المؤلفون: Khan Suleiman A, Faisal Ali, Mpindi John, Parkkinen Juuso A, Kalliokoski Tuomo, Poso Antti, Kallioniemi Olli P, Wennerberg Krister, Kaski Samuel

المصدر: BMC Bioinformatics, Vol 13, Iss 1, p 112 (2012)

مصطلحات موضوعية: Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.biomedcentral.com/1471-2105/13/112; https://doaj.org/toc/1471-2105

URL الوصول: https://doaj.org/article/d81f8d059528452f9250afdee83c732d

المؤلفون: Mpindi John-Patrick, Laasola Petra, Aaltola Anna-Riina, Mäkelä Rami, Rantala Juha K, Nees Matthias, Saviranta Petri, Kallioniemi Olli

المصدر: BMC Genomics, Vol 12, Iss 1, p 162 (2011)

مصطلحات موضوعية: Biotechnology, TP248.13-248.65, Genetics, QH426-470

وصف الملف: electronic resource

Relation: http://www.biomedcentral.com/1471-2164/12/162; https://doaj.org/toc/1471-2164

URL الوصول: https://doaj.org/article/0942862b73014fcf996c6f7b1ba06ae6

المؤلفون: Chakrabarti, Lina, Savery, James, Mpindi, John Patrick, Klover, Judith, Li, Lina, Zhu, Jie

المصدر: Biotechnology Progress ; volume 40, issue 3 ; ISSN 8756-7938 1520-6033

الاتاحة: http://dx.doi.org/10.1002/btpr.3441

المؤلفون: Jamshidi, Maral, Fagerholm, Rainer, Muranen, Taru A., Kaur, Sippy, Potdar, Swapnil, Khan, Sofia, Netti, Eliisa, Mpindi, John-Patrick, Yadav, Bhagwan, Kiiski, Johanna I., Aittomäki, Kristiina, Heikkilä, Päivi, Saarela, Jani, Bützow, Ralf, Blomqvist, Carl, Nevanlinna, Heli

المساهمون: HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, Helsinki University Hospital Area, Faculty Common Matters (Faculty of Biology and Environmental Sciences), Clinicum, Medicum, Department of Pathology, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, INDIVIDRUG - Individualized Drug Therapy, Research Programs Unit, Kristiina Aittomäki / Principal Investigator, HUSLAB, Department of Medical and Clinical Genetics, HUS Diagnostic Center, HUS Comprehensive Cancer Center, Department of Oncology

مصطلحات موضوعية: BRCA2 MUTATIONS, EPITHELIAL-MESENCHYMAL TRANSITION, HER-2, HYBRIDIZATION, INVASION, METASTASIS, MICRORNAS, PROGNOSTIC-FACTORS, PROTEIN EXPRESSION, RESISTANCE, SUPPRESS, anthracycline, breast cancer, chemotherapy, doxorubicin, lapatinib, miR-30, p53, survival, Cancers, Gynaecology and paediatrics

وصف الملف: application/pdf

Relation: Jamshidi , M , Fagerholm , R , Muranen , T A , Kaur , S , Potdar , S , Khan , S , Netti , E , Mpindi , J-P , Yadav , B , Kiiski , J I , Aittomäki , K , Heikkilä , P , Saarela , J , Bützow , R , Blomqvist , C & Nevanlinna , H 2021 , ' High mir-30 expression associates with improved breast cancer patient survival and treatment outcome ' , Cancers , vol. 13 , no. 12 , 2907 . https://doi.org/10.3390/cancers13122907; Bibtex: Jamshidi2021; ORCID: /0000-0002-5895-1808/work/106338589; ORCID: /0000-0001-7306-7175/work/106339167; ORCID: /0000-0002-4089-7209/work/106341583; ORCID: /0000-0002-2778-6918/work/106342198; http://hdl.handle.net/10138/338380; 7c00ac8e-4f00-4c03-a3f7-42f2b30ad718; 85107460681; 000666319300001

