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1
المؤلفون: Lori Krim Gavrin, David Hepworth, Jennifer R. Thomason, Iain Kilty, Joel Adam Goldberg, Christoph W. Zapf, Vikram R. Rao, Brian P. Boscoe, Akshay Patny, Peter T. Symanowicz, Marina W.H. Shen, Kevin J. Curran, Elizabeth Murphy, Martin Hegen, Fabien Vincent, Richard Vargas, Satwik Kamtekar, Heidi M. Morgan, Heidi R. Hope, Richard K. Frisbie, Jeanne S. Chang, Ken Dower, Susan E. Drozda, Strohbach Joseph Walter, Mathias John Paul, David R. Anderson, Jacqueline E. Day, Stephen W. Wright, Ivan J. Samardjiev, Seungil Han, Julia H Shin, Frank Lovering, Andrea G Bree, Arthur Lee, Holly H. Soutter, Joanne Brodfuehrer, John David Trzupek, Brian Samas, Christoph Martin Dehnhardt, Michael Dennis Lowe, Catherine M. Ambler, Seung Won Chung, Eddine Saiah, Nikolaos Papaioannou, Pierce Betsy S, Jiangli Yan, Katherine L. Lee, Lih-Ling Lin, Chulho Choi
المصدر: Journal of Medicinal Chemistry. 60:5521-5542
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Lactams, Stereochemistry, medicine.drug_class, Administration, Oral, Carboxamide, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, medicine, Humans, Structure–activity relationship, Protein Kinase Inhibitors, ADME, Dose-Response Relationship, Drug, Molecular Structure, biology, Drug discovery, Chemistry, Active site, Isoquinolines, IRAK4, Combinatorial chemistry, Interleukin-1 Receptor-Associated Kinases, 030104 developmental biology, Lipophilic efficiency, Lipophilicity, biology.protein, Molecular Medicine
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2
المؤلفون: Eddine Saiah, Lori Krim Gavrin, Rajiah Aldrin Denny
المصدر: Bioorganic & Medicinal Chemistry Letters. 23(7):1935-1944
مصطلحات موضوعية: Models, Molecular, Protein Folding, Clinical Biochemistry, Toxic oligomer, Pharmaceutical Science, Chaperone, Gaucher disease, Computational biology, Biochemistry, Cystic fibrosis, Small Molecule Libraries, Biological pathway, Protein Misfolding Diseases, Drug Discovery, Humans, Proteostasis Deficiencies, HSF1, Molecular Biology, biology, Organic Chemistry, Serum amyloid P (SAP), Small molecule, Proteostasis, Chaperone (protein), biology.protein, Thermodynamics, Molecular Medicine, Protein folding, Glucocerebrosidase, Protein misfolding
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3
المؤلفون: Lori Krim Gavrin, Eddine Saiah
المصدر: MedChemComm. 4:41-51
مصطلحات موضوعية: Pharmacology, Kinase, Organic Chemistry, Pharmaceutical Science, Biology, Biochemistry, Small molecule, Atp competitive, Sequence homology, Activation loop, Drug Discovery, Molecular Medicine, Binding site
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4
المؤلفون: Eddine Saiah, Rajiah Aldrin Denny, Lori Krim Gavrin
المصدر: Journal of Medicinal Chemistry. 55:10823-10843
مصطلحات موضوعية: Models, Molecular, Amyloid, Protein Folding, Receptors, Vasopressin, Prions, Protein Conformation, Plasma protein binding, Small Molecule Libraries, Superoxide dismutase, Superoxide Dismutase-1, Protein structure, Drug Discovery, medicine, Animals, Humans, Prealbumin, Proteostasis Deficiencies, Serum Amyloid A Protein, biology, Superoxide Dismutase, Chemistry, Proteins, Neurodegenerative Diseases, Nephrogenic diabetes insipidus, medicine.disease, nervous system diseases, Transthyretin, Biochemistry, alpha 1-Antitrypsin, Mutation, Unfolded Protein Response, Unfolded protein response, biology.protein, Molecular Medicine, Muramidase, Protein folding, Target protein, Tumor Suppressor Protein p53, Protein Binding
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5
المؤلفون: Desiree H.H. Tsao, Arthur Lee, Lori Krim Gavrin, Franklin J. Moy, Zhang Bao Xu, John C. McKew, Lidia Mosyak, Elizabeth Kieras, Wayne Stochaj, Annette Sievers
المصدر: Journal of Medicinal Chemistry. 53:1238-1249
مصطلحات موضوعية: Models, Molecular, Binding Sites, Magnetic Resonance Spectroscopy, Molecular Structure, Protein Conformation, Kinase, Chemistry, Electron Spin Resonance Spectroscopy, Crystallography, X-Ray, Pyrazolopyrimidine, Paramagnetism, chemistry.chemical_compound, Adenosine Triphosphate, Nuclear magnetic resonance, Drug Discovery, Humans, Molecular Medicine, Spin Labels, Protein Kinase Inhibitors, Protein Kinases, Protein Binding, Proto-oncogene tyrosine-protein kinase Src
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6
المؤلفون: Jennifer Leiter, An T. Vu, Yingru Zhang, Sharon Rosenzweig-Lipson, Fei Ye, Valerie Smith, Stephen Todd Cohn, Douglas M. Ho, Elizabeth Koury, Justin K. Belardi, Darlene C. Deecher, Cheryl A. Mugford, Grace H. Johnston, Gary Paul Stack, Kevin D. Burroughs, Eugene John Trybulski, Scott Cosmi, Jenifer A. Bray, Joseph Peter Sabatucci, Lori Krim Gavrin, Liza Leventhal, Paige Erin Mahaney, Brian J. Platt, Arthur A. Santilli
