المؤلفون: T. Borisova N., A. Nazarenko V., K. Laktionov K., S. Tkachev I., S. Alieva B., V. Breder V., O. Trofimova P., V. Glebovskaya V., A. Fedorova A., D. Marinov T., N. Meshcheriakova A., S. Ivanov M., S. Gerasimov G., Т. Борисова Н., А. Назаренко В., К. Лактионов К., С. Ткачев И., С. Алиева Б., В. Бредер В., О. Трофимова П., В. Глебовская В., А. Федорова А., Д. Маринов Т., Н. Мещерякова А., С. Иванов М., С. Герасимов С.

المصدر: Meditsinskiy sovet = Medical Council; № 20 (2020); 150-156 ; Медицинский Совет; № 20 (2020); 150-156 ; 2658-5790 ; 2079-701X

مصطلحات موضوعية: stereotactic radiotherapy, lung cancer, overall survival, disease-specific survival, radiation toxicity, predictor factors, стереотаксическая радиотерапия, рак легкого, общая выживаемость, опухоль-специфическая выживаемость, лучевая токсичность, предикторные факторы

وصف الملف: application/pdf

Relation: https://www.med-sovet.pro/jour/article/view/5949/5430; Torre L.A., Bray F., Siegel R.L. Ferlay J., Lortet-Tieulent J., Jemal A. et al. Global cancer statistics, 2012. CA: Cancer J Clin. 2015;65(2):87–108. doi:10.3322/caac.21262.; Аксель Е.М., Давыдов М.И. Статистика злокачественных новообразова­ ния в России и странах СНГ в 2012 г. М.; 2014.; Pezzi C.M., Mallin K., Mendez A.S., Gau E.G., Putnam J.B. Jr. Ninety-day mortality after resection for lung cancer is nearly double 30-day mortality. J Thorac Cardiovasc Surg. 2014;148(5):2269–2277. doi:10.1016/j.jtcvs.2014.07.077.; Nanda R.H., Liu Y., Gillespie T.W., Mikell J.L., Ramalingam S.S., Fernandez F.G. et al. Stereotactic body radiation therapy versus no treatment for early stage non-small cell lung cancer in medically inoperable elderly patients: A National Cancer Data Base analysis. Cancer. 2015;121(23):4222–4230. doi:10.1002/cncr.29640.; Dalwadi S.M., Szeja S., Teh B.S., Balter E.B., Farach A.M. Outcomes in elderly stage I non-small cell lung cancer in the stereotactic body radiation therapy era: a surveillance, epidemiology, and end results analysis. Int J Radiat Oncol Biol Phys. 2016;96(S2):S68. doi:10.1016/j.ijrobp.2016.06.174.; Haasbeek C.J., Lagerwaard F.J., Antonisse M.E., Slotman B.J., Senan S. Stage I nonsmall cell lung cancer in patients aged ≥75 years: outcomes after stereotactic radiotherapy. Cancer. 2010;116(2):406–414. doi:10.1002/cncr.24759.; Van den Berg L.L., Klinkenberg T.J., Groen H.J., Widder J. Patterns of Recurrence and Survival after Surgery or Stereotactic Radiotherapy for Early Stage NSCLC. J Thorac Oncol. 2015;10(5):826–831. doi:10.1097/JTO.0000000000000483.; Chang J.Y., Senan S., Paul M.A., Mehran R.J., Louie A.V., Balter P. et al. Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials. Lancet Oncol. 2015;16(6):630–637. doi:10.1016/S1470-2045(15)70168-3.; Давыдов М.И., Полоцкий Б.Е. Современные принципы выбора лечебной тактики и возможность хирургического лечения немелкоклеточного рака легкого. В: Переводчикова Н.И. (ред.). Новое в терапии рака легкого. М.; 2003.; Li L., Ren S., Zhang Y., Guan Y., Zhao J., Liu J. et al. Risk factors for predicting the occult nodal metastasis in T1-2N0M0 NSCLC patients staged by PET/CT: potential value in the clinic. Lung Cancer. 2013;81(2):213–217. doi:10.1016/j.lungcan.2013.04.012.; Onishi H., Araki T., Shirato H., Nagata Y., Hiraoka M., Gomi K. et al. Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer. 2004;101(7):1623–1631. doi:10.1002/cncr.20539.; Katoh N., Soda I., Tamamura H., Takahashi S., Uchinami Y., Ishiyama H. et al. Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumortracking radiotherapy system. Radiat Oncol. 2017;12(1):3–12. doi:10.1186/ s13014-016-0742-3.; Stanic S., Paulus R., Timmerman R.D., Michalski J.M., Barriger R.B., Bezjak A. et al. No clinically significant changes in pulmonary function following stereotactic body radiation therapy for early-stage peripheral non-small cell lung cancer: an analysis of RTOG 0236. Int J Radiat Oncol Biol Phys. 2014;88(5):1092–1099. doi:10.1016/j.ijrobp.2013.12.050.; Ferrero C., Badellino S., Filippi A.R., Focaraccio L., Levra M.G., Levis M. et al. Pulmonary function and quality of life after VMAT-based stereotactic ablative radiotherapy for early stage inoperable NSCLC: a prospective study. Lung Cancer. 2015;89(3):350–356. doi:10.1016/j.lung- can.2015.06.019.; Benedict S.H., Yenice K.M., Followill D., Calvin J.M., Hinson W., Kavanagh B. et al. Stereotactic body radiation therapy: the report of AAPM task group 101. Med Phys. 2010;37(8):4078–4101. doi:10.1118/1.3438081.; Timmerman R., McGarry R., Yiannoutsos C., Papiez L., Tudor K., DeLuca J. et al. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol. 2006;24(30):4833–4839. doi:10.1200/JCO.2006.07.5937.; Aoki M., Sato M., Hirose K., Akimoto Y., Kawaguchi H., Hatayama Y. et al. Radiation-induced rib fracture after stereotactic body radiotherapy with a total dose of 54-56 Gy given in 9-7 fractions for patients with peripheral lung tumor: impact of maximum dose and fraction size. Radiat Oncol. 2015;10:99–106. doi:10.1186/s13014-015-0406-8.; Park Y., Kim H.J., Chang A.R. Predictors of chest wall toxicity after stereotactic ablative radiotherapy using real-time tumor tracking for lung tumors. Radiat Oncol. 2017;12(1):66. doi:10.1186/s13014-017-0857-1.; https://www.med-sovet.pro/jour/article/view/5949

