المؤلفون: Brandon Zimmerman, Leslie A. Dakin, Anne Fortier, Evanthia Nanou, Angelo Blasio, James Mann, Howard Miller, Marissa Fletcher, Tiansheng Wang, Suganthini Nanthakumar, Gizelle McCarthy, Caline Matar, Prachi Matsye, Guanyu Wang, Phillip Snyder, Kevin Daniel, Harsha Swamy, Kelly Sullivan, Franklin Bright, Audrey Powers, Kevin J. Gagnon, Fan Lu, Steven Paula, Suvarna Khare-Pandit, Larry Henry, Martine Hamel, Francois Denis, Olivier Nicolas, Niresh Hariparsad, Shyamesh Kumar, Jennifer Proctor, Timothy Senter, Brinley Furey, Mark E. Bunnage

المصدر: Nature Communications, Vol 16, Iss 1, Pp 1-13 (2025)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/d3abf4c5a7724e19a5dd87eb45a093af

المؤلفون: Jon H. Come (5395523), Timothy J. Senter (1309548), Michael P. Clark (1764619), John J. Court (1764601), Zachary Gale-Day (11663926), Wenxin Gu (1764613), Elaine Krueger (1720042), Jianglin Liang (1764637), Mark Morris (1834648), Suganthini Nanthakumar (2342815), Hardwin O’Dowd (1570984), Francois Maltais (2342827), Ganesh Iyer (2481568), John Andreassi (11663929), Christina Boucher (1562233), Tony Considine (11663932), Cameron S. Moody (1562266), William Taylor (373883), Arun K. Mohanty (11663935), Yulin Huang (447676), Harmon Zuccola (1816819), Joyce Coll (2884850), Kenneth C. Bonanno (2884844), Kevin J. Gagnon (1330194), Lu Gan (33435), Fan Lu (490738), Hong Gao (68166), Ananthisrinivas Chakilam (11663938), Juntyma Engtrakul (11663941), Bin Song (446187), Dan Crawford (8315991), Elisabeth Doyle (1900438), Tal Kramer (11663944), Bryan Vought (11663947), Jonathan Phillips (6332132), Raymond Kemper (11663950), Martin Sanders (11663953), Rebecca Swett (149249), Brinley Furey (11663956), Ray Winquist (11663959), Mark E. Bunnage (1290480), Katrina L. Jackson (2047516), Paul S. Charifson (1720039), Sanjay S. Magavi (11663962)

مصطلحات موضوعية: Biochemistry, Medicine, Neuroscience, Pharmacology, Chemical Sciences not elsewhere classified, cns precluded progression, central nervous system, 0 vlcfa synthesis, 0 vlcfa concentrations, treatment reduced c26, preclinical safety findings, selectively inhibits elovl1, ald patient fibroblasts, 27 , vivo <, reducing c26, findings require, elovl1 accumulation, elovl1 ), type levels, thiazole amides, relevant tissue, pyrazole amides, pathologies observed, highly potent, effective approach, ald )

Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Optimization_of_Pyrazole_Amides_as_Inhibitors_of_ELOVL1/16958665

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00944.s001

المؤلفون: William P. Taylor, Mark Edward Bunnage, Hardwin O'dowd, Michael P. Clark, Dan Crawford, Sanjay Shivayogi Magavi, Bin Song, Jianglin Liang, Timothy J. Senter, Tal Kramer, Juntyma J. Engtrakul, Arun K. Mohanty, Fan Lu, Hong Gao, Yulin Huang, Swett Rebecca Jane, Bryan W. Vought, Ray Winquist, Tony Considine, Ganesh Iyer, Kenneth C. Bonanno, Elisabeth Doyle, Suganthini Nanthakumar, Raymond Kemper, Elaine Krueger, Cameron Stuver Moody, Joyce T. Coll, Paul S. Charifson, John J. Court, Wenxin Gu, Francois Maltais, Gale-Day Zachary, Ananthisrinivas Chakilam, Jon H. Come, John L. Andreassi, Morris Mark A, Brinley Furey, Christina Boucher, Martin Sanders, Harmon J. Zuccola, Gagnon Kevin James, Katrina L. Jackson, Lu Gan, Jonathan A. Phillips

المصدر: Journal of Medicinal Chemistry. 64:17753-17776

مصطلحات موضوعية: endocrine system, endocrine system diseases, Fatty Acid Elongases, Very long chain fatty acid, Central nervous system, Pyrazole, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Adrenoleukodystrophy, Thiazole, chemistry.chemical_classification, Microglia, Substrate (chemistry), medicine.disease, Amides, medicine.anatomical_structure, Enzyme, chemistry, Biochemistry, Pyrazoles, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df83528af04585e5c3ec98c9649f09d
https://doi.org/10.1021/acs.jmedchem.1c00944

المؤلفون: Upul K. Bandarage, Jeremy Green, Suganthini Nanthakumar, Simon Giroux, Jon H. Come, Huai Gao, John Court

المصدر: Bioorganicmedicinal chemistry letters. 33

مصطلحات موضوعية: Indoles, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Protein kinase A, Molecular Biology, Rho-associated protein kinase, Protein Kinase Inhibitors, rho-Associated Kinases, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Cancer, medicine.disease, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Microsome, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582e0b44e579a461b66c0bc5b2e358a8
https://pubmed.ncbi.nlm.nih.gov/33259926