الاتاحة: http://hdl.handle.net/10138/338380

المؤلفون: Khan, Suleiman A., Faisal, Ali, Mpindi, John Patric, Parkkinen, Juuso A., Kalliokoski, Tuomo, Poso, Antti, Kallioniemi, Olli P., Wennerberg, Krister, Kaski, Samuel

مصطلحات موضوعية: Quantitative Biology - Biomolecules, Statistics - Applications

URL الوصول: http://arxiv.org/abs/1112.6015

المؤلفون: Pietarinen, Paavo O., Eide, Christopher A., Ayuda-Duran, Pilar, Potdar, Swapnil, Kuusanmaki, Heikki, Andersson, Emma I., Mpindi, John P., Pemovska, Tea, Kontro, Mika, Heckman, Caroline A., Kallioniemi, Olli, Wennerberg, Krister, Hjorth-Hansen, Henrik, Druker, Brian J., Enserink, Jorrit M., Tyner, Jeffrey W., Mustjoki, Satu, Porkka, Kimmo

المساهمون: Clinicum, University of Helsinki, Hematologian yksikkö, Department of Oncology, Medicum, Department of Clinical Chemistry and Hematology, Institute for Molecular Medicine Finland, Olli-Pekka Kallioniemi / Principal Investigator, Krister Wennerberg / Principal Investigator, Department of Diagnostics and Therapeutics, HUS Comprehensive Cancer Center, Precision Systems Medicine

مصطلحات موضوعية: chronic myeloid leukemia, high-throughput drug screening, ex vivo, tyrosine kinase inhibitors, CD34, CHRONIC MYELOGENOUS LEUKEMIA, DRUG-SENSITIVITY, STEM-CELLS, RESISTANCE, IMATINIB, MECHANISMS, DASATINIB, CRKL, Cancers

وصف الملف: application/pdf

Relation: This work was supported from grants received from Academy of Finland, Finnish Cancer Societies, Signe and Ane Gyllenberg Foundation, Finnish Cancer Institute, Finnish Association of Haematology, Blood Disease Foundation, Eutos project, Paulo Foundation, the Finnish Pharmaceutical Society, and Ariad Pharmaceuticals.; Pietarinen , P O , Eide , C A , Ayuda-Duran , P , Potdar , S , Kuusanmaki , H , Andersson , E I , Mpindi , J P , Pemovska , T , Kontro , M , Heckman , C A , Kallioniemi , O , Wennerberg , K , Hjorth-Hansen , H , Druker , B J , Enserink , J M , Tyner , J W , Mustjoki , S & Porkka , K 2017 , ' Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors ' , Oncotarget , vol. 8 , no. 14 , pp. 22606-22615 . https://doi.org/10.18632/oncotarget.15146; ORCID: /0000-0002-0816-8241/work/39901447; ORCID: /0000-0003-4112-5902/work/39887803; ORCID: /0000-0002-2778-6918/work/39321020; ORCID: /0000-0001-6353-0664/work/133998470; http://hdl.handle.net/10138/312086; ea779774-77e5-43d4-8169-07048b72dc5e; 85016937033; 000398211100028

الاتاحة: http://hdl.handle.net/10138/312086

المؤلفون: Potdar, Swapnil, Ianevski, Aleksandr, Mpindi, John-Patrick, Bychkov, Dmitrii, Fiere, Clement, Ianevski, Philipp, Yadav, Bhagwan, Wennerberg, Krister, Aittokallio, Tero, Kallioniemi, Olli, Saarela, Jani, Östling, Päivi

المساهمون: Institute for Molecular Medicine Finland, University of Helsinki, Computational Systems Medicine, Helsinki Institute for Information Technology, Helsinki Institute of Life Science HiLIFE, Krister Wennerberg / Principal Investigator, Tero Aittokallio / Principal Investigator, Bioinformatics, Olli-Pekka Kallioniemi / Principal Investigator

مصطلحات موضوعية: CELLS, Biochemistry, cell and molecular biology, Computer and information sciences, Mathematics

