vol. 25, no. 3, pp. 299-301.; Cunningham E.T. Jr, Smith J.R., Tugal-Tutkun I., Rothova A., Zierhut M. Uveitis in children and adolescents. Ocul. Immunol. Inflamm., 2016, Vol. 24, no. 4, pp. 365-371.; Deitch I., Amer R., Tomkins-Netzer O., Habot-Wilner Z., Friling R., Neumann R., Kramer M. The effect of anti-tumor necrosis factor alpha agents on the outcome in pediatric uveitis of diverse etiologies. Graefes Arch. Clin. Exp. Ophthalmol., 2018, Vol. 256, no. 4, pp. 801-808.; Dick A.D. Doyne lecture 2016: Intraocular health and the many faces of inflammation. Eye (Lond.), 2017, Vol. 31, no. 1, pp. 87-96.; Dick A.D., Tundia N., Sorg R., Zhao C., Chao J., Joshi A., Skup M. Risk of ocular complications in patients with noninfectious intermediate uveitis, posterior uveitis, or panuveitis. Ophthalmology, 2016, Vol. 123, no. 3, pp. 655-662.; Engelhard S.B., Patel V., Reddy A.K. Intermediate uveitis, posterior uveitis, and panuveitis in the Mid-Atlantic USA. Clin. Ophthalmol. (Auckland, NZ), 2015, no. 9, pp. 1549-1555.; Forrester J.V., Kuffova L., Dick A.D. Autoimmunity, Autoinflammation, and Infection in Uveitis. Am. J. Ophthalmol., 2018, Vol. 189, pp. 77-85.; Forrester J.V., McMenamin P.G., Dando S.J. CNS infection and immune privilege. Nat. Rev. Neurosci., 2018, Vol. 19, no. 11, pp. 655-671.; Foster C.S., Kothari S., Anesi S.D., Vitale A.T., Chu D., Metzinger J.L., Cerón O. The Ocular Immunology and Uveitis Foundation preferred practice patterns of uveitis management. Surv. Ophthalmol., 2016, Vol. 61, no. 1, pp. 1-17.; Friedman D.S., Holbrook J.T., Ansari H., Alexander J., Burke A, Reed S.B., Katz J., Thorne J.E., LightmanS.L., Kempen J.H.; MUST Research Group. Risk of elevated intraocular pressure and glaucoma in patients with uveitis: results of the multicenter uveitis steroid treatment trial. Ophthalmology, 2013, Vol. 120, no. 8, pp. 1571-1579.; Fu X., Chen Y., Chen D. The Role of Gut Microbiome in Autoimmune Uveitis. Ophthalmic Res., 2021, Vol. 64, no. 2, pp. 168-177.; Gery I., Caspi R.R. Tolerance Induction in Relation to the Eye. Front. Immunol., 2018, Vol. 9, 2304. doi:10.3389/fimmu.2018.02304.; Hamam R.N., Barikian A.W., Antonios R.S., Abdulaal M.R., Alameddine R.M., El Mollayess G., Mansour A.M. Intravitreal adalimumab in active noninfectious uveitis: a pilot study. Ocul. Immunol. Inflamm., 2016, Vol. 24, no. 3, pp. 319-326.; Heinz C., Schoonbrood S., Heiligenhaus A. Intermediate uveitis in children and young adults: differences in clinical course, associations and visual outcome. Br. J. Ophthalmol., 2014, Vol. 98, no. 8, pp. 1107-1111.; Horai R., Caspi R.R. Microbiome and Autoimmune Uveitis. Front. Immunol., 2019, Vol. 10, 232. doi:10.3389/fimmu.2019.00232.; Jabs D.A., Belfort R.Jr., Bodaghi B., Graham E., Holland G.N., Lightman S.L., Oden N., Palestine A.G., Smith J.R., Thorne J.E., Trusko B.E. Standardization of Uveitis Nomenclature (SUN) Working Group. Classification Criteria for Syphilitic Uveitis. Am. J. Ophthalmol., 2021,Vol. 228, pp. 182-191.; Jabs D.A., Denniston A.K., Dick А.D., Dunn J.P., Kramer M., Oden N., Okada A.A., Palestine A.G., Read R.W., Thorne J.E., Trusko B.E., Yeh S. The Standardization Of Uveitis Nomenclature Sun Working Group Classification criteria for pars planitis. Am. J. Ophthalmol., 2021. doi:10.1016/j.ajo.2021.03.045.; Jabs D.A., Nussenblatt R.B., Rosenbaum J.T. Perspectives standardization of uveitis nomenclature for reporting clinical data. Results of first international workshop. Am. J. Ophthalmol., 2005, Vol. 140, no. 3, pp. 509-516.; Jayakumar K., Agarwal A., Gupta V. Tubercular intermediate uveitis: The importance of meticulous multidisciplinary assessments. Indian J. Ophthalmol., 2019, Vol. 67, no. 11, pp. 1873-1874.; Kaur C., Foulds W.S., Ling E.A. Blood–retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management. Prog. Retin. Eye Res., 2008, Vol. 27, no. 6, pp. 622-647.; Kempen J.H., van Natta M.L., Altaweel M.M., Dunn J.P., Jabs D.A., Lightman S.L., Thorne J.E., Holbrook J.T. Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group. Factors predicting visual acuity outcome in intermediate, posterior, and panuveitis: the Multicenter Uveitis Steroid Treatment (MUST) trial. Am. J. Ophthalmol., 2015, Vol. 160, no. 6, pp. 1133-1141.; Kerr E.C., Copland D.A., Dick A.D., Nicholson L.B. The dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis. Prog. Retin. Eye Res., 2008, Vol. 27, no. 5, pp. 527-535.; Kosmaczewska A., Przeździecka-Dołyk J., Turno-Kręcicka A., Ciszak L., Szteblich A., Węgrzyn A., Frydecka I., Misiuk-Hojło M. Imbalance in PB IL-17-Secreting and Regulatory Cells in Pars Planitis Is Associated with Dysregulation of IFN-γ-Secreting Cells, Especially in Patients with Clinical Complications. Mediators Inflamm., 2020, Vol. 2020, 9175083. doi:10.1155/2020/9175083.; Leclercq M., Desbois A.C., Domont F., Maalouf G., Touhami S., Cacoub P., Bodaghi B., Saadoun D. Biotherapies in Uveitis. J. Clin. Med., 2020, Vol. 9, no. 11, 3599. doi:10.3390/jcm9113599.; Lee R.W., Nicholson L.B., Sen H.N., Chan C.C., Wei L., Nussenblatt R.B., Dick A.D. Autoimmune and autoinflammatory mechanisms in uveitis. Semin. Immunopathol., 2014, Vol. 36, no. 5, pp. 581-594.; Levinson R.D. Immunogenetics of ocular inflammatory disease. Tissue Antigens, 2007, Vol. 69, no. 2, pp. 105-112.; Levy-Clarke G., Jabs D.A., Read R.W., Rosenbaum J.T., Vitale A., van Gelder R.N. Expert panel recommendations for the use of anti–tumor necrosis factor biologic agents in patients with ocular inflammatory disorders. Ophthalmology, 2014, Vol. 121, no. 3, pp. 785-796.; Liberman P., Gauro F., Berger O., Urzua C.A. Causes of uveitis in a tertiary center in Chile: a cross-sectional retrospective review. Ocul. Immunol. Inflamm., 2015, Vol. 23, no. 4, pp. 339-345.; Lin P., Suhler E.B., Rosenbaum J.T. The future of uveitis treatment. Am. Acad. Ophthalmol., 2014, Vol. 121, no. 1, pp. 365-376.; Lindner E., Steinwender G., Plainer S., Poeschl E.M., Weger M., Ardjomand N., Renner W., El-ShabrawiY. Role of IL-10 gene polymorphisms in intermediate and HLA-B27-associated uveitis. Acta Ophthalmol., 2013, Vol. 91, no. 5, pp. e415-e417.; Llop S.M., Papaliodis G.N. Cataract Surgery Complications in Uveitis Patients: A Review Article. Semin. Ophthalmol., 2018, Vol. 33, no. 1, pp. 64-69.; Llorenç V., Mesquida M., Sainz de la Maza M., Keller J., Molins B., Espinosa G., Hernandez M.V., Gonzalez-Martín J., Adán A. Epidemiology of uveitis in a Western urban multiethnic population. The challenge of globalization. Acta Ophthalmol., 2015, Vol. 93, no. 6, pp. 561-567.; Luca C., Raffaella A., Sylvia M., Valentina M., Fabiana V., Marco C., Annamaria S., Luisa S., Alessandro F., Lucia B., Alessandro Z., Maria P., Matthew C., Alessandra S., Carlo S., Luigi F. Complications in Intermediate Uveitis: Prevalence, Time of Onset, and Effects on Vision in Short-Term and Long-Term Follow-Up. Ocul. Immunol. Inflamm., 2018, Vol. 38, no. 1, pp. 133-142.; Miserocchi E., Fogliato G., Modorati G., Bandello F. Review on the worldwide epidemiology of uveitis. Eur. J. Ophthalmol., 2013, Vol. 23, no. 5, pp. 705-717.; Mölzer C., Heissigerova J., Wilson H.M., Kuffova