الاتاحة: https://www.med-sovet.pro/jour/article/view/5949
https://doi.org/10.21518/2079-701X-2020-20-150-156

المؤلفون: E. Reutova V., L. Laktionova V., D. Marinov T., D. Peregudov A., T. Borisova N., Е. Реутова В., Л. Лактионова В., Д. Маринов Т., Д. Перегудов А., Т. Борисова Н.

المصدر: Meditsinskiy sovet = Medical Council; № 9 (2020); 176-181 ; Медицинский Совет; № 9 (2020); 176-181 ; 2658-5790 ; 2079-701X

مصطلحات موضوعية: ALK translocation, non-small cell lung cancer, targeted therapy, crizotinib, транслокация ALK, немелкоклеточный рак легкого, таргетная терапия, кризотинибтранслокация ALK, кризотиниб

وصف الملف: application/pdf

Relation: https://www.med-sovet.pro/jour/article/view/5721/5219; Sahu A., Prabhash K., Noronha V., Joshi A., Desai S. Crizotinib: A comprehensive review. South Asian J Cancer. 2013;2(2):91–97. doi:10.4103/2278-330X.110506.; Solomon B.J., Mok T., Kim D.W., Wu Y.L., Nakagawa K., Mekhail T. et al. Firstline crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014;371(23):2167–2177. doi:10.1056/NEJMoa1408440.; Shaw A.T., Kim D.W., Nakagawa K., Seto T., Crinó L., Ahn M.-J. et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;368(25):2385–2394. doi:10.1056/NEJMoa1214886. Лактионов К.К., Артамонова Е.В., Бредер В.В., Горбунова В.А., Моисеенко Ф.В., Реутова Е.В. и др. Практические рекомендации по лекарственному лечению немелкоклеточного рака легкого. Злокачественные опухоли. 2019;9(3s2):32–48. Режим доступа: https://rosoncoweb.ru/standarts/RUSSCO/2019/2019-01.pdf. Laktionov K.K., Artamonova E.V., Breder V.V., Gorbunova V.A., Moiseenko F.V., Reutova E.V. et al. Practical guidelines for the medicinal treatment of non-small cell cancer. Zlokachestvennye opukholi = Malignant Tumours. 2019;9(3s2):2–48. (In Russ.) Available at: https://rosoncoweb.ru/standarts/RUSSCO/2019/2019-01.pdf.; Demidova I., Grinevich V., Avdalian A., Imyanitov E., Gikalo М., Savelov et al. Detection of ALK rearrangements in 4002 Russian patients: The utility of different diagnostic approaches Lung Cancer. 2017;103:17–23. 10.1016/j.lungcan.2016.11.001.; Solomon B., Varella-Garcia M., Camidge D.R. ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer. SOJ Thoracic Oncology. 2009;4(12):1450–1454. doi:10.1097/JTO.0b013e3181c4dedb.; Soda M., Choi Y.L., Enomoto M., Takada S., Yamashita Y., Ishikawa S. et al. Identification of the transforming EML4-ALK fusion gene in nonsmall-cell lung cancer. Nature. 2007;448(7153):561–566. doi:10.1038/nature05945.; Shaw A.T., Yeap B.Y., Mino-Kenudson M., Digumarthy S.R., Costa D.B., Heist R.S. et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009;27(26):4247–4253. doi:10.1200/JCO.2009.22.6993.; Демидова И.А., Цепенщикова Е.О., Баринов А.А., Гагарин И.М., Савелов Н.А., Гриневич В.Н., Тюляндин С.А. Определение перестроек гена ALK в селектированной популяции российских больных немелкоклеточным раком легкого. Злокачественные опухоли. 2013;3(7):3–9. doi:10.18027/2224-5057-2013-3-3-9. Demidova I.A., Tepenshchikova E.O., Barinov А.А., Gagarin I.M., Savelov N.A., Grinevich V.N., Tulyandin S.A. Determination of ALK gene rearrangements in a selected population of Russian patients with non-small cell lung cancer. Zlokachestvennye opukholi = Malignant Tumours. 