المؤلفون: Kathrine Loomis, Kristin L. Rockwell, Meihua Tu, Paul A. Amor, Kirk McPherson, William P. Esler, Tereece Banks, Aaron C. Smith, Shawn Cabral, James J. Valentine, Susan Tapley, Kristen Ford, Colin R. Rose, Mark Niosi, Felix Vajdos, Carmen N. Garcia-Irizarry, Shawn D. Doran, James A. Southers, Scott W. Bagley, Margaret S. Landis, Alan M. Mathiowetz, Daniel W. Kung, David A. Griffith

المصدر: Bioorganicmedicinal chemistry letters. 25(22)

مصطلحات موضوعية: Gene isoform, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Models, Biological, Small Molecule Libraries, chemistry.chemical_compound, Enzyme activator, Inhibitory Concentration 50, Acetyl Coenzyme A, Diamine, Drug Discovery, Animals, Humans, Spiro Compounds, Enzyme Inhibitors, Molecular Biology, Molecular Structure, Drug discovery, Organic Chemistry, Acetyl-CoA carboxylase, Pyruvate carboxylase, Rats, Enzyme Activation, chemistry, Lipogenesis, Hepatocytes, Molecular Medicine, Lead compound, Acetyl-CoA Carboxylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97747d7f1eb5d78c33f023f1c9e7174
https://pubmed.ncbi.nlm.nih.gov/26411795

المؤلفون: Dawn Mather, Mark Niosi, Susan Tapley, Christian Perreault, Michael John Munchhof, Angel Guzman-Perez, Jian-Cheng Li, Robert L. Dow, Melissa P. Andrews, Jennifer L. LaPerle, Leena Patel, William J. Zavadoski, Qifang Li, E. Michael Gibbs

المصدر: Bioorganicmedicinal chemistry. 21(17)

مصطلحات موضوعية: Carboxylic acid, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Oxadiazole, Administration, Oral, Mice, Obese, Biochemistry, Polar surface area, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, Distribution (pharmacology), Moiety, Animals, Humans, Diacylglycerol O-Acyltransferase, Obesity, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Oxadiazoles, Organic Chemistry, Rats, Mice, Inbred C57BL, Oxazepines, Enzyme, chemistry, Permeability (electromagnetism), Molecular Medicine, Pharmacophore, Half-Life, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4dad263bd8eb51ef40984fc855a78be
https://pubmed.ncbi.nlm.nih.gov/23871442

المؤلفون: Katherine Loomis, Kevin Daniel Freeman-Cook, Zhengrong Zhao, Susan Tapley, Dennis Paul Phillion, Richard L. Elliott, Steven B. Coffey, Christopher S. Jones, Kevin E. Henegar, Kirk McPherson, Chris Limberakis, Scott Bader, Janet A. Houser, Leanne M. Buzon, Angel Guzman-Perez, Shawn D. Doran, Wei Song, Betsy Pierce, Kendra Louise Nelson, Meihua Tu, William P. Esler, Kenneth J. DiRico, Sharad B. Murdande, Jeffrey W. Corbett, Paul A. Amor, Eliot Sugarman

المصدر: Journal of medicinal chemistry. 55(2)

مصطلحات موضوعية: Prioritization, Quantitative structure–activity relationship, Indazoles, Indoles, Quantitative Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Humans, Hypoglycemic Agents, Spiro Compounds, Muscle, Skeletal, Chemistry, Acetyl-CoA carboxylase, Pyruvate carboxylase, Rats, Isoenzymes, Biochemistry, Liver, Lipophilic efficiency, Rat liver, Drug Design, Molecular Medicine, Pyrazoles, Benzimidazoles, Acetyl-CoA Carboxylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c9f7d939bcab8b1a7e28a3e8df0533
https://pubmed.ncbi.nlm.nih.gov/22148323

المؤلفون: Tara B. Manion, Michael Patrick Pence, Jennifer L. LaPerle, David W. Piotrowski, Susan Tapley, Paul DaSilva-Jardine, R. Kirk McPherson, Robert L. Dow, Angel Guzman-Perez, William J. Zavadoski, Gregory S. Walker, E. Michael Gibbs, Jian-Cheng Li, John Litchfield, Eliot Sugarman, Michael John Munchhof

المصدر: ACS medicinal chemistry letters. 2(5)

مصطلحات موضوعية: Triglyceride, business.industry, Organic Chemistry, Pharmacology, medicine.disease, Biochemistry, chemistry.chemical_compound, Biosynthesis, chemistry, Pharmacokinetics, In vivo, Diabetes mellitus, Drug Discovery, Knockout mouse, medicine, business, IC50, Diacylglycerol kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8293e8fce98fd024b807c1aee4957c08
https://pubmed.ncbi.nlm.nih.gov/24900321

المؤلفون: H. James Harwood, R. Kirk McPherson, Susan Tapley, Leanne M. Buzon, Kevin Daniel Freeman-Cook, Steven B. Coffey, Richard L. Elliott, Darcy Kohls, Liang Tong, Felix Vajdos, Meihua Tu, Eliot Sugarman, Shawn D. Doran, Francis Rajamohan, Eric S. Marr, Hailong Zhang, Wei Song, Kenneth J. DiRico, Jeffrey W. Corbett, Janet A. Houser, Sharad B. Murdande, William P. Esler, Martha L. Minich, Christopher J. Jones

المصدر: Bioorganicmedicinal chemistry letters. 20(7)

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Isozyme, Small Molecule Libraries, Structure-Activity Relationship, Drug Discovery, Transferase, Animals, Humans, Enzyme Inhibitors, Molecular Biology, biology, Drug discovery, Chemistry, Organic Chemistry, Acetyl-CoA carboxylase, Acetyl-CoA Carboxylase 1, Small molecule, Pyruvate carboxylase, Rats, Isoenzymes, Enzyme inhibitor, biology.protein, Molecular Medicine, Acetyl-CoA Carboxylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c15f1a6bcbbc031e2169b1cbccc4dfb
https://pubmed.ncbi.nlm.nih.gov/20219367

المؤلفون: Dawn Mather, Susan Tapley, Jennifer L. LaPerle, Melissa P. Andrews, E. Michael Gibbs, Mark Niosi, Angel Guzman-Perez, Christian Perreault, Qifang Li, William J. Zavadoski, Jian-Cheng Li, Robert L. Dow, Leena Patel, Michael John Munchhof

المصدر: Bioorganic & Medicinal Chemistry. 21:6855

مصطلحات موضوعية: Orally active, Chemistry, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Key (cryptography), Pharmaceutical Science, Molecular Medicine, Pharmacophore, Molecular Biology, Biochemistry, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::20f39b7e1b38f6c3d2c012bc64911869
https://doi.org/10.1016/j.bmc.2013.08.060