المؤلفون: Scott H. Henderson (5315468), Fiona Sorrell (9095199), James Bennett (154826), Oleg Fedorov (244326), Marcus T. Hanley (9095202), Paulo H. Godoi (6400943), Roberta Ruela de Sousa (11224367), Sean Robinson (832893), Alexander Ashall-Kelly (11224370), Iva Hopkins Navratilova (9095205), Daryl S. Walter (2355013), Jonathan M. Elkins (1288767), Simon E. Ward (2237998)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, regulated kinase 1a, ray crystallography leads, pyrazolo ­[ 1, neuronal progenitor cells, good physicochemical properties, exhibited good permeability, >]­ pyridazine inhibitors, viable lead series, including alzheimer ’, excellent ligand efficiencies, 11 , >]­ pyridazines, vivo <, b <, specificity tyrosine, resolution x, oncologic indications, new therapies, neurodegenerative diseases, glycoprotein liability

Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Characterization_of_Selective_and_Ligand-Efficient_DYRK_Inhibitors/15097472

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01115.s004

المؤلفون: Scott H. Henderson (5315468), Fiona Sorrell (9095199), James Bennett (154826), Oleg Fedorov (244326), Marcus T. Hanley (9095202), Paulo H. Godoi (6400943), Roberta Ruela de Sousa (11224367), Sean Robinson (832893), Alexander Ashall-Kelly (11224370), Iva Hopkins Navratilova (9095205), Daryl S. Walter (2355013), Jonathan M. Elkins (1288767), Simon E. Ward (2237998)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, regulated kinase 1a, ray crystallography leads, pyrazolo ­[ 1, neuronal progenitor cells, good physicochemical properties, exhibited good permeability, >]­ pyridazine inhibitors, viable lead series, including alzheimer ’, excellent ligand efficiencies, 11 , >]­ pyridazines, vivo <, b <, specificity tyrosine, resolution x, oncologic indications, new therapies, neurodegenerative diseases, glycoprotein liability

Relation: https://figshare.com/articles/dataset/Discovery_and_Characterization_of_Selective_and_Ligand-Efficient_DYRK_Inhibitors/15097463

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01115.s001

المؤلفون: Scott H. Henderson (5315468), Fiona Sorrell (9095199), James Bennett (154826), Oleg Fedorov (244326), Marcus T. Hanley (9095202), Paulo H. Godoi (6400943), Roberta Ruela de Sousa (11224367), Sean Robinson (832893), Alexander Ashall-Kelly (11224370), Iva Hopkins Navratilova (9095205), Daryl S. Walter (2355013), Jonathan M. Elkins (1288767), Simon E. Ward (2237998)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, regulated kinase 1a, ray crystallography leads, pyrazolo ­[ 1, neuronal progenitor cells, good physicochemical properties, exhibited good permeability, >]­ pyridazine inhibitors, viable lead series, including alzheimer ’, excellent ligand efficiencies, 11 , >]­ pyridazines, vivo <, b <, specificity tyrosine, resolution x, oncologic indications, new therapies, neurodegenerative diseases, glycoprotein liability

Relation: https://figshare.com/articles/dataset/Discovery_and_Characterization_of_Selective_and_Ligand-Efficient_DYRK_Inhibitors/15097466

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01115.s002

المؤلفون: Scott H. Henderson (5315468), Fiona Sorrell (9095199), James Bennett (154826), Oleg Fedorov (244326), Marcus T. Hanley (9095202), Paulo H. Godoi (6400943), Roberta Ruela de Sousa (11224367), Sean Robinson (832893), Alexander Ashall-Kelly (11224370), Iva Hopkins Navratilova (9095205), Daryl S. Walter (2355013), Jonathan M. Elkins (1288767), Simon E. Ward (2237998)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, regulated kinase 1a, ray crystallography leads, pyrazolo ­[ 1, neuronal progenitor cells, good physicochemical properties, exhibited good permeability, >]­ pyridazine inhibitors, viable lead series, including alzheimer ’, excellent ligand efficiencies, 11 , >]­ pyridazines, vivo <, b <, specificity tyrosine, resolution x, oncologic indications, new therapies, neurodegenerative diseases, glycoprotein liability

Relation: https://figshare.com/articles/dataset/Discovery_and_Characterization_of_Selective_and_Ligand-Efficient_DYRK_Inhibitors/15097469

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01115.s003