وصف الملف: application/pdf

Relation: The FIMM High-Throughput Biomedicine Unit is financially supported by the University of Helsinki and Biocenter Finland. The work has received funding from the Sigrid Juselius Foundation, Cancer Society of Finland, Academy of Finland [292611, 326238 and 310507 to T.A.], the Magnus Ehrnrooth Foundation, Biocentrum Helsinki and St. Baldrick's Foundation.; Potdar , S , Ianevski , A , Mpindi , J-P , Bychkov , D , Fiere , C , Ianevski , P , Yadav , B , Wennerberg , K , Aittokallio , T , Kallioniemi , O , Saarela , J & Östling , P 2020 , ' Breeze : an integrated quality control and data analysis application for high-throughput drug screening ' , Bioinformatics , vol. 36 , no. 11 , pp. 3602-3604 . https://doi.org/10.1093/bioinformatics/btaa138; ORCID: /0000-0001-7306-7175/work/79518992; ORCID: /0000-0002-0886-9769/work/79519404; ORCID: /0000-0002-7780-482X/work/79519807; ORCID: /0000-0002-2778-6918/work/79521370; http://hdl.handle.net/10138/318495; a6e7f01e-b018-4dbd-a6c1-3979b3525272; 000550117300053

الاتاحة: http://hdl.handle.net/10138/318495

المؤلفون: Pellinen, Teijo, Blom, Sami, Sanchez, Sara, Välimäki, Katja, Mpindi, John-Patrick, Azegrouz, Hind, Strippoli, Raffaele, Nieto, Raquel, Viton, Mariano, Palacios, Irene, Turkki, Riku, Wang, Yinhai, Sanchez-Alvarez, Miguel, Nordling, Stig, Bützow, Anna, Mirtti, Tuomas, Rannikko, Antti, Montoya, Maria C., Kallioniemi, Olli, del Pozo, Miguel A.

المساهمون: Institute for Molecular Medicine Finland, Olli-Pekka Kallioniemi / Principal Investigator, Precision Systems Medicine, Johan Edvard Lundin / Principal Investigator, Medicum, Department of Pathology, HUSLAB, Clinicum, Department of Surgery, Urologian yksikkö, HUS Abdominal Center

مصطلحات موضوعية: Biomedicine, Cancers

وصف الملف: application/pdf

Relation: This study was supported by grants SAF2011-25047 and CSD2009-0016 from Spanish Ministry of Science and Innovation (MICINN), SAF2014-51876-R from Spanish Ministry of Economy and Competitiveness (MINECO) and co-funded by FEDER funds, 674/C/2013 from Fundacio La Marato de TV3, and AICR 15-0404 from the Worldwide Cancer Research Foundation (to M.A.dP.), by BIO2014-62200-EXP (to M.M.) as well as from the Academy of Finland Center of Excellence in Translational Cancer Biology (251314), Sigrid Juselius Foundation, and Cancer Society of Finland (to O.K.). T.P. was funded by CNIC Postdoctoral Program and by the Academy of Finland Post-doctoral fellow position (253662). Additional funding was from Emil Aaltonen foundation, Wihuri foundations, and Magnus Ehrnrooth foundation (to T.P.). Montserrat Arroyo (CNIC Cellomics Unit) helped in performing the screening. The CNIC is supported by MINECO and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; Pellinen , T , Blom , S , Sanchez , S , Välimäki , K , Mpindi , J-P , Azegrouz , H , Strippoli , R , Nieto , R , Viton , M , Palacios , I , Turkki , R , Wang , Y , Sanchez-Alvarez , M , Nordling , S , Bützow , A , Mirtti , T , Rannikko , A , Montoya , M C , Kallioniemi , O & del Pozo , M A 2018 , ' ITGB1-dependent upregulation of Caveolin-1 switches TGF beta signalling from tumour-suppressive to oncogenic in prostate cancer ' , Scientific Reports , vol. 8 , no. 1 , 2338 . https://doi.org/10.1038/s41598-018-20161-2; Bibtex: urn:e45501dfb00f666751908899a9bc746b; ORCID: /0000-0003-0455-9891/work/42819270; ORCID: /0000-0002-4261-3484/work/42819737; ORCID: /0000-0002-8690-6983/work/42819764; ORCID: /0000-0002-1878-8911/work/42819800; http://hdl.handle.net/10138/233448; 0ecbcf5c-420a-4df1-a6e6-942e69a548fa; 85041665506; 000424087700010

الاتاحة: http://hdl.handle.net/10138/233448

المؤلفون: Kolberg, Matthias, Bruun, Jarle, Murumagi, Astrid, Mpindi, John P., Bergsland, Christian H., Holand, Maren, Eilertsen, Ina A., Danielsen, Stine A., Kallioniemi, Olli, Lothe, Ragnhild A.