المصدر: Journal of Medicinal Chemistry. 51:4038-4049
مصطلحات موضوعية: Male, Models, Molecular, Pain, Venlafaxine, Pharmacology, Cell Line, Norepinephrine (medication), Mice, Norepinephrine, Structure-Activity Relationship, Norepinephrine reuptake inhibitor, Dopamine, Drug Discovery, Ethylamines, medicine, Animals, Humans, Serotonin transporter, Dopamine transporter, Molecular Structure, Symporters, biology, Chemistry, Cyclohexanols, Rats, biology.protein, Molecular Medicine, Female, Serotonin, WY-46824, medicine.drug
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7
المؤلفون: Jennifer R. Thomason, J. Perry Hall, Kristin Janz, Huan-Qiu Li, Lori Krim Gavrin, Jean-Baptiste Telliez, Lih-Ling Lin, Neelu Kaila, John W. Cuozzo, Sang Hsu, Neal Green, Tam Steve Yik-Kai, Qin Wang, Yonghan Hu, Cheryl Nickerson-Nutter, Dennis Powell
المصدر: Bioorganic & Medicinal Chemistry. 15:6425-6442
مصطلحات موضوعية: Lipopolysaccharides, Stereochemistry, p38 mitogen-activated protein kinases, Clinical Biochemistry, Pharmaceutical Science, Protein Serine-Threonine Kinases, Binding, Competitive, p38 Mitogen-Activated Protein Kinases, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Proto-Oncogene Proteins, Nitriles, Drug Discovery, Animals, Structure–activity relationship, Cycloheptanes, Enzyme Inhibitors, Naphthyridines, Protein Kinase Inhibitors, Molecular Biology, biology, Bicyclic molecule, Tumor Necrosis Factor-alpha, Kinase, Organic Chemistry, Intracellular Signaling Peptides and Proteins, MAP Kinase Kinase Kinases, Rats, ErbB Receptors, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Mitogen-Activated Protein Kinases, Signal transduction, Lead compound
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8
المؤلفون: Jean-Baptiste Telliez, Tam Steve Yik-Kai, Neal Green, Huan-Qiu Li, Yonghan Hu, Cheryl Nickerson-Nutter, Neelu Kaila, Lori Krim Gavrin, Jennifer R. Thomason, J. Perry Hall, John W. Cuozzo, Sang Hsu, Kristin Janz, Lih-Ling Lin
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:6067-6072
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Arthritis, Pharmacology, Biochemistry, Monocytes, Arthritis, Rheumatoid, Structure-Activity Relationship, Nitriles, Drug Discovery, medicine, Humans, Protein kinase A, Molecular Biology, Whole blood, chemistry.chemical_classification, Molecular Structure, Tumor Necrosis Factor-alpha, Kinase, Organic Chemistry, Imidazoles, MAP Kinase Kinase Kinases, medicine.disease, In vitro, Cross-Linking Reagents, Enzyme, chemistry, Quinolines, Molecular Medicine, Phosphorylation, Signal transduction
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9
المؤلفون: Neelu Kaila, Neal Green, Huan-Qiu Li, Yonghan Hu, Jennifer R. Thomason, J. Perry Hall, Ariamala Gopalsamy, Tam Steve Yik-Kai, Kristin Janz, Lih-Ling Lin, Greg Ciszewski, Jean-Baptiste Telliez, Lori Krim Gavrin, John W. Cuozzo, Sang Hsu
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:5288-5292
مصطلحات موضوعية: medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Arthritis, Pharmacology, Biochemistry, Chemical synthesis, Arthritis, Rheumatoid, Structure-Activity Relationship, Proto-Oncogene Proteins, Nitriles, Drug Discovery, medicine, Humans, Structure–activity relationship, Naphthyridines, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, biology, Tumor Necrosis Factor-alpha, Chemistry, Kinase, Organic Chemistry, MAP Kinase Kinase Kinases, medicine.disease, Cytokine, Enzyme inhibitor, biology.protein, Molecular Medicine, Signal transduction
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10
المؤلفون: Jennifer Leiter, Kevin D. Burroughs, Eugene John Trybulski, Douglas John Jenkins, Grace H. Johnston, Darlene C. Deecher, Jenifer A. Bray, Lori Krim Gavrin, Douglas M. Ho, Lisa Nogle, Christine Huselton, Paige Erin Mahaney, Scott Cosmi, Peter D. Alfinito, Cheryl A. Mugford
مصطلحات موضوعية: biology, Chemistry, Organic Chemistry, Transporter, Pharmacology, Biochemistry, Norepinephrine transporter, Norepinephrine reuptake inhibitor, Dopamine, Drug Discovery, biology.protein, medicine, Potency, Serotonin, Serotonin transporter, Dopamine transporter, medicine.drug
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11
المؤلفون: Brian A. Provencher, Walter W. Massefski, John C. McKew, Gregory M. Ciszewski, Arthur Lee, Stephen D. Huhn, Derek Cecil Cole, Lori Krim Gavrin
المصدر: The Journal of organic chemistry. 72(3)
مصطلحات موضوعية: Reaction mechanism, Chemistry, Organic Chemistry, Anti-Inflammatory Agents, General Medicine, Pyrimidinones, Chemical synthesis, Combinatorial chemistry, Pyrazolopyrimidine, chemistry.chemical_compound, Schistosomicides, Isomerism, Models, Chemical, Electrophile, Structural isomer, Organic chemistry, Pyrazoles, Uracil