L., Forrester J.V. Immune Privilege: The Microbiome and Uveitis. Front. Immunol., 2021, Vol. 11, 608377. doi:10.3389/fimmu.2020.608377.; Ness T., Boehringer D., Heinzelmann S. Intermediate uveitis: pattern of etiology, complications, treatment and outcome in a tertiary academic center. Orphanet J. Rare Dis., 2017, Vol. 12, no. 1, 81. doi:10.1186/s13023-017-0638-9.; Nguyen Q.D., Merrill P.T., Jaffe G.J., Dick A.D., Kurup S.K., Sheppard J., Schlaen A., Pavesio C., Cimino L., van Calster J., Camez A.A., Kwatra N.V., Song A.P., Kron M., Tari S., Brézin A.P. Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial. Lancet, 2016, Vol. 388, no. 10050, pp. 1183-1192.; Ozdal P.C., Berker N., Tugal-Tutkun I. Pars planitis: Epidemiology, clinical characteristics, management and visual prognosis. J. Ophthalmic Vis. Res., 2015, Vol. 10, no. 4, pp. 469-480.; Ozzello D.J., Palestine A.G. Factors affecting therapeutic decisions in intermediate and posterior uveitis. Am. J. Ophthalmol., 2015, Vol. 159, no. 2, pp. 213-220.; Pålsson S., Andersson Grönlund M., Skiljic D., Zetterberg M. Phacoemulsification with primary implantation of an intraocular lens in patients with uveitis. Clin. Ophthalmol. (Auckland, NZ), 2017, Vol. 11, pp. 1549-1555.; Parchand S., Tandon M., Gupta V., Gupta A. Intermediate uveitis in Indian population. J. Ophthal. Inflamm. Infect., 2011, no. 1, pp. 65-70.; Perez V.L., Caspi R.R. Immune mechanisms in inflammatory and degenerative eye disease. Trends Immunol., 2015, Vol. 36, no. 6, pp. 354-363.; Perez V.L., Papaliodis G.N., Chu D., Anzaar F., Christen W., Foster C.S. Elevated levels of interleukin 6 in the vitreous fluid of patients with pars planitis and posterior uveitis: the Massachusetts eye & ear experience and review of previous studies. Ocul. Immunol. Inflamm., 2004, Vol. 12, no. 3, pp. 193-202.; Placinta I.A., Udaondo P. Multimodal imaging in intermediate tuberculous uveitis. Arch. Soc. Esp. Oſtalmol. (Engl. Ed.), 2020, Vol. 95, no. 5, pp. e37-e38.; Przeździecka-Dołyk J., Węgrzyn A., Turno-Kręcicka A., Misiuk-Hojło M. Immunopathogenic background of pars planitis. Arch. Immunol. Ther. Exp., 2015, Vol. 64, no. 2, pp. 127-137.; Ratra D., Barh A., Banerjee M., Ratra V., Biswas J. Safety and Efficacy of Intravitreal Dexamethasone Implant for Refractory Uveitic Macular Edema in Adults and Children. Ocul. Immunol. Inflamm., 2018, Vol. 26, no. 7, pp. 1034-1040.; Raveney B.J., Copland D.A., Dick A.D., Nicholson L.B. TNFR1-dependent regulation of myeloid cell function in experimental autoimmune uveoretinitis. J. Immunol., 2009, Vol. 183, no. 4, pp. 2321-2329.; Roemer S., Bissig A., Rocca A., Du Pasquier R., Guex-Crosier Y. Efficacy of natalizumab in intermediate uveitis related to multiple sclerosis: a case report. Klin. Monbl für Augenheilkd, 2018, Vol. 235, no. 4, pp. 476-477.; Rothova A., Hajjaj A., de Hoog J., Thiadens A.A.H.J., Dalm V.A.S.H. Uveitis causes according to immune status of patients. Acta Ophthalmol., 2019, Vol. 97, no. 1, pp. 53-59.; Schwartzman S., Schwartzman M. The use of biologic therapies in uveitis. Clin. Rev. Allergy Immunol., 2015, Vol. 49, no. 3, pp. 307-316.; Sen H.N., Abreu F.M., Louis T.A., Sugar E.A., Altaweel M.M., Elner S.G., Holbrook J.T., Jabs D.A., Kim R.Y., Kempen J.H. Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study Research Group. Cataract surgery outcomes in Uveitis: the multicenter Uveitis steroid treatment trial. Ophthalmology, 2016, Vol. 123, no. 1, pp. 183-190.; Shah A., Biswas J. Cytopathology and Polymerase Chain Reaction of Vitreous Fluid in Tubercular Intermediate Uveitis. Ocul. Immunol. Inflamm., 2020, pp. 1-3.; Shechter R., London A., Schwartz M. Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates. Nat. Rev. Immunol., 2013, Vol. 13, no. 3, pp. 206-218.; Shorstein N.H., Liu L., Waxman M.D., Herrinton L.J. Comparative effectiveness of three prophylactic strategies to prevent clinical macular edema aſter phacoemulsification surgery. Ophthalmology, 2015, Vol. 122, no. 12, pp. 2450-2456.; Shoughy S.S., Kozak I., Tabbara K.F. Associations of Systemic Diseases with Intermediate Uveitis. Ophthalmic Epidemiol., 2016, Vol. 23, no. 1, pp. 27-31.; Standardization of Uveitis Nomenclature (SUN) Working Group. Classification Criteria for Multiple Sclerosis-Associated Intermediate Uveitis. Am. J. Ophthalmol., 2021, Vol. 228, pp. 72-79.; Standardization of Uveitis Nomenclature (SUN) Working Group. Classification Criteria for Sarcoidosis-Associated Uveitis. Am. J. Ophthalmol., 2021, Vol. 228, pp. 220-230.; Standardization of Uveitis Nomenclature (SUN) Working Group. Classification Criteria for Intermediate Uveitis, Non-Pars Planitis Type. Am. J. Ophthalmol., 2021, Vol. 228, pp. 159-164.; Standardization of Uveitis Nomenclature (SUN) Working Group. Development of Classification Criteria for the Uveitides. Am. J. Ophthalmol., 2021, Vol. 228, pp. 96-105.; Stanford M.R., Vaughan R.W., Kondeatis E., Chen Y., Edelsten C.E., Graham E.M., Wallace G.R. Are cytokine gene polymorphisms associated with outcome in patients with idiopathic intermediate uveitis in the United Kingdom? Br. J. Ophthalmol., 2005, Vol. 89. no. 8, pp. 1013-1016.; Sugita S., Horie S., Yamada Y., Mochizuki M. Inhibition of B-cell activation by retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci., 2010, Vol. 51, Iss. 11, pp. 5783-5788.; Sugita S., Kawazoe Y., Imai A., Usui Y., Iwakura Y., Isoda K., Ito M., Mochizuki M. Mature dendritic cell suppression by IL-1 receptor antagonist on retinal pigment epithelium cells. Invest. Ophthalmol. Vis. Sci., 2013, Vol. 54, Iss. 5, pp. 3240-3249.; Sugita S. Role of ocular pigment epithelial cells in immune privilege. Arch. Immunol. Ther. Exp., 2009, Vol. 57, no. 4, pp. 263-268.; Sugita S., Horie S., Yamada Y., Kawazoe Y., Takase H., Mochizuki M. Suppression of interleukin-17-producing T-helper 17 cells by retinal pigment epithelial cells. Jpn J. Ophthalmol., 2011, Vol. 55, pp. 565-575.; Sugita S., Kawazoe Y., Imai A., Usui Y., Takahashi M., Mochizuki M. Suppression of IL-22-producing T helper 22 cells by RPE cells via PD-L1/PD-1 interactions. Invest. Ophthalmol. Vis. Sci., 2013, Vol. 54, Iss. 10, pp. 6926-6933.; Sun M.M., Levinson R.D., Filipowicz A., Anesi S., Kaplan H.J., Wang W., Goldstein D.A., Gangaputra S., Swan R.T., Sen H.N., Gordon L.K. Uveitis in Patients Treated with CTLA-4 and PD-1 Checkpoint Blockade Inhibition. Ocul. Immunol. Inflamm., 2020, Vol. 28, no. 2, pp. 217-227.; Takai Y., Tanito M., Ohira A. Multiplex cytokine analysis of aqueous humor in eyes with primary open-angle glaucoma, exfoliation glaucoma, and cataract. Invest. Ophthalmol. Vis. Sci., 2012, Vol. 53, Iss. 1, pp. 241-247.; Tekin K., Erol Y.O., Sargon M.F., Inanc M., Ozdal P.C., Berker N. Effects of Fuchs uveitis syndrome on the ultrastructure of the anterior lens epithelium: A transmission electron microscopic study. Indian J. Ophthalmol., 2017, Vol. 65, no. 12, pp. 1459-1464.; Ten Berge J.C., Schreurs M.W.J., van Daele P.L.A., Rothova A. Autoimmunity in uveitis. Acta Ophthalmol., 2018, Vol. 96, no. 5, pp. 481-485.; Thorne J.E., Skup M., Tundia N., Macaulay D., Revol C., Chao J., Joshi A., Dick