المؤلفون: Chaim Gilon (2061241), Michal Klazas (11752309), Adi Lahiani (4726647), Adi Schumacher-Klinger (9632462), Shira Merzbach (11752312), Johnny N. Naoum (11752315), Haim Ovadia (450228), Limor Rubin (9947803), Susan Cornell-Kennon (2358031), Erik M. Schaefer (9199976), Jehoshua Katzhendler (2532127), Cezary Marcinkiewicz (2470129), Amnon Hoffman (2044624), Philip Lazarovici (299587)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, α4 integrin antibodies, developing new therapies, design may pave, conformational diversity based, central nervous system, 4 – 4, target ” effects, adverse effects associated, experimental autoimmune encephalomyelitis, data justify visabron, blocking leukocyte trafficking, toxic effects, leukocyte activation, autoimmune diseases, vivo <, vitro <, viper venom, tissue pathology, significant tolerability, serum stability, sequence tmld, proteinous disintegrin

Relation: https://figshare.com/articles/journal_contribution/Synthesis_and_Pharmacological_Characterization_of_Visabron_a_Backbone_Cyclic_Peptide_Dual_Antagonist_of_4_1_VLA-4_9_1_Integrin_for_Therapy_of_Multiple_Sclerosis/17078020

الاتاحة: https://doi.org/10.1021/jacsau.1c00496.s001

المؤلفون: Mina Kim, Kyung-Ho Jung, Jung Lim Kim, Hyun-Jung Koo, Hye Jin Jung, Hyunjong Lee, Kyung-Han Lee

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Plant Biology, Space Science, Chemical Sciences not elsewhere classified, α4 integrin level, target delivery properties, proteasome inhibitor bortezomib, positron emission tomography, humanized monoclonal antibody, 7 days postinjection, expressing molt4 human, 93 ± 0, 51 ± 0, 33 ± 0, 22 ± 0, 12 ± 0, cultured molt4 cells, biodistribution studies confirmed, 89 , molt4 leukemia tumors, g ), followed, tumor vla4 regulation

Relation: https://figshare.com/articles/dataset/Imaging_Very_Late_Antigen_4_on_MOLT4_Leukemia_Tumors_with_Cysteine_Site-Specific_sup_89_sup_Zr-Labeled_Natalizumab_Immuno-Positron_Emission_Tomography/25101252

الاتاحة: https://doi.org/10.1021/acs.molpharmaceut.3c01024.s001

المؤلفون: Goldfinger, Lawrence E., Han, Jaewon, Kiosses, William B., Howe, Alan K., Ginsberg, Mark H.

المصدر: The Journal of Cell Biology, 2003 Aug . 162(4), 731-741.

URL الوصول: https://www.jstor.org/stable/1621777

المؤلفون: Rohan Chawla, Madhu Nath, Laxmi Moksha, Tapas C Nag, Thirumurthy Velpandian

المصدر: Indian Journal of Ophthalmology, Vol 66, Iss 10, Pp 1441-1445 (2018)

مصطلحات موضوعية: α4 integrin intravitreal injection, electroretinogram, natalizumab, uveitis, Ophthalmology, RE1-994

وصف الملف: electronic resource

Relation: http://www.ijo.in/article.asp?issn=0301-4738;year=2018;volume=66;issue=10;spage=1441;epage=1445;aulast=Chawla; https://doaj.org/toc/0301-4738; https://doaj.org/toc/1998-3689

URL الوصول: https://doaj.org/article/0226d56d496748c3866315897af14c79

المؤلفون: Kathleen M. Woods Ignatoski, Navdeep K. Grewal, Sonja Markwart, Donna L. Livant, Stephen P. Ethier

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 2, Pp 128-134 (2003)

مصطلحات موضوعية: Rac 1, p38MAPK, α4 integrin, invasion, erbB-2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558603800040; https://doaj.org/toc/1476-5586; https://doaj.org/toc/1522-8002

URL الوصول: https://doaj.org/article/f6b5fa36f950403288dee93d2ebec07c

المؤلفون: K Nakajima, Fumihito Hirai, Mamoru Watanabe, Y Ishiguro, K Kanke, Kenji Watanabe, T Ohmori, Tetsuya Ishida, Kiyonori Kobayashi, Toshifumi Hibi, Katsuyoshi Matsuoka