2013;3(7):3–9. (In Russ.) doi:10.18027/2224-5057-2013-3-3-9.; Camidge D.R., Bang Y.J., Kwak E.L., Iafrate A.J., Varella-Garcia M., Fox S.B. et al. Activity and safety of crizotinib in patients with ALK-positive non-smallcell lung cancer: updated results from a phase 1 study. Lancet Oncol. 2012;13(10):1011–1019. doi:10.1016/S1470-2045(12)70344-3.; Blackhall F., Ross Camidge D., Shaw A.T., Soria J.C., Solomon B.J., Mok T. et al. Final results of the large-scale multinational trial PROFILE 1005: efficacy and safety of crizotinib in previously treated patients with advanced/metastatic ALK-positive non-small-cell lung cancer. ESMO Open. 2017;2(3):e000219. doi:10.1136/esmoopen-2017-000219.; Shaw A.T., Kim T.M., Crinò L., Gridelli C., Kiura K., Liu G. et al. Ceritinib versus chemotherapy in patients with ALK-rearranged non-small-cell lung cancer previously given chemotherapy and crizotinib (ASCEND-5): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2017;18(7):874–886. doi:10.1016/S1470-2045(17)30339-X.; Novello S., Mazières J., Oh I.J., de Castro J., Migliorino M. R., Helland Å. et al. Alectinib versus chemotherapy in crizotinib-pretreated anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer: results from the phase III ALUR study. Ann Oncol. 2018;29(6):1409–1416. doi:10.1093/annonc/mdy121.; Huber R.M., Hansen K.H., Paz-Ares Rodriguez L., West H.L., Reckamp K.L., Leighl N.B. et al. Brigatinib in Crizotinib-Refractory ALK+ NSCLC: 2-Year Follow-up on Systemic and Intracranial Outcomes in the Phase 2 ALTA Trial. J Thorac Oncol. 2020;15(3):404–415. doi:10.1016/j.jtho.2019.11.004.; Solomon B.J., Besse B., Bauer T.M., Felip E., Soo R.A., Camidge D.R. et al. Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study. Lancet Oncol. 2018;19(12):1654– 1667. doi:10.1016/S1470-2045(18)30649-1.; Rangachari D., Le X., Shea M., Huberman M. S., Van der Laan P.A., Kobayashi S.S., Costa D.B. Cases of ALK-Rearranged Lung Cancer with 5-Year ProgressionFree Survival with Crizotinib as Initial Precision Therapy. J Thorac Oncol. 2017;12(11):e175-e177. doi:10.1016/j.jtho.2017.06.002.; Solomon B.J., Kim D.W., Wu Y.L., Nakagawa K., Mekhail T., Felip E. et al. Final Overall Survival Analysis From a Study Comparing First-Line Crizotinib Versus Chemotherapy in ALK-Mutation-Positive Non-Small-Cell Lung Cancer. J Clin Oncol. 2018;36(22):2251–2258. doi:10.1200/JCO.2017.77.4794.; Duruisseaux M., Besse B., Cadranel J., Pérol M., Mennecier B., Bigay-Game L. et al. Overall survival with crizotinib and next-generation ALK inhibitors in ALK-positive non-small-cell lung cancer (IFCT-1302 CLINALK): a French nationwide cohort retrospective study. Oncotarget. 2017;8(13):21903– 21917. doi:10.18632/oncotarget.15746.; Peters S., Camidge D.R., Shaw A.T., Gadgeel S., Ahn J.S., Kim D.W. et al. Alectinib versus crizotinib in untreated ALK-positive non-small-cell lung cancer. N Engl J Med. 2017;377:829–838. doi:10.1056/NEJMoa1704795.; Sakakibara-Konishi J., Kitai H., Ikezawa Y., Hatanaka Y., Sasaki T., Yoshida R. et al. Response to Crizotinib Re-administration After Progression on Lorlatinib in a Patient With ALK-rearranged Non-small-cell Lung Cancer. Clinical Lung Cancer. 2019;20(5):e555-e559. doi:10.1016/j.cllc.2019.06.021.; Shaw A.T., Friboulet L., Leshchiner I., Gainor J.F., Bergqvist S., Brooun A. et al. Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F. N Engl J Med. 2016;374(1):54–61. doi:10.1056/NEJMoa1508887.; https://www.med-sovet.pro/jour/article/view/5721