A.D. Direct and indirect resource use, healthcare costs and work force absence in patients with non-infectious intermediate, posterior or panuveitis. Acta Ophthalmol., 2016, Vol. 94, no. 5, pp. e331-339.; Tode J., Richert E., Koinzer S., Klettner A., Pickhinke U., Garbers C., Rose-John S., Nölle B., Roider J. Intravitreal injection of anti-interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice. Cytokine, 2017, Vol. 96, pp. 8-15.; Tomkins-Netzer O., Lightman S., Drye L., Kempen J., Holland G.N., Rao N.A., Stawell R.J., Vitale A., Jabs D.A.; Outcome of treatment of uveitic macular edema: the multicenter uveitis steroid treatment trial 2-year results. Ophthalmology, 2015, Vol. 122, no. 11, pp. 2351-2359.; Tsirouki T., Dastiridou A., Symeonidis C., Tounakaki O., Brazitikou I., Kalogeropoulos C., Androudi S. A Focus on the Epidemiology of Uveitis. Ocul. Immunol. Inflamm., 2018, Vol. 26, no. 1, pp. 2-16.; Valentincic N.V., de Groot-Mijnes J.D., Kraut A., Korosec P., Hawlina M., Rothova A. Intraocular and serum cytokine profiles in patients with intermediate uveitis. Mol. Vis., 2011, Vol. 17, pp. 2003-2010.; Verhagen F.H., Bekker C.P.J., Rossato M., Hiddingh S., de Vries L., Devaprasad A., Pandit A., Ossewaardevan Norel J., Ten Dam N., Moret-Pot M.C.A., Imhof S.M., de Boer J.H., Radstake T.R.D.J., Kuiper J.J.W. A disease-associated microRNA cluster links inflammatory pathways and an altered composition of leukocyte subsets to noninfectious uveitis. Invest. Ophthalmol. Vis. Sci., 2018, Vol. 59, Iss. 2, pp. 878-888.; Vidović-Valentinčič N., Kraut A., Hawlina M., Stunf S., Rothova A. Intermediate uveitis: long-term course and visual outcome. Br. J. Ophthalmol, 2009, Vol. 93, no. 4, pp. 477-480.; Weinstein J.E., Pepple K.L. Cytokines in uveitis. Curr. Opin. Ophthalmol., 2018, Vol. 29, no. 3, pp.267-274.; Wen X., Hu X., Miao L., Ge X., Deng Y., Bible P.W., Wei L. Epigenetics, microbiota, and intraocular inflammation: New paradigms of immune regulation in the eye. Prog. Retin. Eye Res., 2018, Vol. 64, pp. 84-95.; Williams K.A., Esterman A.J., Bartlett C., Holland H., Hornsby N.B., Coster D.J. How effective is penetrating corneal transplantation? Factors influencing long-term outcome in multivariate analysis. Transplantation, 2006, Vol. 81, no. 6, pp. 896-901.; Winterhalter S., Behrens U.D., Salchow D., Joussen A.M., Pleyer U. Dexamethasone implants in paediatric patients with noninfectious intermediate or posterior uveitis: first prospective exploratory case series. BMC Ophthalmol., 2017, Vol. 17, no. 1, 252. doi:10.1186/s12886-017-0648-3.; Yoshimura T., Sonoda K.H., Ohguro N., Ohsugi Y., Ishibashi T., Cua D.J., Kobayashi T., Yoshida H., Yoshimura A. Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis. Rheumatology (Oxford), 2009, Vol. 48, no. 4, pp. 347-354.; You C., Sahawneh H.F., Sahawneh M.L., Kubaisi B., Schmidt A., Foster C.S. A review and update on orphan drugs for the treatment of noninfectious uveitis. Clin. Ophthalmol., 2017, Vol. 11, pp. 257-265.; Yuen B.G., Tham V.M., Browne E.N., Weinrib R., Borkar D.S., Parker J.V., Uchida A., Vinoya A.C., Acharya N.R. Association between smoking and uveitis: results from the Pacific Ocular Inflammation Study. Ophthalmology, 2015, Vol. 122, no. 6, pp. 1257-1261.; Zola M., Briamonte C., Lorenzi U., Machetta F., Grignolo F.M., Fea A.M. Treatment of refractory uveitic macular edema: results of a first and second implant of long-acting intravitreal dexamethasone. Clin. Ophthalmol. (Auckland, NZ), 2017, Vol. 11, pp. 1949-1956.; https://www.mimmun.ru/mimmun/article/view/2395