المصدر: Journal of Crohn's and Colitis. 15:S031-S032

مصطلحات موضوعية: medicine.medical_specialty, business.industry, medicine.medical_treatment, Gastroenterology, Antagonist, General Medicine, Placebo, medicine.disease, Ulcerative colitis, Double blind, Induction therapy, Internal medicine, Disease remission, medicine, α4 integrin, business, Neoadjuvant therapy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e190f8b66edd0d8321b1e1d4e192429d
https://doi.org/10.1093/ecco-jcc/jjab075.033

المؤلفون: Yuta Hirano, Motoki Ichikawa, Kunitoshi Kobayashi, Chang-Sung Koh, Yuhji Inaba, Byung S. Kim, Hiroki Tomiki

المصدر: International Immunology

مصطلحات موضوعية: 0301 basic medicine, Multiple Sclerosis, Integrin alpha4, Immunology, Integrin, Mice, Inbred Strains, Peripheral blood mononuclear cell, TMEV-induced demyelinating disease (TMEV-IDD), Mice, 03 medical and health sciences, 0302 clinical medicine, Natalizumab, Antigen, Theilovirus, medicine, Demyelinating disease, Animals, Immunology and Allergy, Original Research, biology, business.industry, Multiple sclerosis, General Medicine, medicine.disease, Disease Models, Animal, 030104 developmental biology, Theiler’s murine encephalomyelitis virus (TMEV), α4 integrin inhibitor, biology.protein, Female, α4 integrin, Antibody, business, 030217 neurology & neurosurgery, CD8, Demyelinating Diseases, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dff04a4e0ff58176d7edc2643671de5
https://doi.org/10.1093/intimm/dxw045

المؤلفون: Ellen M. Mowry, Irene Cortese, Nathan T Tagg, Kaylan Fenton, Daniel S. Reich, Matthew K. Schindler, Robert W Foley

المصدر: Multiple Sclerosis Journal. 23:1424-1427

مصطلحات موضوعية: Adult, Pathology, medicine.medical_specialty, medicine.drug_class, Central nervous system, Monoclonal antibody, law.invention, 03 medical and health sciences, Multiple Sclerosis, Relapsing-Remitting, 0302 clinical medicine, Natalizumab, Recurrence, law, medicine, Humans, Immunologic Factors, Meningitis, Aseptic, 030212 general & internal medicine, α4 integrin, business.industry, Multiple sclerosis, Aseptic meningitis, medicine.disease, medicine.anatomical_structure, Neurology, Immunology, Recombinant DNA, Female, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5f91eca2731012ea4574f8ff94386e
https://doi.org/10.1177/1352458517702533

المؤلفون: Rehana Z. Hussain, Todd N. Eagar, Richard Doelger, Valerie Granados, William A. Miller-Little, Olaf Stüve, Petra D. Cravens, Darin T. Okuda, Emily Herndon

المصدر: Neurology® Neuroimmunology & Neuroinflammation

مصطلحات موضوعية: 0301 basic medicine, Central Nervous System, Adoptive cell transfer, Encephalomyelitis, Integrin alpha4, T-Lymphocytes, Disease, Mice, 0302 clinical medicine, immune system diseases, Bone Marrow, Medicine, α4 integrin, Mice, Knockout, B-Lymphocytes, biology, Experimental autoimmune encephalomyelitis, Brain, Adoptive Transfer, ddc, medicine.anatomical_structure, Neurology, Spinal Cord, Cytokines, medicine.symptom, Encephalomyelitis, Autoimmune, Experimental, T cell, Antigens, CD19, Inflammation, Affect (psychology), Article, CD19, Myelin oligodendrocyte glycoprotein, 03 medical and health sciences, Antigen, 030225 pediatrics, Animals, business.industry, Correction, medicine.disease, Molecular biology, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Cancer research, biology.protein, Neurology (clinical), Lymph Nodes, business, 030217 neurology & neurosurgery, Spleen

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83aa286482af82048134aa19b22320fe
https://pubmed.ncbi.nlm.nih.gov/31403056

المؤلفون: Theo Rispens, Zoé L. E. van Kempen, Joep Killestein, Anja ten Brinke, Iris Claessen, Annick de Vries, Bob W. van Oosten, Djoeke Doesburg, Johannis A. van Rossum