الاتاحة: https://www.med-sovet.pro/jour/article/view/5721
https://doi.org/10.21518/2079-701X-2020-9-176-181

المؤلفون: K. Laktionov K., D. Yudin I., V. Breder V., E. Reutova V., K. Laktionov P., D. Marinov T., D. Peregudov A., M. Ardzinba S., К. Лактионов К., Д. Юдин И., В. Бредер В., Е. Реутова В., К. Лактионов П., Д. Маринов Т., Д. Перегудов А., М. Ардзинба С.

المصدر: Meditsinskiy sovet = Medical Council; № 10 (2019); 110-114 ; Медицинский Совет; № 10 (2019); 110-114 ; 2658-5790 ; 2079-701X ; 10.21518/2079-701X-2019-10

مصطلحات موضوعية: NSCLC, EGFR, tyrosine kinase inhibitors, integrated chemotherapy, НМРЛ, ингибиторы тирозинкиназы, интегрированная химиотерапия

وصف الملف: application/pdf

Relation: https://www.med-sovet.pro/jour/article/view/3060/2984; Rosell R., Carcereny E., Gervais R. et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive nonsmall-cell lung cancer (EURTAC): a multicentre, open-label, randomized phase 3 trial. Lancet Oncol. 2012;13(3):239-246.; Sequist L.V., Yang J.C., Yamamoto N. et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31:3327-3334.; Mok T.S., Wu Y.L., Thongprasert S. et al. Gefitinib or carboplatinpaclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361:947-957.; Pu-Yun OuYang, Zhen Su, Yan-Ping Mao, Wuguo Deng, Fang-Yun Xie Combination of EGFR-TKIs and Chemotherapy as First-Line Therapy for Advanced NSCLC: A Meta-Analysis. PLOS ONE. 2013 November 8;8(Issue 11):e79000. www.plosone.org; Kanda S., Horinouchi H., Fujiwara Y., Nokihara H., Yamamoto N., Sekine I., Kunitoh H., Kubota K., Tamura T., Ohe Y. Cytotoxic chemotherapy may overcome the development of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) therapy. Lung Cancer. 2015 Sep;89(3):287-93.; Soria J.-C., Ohe Y., Vansteenkiste J. et al. FLAURA Investigators. Osimertinib in untreated EGFRmutated advanced non-small-cell lung cancer. N Engl J Med. 2018;278(2):113-125.; Bean J., Brennan C., Shih J.Y., Riely G., Viale A., Wang L. et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA. 2007;104:20932–20937.; Engleman J.A., Zejnullahu K., Mitsudomi T., Song Y., Hyland C., Park J.O. et al. MET amplification leads to gefitinib resistance in lung cancer by activation ERBB3 signaling. Science. 2007;316:1039–1043.; Yu H.A., Arcila M.E., Rekhtman N., Sima C.S., Zakowski M.F., Pao W. et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res. 2013;19:2240–2247.; Soria J.C., Wu Y.L., Nakagawa K. et al. Gefi tinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation-positive non-smallcell lung cancer after progression on first-line gefi tinib (IMPRESS): a phase 3 randomised trial. Lancet Oncol. 2015;16:990–98.; Saito H., Fukuhara T. et al. Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous nonsmall- cell lung cancer (NEJ026): interim analysis of an open-label, randomised, multicentre, phase 3 trial. Lancet Oncol. 2019;20:625–35.; Nakamura A., Inoue A. et al. Phase III study comparing gefitinib monotherapy (G) to combination therapy with gefitinib, carboplatin, and pemetrexed (GCP) for untreated patients (pts) with advanced non-small cell lung cancer (NSCLC) with EGFR mutations (NEJ009). Journal of Clinical Oncology. 2018 May 20;36(15_suppl):9005-9005.; https://www.med-sovet.pro/jour/article/view/3060

الاتاحة: https://www.med-sovet.pro/jour/article/view/3060
https://doi.org/10.21518/2079-701X-2019-10-110-114

المؤلفون: L. Nelyubina A., E. Reutova V., K. Laktionov K., D. Yudin I., D. Marinov T., E. Kozak N., V. Mochalnikova V., Л. Нелюбина А., Е. Реутова В., К. Лактионов К., Д. Юдин И., Д. Маринов Т., Е. Козак Н., В. Мочальникова В.

المصدر: Meditsinskiy sovet = Medical Council; № 19 (2018); 130-135 ; Медицинский Совет; № 19 (2018); 130-135 ; 2658-5790 ; 2079-701X ; 10.21518/2079-701X-2018-19

مصطلحات موضوعية: non-small cell lung cancer, activating mutations, EGFR, small cell cancer, EGFR tyrosine kinase inhibitors, resistance, rebiopsy, немелкоклеточный рак легкого, активирующие мутации, мелкоклеточный рак, ингибиторы тирозинкиназ EGFR, резистентность, ребиопсия

