المؤلفون: Joseph A Leedale, Baltasar Lucendo-Villarin, Jose Meseguer-Ripolles, Alvile Kasarinaite, Steven D Webb, David C Hay

المصدر: PLoS ONE, Vol 16, Iss 2, p e0244070 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/f606f79e86c84e768d428358c04cb832

المؤلفون: Joseph A. Leedale (7903754), Baltasar Lucendo-Villarin (10113133), Jose Meseguer-Ripolles (5070326), Alvile Kasarinaite (10113136), Steven D. Webb (7160372), David C. Hay (5070335)

مصطلحات موضوعية: Cell Biology, Genetics, Physiology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, oxygen gradients, zonated liver function, cell culture conditions, fidelity PSC-derived liver tissue, animal cell lines, liver physiology, modelling, vivo, PSC-derived liver sphere systems, cell types, cell-derived liver tissue, cell-specific oxygen uptake, model

Relation: https://figshare.com/articles/journal_contribution/S1_File_-/13758358

الاتاحة: https://doi.org/10.1371/journal.pone.0244070.s001

المؤلفون: Joseph A. Leedale, Jonathan A. Kyffin, Amy L. Harding, Helen E. Colley, Craig Murdoch, Parveen Sharma, Dominic P. Williams, Steven D. Webb, Rachel N. Bearon

مصطلحات موضوعية: Systems Biology, Computational Biology, Biological Mathematics, drug transport, spheroid, organoid, hepatocytes, systems pharmacology, mathematical modelling

Relation: https://figshare.com/articles/presentation/Supplementary_Animations_from_Multiscale_modelling_of_drug_transport_and_metabolism_in_liver_spheroids/10595939

الاتاحة: https://doi.org/10.6084/m9.figshare.10595939.v1
https://figshare.com/articles/presentation/Supplementary_Animations_from_Multiscale_modelling_of_drug_transport_and_metabolism_in_liver_spheroids/10595939

المؤلفون: Joseph A. Leedale, Jonathan A. Kyffin, Amy L. Harding, Helen E. Colley, Craig Murdoch, Parveen Sharma, Dominic P. Williams, Steven D. Webb, Rachel N. Bearon

مصطلحات موضوعية: Systems Biology, Computational Biology, Biological Mathematics, drug transport, spheroid, organoid, hepatocytes, systems pharmacology, mathematical modelling

Relation: https://figshare.com/articles/journal_contribution/Supplementary_material_from_Multiscale_modelling_of_drug_transport_and_metabolism_in_liver_spheroids/10595936

الاتاحة: https://doi.org/10.6084/m9.figshare.10595936.v1
https://figshare.com/articles/journal_contribution/Supplementary_material_from_Multiscale_modelling_of_drug_transport_and_metabolism_in_liver_spheroids/10595936

المؤلفون: Joseph A. Leedale (7903754), Baltasar Lucendo-Villarin (10113133), Jose Meseguer-Ripolles (5070326), Alvile Kasarinaite (10113136), Steven D. Webb (7160372), David C. Hay (5070335)

مصطلحات موضوعية: Cell Biology, Genetics, Physiology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, oxygen gradients, zonated liver function, cell culture conditions, fidelity PSC-derived liver tissue, animal cell lines, liver physiology, modelling, vivo, PSC-derived liver sphere systems, cell types, cell-derived liver tissue, cell-specific oxygen uptake, model

Relation: https://figshare.com/articles/figure/Liver_sphere_functional_characterisation_/13758385

الاتاحة: https://doi.org/10.1371/journal.pone.0244070.g006

المؤلفون: Joseph A. Leedale (7903754), Baltasar Lucendo-Villarin (10113133), Jose Meseguer-Ripolles (5070326), Alvile Kasarinaite (10113136), Steven D. Webb (7160372), David C. Hay (5070335)

مصطلحات موضوعية: Cell Biology, Genetics, Physiology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, oxygen gradients, zonated liver function, cell culture conditions, fidelity PSC-derived liver tissue, animal cell lines, liver physiology, modelling, vivo, PSC-derived liver sphere systems, cell types, cell-derived liver tissue, cell-specific oxygen uptake, model

Relation: https://figshare.com/articles/figure/Optimising_spheroid_properties_/13758376

الاتاحة: https://doi.org/10.1371/journal.pone.0244070.g004

المؤلفون: Joseph A. Leedale (7903754), Baltasar Lucendo-Villarin (10113133), Jose Meseguer-Ripolles (5070326), Alvile Kasarinaite (10113136), Steven D. Webb (7160372), David C. Hay (5070335)

مصطلحات موضوعية: Cell Biology, Genetics, Physiology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, oxygen gradients, zonated liver function, cell culture conditions, fidelity PSC-derived liver tissue, animal cell lines, liver physiology, modelling, vivo, PSC-derived liver sphere systems, cell types, cell-derived liver tissue, cell-specific oxygen uptake, model

Relation: https://figshare.com/articles/figure/Model_geometry_/13758364

الاتاحة: https://doi.org/10.1371/journal.pone.0244070.g001

المؤلفون: Joseph A. Leedale (7903754), Baltasar Lucendo-Villarin (10113133), Jose Meseguer-Ripolles (5070326), Alvile Kasarinaite (10113136), Steven D. Webb (7160372), David C. Hay (5070335)