المساهمون: AII - Inflammatory diseases, Amsterdam Neuroscience - Neuroinfection & -inflammation, Neurology, Landsteiner Laboratory, AII - Infectious diseases

المصدر: Journal of Neurology, 266(7), 1804-1805. D. Steinkopff-Verlag
Journal of neurology, 266(7), 1804-1805. D. Steinkopff-Verlag
van Kempen, Z L E, van Rossum, J A, Doesburg, D, Claessen, I, de Vries, A, ten Brinke, A, van Oosten, B W, Rispens, T & Killestein, J 2019, ' Anti-natalizumab antibodies during 8 years of natalizumab treatment: effect on natalizumab concentration and α4-integrin receptor saturation ', Journal of Neurology, vol. 266, no. 7, pp. 1804-1805 . https://doi.org/10.1007/s00415-019-09327-8

مصطلحات موضوعية: biology, business.industry, Pharmacology, Natalizumab, Neurology, medicine, biology.protein, Treatment effect, Neurology (clinical), α4 integrin, Antibody, Saturation (chemistry), Receptor, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c8c1dad9e37f086df7650ff33731be
https://doi.org/10.1007/s00415-019-09327-8

المؤلفون: Ikuyo NAKAJIMA, Koichi CHIKUNI, Susumu MUROYA

المصدر: Nihon Chikusan Gakkaiho. 2001, 72(6):505

المؤلفون: Tatyana Ulyanova, Grigorios Georgolopoulos, Thalia Papayannopoulou

المصدر: Exp Hematol

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Integrin, Integrin alpha5, Integrin alpha4beta1, Biology, Article, Fight-or-flight response, Mice, 03 medical and health sciences, 0302 clinical medicine, Erythroid Cells, Stress, Physiological, hemic and lymphatic diseases, Genetics, Animals, Erythropoiesis, α4 integrin, Stem Cell Niche, Molecular Biology, Mice, Knockout, Integrin beta1, Macrophages, β1 integrin, Cell Biology, Hematology, Cell biology, Haematopoiesis, 030104 developmental biology, 030220 oncology & carcinogenesis, Erythroid cell, biology.protein, α5 integrin, Integrin alpha5beta1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ffa1381ab4105d3e28f6c02b93729c
https://doi.org/10.1016/j.exphem.2019.12.004

المؤلفون: Roland Martin, Christoph Heesen, Sven Schippling

المصدر: Aktuelle Neurologie. 35:169-176

مصطلحات موضوعية: medicine.drug_class, business.industry, Multiple sclerosis, medicine.disease, Bioinformatics, Monoclonal antibody, Neuroprotection, Cell therapy, Natalizumab, Advanced phase, Immunology, medicine, Neurology (clinical), α4 integrin, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e0eca1f90e73ae76967f2b7c52a8e952
https://doi.org/10.1055/s-2008-1067375

المؤلفون: Edward C. Lawson, William A. Kinney, Carol M. Fisher, Bruce E. Maryanoff, Rosemary J. Santulli, Bruce P. Damiano

المصدر: Letters in Drug Design & Discovery. 2:601-605

مصطلحات موضوعية: Stereochemistry, Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Alpha (ethology), α4 integrin, Pyrrole derivatives, Biological evaluation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3ed9b153c2bd66e97201940cb8590c7d
https://doi.org/10.2174/157018005774717280

المؤلفون: Donna L. Livant, Kathleen M. Woods Ignatoski, Stephen P. Ethier, Navdeep K. Grewal, Sonja Markwart

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 2, Pp 128-134 (2003)

مصطلحات موضوعية: Cancer Research, Pyridines, Receptor, ErbB-2, Integrin alpha4, Cell Separation, CD49c, p38 Mitogen-Activated Protein Kinases, Collagen receptor, 0302 clinical medicine, Enzyme Inhibitors, Cytoskeleton, Genes, Dominant, 0303 health sciences, Imidazoles, Flow Cytometry, invasion, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cell biology, Protein Transport, Cell Transformation, Neoplastic, Phenotype, Integrin alpha M, 030220 oncology & carcinogenesis, p38MAPK, Integrin, beta 6, Electrophoresis, Polyacrylamide Gel, Signal transduction, Mitogen-Activated Protein Kinases, Signal Transduction, Research Article, Rac 1, Integrin, Down-Regulation, Biology, Models, Biological, lcsh:RC254-282, Cell Line, 03 medical and health sciences, Downregulation and upregulation, Cell Line, Tumor, Humans, Neoplasm Invasiveness, 030304 developmental biology, Integrin binding, erbB-2, Cell Membrane, Actins, Fibronectins, Retroviridae, biology.protein, α4 integrin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64ab1638f39af7a893cb0cfe35f7019