المساهمون: Institute for Molecular Medicine Finland, University of Helsinki, Olli-Pekka Kallioniemi / Principal Investigator, Precision Systems Medicine

مصطلحات موضوعية: drug screen, MPNST, pharmacology, Schwann cell, NEUROFIBROMATOSIS TYPE-1 PATIENTS, SCHWANNOMA CELL-LINE, SOFT-TISSUE SARCOMA, PHASE-II, CANCER-THERAPY, IN-VITRO, KINASE 1, GENE, GROWTH, RAS, Cancers

وصف الملف: application/pdf

Relation: The authors are grateful for the technical support from Jani Saarela and Laura Turunen at the High Throughput Biomedicine Unit (HTBU) at the Institute for Molecular Medicine Finland (FIMM) and to Disha Malani, Akira Hirasawa, Minna Suvela, and Alun Parsons at FIMM for generating data for the reference DSRT dataset. The authors also thank Mariliina Arjama at FIMM for excellent technical assistance with the drug testing, and Merete Hektoen, Mette Ekn ae s, and Sharmini Alagaratnam at the Department of Molecular Oncology (Oslo University Hospital) for excellent technical assistance with cell culturing and DNA analyses. This study was supported by grants to R.A.L. from the Research Council of Norway through its Centers of Excellence funding scheme (Project Number 179571, supporting M.K. as scientist) and through Norwegian Cancer Genomics Consortium (Project Number 218241, S.A.D scientist), from the Norwegian Cancer Society (Grant No. PR-2006-0442, J.B. post doc), from the South-Eastern Norway Regional Health Authority (Grant No. 2016123, C.B. PhD student), from the Faculty of Medicine, University of Oslo (M.H. PhD student), and from Stiftelsen Kristian Gerhard Jebsen (I.A.E. PhD student); and to O.K. from the Academy of Finland (Center of Excellence for Translational Cancer Biology), Cancer Society of Finland, and Sigrid Juselius Foundation.; Kolberg , M , Bruun , J , Murumagi , A , Mpindi , J P , Bergsland , C H , Holand , M , Eilertsen , I A , Danielsen , S A , Kallioniemi , O & Lothe , R A 2017 , ' Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors ' , Molecular oncology , vol. 11 , no. 9 , pp. 1156-1171 . https://doi.org/10.1002/1878-0261.12086; ORCID: /0000-0002-7797-188X/work/128027035; http://hdl.handle.net/10138/248406; a167d335-126c-4636-92cd-5e67863a9ad6; 85021816351; 000408847000004

الاتاحة: http://hdl.handle.net/10138/248406

المؤلفون: Pulkka, Olli-Pekka, Mpindi, John-Patrick, Tynninen, Olli, Nilsson, Bengt, Kallioniemi, Olli, Sihto, Harri, Joensuu, Heikki

المساهمون: Clinicum, Translational Cancer Biology (TCB) Research Programme, Department of Oncology, University of Helsinki, Olli-Pekka Kallioniemi / Principal Investigator, Institute for Molecular Medicine Finland, HUSLAB, Department of Pathology, Medicum, Heikki Joensuu / Principal Investigator, Research Programs Unit, HUS Comprehensive Cancer Center, Precision Systems Medicine

