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1Academic Journal
المؤلفون: Guzik, Katarzyna, Zak, Krzysztof M., Grudnik, Przemyslaw, Magiera, Katarzyna, Musielak, Bogdan, Törner, Ricarda, Skalniak, Lukasz, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.
المصدر: Guzik , K , Zak , K M , Grudnik , P , Magiera , K , Musielak , B , Törner , R , Skalniak , L , Dömling , A , Dubin , G & Holak , T A 2017 , ' Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1 ' , Journal of Medicinal Chemistry , vol. 60 , no. 13 , pp. 5857-5867 . https://doi.org/10.1021/acs.jmedchem.7b00293
مصطلحات موضوعية: (2 methyl 3 biphenylyl)methanol, 1 [[3 bromo 4 [(2 methyl 3 phenylphenyl)methoxy]phenyl]methyl]piperidine 2 carboxylic acid, 1 [[5 chloro 2 [(3 cyanophenyl)methoxy] 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy]phenyl] methyl] 4 hydroxypyrrolidine 2 carboxylic acid hydrochloride, 2 [[[2 [(3 cyanophenyl)methoxy] 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 5 methylphenyl] methyl]amino] 3 hydroxypropanoic acid hydrochloride, 2 [[[2,6 dimethoxy 4 [(2 methyl 3 phenylphenyl)methoxy]phenyl]methyl]amino] 3 methylbutan 1 ol hydrochloride, 2 methoxy 6 [(2 methyl 3 phenylphenyl)methoxy]pyridine 3 carbaldehyde, 2,6 dimethoxy 4 [(2 methyl 3 phenylphenyl)methoxy]benzaldehyde, 3 [4 chloro 5 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 formylphenoxymethyl]benzonitrile, 3 [5 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 formyl 4 methylphenoxymethyl]benzonitrile, 3 bromo 4 [(2 methyl 3 phenylphenyl)methoxy]benzaldehyde, 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 hydroxy 5 methylbenzaldehyde, 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2,5 difluorobenzaldehyde, 4 [[[4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2methylphenyl]methoxy] 2,5 difluorophenyl]methyl]amino] 3 hydroxybutanoic acid hydrochloride, 5 chloro 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 hydroxybenzaldehyde, [3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methanol, immunomodulating agent, n [2 [[[2 methoxy 6 [(2 methyl 3 phenylphenyl)methoxy]pyridin 3 yl]methyl]amino]ethyl]acetamide hydrochloride, programmed death 1 ligand 1, protein inhibitor, unclassified drug, article, cancer immunotherapy, crystallization, dimerization, drug determination, drug structure, drug synthesis, heteronuclear multiple quantum coherence, human, hydrophobicity
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المؤلفون: Przemyslaw Grudnik, Lukasz Skalniak, Bogdan Musielak, Katarzyna Magiera, Grzegorz Dubin, Tad A. Holak, Krzysztof M. Zak, Ricarda Törner, Alexander Dömling, Katarzyna Guzik
المساهمون: Drug Design, Medicinal Chemistry and Bioanalysis (MCB)
المصدر: Journal of Medicinal Chemistry, 60(13), 5857-5867. AMER CHEMICAL SOC
مصطلحات موضوعية: 0301 basic medicine, 4 benzodioxin 6 yl) 2 methylphenyl]methanol, crystallization, medicine.medical_treatment, 4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 hydroxy 5 methylbenzaldehyde, 2,6 dimethoxy 4 [(2 methyl 3 phenylphenyl)methoxy]benzaldehyde, Programmed Cell Death 1 Receptor, 6 dimethoxy 4 [(2 methyl 3 phenylphenyl)methoxy]phenyl]methyl]amino] 3 methylbutan 1 ol hydrochloride, 4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2, IC50, X ray analysis, Crystallography, X-Ray, B7-H1 Antigen, 1 [[3 bromo 4 [(2 methyl 3 phenylphenyl)methoxy]phenyl]methyl]piperidine 2 carboxylic acid, 0302 clinical medicine, Protein structure, Cancer immunotherapy, 6 dimethoxy 4 [(2 methyl 3 phenylphenyl)methoxy]benzaldehyde, 4 benzodioxin 6 yl) 2methylphenyl]methoxy] 2, Drug Discovery, Protein Interaction Maps, drug determination, 3 [4 chloro 5 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 formylphenoxymethyl]benzonitrile, dimerization, biology, 4 [[[4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2methylphenyl]methoxy] 2,5 difluorophenyl]methyl]amino] 3 hydroxybutanoic acid hydrochloride, Chemistry, heteronuclear multiple quantum coherence, article, Nuclear magnetic resonance spectroscopy, 5 difluorobenzaldehyde, protein function, Ligand (biochemistry), Small molecule, unclassified drug, 2 methoxy 6 [(2 methyl 3 phenylphenyl)methoxy]pyridine 3 carbaldehyde, Molecular Docking Simulation, 030220 oncology & carcinogenesis, [3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methanol, Molecular Medicine, [3 (2, medicine.drug_class, Stereochemistry, 3 dihydro 1, 2 [[[2 [(3 cyanophenyl)methoxy] 4 [[3 (2, 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2,5 difluorobenzaldehyde, 4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 hydroxybenzaldehyde, 3 [4 chloro 5 [[3 (2, Monoclonal antibody, oligomerization, 4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 5 methylphenyl] methyl]amino] 3 hydroxypropanoic acid hydrochloride, Small Molecule Libraries, 3 [5 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 formyl 4 methylphenoxymethyl]benzonitrile, 03 medical and health sciences, 3 bromo 4 [(2 methyl 3 phenylphenyl)methoxy]benzaldehyde, PD-L1, n [2 [[[2 methoxy 6 [(2 methyl 3 phenylphenyl)methoxy]pyridin 3 yl]methyl]amino]ethyl]acetamide hydrochloride, 5 chloro 4 [[3 (2, medicine, 3 [5 [[3 (2, (2 methyl 3 biphenylyl)methanol, Humans, 2 [[[2, human, protein interaction, protein structure, protein expression, hydrophobicity, nuclear magnetic resonance spectroscopy, 1 [[5 chloro 2 [(3 cyanophenyl)methoxy] 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy]phenyl] methyl] 4 hydroxypyrrolidine 2 carboxylic acid hydrochloride, 4 benzodioxin 6 yl) 2 methylphenyl]methoxy]phenyl] methyl] 4 hydroxypyrrolidine 2 carboxylic acid hydrochloride, cancer immunotherapy, 2 [[[2,6 dimethoxy 4 [(2 methyl 3 phenylphenyl)methoxy]phenyl]methyl]amino] 3 methylbutan 1 ol hydrochloride, 5 difluorophenyl]methyl]amino] 3 hydroxybutanoic acid hydrochloride, 1 [[5 chloro 2 [(3 cyanophenyl)methoxy] 4 [[3 (2, Immune checkpoint, 4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 formylphenoxymethyl]benzonitrile, programmed death 1 ligand 1, drug structure, 030104 developmental biology, 4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 formyl 4 methylphenoxymethyl]benzonitrile, protein inhibitor, 2 [[[2 [(3 cyanophenyl)methoxy] 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 5 methylphenyl] methyl]amino] 3 hydroxypropanoic acid hydrochloride, 5 chloro 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 hydroxybenzaldehyde, 4 [[3 (2, biology.protein, drug synthesis, immunomodulating agent, 4 [[[4 [[3 (2, Protein Multimerization, 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 hydroxy 5 methylbenzaldehyde
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