المؤلفون: Madhu Nath, Laxmi Moksha, Tapas Chandra Nag, Thirumurthy Velpandian, Rohan Chawla

المصدر: Indian Journal of Ophthalmology, Vol 66, Iss 10, Pp 1441-1445 (2018)
Indian Journal of Ophthalmology

مصطلحات موضوعية: medicine.medical_specialty, genetic structures, electroretinogram, Outer plexiform layer, Retina, α4 integrin intravitreal injection, 03 medical and health sciences, natalizumab, 0302 clinical medicine, Natalizumab, lcsh:Ophthalmology, Ophthalmology, Electroretinography, Animals, Immunologic Factors, Medicine, Prospective Studies, Dose-Response Relationship, Drug, medicine.diagnostic_test, business.industry, Fundus photography, medicine.disease, eye diseases, Disease Models, Animal, medicine.anatomical_structure, lcsh:RE1-994, Intravitreal Injections, Toxicity, Inner nuclear layer, uveitis, 030221 ophthalmology & optometry, Original Article, Rabbits, sense organs, business, Erg, 030217 neurology & neurosurgery, Uveitis, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed894827cbd60263784e5469d46cb898
https://doi.org/10.4103/ijo.ijo_425_18

المؤلفون: Justin M. Honce, Eric Nyberg, Lidia Nagae

المصدر: Multiple Sclerosis International, Vol 2015 (2015)
Multiple Sclerosis International

مصطلحات موضوعية: Oncology, medicine.medical_specialty, business.industry, Multiple sclerosis, Progressive multifocal leukoencephalopathy, Review Article, Disease, medicine.disease, lcsh:RC346-429, Discontinuation, Natalizumab, Neuroimaging, Immune reconstitution inflammatory syndrome, Internal medicine, medicine, Neurology (clinical), α4 integrin, business, lcsh:Neurology. Diseases of the nervous system, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93dbfaa03ffb76ce9a5bdfd9dcf8228
https://doaj.org/article/e491577b615b4f1296e4dd4835cd247a

المؤلفون: Jörg Metzler, Eduard F. Stange

المصدر: Medizinische Klinik. 97:290-297

مصطلحات موضوعية: Interleukin 11, Gynecology, Interleukin 10, medicine.medical_specialty, business.industry, Gastroenterology, Medicine, Surgery, General Medicine, α4 integrin, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff06af1f244077ec92f19df793d54d1d
https://doi.org/10.1007/s00063-002-1156-6

المؤلفون: Avinash Thakur, Ludwig Kappos, Ying Zhang, Tobias Derfuss, Heinz Wiendl, Marina Savelieva, John M. Kovarik, Richa Chhabra, Davorka Tomic

المصدر: Neurology® Neuroimmunology & Neuroinflammation

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Randomization, business.industry, Washout, Gastroenterology, Fingolimod, Article, Discontinuation, Disease activity, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Natalizumab, Neurology, Internal medicine, medicine, Neurology (clinical), α4 integrin, Receptor, business, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba67f511a42a9fa53dbe4fafc13251b
https://doi.org/10.1212/nxi.0000000000000388

المؤلفون: Christoph Kleinschnitz, Friederike Langhauser, Heinz Wiendl

المصدر: Stroke. 45

مصطلحات موضوعية: Advanced and Specialized Nursing, medicine.medical_specialty, Blocking (radio), business.industry, Disease, medicine.disease, Clinical trial, Brain ischemia, Natalizumab, medicine, Physical therapy, Neurology (clinical), α4 integrin, Animal studies, Cardiology and Cardiovascular Medicine, Intensive care medicine, business, Stroke, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e4eb26bf4f3ccea15909fe7da4e8db07
https://doi.org/10.1161/strokeaha.114.006634