المؤلفون: Joshua R. Leeman, Joyce T. Coll, Upul K. Bandarage, Derek B. Lowe, Alex Aronov, Christine Memmott, Jacque Zwahlen, Kenneth C. Bonanno, Emanuele Perola, William P. Taylor, Christopher A. Lepre, Dean M. Wilson, Yi Zhou, Rene Rijnbrand, Dominique Bonafoux, Fan Lu, Bhisetti Govinda Rao, Ernst ter Haar, Suganthini Nanthakumar

المصدر: Journal of Medicinal Chemistry. 59:7138-7151

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, viruses, JC virus, medicine.disease_cause, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, medicine, Structure–activity relationship, Enzyme Inhibitors, Cytotoxicity, Dose-Response Relationship, Drug, Molecular Structure, biology, Drug discovery, Chemistry, DNA Helicases, virus diseases, Helicase, JC Virus, Virology, Molecular biology, BK virus, 030104 developmental biology, BK Virus, Vero cell, biology.protein, Molecular Medicine, Triazolopyridine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e87d9079517681b68b3a5d2fc70a1a
https://doi.org/10.1021/acs.jmedchem.6b00486

المؤلفون: Nigel Ewing, Judy Straub, Ursula A. Germann, James W. Janetka, Alex Aronov, Ernst ter Haar, Jeremy Green, Mark N. Namchuk, Guy W. Bemis, Xiaoling Xie, William Markland, Michael R. Hale, Pamella J. Ford, Gabriel Martinez-Botella, Guanjing Chen, Qing Tang, Francois Maltais, Marc Jacobs, Jingrong Cao, Srinivasu Poondru, Suganthini Nanthakumar

المصدر: Journal of Medicinal Chemistry. 52:6362-6368

مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, MAPK/ERK pathway, Conformational change, biology, Chemistry, Cell growth, Molecular Conformation, Substrate Specificity, Cell biology, Enzyme, Antitarget, Biochemistry, Cell culture, Drug Design, Mitogen-activated protein kinase, Drug Discovery, biology.protein, Molecular Medicine, Pyrroles, Signal transduction, Extracellular Signal-Regulated MAP Kinases, Protein Kinase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4fa59a8f55914383a31fbef490e3a2
https://doi.org/10.1021/jm900630q

المؤلفون: William Markland, Ernst ter Haar, Darshana Zhaveri, Guy W. Bemis, Thomas Hoock, Martin Connors, Francesco G. Salituro, Shawn D. Britt, Cochran John E, Suganthini Nanthakumar, Edmund Harrington, Jian Wang, Luc J. Farmer, Paul Taslimi

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:6231-6235

مصطلحات موضوعية: Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Syk, chemical and pharmacologic phenomena, Crystallography, X-Ray, environment and public health, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, hemic and lymphatic diseases, Drug Discovery, Animals, Combinatorial Chemistry Techniques, Syk Kinase, Mast Cells, Thiazole, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Intracellular Signaling Peptides and Proteins, Degranulation, hemic and immune systems, Biological activity, Protein-Tyrosine Kinases, In vitro, Rats, Thiazoles, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, Drug Design, Microsomes, Liver, biology.protein, Molecular Medicine, biological phenomena, cell phenomena, and immunity, Signal transduction, Spleen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2a734cf4205416eba869a8c2e13177
https://doi.org/10.1016/j.bmcl.2008.09.106

المؤلفون: Jon H. Come, Huai Gao, Scott Carrier, Mark W. Ledeboer, Youssef L. Bennani, Elaine Kolaczkowski, Dina Shlyakter, James K. Hogan, John P. Duffy, Suganthini Nanthakumar, Bin Fan, Francesco G. Salituro, Thomas Hoock, Albert C. Pierce, Harmon J. Zuccola, Tsai Wanjung, S. Pazhanisamy, Lora Swenson, Richard Zessis, David Messersmith, Sudipta Mahajan

المصدر: Bioorganicmedicinal chemistry letters. 19(23)

مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, Polycythemia vera, Myeloproliferative Disorders, hemic and lymphatic diseases, Drug Discovery, medicine, Kinase activity, Myelofibrosis, Molecular Biology, Protein Kinase Inhibitors, chemistry.chemical_classification, Janus kinase 2, biology, Molecular Structure, Essential thrombocythemia, Organic Chemistry, food and beverages, Stereoisomerism, Janus Kinase 2, medicine.disease, In vitro, Enzyme, Pyrimidines, chemistry, Cancer research, biology.protein, Molecular Medicine, Pyrazoles, hormones, hormone substitutes, and hormone antagonists, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ff8c738e89c07bfdc50af0f59cdb1f
https://pubmed.ncbi.nlm.nih.gov/19857967

المؤلفون: Alex M. Aronov, Qing Tang, Gabriel Martinez-Botella, Guy W. Bemis, Jingrong Cao, Guanjing Chen, Nigel P. Ewing, Pamella J. Ford, Ursula A. Germann, Jeremy Green, Michael R. Hale, Marc Jacobs, James W. Janetka, Francois Maltais, William Markland, Mark N. Namchuk, Suganthini Nanthakumar, Srinivasu Poondru, Judy Straub, Ernst ter Haar

المصدر: Journal of Medicinal Chemistry; Oct2009, Vol. 52 Issue 20, p6362-6368, 7p