مصطلحات موضوعية: gastrointestinal stromal tumour, ITGA4, survival, metastasis, proliferation, invasion, POOR-PROGNOSIS, CELL-GROWTH, RECURRENCE, IMATINIB, CANCER, VLA-4, RISK, KIT, INACTIVATION, Cancers, Biomedicine, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: The authors thank Marko Salmikangas and Nanna Merikoski for technical support. This study was supported by the Academy of Finland (Center of Excellence for Translational Cancer Biology), the Cancer Society of Finland, Jane and Aatos Erkko Foundation, the HUCH Research Funds and Sigrid Juselius Foundation.; Pulkka , O-P , Mpindi , J-P , Tynninen , O , Nilsson , B , Kallioniemi , O , Sihto , H & Joensuu , H 2018 , ' Clinical relevance of integrin alpha 4 in gastrointestinal stromal tumours ' , Journal of Cellular and Molecular Medicine , vol. 22 , no. 4 , pp. 2220-2230 . https://doi.org/10.1111/jcmm.13502; ORCID: /0000-0003-0281-2507/work/43955748; ORCID: /0000-0002-9151-6760/work/43956559; ORCID: /0000-0001-5265-5509/work/116550043; http://hdl.handle.net/10138/234502; 9541ebbf-57ba-4f80-aefc-b14f0a9dc738; 85041201597; 000428418200017

الاتاحة: http://hdl.handle.net/10138/234502

المؤلفون: Pulkka, Olli‐Pekka, Mpindi, John‐Patrick, Tynninen, Olli, Nilsson, Bengt, Kallioniemi, Olli, Sihto, Harri, Joensuu, Heikki

المساهمون: Academy of Finland, Syöpäjärjestöt, Jane ja Aatos Erkon Säätiö, Sigrid Juséliuksen Säätiö

المصدر: Journal of Cellular and Molecular Medicine ; volume 22, issue 4, page 2220-2230 ; ISSN 1582-1838 1582-4934

الاتاحة: https://doi.org/10.1111/jcmm.13502
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjcmm.13502
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jcmm.13502
https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jcmm.13502

المؤلفون: Hildebrand, Sebastian, Hultin, Sara, Subramani, Aravindh, Petropoulos, Sophie, Zhang, Yuanyuan, Cao, Xiaofang, Mpindi, John, Kalloniemi, Olli, Johansson, Staffan, Majumdar, Arindam, Lanner, Fredrik, Holmgren, Lars

المصدر: Scientific Reports. 7(1)

وصف الملف: electronic

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-339873
https://doi.org/10.1038/s41598-017-10102-w
https://uu.diva-portal.org/smash/get/diva2:1176791/FULLTEXT01.pdf

المؤلفون: Mpindi, John-Patrick, Potdar, Swapnil, Bychkov, Dmitrii, Saarela, Jani, Saeed, Khalid, Wennerberg, Krister, Aittokallio, Tero, Östling, Päivi, Kallioniemi, Olli

المساهمون: Institute for Molecular Medicine Finland, Olli-Pekka Kallioniemi / Principal Investigator, Krister Wennerberg / Principal Investigator, Tero Aittokallio / Principal Investigator, Bioinformatics

مصطلحات موضوعية: Biomedicine

وصف الملف: application/pdf

Relation: Mpindi , J-P , Potdar , S , Bychkov , D , Saarela , J , Saeed , K , Wennerberg , K , Aittokallio , T , Östling , P & Kallioniemi , O 2015 , ' Impact of normalization methods on high-throughput screening data with high hit rates and drug testing with dose-response data ' , Bioinformatics , vol. 31 , no. 23 , pp. 3815-3821 . https://doi.org/10.1093/bioinformatics/btv455; ORCID: /0000-0001-7306-7175/work/31491105; ORCID: /0000-0002-0886-9769/work/41148386; ORCID: /0000-0002-2778-6918/work/30632897; http://hdl.handle.net/10138/225095; 896a7644-1519-4d29-9cd4-a735947f167f; 84950296105; 000366378400014

الاتاحة: http://hdl.handle.net/10138/225095

المؤلفون: Aakula, Anna, Kohonen, Pekka, Leivonen, Suvi-Katri, Makela, Rami, Hintsanen, Petteri, Mpindi, John Patrick, Martens-Uzunova, Elena, Aittokallio, Tero, Jenster, Guido, Perala, Merja, Kallioniemi, Olli, Ostling, Paivi

