المؤلفون: Claudia Andrea Vilchis-Nestor, María Luisa Roldán, Angelina Leonardi, Juan G. Navea, Teresita Padilla-Benavides, Liora Shoshani

المصدر: International Journal of Molecular Sciences; Volume 20; Issue 9; Pages: 2111

مصطلحات موضوعية: Na + ,K + -ATPase, β 1 subunit, Ouabain, cSrc, pNaKtide, cell adhesion

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Biophysics; https://dx.doi.org/10.3390/ijms20092111

الاتاحة: https://doi.org/10.3390/ijms20092111

المؤلفون: Claudia Andrea Vilchis-Nestor, María Luisa Roldán, Angelina Leonardi, Juan G. Navea, Teresita Padilla-Benavides, Liora Shoshani

المصدر: International Journal of Molecular Sciences, Vol 20, Iss 9, p 2111 (2019)

مصطلحات موضوعية: Na + ,K + -ATPase, β 1 subunit, Ouabain, cSrc, pNaKtide, cell adhesion, Biology (General), QH301-705.5, Chemistry, QD1-999

Relation: https://www.mdpi.com/1422-0067/20/9/2111; https://doaj.org/toc/1422-0067; https://doaj.org/article/80d2b535bd744ab399fefa768a6d0107

الاتاحة: https://doi.org/10.3390/ijms20092111
https://doaj.org/article/80d2b535bd744ab399fefa768a6d0107

المؤلفون: Claudia Andrea Vilchis-Nestor, María Luisa Roldán, Angelina Leonardi, Juan G. Navea, Teresita Padilla-Benavides, Liora Shoshani

المصدر: International Journal of Molecular Sciences, Vol 20, Iss 9, p 2111 (2019)

مصطلحات موضوعية: Na + ,K + -ATPase, β 1 subunit, Ouabain, cSrc, pNaKtide, cell adhesion, Biology (General), QH301-705.5, Chemistry, QD1-999, socio, envir

Relation: https://doi.org/10.3390/ijms20092111

الاتاحة: https://doi.org/10.3390/ijms20092111

المؤلفون: Uebachs, Mischa, Albus, Christina, Opitz, Thoralf, Isom, Lori, Niespodziany, Isabelle, Wolff, Christian, Beck, Heinz

المساهمون: Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, U.S.A., Department of Epileptology, University of Bonn, Bonn, Germany, UCB Pharma, Braine l’Alleud, Belgium

مصطلحات موضوعية: Carbamazepine, Sodium Channel Beta Subunits, β 1 Subunit, Persistent Sodium Current, I NaP, Epilepsy, Lacosamide, Medicine (General), Health Sciences