وصف الملف: application/pdf

Relation: https://www.med-sovet.pro/jour/article/view/2761/2713; Rosell R, Carcereny E, Gervais R et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive nonsmall-cell lung cancer (EU_ RTAC): a multicentre, open-label, randomized phase 3 trial. Lancet Oncol, 2012, 13(3): 239-246.; Sequist LV, Yang JC, Yamamoto N, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol, 2013, 31: 3327-3334.; Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol, 2012, 13: 239-246.; Nishino M, Cardarella S, Jackman DM et al. RECIST 1.1 in NSLC patients with EGFR mutations treated with EGFR tyrosine kinase inhibitors: comparison with RECIST 1.0. AJR Am J Roentgenol, 2013, 201: W64-71.; Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatinpaclitaxel in pulmonary adenocarcinoma. N Engl J Med, 2009, 361: 947-957.; Mok TS, Wu YL, Ahn MJ, et al. Osimertinib or platinumpemetrexed in EGFR T790M-positive lung cancer. N Engl J Med, 2017, 376: 629-640.; Riely GJ, Yu HA. EGFR: the paradigm of an oncogene-driven lung cancer. Clin Cancer Res, 2015, 21: 2221-2226.; Yu PP, Vose JM, Hayes DF. Genetic cancer susceptibility testing: increased technology, increased complexity. J Clin Oncol, 2015, 33: 3533-3534.; Yu HA, Arcila ME, Rekhtman N, et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res, 2013, 19: 2240-2247.; Finlay MR, Anderton M, Ashton S, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem, 2014, 57: 8249-8267.; Gainor JF, Shaw AT. Emerging paradigms in the development of resistance to tyrosine kinase inhibitors in lung cancer. J Clin Oncol, 2013, 31: 3987-3996.; Onitsuka T, Uramoto H, Nose N, et al. Acquired resistance to gefitinib: the contribution of mechanisms other than the T790M, MET, and HGF status. Lung Cancer, 2010, 68: 198-203.; Lfnger CJ. Epidermal growth factor receptor inhibition in mutation-positive non-small-cell lung cancer: is afatinib better or simply newer? J Clin Oncol, 2013, 31: 3303-3306.; Sequist LV, Waltman BA, Dias-Santagata D, Digumarthy S, Turke AB, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med, 2011 Mar 23, 3(75): 75ra26.; Thomson S, Buck E, Petti F, Griffin G et al. Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Res, 2005 Oct 15, 65(20): 9455-62.; Qiuxiang Ou, Xue Wu, Hua Bao et al. Investigating novel resistance mechanisms to third generation EGFR TKI osimertinib in non-small cell lung cancer patients using next generation sequencing. J Clin Oncol, 2017, suppl 2572.; https://www.med-sovet.pro/jour/article/view/2761

الاتاحة: https://www.med-sovet.pro/jour/article/view/2761
https://doi.org/10.21518/2079-701X-2018-19-130-135

المؤلفون: К. LAKTIONOV К., М. PEREGUDOVA V., V. BREDER V., E. REUTOVA V., D. PEREGUDOV A., M. ARDZINBA S., P. CHERNENKO A., D. MARINOV T., К. ЛАКТИОНОВ К., М. ПЕРЕГУДОВА В., В. БРЕДЕР В., Е. РЕУТОВА В., Д. ПЕРЕГУДОВ А., М. АРДЗИНБА С., П. ЧЕРНЕНКО А., Д. МАРИНОВ Т.

المصدر: Meditsinskiy sovet = Medical Council; № 10 (2016); 66-72 ; Медицинский Совет; № 10 (2016); 66-72 ; 2658-5790 ; 2079-701X ; 10.21518/2079-701X-2016-10

مصطلحات موضوعية: non-small-cell lung cancer, adenocarcinoma, EGFR mutation, Del19, L858R, afatinib, немелкоклеточный рак легкого, аденокарцинома, мутация гена EGFR, афатиниб

وصف الملف: application/pdf

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Published online ahead of print at www.jco.org on August 31, 2015. doi:10.1200/JCO.2014.60.6624 Clin Oncol, 33. © 2015 by American Society of Clinical Oncology.; https://www.med-sovet.pro/jour/article/view/1407

الاتاحة: https://www.med-sovet.pro/jour/article/view/1407
https://doi.org/10.21518/2079-701X-2016-10-66-72