المساهمون: Institute for Molecular Medicine Finland, Research Programs Unit, Genome-Scale Biology (GSB) Research Program, Tero Aittokallio / Principal Investigator, Olli-Pekka Kallioniemi / Principal Investigator, Bioinformatics

مصطلحات موضوعية: Functional high-throughput screening, MicroRNA, Prostate cancer, Reverse-phase protein array, RECEPTOR, GROWTH, MIGRATION, MIR-148A, PATHWAY, TARGETS, BREAST, LINES, Surgery, anesthesiology, intensive care, radiology

وصف الملف: application/pdf

Relation: The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement No. 201438.25, Academy of Finland Centre of Excellence in "Translational Genome-Scale Biology", Cancer Society of Finland, Sigrid Juselius Foundation, Swedish Research Council for Medicine and personal grants from Academy of Finland to S-KL, TA, and PO.; Aakula , A , Kohonen , P , Leivonen , S-K , Makela , R , Hintsanen , P , Mpindi , J P , Martens-Uzunova , E , Aittokallio , T , Jenster , G , Perala , M , Kallioniemi , O & Ostling , P 2016 , ' Systematic Identification of MicroRNAs That Impact on Proliferation of Prostate Cancer Cells and Display Changed Expression in Tumor Tissue ' , European Urology , vol. 69 , no. 6 , pp. 1120-1128 . https://doi.org/10.1016/j.eururo.2015.09.019; ORCID: /0000-0002-0886-9769/work/41148362; ORCID: /0000-0003-3224-0757/work/42416253; http://hdl.handle.net/10138/224030; 72a282d3-689c-4703-a76c-d553a8d82e45; 84950244331; 000377047400039

الاتاحة: http://hdl.handle.net/10138/224030

المؤلفون: Pietarinen, Paavo O, Eide, Christopher A, Ayuda-Duran, Maria del Pilar, Potdar, Swapnil, Kuusanmäki, Heikki, Andersson, Emma I, Mpindi, John P, Pemovska, Tea, Kontro, Mika, Heckman, Caroline A., Kallioniemi, Olli, Wennerberg, Krister, Hjorth-Hansen, Henrik, Druker, Brian J, Enserink, Jorrit, Tyner, Jeffrey W., Mustjoki, Satu, Porkka, Kimmo

المصدر: 1949-2553.

Relation: http://urn.nb.no/URN:NBN:no-88674; Pietarinen, Paavo O Eide, Christopher A Ayuda-Duran, Maria del Pilar Potdar, Swapnil Kuusanmäki, Heikki Andersson, Emma I Mpindi, John P Pemovska, Tea Kontro, Mika Heckman, Caroline A. Kallioniemi, Olli Wennerberg, Krister Hjorth-Hansen, Henrik Druker, Brian J Enserink, Jorrit Tyner, Jeffrey W. Mustjoki, Satu Porkka, Kimmo . Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors. OncoTarget. 2017, 8(14), 22606-22615; http://hdl.handle.net/10852/86007; 1484112; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=OncoTarget&rft.volume=8&rft.spage=22606&rft.date=2017; OncoTarget; 14; 22606; 22615; https://doi.org/10.18632/oncotarget.15146; URN:NBN:no-88674; Fulltext https://www.duo.uio.no/bitstream/handle/10852/86007/1/Pietarinen%2B2017%2B15146-224444-5-PB.pdf

الاتاحة: http://hdl.handle.net/10852/86007
http://urn.nb.no/URN:NBN:no-88674
https://doi.org/10.18632/oncotarget.15146

المؤلفون: Saeed, Khalid, Rahkama, Vesa-Pekka, Eldfors, Samuli, Bychkov, Dmitrii, Mpindi, John Patrick, Yadav, Bhagwan, Paavolainen, Lassi Olavi, Aittokallio, Tero Antero, Heckman, Caroline Akemi, Wennerberg, Johan Krister, Rannikko, Antti Sakari, Horvath, Peter, Mirtti, Tuomas Kristian, Peehl, D, Kallioniemi, Olli-Pekka, Östling, Päivi Kristiina, af Hällström, Taija Maria