وصف الملف: application/pdf

Relation: Uebachs, Mischa; Albus, Christina; Opitz, Thoralf; Isom, Lori; Niespodziany, Isabelle; Wolff, Christian; Beck, Heinz (2012). "Loss of β 1 accessory Na + channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high‐frequency firing via differential effects on persistent Na + currents." Epilepsia 53(11).; https://hdl.handle.net/2027.42/94523; Epilepsia; Sekerli M, Negro CAD, Lee RH, Butera RJ. ( 2004 ) Estimating action potential thresholds from neuronal time‐series: new metrics and evaluation of methodologies. IEEE Trans Biomed Eng 51: 1665 – 1672.; Wallace RH, Wang DW, Singh R, Scheffer IE, George A Jr, Phillips HA, Saar K, Reis A, Johnson EW, Sutherland GR, Berkovic SF, Mulley JC. ( 1998 ) Febrile seizures and generalized epilepsy associated with a mutation in the Na + ‐channel beta1 subunit gene SCN1B. Nat Genet 19: 366 – 370.; Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O’Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LL. ( 2004 ) Mice lacking sodium channel beta1 subunits display defects in neuronal excitability sodium channel expression and nodal architecture. J Neurosci 24: 4030 – 4042.; Cross SA, Curran MP. ( 2009 ) Lacosamide: in partial‐onset seizures. Drugs 69: 449 – 459.; Duncan GE, Kohn H. ( 2005 ) The novel antiepileptic drug lacosamide blocks behavioral and brain metabolic manifestations of seizure activity in the 6 Hz psychomotor seizure model. Epilepsy Res 67: 81 – 87.; Ellerkmann RK, Remy S, Chen J, Sochivko D, Elger CE, Urban BW, Becker A, Beck H. ( 2003 ) Molecular and functional changes in voltage‐dependent Na + channels following pilocarpine‐induced status epilepticus in rat dentate granule cells. Neuroscience 119: 323 – 333.; Errington AC, Stöhr T, Heers C, Lees G. ( 2008 ) The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage‐gated sodium channels. Mol Pharmacol 73: 157 – 169.; Gastaldi M, Robaglia‐Schlupp A, Massacrier A, Planells R, Cau P. ( 1998 ) mRNA coding for voltage‐gated sodium channel beta2 subunit in rat central nervous system: cellular distribution and changes following kainate‐induced seizures. Neurosci Lett 249: 53 – 56.; Greenaway C, Ratnaraj N, Sander JW, Patsalos PN. ( 2011 ) Saliva and serum lacosamide concentrations in patients with epilepsy. Epilepsia 52: 258 – 263.; Kazen‐Gillespie KA, Ragsdale DS, D’Andrea MR, Mattei LN, Rogers KE, Isom LL. ( 2000 ) Cloning localization and functional expression of sodium channel beta1A subunits. J Biol Chem 275: 1079 – 1088.; Kellinghaus C. ( 2009 ) Lacosamide as treatment for partial epilepsy: mechanisms of action, pharmacology, effects, and safety. Ther Clin Risk Manag 5: 757 – 766.; Kuo CC, Huang RC, Lou BS. ( 2000 ) Inhibition of Na + current by diphenhydramine and other diphenyl compounds: molecular determinants of selective binding to the inactivated channels. Mol Pharmacol 57: 135 – 143.; Lees G, Stöhr T, Errington AC. ( 2006 ) Stereoselective effects of the novel anticonvulsant lacosamide against 4‐AP induced epileptiform activity in rat visual cortex in vitro. Neuropharmacology 50: 98 – 110.; Meadows LS, Malhotra J, Loukas A, Thyagarajan V, Kazen‐Gillespie KA, Koopman MC, Kriegler S, Isom LL, Ragsdale DS. ( 2002 ) Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1. J Neurosci 22: 10699 – 10709.; Müller A, Kukley M, Uebachs M, Beck H, Dietrich D. ( 2007 ) Nanodomains of single Ca 2+ channels contribute to action potential repolarization in cortical neurons. J Neurosci 27: 483 – 495.; Nicot A, Ratnakar PV, Ron Y, Chen CC, Elkabes S. ( 2003 ) Regulation of gene expression in experimental autoimmune encephalomyelitis indicates early neuronal dysfunction. Brain 126: 398 – 412.; Patino GA, Claes LRF, Lopez‐Santiago LF, Slat EA, Dondeti RSR, Chen C, O’Malley HA, Gray CBB, Miyazaki H, Nukina N, Oyama F, Jonghe PD, Isom LL. ( 2009 ) A functional null mutation of SCN1B in a patient with Dravet syndrome. J Neurosci 29: 10764 – 10778.; Ragsdale DS, McPhee JC, Scheuer T, Catterall WA. ( 1996 ) Common molecular determinants of local anesthetic antiarrhythmic and anticonvulsant block of voltage‐gated Na + channels. Proc Natl Acad Sci USA 93: 9270 – 9275.; Sashihara S, Greer CA, Oh Y, Waxman SG. ( 1996 ) Cell‐specific differential expression of Na + ‐channel beta 1‐subunit mRNA in the olfactory system during postnatal development and after denervation. J Neurosci 16: 702 – 713.; Schaub C, Uebachs M, Beck H. ( 2007 ) Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy. Epilepsia 48: 1339 – 1350.; Sheets PL, Heers C, Stoehr T, Cummins TR. ( 2008 ) Differential block of sensory neuronal voltage‐gated sodium channels by lacosamide [(2R)‐2‐(acetylamino)‐N‐benzyl‐3‐methoxypropanamide] lidocaine and carbamazepine. J Pharmacol Exp Ther 326: 89 – 99.; Stöhr T, Kupferberg HJ, Stables JP, Choi D, Harris RH, Kohn H, Walton N, White HS. ( 2007 ) Lacosamide a novel anti‐convulsant drug shows efficacy with a wide safety margin in rodent models for epilepsy. Epilepsy Res 74: 147 – 154.; Sun GC, Werkman TR, Battefeld A, Clare JJ, Wadman WJ. ( 2007 ) Carbamazepine and topiramate modulation of transient and persistent sodium currents studied in HEK293 cells expressing Na V 1.3 alpha‐subunit. Epilepsia 48: 774 – 782.; Taverna S, Mantegazza M, Franceschetti S, Avanzini G. ( 1998 ) Valproate selectively reduces the persistent fraction of Na + current in neocortical neurons. Epilepsy Res 32: 304 – 308.; Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H. ( 2010 ) Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. J Neurosci 30: 8489 – 8501.; Vervaeke K, Hu H, Graham LJ, Storm JF. ( 2006 ) Contrasting effects of the persistent Na + current on neuronal excitability and spike timing. Neuron 49: 257 – 270.; Wang Y, Park KD, Salome C, Wilson SM, Stables JP, Liu R, Khanna R, Kohn H. ( 2011 ) Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage‐gated sodium channels. ACS Chem Neurosci 2: 90 – 106.; Xu J, Kang N, Jiang L, Nedergaard M, Kang J. ( 2005 ) Activity‐dependent long‐term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons. J Neurosci 25: 1750 – 1760.; Yang YC, Hsieh JY, Kuo CC. ( 2009 ) The external pore loop interacts with S6 and S3‐S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na + channel. J Gen Physiol 134: 95 – 113.; Yue C, Remy S, Su H, Beck H, Yaari Y. ( 2005 ) Proximal persistent Na + channels drive spike afterdepolarizations and associated bursting in adult CA1 pyramidal cells. J Neurosci 25: 9704 – 9720.; Andurkar SV, Stables JP, Kohn H. ( 1999 ) The anticonvulsant activities of N‐benzyl 3‐methoxypropionamides. Bioorg Med Chem 7: 2381 – 2389.; Brandt C, Heile A, Potschka H, Stoehr T, Löscher W. ( 2006 ) Effects of the novel antiepileptic drug lacosamide on the development of amygdala kindling in rats. Epilepsia 47: 1803 – 1809.

الاتاحة: https://hdl.handle.net/2027.42/94523
https://doi.org/10.1111/j.1528-1167.2012.03675.x