المؤلفون: Xiaolong Gao, Han-I Yeh, Zhengrong Yang, Chen Fan, Fan Jiang, Rebecca J. Howard, Erik Lindahl, John C. Kappes, Tzyh-Chang Hwang

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/86b783d0ca63434bb3730316e05145d3

المؤلفون: Xinxiu Fang, Jiunn-Tyng Yeh, Tzyh-Chang Hwang

المصدر: Frontiers in Molecular Biosciences, Vol 9 (2022)

مصطلحات موضوعية: CFTR, premature termination codon, nonsense mutations, CFTR correctors, read-through reagent, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2022.921680/full; https://doaj.org/toc/2296-889X

URL الوصول: https://doaj.org/article/4e430ee905ab43e39072ecb308e8adb4

المؤلفون: Winnie Khor, Tzyh-Chang Hwang, Chih-Chien Wang, Aliaksandr A. Yarmishyn, Jiunn-Tyng Yeh, Shih-Hwa Chiou, Shih-Jie Chou

المصدر: Stem Cell Research, Vol 60, Iss , Pp 102683- (2022)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506122000320; https://doaj.org/toc/1873-5061

URL الوصول: https://doaj.org/article/d320ba5238754044b926d5f68138bc5b

المؤلفون: Tzyh-Chang Hwang, Ineke Braakman, Peter van der Sluijs, Isabelle Callebaut

المساهمون: Institute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taiwan, Cellular Protein Chemistry, Bijvoet Centre for Biomolecular Research, Utrecht University, Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Journal of Cystic Fibrosis
Journal of Cystic Fibrosis, 2022, ⟨10.1016/j.jcf.2022.09.010⟩

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, [SDV]Life Sciences [q-bio], Pediatrics, Perinatology and Child Health, modulator, ABC transporter, potentiator, CFTR, corrector

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc78ad332251c42349e84b7d391c71a
https://doi.org/10.1016/j.jcf.2022.09.010

المؤلفون: Gert de Wilde, Maarten Gees, Sara Musch, Katleen Verdonck, Mia Jans, Anne-Sophie Wesse, Ashvani K. Singh, Tzyh-Chang Hwang, Thierry Christophe, Mathieu Pizzonero, Steven Van der Plas, Nicolas Desroy, Marlon Cowart, Pieter Stouten, Luc Nelles, Katja Conrath

المصدر: Frontiers in Pharmacology, Vol 10 (2019)

مصطلحات موضوعية: cystic fibrosis transmembrane conductance regulator (CFTR), cystic fibrosis, chloride channel, electrophysiology, protein misfolding, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.00514/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/8d68380c55104f5f99c3962f9d0c136b

المؤلفون: Maarten Gees, Sara Musch, Steven Van der Plas, Anne-Sophie Wesse, Ann Vandevelde, Katleen Verdonck, Oscar Mammoliti, Tzyh-Chang Hwang, Kathleen Sonck, Pieter Stouten, Andrew M. Swensen, Mia Jans, Jan Van der Schueren, Luc Nelles, Martin Andrews, Katja Conrath

المصدر: Frontiers in Pharmacology, Vol 9 (2018)

مصطلحات موضوعية: CF, CFTR, potentiator, bronchial epithelial cells, electrophysiology, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2018.01221/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/99852fe337bc4182a943b73d103f71f5

المؤلفون: Jingyao Zhang, Ying-Chun Yu, Jiunn-Tyng Yeh, Tzyh-Chang Hwang

المصدر: PLoS ONE, Vol 13, Iss 12, p e0209862 (2018)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/e6c4c1118f51469ba91e3b394fc2e79b

المؤلفون: Han-I, Yeh, Katy J, Sutcliffe, David N, Sheppard, Tzyh-Chang, Hwang

المصدر: Handbook of experimental pharmacology.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::766c12410966fd42356f1f208401aea3
https://pubmed.ncbi.nlm.nih.gov/35972584

المؤلفون: Han-I Yeh, Katy J. Sutcliffe, David N. Sheppard, Tzyh-Chang Hwang

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c17070197a08e48beebaead62dd417eb
https://doi.org/10.1007/164_2022_597

المؤلفون: Xinxiu Fang, Jiunn-Tyng Yeh, Tzyh-Chang Hwang

مصطلحات موضوعية: Biochemistry, Molecular Biology, Structural Biology, Enzymes, Protein Trafficking, Proteomics and Intermolecular Interactions (excl. Medical Proteomics), Receptors and Membrane Biology, Signal Transduction, Structural Biology (incl. Macromolecular Modelling), Synthetic Biology, CFTR, premature termination codon, nonsense mutations, CFTR correctors, read-through reagent