المساهمون: Institute for Molecular Medicine Finland, Olli-Pekka Kallioniemi / Principal Investigator, Helsinki Institute for Information Technology, Tero Aittokallio / Principal Investigator, Research Programs Unit, Krister Wennerberg / Principal Investigator, Clinicum, Department of Surgery, Urologian yksikkö, Medicum, Department of Pathology, Bioinformatics, HUS Abdominal Center, Precision Systems Medicine

مصطلحات موضوعية: Surgery, anesthesiology, intensive care, radiology

وصف الملف: application/pdf

Relation: Saeed , K , Rahkama , V-P , Eldfors , S , Bychkov , D , Mpindi , J P , Yadav , B , Paavolainen , L O , Aittokallio , T A , Heckman , C A , Wennerberg , J K , Rannikko , A S , Horvath , P , Mirtti , T K , Peehl , D , Kallioniemi , O-P , Östling , P K & af Hällström , T M 2017 , ' Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer ' , European Urology , vol. 71 , no. 3 , pp. 319-327 . https://doi.org/10.1016/j.eururo.2016.04.019; ORCID: /0000-0003-0455-9891/work/33058449; ORCID: /0000-0002-4261-3484/work/31552175; ORCID: /0000-0002-0886-9769/work/41148399; ORCID: /0000-0001-5056-4750/work/33527224; ORCID: /0000-0003-1508-2718/work/98163291; http://hdl.handle.net/10138/178736; 10a13558-1204-415c-b36c-8c6fa24a7e61; 84965048641; 000396333700008

الاتاحة: http://hdl.handle.net/10138/178736

المؤلفون: Kolberg, Matthias, Bruun, Jarle, Murumägi, Astrid, Mpindi, John P., Bergsland, Christian H., Høland, Maren, Eilertsen, Ina A., Danielsen, Stine A., Kallioniemi, Olli, Lothe, Ragnhild A.

المساهمون: Norges Forskningsråd, Kreftforeningen, Helse Sør-Øst RHF, Universitetet i Oslo, Stiftelsen Kristian Gerhard Jebsen, Suomen Akatemia, Syöpäjärjestöt, Sigrid Juséliuksen Säätiö

المصدر: Molecular Oncology ; volume 11, issue 9, page 1156-1171 ; ISSN 1574-7891 1878-0261

الاتاحة: http://dx.doi.org/10.1002/1878-0261.12086
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F1878-0261.12086
https://onlinelibrary.wiley.com/doi/pdf/10.1002/1878-0261.12086
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/1878-0261.12086
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/1878-0261.12086

المؤلفون: Lehtinen, Laura, Vesterkvist, Pia, Roering, Pia, Korpela, Taina, Hattara, Liisa, Kaipio, Katja, Mpindi, John-Patrick, Hynninen, Johanna, Auranen, Annika, Davidson, Ben, Haglund, Caj, Iljin, Kristiina, Grenman, Seija, Siitari, Harri, Carpen, Olli

المصدر: Lehtinen , L , Vesterkvist , P , Roering , P , Korpela , T , Hattara , L , Kaipio , K , Mpindi , J-P , Hynninen , J , Auranen , A , Davidson , B , Haglund , C , Iljin , K , Grenman , S , Siitari , H & Carpen , O 2016 , ' REG4 Is Highly Expressed in Mucinous Ovarian Cancer: A Potential Novel Serum Biomarker ' , PLoS ONE , vol. 11 , no. 3 , e0151590 . https://doi.org/10.1371/journal.pone.0151590

مصطلحات موضوعية: ovarian cancer, biomarker, REG4, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الاتاحة: https://cris.vtt.fi/en/publications/5fc74b25-e6f1-4d9c-941e-0f977e5c4152
https://doi.org/10.1371/journal.pone.0151590

المؤلفون: Kangaspeska, Sara, Hultsch, Susanne, Jaiswal, Alok, Edgren, Henrik, Mpindi, John-Patrick, Eldfors, Samuli, Bruck, Oscar, Aittokallio, Tero, Kallioniemi, Olli

