المؤلفون: Sven Ruf, Britta Böhnisch, Katja Kroll, Christian Buning, Alexander Liesum, Herman Schreuder, Thorsten Sadowski

المصدر: Biochemical and Biophysical Research Communications. 445:451-456

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, Biophysics, Cathepsin A, Crystallography, X-Ray, Ligands, Biochemistry, Serine, chemistry.chemical_compound, Cathepsin O, Tetrahedral carbonyl addition compound, Drug Discovery, Hydrolase, Humans, Molecular Targeted Therapy, Carboxylate, Molecular Biology, biology, Chemistry, Active site, Cell Biology, Recombinant Proteins, Cardiovascular Diseases, biology.protein, Oxyanion hole, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded4d232a133ff994fb823478089514e
https://doi.org/10.1016/j.bbrc.2014.02.014

المؤلفون: Herman Schreuder, Heike Enke, Matthias Schiell, Heike Di. Stump, Luigi Toti, Jörg Czech, Vasant Kumar, Alexander Liesum, Vincent Morrison, Timo H. J. Niedermeyer, Holger Hoffmann, Daniel B. Kramer, Christine Klemke-Jahn, Michael Kurz, Petra Lönze, Christopher Kallus, Mark Brönstrup, Armin Bauer

المساهمون: Helmholtz Centre of infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.

المصدر: Scientific Reports
'Scientific Reports ', vol: 6, pages: 32958-1-32958-9 (2016)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Carboxypeptidase B2, medicine.medical_treatment, Crystallography, X-Ray, Cyanobacteria, 01 natural sciences, Peptides, Cyclic, Fibrin, Article, 03 medical and health sciences, Structure-Activity Relationship, Bacterial Proteins, Catalytic Domain, Fibrinolysis, medicine, Structure–activity relationship, Humans, chemistry.chemical_classification, Multidisciplinary, Protease, biology, 010405 organic chemistry, Chemistry, Active site, Carboxypeptidase, Cyclic peptide, Carboxypeptidase B, 0104 chemical sciences, 030104 developmental biology, Biochemistry, biology.protein, Crystallization

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdd5b909e8f9ba27c50b07dc43e0ff0
https://hdl.handle.net/10033/621048

المؤلفون: Armin Walser, Silke Herok, Uwe Heinelt, Peter-Michael Blohm, Hans Matter, Detlev Schneider, Volker Brachvogel, Petra Lönze, Alexander Liesum, Elisabeth Defossa, Andrea Müller, Herman Schreuder, Peter Wildgoose, Fahad Al-Obeidi

المصدر: Journal of Medicinal Chemistry. 45:2749-2769

مصطلحات موضوعية: Models, Molecular, Quantitative structure–activity relationship, Indoles, Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Molecular model, Stereochemistry, Factor Xa Inhibitor, Amidines, Quantitative Structure-Activity Relationship, Stereoisomerism, Crystallography, X-Ray, Drug Discovery, Hydrolase, medicine, Binding site, Binding Sites, biology, Chemistry, Amides, Docking (molecular), Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Factor Xa Inhibitors, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a726565af642ccfaba27630b1476d74a
https://doi.org/10.1021/jm0111346

المؤلفون: Milan Fábry, Anusch Peyman, Rolf Hilgenfeld, Alexander Liesum, Karl-Heinz Budt, Jochen Knolle, Juraj Sedlacek, Harald Berchtold, Gudrun Lange-Savage

المصدر: European Journal of Biochemistry. 248:313-322

مصطلحات موضوعية: Models, Molecular, Polyproteins, Protein Conformation, Stereochemistry, medicine.medical_treatment, Dimer, Molecular Sequence Data, Diol, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Protein structure, HIV Protease, medicine, Structure–activity relationship, chemistry.chemical_classification, Protease, biology, Active site, Valine, HIV Protease Inhibitors, Crystallography, Enzyme, chemistry, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eac75eb4346a1fc19081faa07511f50
https://doi.org/10.1111/j.1432-1033.1997.00313.x