Relation: https://figshare.com/articles/figure/Image2_Pharmacological_Responses_of_the_G542X-CFTR_to_CFTR_Modulators_tiff/20140454

الاتاحة: https://doi.org/10.3389/fmolb.2022.921680.s002
https://figshare.com/articles/figure/Image2_Pharmacological_Responses_of_the_G542X-CFTR_to_CFTR_Modulators_tiff/20140454

المؤلفون: Winnie Khor, Tzyh-Chang Hwang, Chih-Chien Wang, Aliaksandr A. Yarmishyn, Jiunn-Tyng Yeh, Shih-Hwa Chiou, Shih-Jie Chou

المصدر: Stem Cell Research, Vol 60, Iss, Pp 102683-(2022)

مصطلحات موضوعية: Cystic Fibrosis, QH301-705.5, Codon, Nonsense, Induced Pluripotent Stem Cells, Mutation, Cystic Fibrosis Transmembrane Conductance Regulator, Humans, Cell Biology, General Medicine, Biology (General), Developmental Biology, Cell Line

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00dee303d2d0b037adc39a9aa107925
https://pubmed.ncbi.nlm.nih.gov/35091309

المؤلفون: Andrés Jara-Oseguera, Tzyh-Chang Hwang

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f55c896a21e419c2b4f5c5a83b795a89
https://doi.org/10.7554/elife.74693.sa1

المؤلفون: Tzyh Chang Hwang, Pei Lun Kuo, Ying Chun Yu, Chun Kuang Tsai, Han I. Yeh, Hsin Tuan Huang

المصدر: J Physiol

مصطلحات موضوعية: Mutation, Binding Sites, biology, Cystic Fibrosis, Physiology, Chemistry, Mutant, Cystic Fibrosis Transmembrane Conductance Regulator, ATP-binding cassette transporter, medicine.disease_cause, Small molecule, Cystic fibrosis transmembrane conductance regulator, Article, Cell biology, Adenosine Triphosphate, Protein Domains, ATP hydrolysis, Chloride Channels, medicine, Chloride channel, biology.protein, Humans, Binding site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41fb6a14238062eaea880183d4463c3
https://europepmc.org/articles/PMC8527797/

المؤلفون: C. Tse, Ying Jia, X. Wang, Liu Bo, Douglas M. Cyr, Torben R. Neelands, Wenqing Gao, Xenia B. Searle, Ashvani K. Singh, Timothy A. Vortherms, Hong Y. Ren, Andrew M. Swensen, Corina Balut, Arlene M. Manelli, Sara Alani, Philip R. Kym, K. Conrath, Tzyh Chang Hwang, Yihong Fan

المصدر: J Pharmacol Exp Ther

مصطلحات موضوعية: 0301 basic medicine, Protein Folding, Cystic Fibrosis Transmembrane Conductance Regulator, Respiratory Mucosa, Pharmacology, medicine.disease_cause, Benzoates, Cystic fibrosis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Chlorides, Cricetinae, Membrane Transport Modulators, medicine, Animals, Humans, Benzopyrans, Cells, Cultured, Mutation, Binding Sites, Errata, biology, Cell Membrane, Lumacaftor, HEK 293 cells, Potentiator, medicine.disease, Small molecule, In vitro, Cystic fibrosis transmembrane conductance regulator, Protein Transport, HEK293 Cells, 030104 developmental biology, chemistry, biology.protein, Molecular Medicine, 030217 neurology & neurosurgery, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a61d3189fed304b0edc5967e5538659
https://doi.org/10.1124/jpet.119.261800

المؤلفون: Tzyh Chang Hwang, Jiunn Tyng Yeh

المصدر: The Journal of Physiology. 598:517-541

مصطلحات موضوعية: 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Physiology, Nonsense mutation, Cystic Fibrosis Transmembrane Conductance Regulator, ATP-binding cassette transporter, medicine.disease_cause, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Missense mutation, Gene, Pyrans, Mutation, biology, Lumacaftor, Wild type, Cystic fibrosis transmembrane conductance regulator, Cell biology, 030104 developmental biology, chemistry, Codon, Nonsense, biology.protein, Pyrazoles, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf2fbee691a1877d849672afcee58b1
https://doi.org/10.1113/jp278418