المساهمون: Institute for Molecular Medicine Finland, Olli-Pekka Kallioniemi / Principal Investigator, Tero Aittokallio / Principal Investigator, Bioinformatics

مصطلحات موضوعية: Tamoxifen resistance, Breast cancer, High-throughput drug testing, Exome-sequencing, Drug resistance, ESTROGEN-RECEPTOR-ALPHA, GROWTH-FACTOR RECEPTOR, COPY-NUMBER ALTERATION, ACTIVATED PROTEIN-KINASE, ANTIESTROGEN RESISTANCE, FUNCTIONAL SCREEN, MCF-7 CELLS, IN-VITRO, ER-ALPHA, Cancers

وصف الملف: application/pdf

Relation: The authors would like to express their sincerest thanks to Bhagwan Yadav, Swapnil Potdar, Dmitrii Bychkov, Ida Lindenschmidt and the whole FIMM Technology Centre personnel for their invaluable help in the drug testing and sequencing. Mariliina Arjama is acknowledged for excellent technical assistance, and Jing Tang for providing curated drug target (KIBA) data. This work was supported by Academy of Finland Post-Doctoral Researcher Grant (SK) and Research Grants 269862, 272437 and 279163 (TA) (www.aka.fi), the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no 258068; EU-FP7-Systems Microscopy NoE (SH), Academy of Finland Centre of Excellence, Integrative Life Science (ILS) doctoral program (AJ) (www.finbionet.fi/ils/), the Sigrid Juselius Foundation (http://sigridjuselius.fi), and the Cancer Society of Finland (www.cancer.fi).; Kangaspeska , S , Hultsch , S , Jaiswal , A , Edgren , H , Mpindi , J-P , Eldfors , S , Bruck , O , Aittokallio , T & Kallioniemi , O 2016 , ' Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer ' , BMC Cancer , vol. 16 , 378 . https://doi.org/10.1186/s12885-016-2452-5; ORCID: /0000-0002-0886-9769/work/41148389; ORCID: /0000-0001-5056-4750/work/33527226; ORCID: /0000-0002-7842-9419/work/137864715; http://hdl.handle.net/10138/165052; 4d0cf5c2-2cf7-4cf6-9a93-c213a1a82a6d; 84976871462; 000379119500001

الاتاحة: http://hdl.handle.net/10138/165052

المؤلفون: Khan, Suleiman A., Faisal, Ali, Mpindi, John Patrick, Parkkinen, Juuso A., Kalliokoski, Tuomo, Poso, Antti, Kallioniemi, Olli P., Wennerberg, Krister, Kaski, Samuel

المساهمون: Institute for Molecular Medicine Finland, Helsinki Institute for Information Technology, Department of Computer Science

مصطلحات موضوعية: SMALL MOLECULES, EXPRESSION, DISCOVERY, FRAMEWORK, MECHANISM, Biomedicine

وصف الملف: application/pdf

Relation: SuK, AF, JP, and SaK belong to the Adaptive Informatics Research Center at Aalto University School of Science. This work was supported by the Academy of Finland [Center of Excellence funding no. 213502 (Translational Genome-scale Biology) and funding no. 140057 (Computational modeling of the biological effects of chemicals)], the PASCAL2 Network of Excellence, ICT [216886], Sigrid Juselius Foundation, Cancer Society of Finland, the Jane and Aatos Erkko Foundation, the HBGS graduate school (J-PM), the FICS graduate school (SuK and AF), and the HECSE graduate school (JP).; Khan , S A , Faisal , A , Mpindi , J P , Parkkinen , J A , Kalliokoski , T , Poso , A , Kallioniemi , O P , Wennerberg , K & Kaski , S 2012 , ' Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs ' , BMC Bioinformatics , vol. 13 , pp. Article Number: 112 . https://doi.org/10.1186/1471-2105-13-112; http://hdl.handle.net/10138/162793; 26245ddc-638c-4b46-8447-92fb65253925; 84861545549; 000312892600001

الاتاحة: http://hdl.handle.net/10138/162793