مصطلحات موضوعية: Cell Biology, Genetics, Physiology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, oxygen gradients, zonated liver function, cell culture conditions, fidelity PSC-derived liver tissue, animal cell lines, liver physiology, modelling, vivo, PSC-derived liver sphere systems, cell types, cell-derived liver tissue, cell-specific oxygen uptake, model

Relation: https://figshare.com/articles/figure/Model_simulation_/13758370

الاتاحة: https://doi.org/10.1371/journal.pone.0244070.g002

المؤلفون: Joseph A. Leedale (7903754), Baltasar Lucendo-Villarin (10113133), Jose Meseguer-Ripolles (5070326), Alvile Kasarinaite (10113136), Steven D. Webb (7160372), David C. Hay (5070335)

مصطلحات موضوعية: Cell Biology, Genetics, Physiology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, oxygen gradients, zonated liver function, cell culture conditions, fidelity PSC-derived liver tissue, animal cell lines, liver physiology, modelling, vivo, PSC-derived liver sphere systems, cell types, cell-derived liver tissue, cell-specific oxygen uptake, model

Relation: https://figshare.com/articles/figure/Impact_of_varying_spheroid_properties_/13758373

الاتاحة: https://doi.org/10.1371/journal.pone.0244070.g003

المؤلفون: Joseph A. Leedale (7903754), Baltasar Lucendo-Villarin (10113133), Jose Meseguer-Ripolles (5070326), Alvile Kasarinaite (10113136), Steven D. Webb (7160372), David C. Hay (5070335)

مصطلحات موضوعية: Cell Biology, Genetics, Physiology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, oxygen gradients, zonated liver function, cell culture conditions, fidelity PSC-derived liver tissue, animal cell lines, liver physiology, modelling, vivo, PSC-derived liver sphere systems, cell types, cell-derived liver tissue, cell-specific oxygen uptake, model

Relation: https://figshare.com/articles/figure/Sensitivity_analysis_of_the_optimised_parameters_/13758379

الاتاحة: https://doi.org/10.1371/journal.pone.0244070.g005

المؤلفون: Joseph A. Leedale (7903754), Baltasar Lucendo-Villarin (10113133), Jose Meseguer-Ripolles (5070326), Alvile Kasarinaite (10113136), Steven D. Webb (7160372), David C. Hay (5070335)

مصطلحات موضوعية: Cell Biology, Genetics, Physiology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, oxygen gradients, zonated liver function, cell culture conditions, fidelity PSC-derived liver tissue, animal cell lines, liver physiology, modelling, vivo, PSC-derived liver sphere systems, cell types, cell-derived liver tissue, cell-specific oxygen uptake, model

Relation: https://figshare.com/articles/dataset/Quantitative_oxygen_metrics_mmol_L_mmHg_and_for_concentrations_within_the_media_/13758406

الاتاحة: https://doi.org/10.1371/journal.pone.0244070.t002

المؤلفون: Joseph A. Leedale (7903754), Baltasar Lucendo-Villarin (10113133), Jose Meseguer-Ripolles (5070326), Alvile Kasarinaite (10113136), Steven D. Webb (7160372), David C. Hay (5070335)

مصطلحات موضوعية: Cell Biology, Genetics, Physiology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, oxygen gradients, zonated liver function, cell culture conditions, fidelity PSC-derived liver tissue, animal cell lines, liver physiology, modelling, vivo, PSC-derived liver sphere systems, cell types, cell-derived liver tissue, cell-specific oxygen uptake, model

Relation: https://figshare.com/articles/figure/Multiple_spheroids_per_well_Random_array_/13758394

الاتاحة: https://doi.org/10.1371/journal.pone.0244070.g008

المؤلفون: Joseph A. Leedale (7903754), Baltasar Lucendo-Villarin (10113133), Jose Meseguer-Ripolles (5070326), Alvile Kasarinaite (10113136), Steven D. Webb (7160372), David C. Hay (5070335)

مصطلحات موضوعية: Cell Biology, Genetics, Physiology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, oxygen gradients, zonated liver function, cell culture conditions, fidelity PSC-derived liver tissue, animal cell lines, liver physiology, modelling, vivo, PSC-derived liver sphere systems, cell types, cell-derived liver tissue, cell-specific oxygen uptake, model

Relation: https://figshare.com/articles/figure/Multiple_spheroids_per_well_Random_array_with_ordered_size_distribution_/13758397

الاتاحة: https://doi.org/10.1371/journal.pone.0244070.g009

المؤلفون: Joseph A. Leedale (7903754), Baltasar Lucendo-Villarin (10113133), Jose Meseguer-Ripolles (5070326), Alvile Kasarinaite (10113136), Steven D. Webb (7160372), David C. Hay (5070335)

مصطلحات موضوعية: Cell Biology, Genetics, Physiology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, oxygen gradients, zonated liver function, cell culture conditions, fidelity PSC-derived liver tissue, animal cell lines, liver physiology, modelling, vivo, PSC-derived liver sphere systems, cell types, cell-derived liver tissue, cell-specific oxygen uptake, model

Relation: https://figshare.com/articles/dataset/Quantitative_oxygen_metrics_mmol_L_mmHg_and_for_concentrations_within_the_spheroid_array_/13758400

الاتاحة: https://doi.org/10.1371/journal.pone.0244070.t001