المؤلفون: Ru¨diger Storm, Andreas Plaas-Link, Alexander Liesum, Rolf Hilgenfeld

المصدر: Journal of Crystal Growth. 122:330-336

مصطلحات موضوعية: Diffraction, Chemistry, Crystal growth, Bacterial enzymes, Condensed Matter Physics, Space (mathematics), law.invention, Inorganic Chemistry, chemistry.chemical_compound, Crystallography, Thermolysin, law, Area detector, Materials Chemistry, Lysozyme, Crystallization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f59a74806f516d7cb87984d6f7722104
https://doi.org/10.1016/0022-0248(92)90265-k

المؤلفون: Jens Pohl, Masayoshi Koyama, Michael Kruse, Alexander Liesum, Herman Schreuder

المصدر: Biochemical and biophysical research communications. 329(3)

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Protein Conformation, medicine.medical_treatment, Molecular Sequence Data, Biophysics, Crystal structure, Biology, Protein Serine-Threonine Kinases, Bone Morphogenetic Protein Receptors, Type II, Biochemistry, Epitope, Mice, Structure-Activity Relationship, Growth Differentiation Factor 5, medicine, Animals, Humans, Computer Simulation, Receptors, Growth Factor, Amino Acid Sequence, Receptor, Molecular Biology, Bone Morphogenetic Protein Receptors, Type I, Binding Sites, Crystallography, Sequence Homology, Amino Acid, Growth factor, Insulin-like growth factor 2 receptor, Cystine knot, Growth differentiation factor, Cell Biology, BMPR2, Bone Morphogenetic Proteins, Stromal Cells, Crystallization, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a6bc28b7adcdd9f093f72c4f4fd1fc
https://pubmed.ncbi.nlm.nih.gov/15752764

المؤلفون: Werner Aretz, Klaus Sauber, Wolfgang Kabsch, Karin Fritz-Wolf, Alexander Liesum, Gudrun Lange, Herman Schreuder, Klaus Peter Koller

المصدر: Protein Science

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Molecular Sequence Data, Penicillin amidase, Crystallography, X-Ray, Biochemistry, Article, Catalysis, Amidohydrolases, Serine, chemistry.chemical_compound, Catalytic triad, Hydrolase, Amino Acid Sequence, Molecular Biology, Histidine, Cephalosporin Antibiotic, chemistry.chemical_classification, Cephalosporin C, Anti-Bacterial Agents, Cephalosporins, Enzyme, Models, Chemical, chemistry, Mutation, Penicillin Amidase, Dimerization, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2067014d33485adda53fc9fbc299e4
http://onlinelibrary.wiley.com/doi/10.1110/ps.27502/full

المؤلفون: Corinna Lippmann, H.G. Wittmann, Winfried Hinrichs, Ada Yonath, Wolfram Saenger, Julia Hoven, Alexander Liesum, Volker A. Erdmann, Christoph W. Müller, Anke Müller-Fahrnow, Keith S. Wilson, Z. Dauter, Gabriela Weber, Martina Düvel, Andreas Plaas-Link, Christian Betzel, Rolf Hilgenfeld, Georg E. Schulz, Karin Stegen

المصدر: FEBS Letters. 259:194-198

مصطلحات موضوعية: Diffraction, Chemistry, Biophysics, Crystal growth, Cell Biology, Biochemistry, law.invention, Crystal, Crystallography, Structural Biology, Chemical physics, law, Genetics, Microgravity, Crystallization, Protein crystallization, Molecular Biology, Macromolecule

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a979eb09e90dd7e4b9d94903d8194b
https://doi.org/10.1016/0014-5793(89)81526-1

المؤلفون: Rüdiger Storm, Alexander Liesum, Rolf Hilgenfeld, Hubert J. Metzner, Hermann Karges

المصدر: FEBS Letters. (1-2):110-112

مصطلحات موضوعية: Blood coagulation factor XIII, Placenta, Biophysics, Biochemistry, law.invention, X-Ray Diffraction, Structural Biology, law, Pregnancy, Genetics, medicine, Humans, Crystallization, Molecular Biology, X-ray crystallography, Enzyme Precursors, Chromatography, Factor XIII, Chemistry, Crystallization robotic, Human placenta, Cell Biology, Transglutaminase, Crystallography, Robotic systems, Orthorhombic crystal system, Female, Protein crystallization, Monoclinic crystal system, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6285fc6d90a44fc50d63a6ca2052ce