المؤلفون: A. M. Manelli, Y. Jia, Philip R. Kym, X. Wang, Timothy A. Vortherms, S. Alani, Wenqing Gao, C. Balut, Ashvani K. Singh, Tzyh Chang Hwang, Douglas M. Cyr, H. Y. Ren, Andrew M. Swensen, Y. Fan, Torben R. Neelands, K. Conrath, C. Tse, Xenia B. Searle, Liu Bo

المصدر: The Journal of pharmacology and experimental therapeutics. 374(3)

مصطلحات موضوعية: Pharmacology, Chemistry, Protein processing, Molecular Medicine, Computational biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f06a07779c4c9652d155ca898680f4
https://pubmed.ncbi.nlm.nih.gov/31732698

المؤلفون: Tzyh Chang Hwang, Jiunn Tyng Yeh, Jingyao Zhang, Han I. Yeh, Samantha Destefano, Ying Chun Yu

المصدر: The Journal of General Physiology

مصطلحات موضوعية: 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Cystic Fibrosis, Physiology, Protein domain, Regulator, Reviews, Cystic Fibrosis Transmembrane Conductance Regulator, Review, medicine.disease_cause, Cystic fibrosis, 03 medical and health sciences, Protein Domains, medicine, Animals, Humans, Mutation, biology, Chemistry, respiratory system, medicine.disease, Transmembrane protein, Cystic fibrosis transmembrane conductance regulator, Cell biology, 030104 developmental biology, Chloride channel, biology.protein, Ion Channel Gating, Function (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa797a6233d92838971442d41200b726
https://doi.org/10.1085/jgp.201711946

المؤلفون: Han-I Yeh, Tzyh-Chang Hwang

المصدر: European Respiratory Journal. 59:2102380

مصطلحات موضوعية: Pulmonary and Respiratory Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5a5beaf2ed9dd68503aecd5feee2a68b
https://doi.org/10.1183/13993003.02380-2021

المؤلفون: Sofia Ramalho, Karl Kunzelmann, Hugo M. Botelho, Tzyh Chang Hwang, Jiunn Tyng Yeh, Iveta Valášková, Tereza Doušová, Luka A. Clarke, A. Holubová, Carlos M. Farinha, Iris A.L. Silva, Margarida D. Amaral, R. Centeio, Violeta Railean

المصدر: Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
Biochim Biophys Acta Mol Basis Dis

مصطلحات موضوعية: 0301 basic medicine, Indoles, Cystic Fibrosis, Genotype, Blotting, Western, Aminopyridines, Cystic Fibrosis Transmembrane Conductance Regulator, Fluorescent Antibody Technique, Disease, Quinolones, Aminophenols, Cystic fibrosis, Article, 03 medical and health sciences, 0302 clinical medicine, medicine, Organoid, Humans, Benzodioxoles, Allele, Precision Medicine, Molecular Biology, Alleles, business.industry, Alternative splicing, medicine.disease, Precision medicine, 3. Good health, Electrophysiology, 030104 developmental biology, RNA splicing, Mutation, Cancer research, Molecular Medicine, Personalized medicine, business, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b98b730172cc6c7bc449650cd9aefeb

المؤلفون: Anne Sophie Wesse, Nicolas Desroy, Mathieu Rafaël Pizzonero, Mia Jans, Steven Emiel Van Der Plas, Katleen Verdonck, Katja Conrath, Tzyh Chang Hwang, Ashvani K. Singh, Gert Jules Hector De Wilde, Thierry Christophe, Pieter F. W. Stouten, Maarten Gees, Luc Nelles, Sara Musch, Marlon Cowart

المصدر: Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology

مصطلحات موضوعية: 0301 basic medicine, chloride channel, Computational biology, medicine.disease_cause, Cystic fibrosis, Unmet needs, cystic fibrosis, 03 medical and health sciences, 0302 clinical medicine, medicine, Pharmacology (medical), protein misfolding, Original Research, Pharmacology, Mutation, biology, business.industry, lcsh:RM1-950, medicine.disease, electrophysiology, Cystic fibrosis transmembrane conductance regulator, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, 030220 oncology & carcinogenesis, Chloride channel, biology.protein, cystic fibrosis transmembrane conductance regulator (CFTR), business, Cftr modulator

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d914b2d0b2021abba128959645f2bf
https://www.frontiersin.org/article/10.3389/fphar.2019.00514/full